Details of Disease

General Information of Disease (ID: DISVT5Q7)

• Disease Name: Viral hepatitis
• Synonyms: viral hepatitis with hepatic coma; unspecified viral hepatitis with hepatic coma; viral human hepatitis; Viruses caused hepatitis; viral Hepatitis; Hepatitis viral; Viruses hepatitis; human viral hepatitis
• Definition: An acute or chronic inflammation of the liver parenchyma caused by viruses. Representative examples include hepatitis A, B, and C, cytomegalovirus hepatitis, and herpes simplex hepatitis.|Editor note: consider adding term for viral
• Disease Hierarchy:
  DISDI77C: Primary viral infectious disease
  DISARSGM: Gastrointestinal infection
  DISXXX35: Hepatitis
  DISEM33Q: Infectious disease
  DISVT5Q7: Viral hepatitis
• Disease Identifiers:
  MONDO ID: MONDO_0006011
  UMLS CUI: C0042721
  MedGen ID: 22652
  HPO ID: HP:0006562
  SNOMED CT ID: 3738000

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IFNL3	TTRF4Q2	Limited	Biomarker	[1]
APOA2	TTGQA9W	Strong	Biomarker	[2]
F10	TTCIHJA	Strong	Biomarker	[3]
FGL2	TTYBS89	Strong	Altered Expression	[4]
IFNAR2	TTMQB37	Strong	Biomarker	[5]
KLRC1	TTC4IMS	Strong	Altered Expression	[6]
PNPLA3	TTEUAEH	Strong	Genetic Variation	[7]

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
GPT	DER5HFI	Limited	Biomarker	[8]
TPMT	DEFQ8VO	Disputed	Genetic Variation	[9]

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCL3L1	OTQXCYB1	Strong	Genetic Variation	[10]
FBL	OTRODIE5	Strong	Biomarker	[11]
FKBP11	OTY2GC67	Strong	Altered Expression	[12]
IL18BP	OTW0LRYZ	Strong	Biomarker	[13]
LGALS3BP	OT9AGQKH	Strong	Biomarker	[14]

References

• [1] Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil.Rev Soc Bras Med Trop. 2017 Jul-Aug;50(4):470-477. doi: 10.1590/0037-8682-0450-2016.
• [2] Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function.J Immunol. 2011 Mar 15;186(6):3410-20. doi: 10.4049/jimmunol.1002924. Epub 2011 Feb 7.
• [3] Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection.J Immunol. 2004 May 1;172(9):5693-701. doi: 10.4049/jimmunol.172.9.5693.
• [4] Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B.World J Gastroenterol. 2005 Nov 28;11(44):6936-40. doi: 10.3748/wjg.v11.i44.6936.
• [5] Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis.J Hepatol. 2018 Apr;68(4):682-690. doi: 10.1016/j.jhep.2017.11.029. Epub 2017 Dec 21.
• [6] Phenotypic characteristics of natural killer cells in acute hepatitis.J Microbiol. 2013 Apr;51(2):247-51. doi: 10.1007/s12275-013-2522-1. Epub 2013 Apr 27.
• [7] Combination of PNPLA3 and TLL1 polymorphism can predict advanced fibrosis in Japanese patients with nonalcoholic fatty liver disease.J Gastroenterol. 2018 Mar;53(3):438-448. doi: 10.1007/s00535-017-1372-8. Epub 2017 Jul 25.
• [8] Shiftwork Is Not Associated with Increased Risk of NAFLD: Findings from the National Health and Nutrition Examination Survey.Dig Dis Sci. 2017 Feb;62(2):526-533. doi: 10.1007/s10620-016-4401-1. Epub 2016 Dec 19.
• [9] Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases.Liver Int. 2007 Feb;27(1):95-100. doi: 10.1111/j.1478-3231.2006.01392.x.
• [10] Lower copy numbers of the chemokine CCL3L1 gene in patients with chronic hepatitis C.J Hepatol. 2010 Feb;52(2):153-9. doi: 10.1016/j.jhep.2009.11.001. Epub 2009 Nov 27.
• [11] Using AST-platelet ratio index and fibrosis 4 index for detecting chronic hepatitis C in a large-scale community screening.PLoS One. 2019 Oct 22;14(10):e0222196. doi: 10.1371/journal.pone.0222196. eCollection 2019.
• [12] Identification of FKBP11 as a biomarker for hepatocellular carcinoma.Anticancer Res. 2013 Jun;33(6):2763-9.
• [13] Inherited IL-18BP deficiency in human fulminant viral hepatitis. J Exp Med. 2019 Aug 5;216(8):1777-1790. doi: 10.1084/jem.20190669. Epub 2019 Jun 18.
• [14] On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon add-on therapy.J Med Virol. 2019 Aug;91(8):1499-1509. doi: 10.1002/jmv.25465. Epub 2019 Apr 16.