Details of Disease | DrugMAP

General Information of Disease (ID: DISQOQJU)

Disease Name	Nongerminomatous germ cell tumor
Synonyms	NSGCT; non-dysgerminomatous germ cell tumour; Nongerminomatous germ cell tumor Including central nervous system; Nongerminomatous germ cell tumour Including central nervous system; Nongerminomatous germ cell tumour; non-seminomatous germ cell tumour; non-dysgerminomatous germ cell tumor; non-germinomatous germ cell tumor; non-germinomatous germ cell tumour; Nongerminomatous germ cell tumor; non-seminomatous germ cell tumor
Definition	A term that refers to teratoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, or mixed forms of these tumors.
Disease Hierarchy	DIS62070: Germ cell tumor DISQOQJU: Nongerminomatous germ cell tumor
Disease Identifiers	MONDO ID MONDO_0021656 MESH ID C537844 UMLS CUI C1266158 MedGen ID 220426 SNOMED CT ID 128766005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AFP	TTCFEA1	Strong	Biomarker	[1]
MAGEA1	TT63M7Q	Strong	Altered Expression	[2]
SLAMF7	TT7ILZ1	Strong	Biomarker	[3]
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This Disease Is Related to 7 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DDX4	OTQOV093	Limited	Altered Expression	[4]
CLSTN1	OTQN35G2	Strong	Biomarker	[3]
ITPRID2	OTO3JDX5	Strong	Biomarker	[3]
MAGED4B	OTO37U7W	Strong	Altered Expression	[2]
MYOZ2	OTMEIQJA	Strong	Biomarker	[3]
TCF7L1	OTTUTF0O	Strong	Biomarker	[5]
TRIM44	OT0B1T2B	Strong	Altered Expression	[6]
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⏷ Show the Full List of 7 DOT(s)

References

1	Treatment and Outcome of Patients with Stage IS Testicular Cancer: A Retrospective Study from the Spanish Germ Cell Cancer Group.J Urol. 2019 Oct;202(4):742-747. doi: 10.1097/JU.0000000000000366. Epub 2019 Sep 6.
2	Expression of MAGE genes in testicular germ cell tumors.Urology. 1999 Apr;53(4):843-7. doi: 10.1016/s0090-4295(98)00618-9.
3	Economy of Standards: European Association of Urology Guideline Changes Influence Treatment Costs in Stage I Testicular Cancer Patients.Urol Int. 2018;100(3):279-287. doi: 10.1159/000486343. Epub 2018 Mar 7.
4	VASA is a specific marker for both normal and malignant human germ cells.Lab Invest. 2002 Feb;82(2):159-66. doi: 10.1038/labinvest.3780408.
5	Wnt suppressor and stem cell regulator TCF7L1 is a sensitive immunohistochemical marker to differentiate testicular seminoma from non-seminomatous germ cell tumor.Exp Mol Pathol. 2019 Oct;110:104293. doi: 10.1016/j.yexmp.2019.104293. Epub 2019 Aug 2.
6	A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor.Cancer Sci. 2017 Jan;108(1):32-41. doi: 10.1111/cas.13105. Epub 2016 Dec 1.