Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEIU0XN)

DME Name	N-acylhomoserine lactone acylase (lacA)
Synonyms	Acyl-homoserine lactone acylase; Acyl-HSL acylase; AHL acylase; AHL amidase; AHL-acylase; Protein related to penicillin acylase; AVS7_00617
Gene Name	AVS7_00617
UniProt ID	A0A0A1VBK6_9BURK
INTEDE ID	DME1021
EC Number	EC: 3.5.1.97 Hydrolases Carbon-nitrogen hydrolase Linear amide hydrolase EC: 3.5.1.97
Lineage	Species: Acidovorax ebreus Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Comamonadaceae Genus: Acidovorax Species: Acidovorax ebreus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MRESIHRGAWPRSVLTLAAVAALAACGGSGGGDGSTYSAEIRRTTMGVPHIKAGNWGSAG YGFGYVQAQDNLCTMADSFLTYRGERSRHLGGSAQLVYNSTLGRPRNIDSDFFHRHVISD EAVDRTMAAQPAKLLQMVEGFAAGYNRYVREAKAGGSAHAACRSEAWVQPITARDVWRRI YAANLAGGYSNFAEAIANAQPPQAKAGAQEPAAFEPGRTRAPSLQVGGELGVGSNMYGFG TAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWS HTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSE FGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASI PWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECD WLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTL RTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTV NGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGI NAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCS ENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSA GQWLRVPFTEAEITGNADYRTATVKE
Function	This enzyme catalyzes the conversion of N-acyl-L-homoserine lactone to N-acyl-L-homoserine.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

5 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[1]
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[1]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[1]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[1]
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1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[1]
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References

1	A novel quorum-quenching N-acylhomoserine lactone acylase from Acidovorax sp. strain MR-S7 mediates antibiotic resistance. Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00080-17.