Details of Drug Off-Target (DOT)
General Information of Drug Off-Target (DOT) (ID: OT2VQWK3)
DOT Name | Exonuclease mut-7 homolog (EXD3) | ||||
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Synonyms | EC 3.1.-.-; Exonuclease 3'-5' domain-containing protein 3 | ||||
Gene Name | EXD3 | ||||
Related Disease | |||||
UniProt ID | |||||
3D Structure | |||||
EC Number | |||||
Pfam ID | |||||
Sequence |
MDPGDPAGDPAAGERHRMGRDPLLLLQALQTLWSTRERKQLREEAWRGFAALDDPLAGLL
DMLESCRGQRGEGPSLAAWISHQLQCWLQAQPCPSLAQHSLRLKQLQARAVKVLTESPPS LAAPLASIFQLQDADRSCLLAHVHRLHHEGRFREAATLGATLKLQSELGVEKMSIPLLLQ DKVALVERYVAGFPDLQRRLLVLMDSWCQPGFDIKDVARRYPEVTSLSLEKLSPKALSRQ VLRLQERYGVAPALCPNAAIQQRLAALRHLCHKRFVEKSLSQENWTDHVQGLVGQSPWLQ EQLSQLLVSHSDPVTAAQCAMELLLPEERLPAAVAVELRRFRLQGRATEADSRLEVKDMK DRYYQLPIPRENVHLLASWEDLTRHEGALLQCHQVVGVDVEWTPVFVAGGRPRPSLLQVA VEGHVFLLDVLALSQPPTGQGAQAFSRLVAQLLSDPSITKLGYGMVGDLQKLGTSCPALA HVEKQILGGMDLLLVHRQMRVASVPAPAVDRARELRGLSLLVQQVLGTALDKTQQLSNWD RRPLCEEQVIYAAADAYCLLEVHQALCREPARFHLSEDLAGSRRPRHRERPGARKPPGLQ KASAPAAPRQVPVAVAVSEGAAPQIPARAFRVVCDNMLQGLARSLRCLGVDARMLGNGED HRRAAEVARQEGRIILTSGQPFHKLRAQVGAGRCLSVDCSLKAQQQAKAVLKHFNVRVTH ADIFSRCQACNCDQYLKVSRDMMKQLMWLSSHQEGPRSSGDEATQSQAVQEPGPAPDAAP EGCTYDRPCRWLQMADLRAETPDMLADGTRLQLAGVPVGVLRTPGLRCFYCCTGCGKVFW DGSHLGRVATHFRDMLESAPSPCEPSPAPSPASSPF |
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Function | Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs. | ||||
Molecular Interaction Atlas (MIA) of This DOT
1 Disease(s) Related to This DOT
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Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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3 Drug(s) Affected the Post-Translational Modifications of This DOT
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7 Drug(s) Affected the Gene/Protein Processing of This DOT
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References