Details of Disease

General Information of Disease (ID: DISZ2WZW)

Disease Name	Motion sickness
Synonyms	motion sickness; travel sickness
Disease Class	NF08: External causes effect
Definition	A sensation of discomfort that results from a discordant relationship between visualized movement and any movement sensed by the vestibular system, which is characterized by dizziness, nausea, and vomiting.
Disease Hierarchy	DISUEW2W: Hereditary otorhinolaryngologic disease DISRDGIM: Inherited auditory system disease DISI6MRP: Inner ear disease DISZ2WZW: Motion sickness
ICD Code	ICD-11 ICD-11: NF08.3 ICD-10 ICD-10: T75.3 ICD-9 ICD-9: 994.6 Expand ICD-11 'NF08.3 Expand ICD-10 'T75.3 Expand ICD-9 994.6
Disease Identifiers	MONDO ID MONDO_0008015 MESH ID D009041 UMLS CUI C0026603 OMIM ID 158280 MedGen ID 44503 SNOMED CT ID 37031009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PHN-021	DMERIQM	Phase 2	NA	[1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
HNMT	TT2B6EV	Strong	Altered Expression	[2]
HRH1	TTTIBOJ	Strong	Altered Expression	[3]
MAP2K5	TTV3O87	Strong	Genetic Variation	[4]
------------------------------------------------------------------------------------

This Disease Is Related to 15 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AUTS2	OTAEXHSC	Strong	Genetic Variation	[4]
CELF2	OTLJJ4VT	Strong	Genetic Variation	[4]
COPE	OTBKHBT7	Strong	Genetic Variation	[5]
CPNE4	OTTAGM5L	Strong	Genetic Variation	[4]
EFHD2	OTM9VMN3	Strong	Biomarker	[6]
GPD2	OTV232Y7	Strong	Genetic Variation	[4]
HOXB3	OT9UC5PE	Strong	Genetic Variation	[4]
HOXD3	OTBUZ35T	Strong	Genetic Variation	[4]
LRP1B	OT4YZG2N	Strong	Genetic Variation	[4]
NLGN1	OTGHRRFQ	Strong	Genetic Variation	[4]
PDZRN4	OTHPD5LB	Strong	Genetic Variation	[4]
POU6F2	OTNSW95F	Strong	Genetic Variation	[4]
PRDM16	OT0BGA27	Strong	Genetic Variation	[4]
SDK1	OTX26906	Strong	Genetic Variation	[4]
ST18	OTPRIMTA	Strong	Genetic Variation	[4]
------------------------------------------------------------------------------------


⏷ Show the Full List of 15 DOT(s)

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029005)
2	Reduction of Motion Sickness Through Targeting Histamine N-Methyltransferase in the Dorsal Vagal Complex of the Brain.J Pharmacol Exp Ther. 2018 Mar;364(3):367-376. doi: 10.1124/jpet.117.244475. Epub 2018 Jan 3.
3	Ameliorative Effect of Hesperidin Against Motion Sickness by Modulating Histamine and Histamine H1 Receptor Expression.Neurochem Res. 2020 Feb;45(2):371-384. doi: 10.1007/s11064-019-02923-0. Epub 2019 Nov 28.
4	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.Hum Mol Genet. 2015 May 1;24(9):2700-8. doi: 10.1093/hmg/ddv028. Epub 2015 Jan 26.
5	Sensation Seeking and Adaptation in Parabonauts.Front Psychol. 2018 Mar 9;9:296. doi: 10.3389/fpsyg.2018.00296. eCollection 2018.
6	Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice.Sci Rep. 2017 Jan 27;7:40986. doi: 10.1038/srep40986.