Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTINGL1Q)

DOT Name Uncharacterized protein C8orf76 (C8ORF76)
Gene Name C8ORF76
UniProt ID
CH076_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF17826
Sequence
MDSGCWLFGGEFEDSVFEERPERRSGPPASYCAKLCEPQWFYEETESSDDVEVLTLKKFK
GDLAYRRQEYQKALQEYSSISEKLSSTNFAMKRDVQEGQARCLAHLGRHMEALEIAANLE
NKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLGPA
LSAALASSQKQHSFTSSDKTIKSFFPHSGKDCLLCFPETLPESSLFSVEANSSNSQKNEK
ALTNIQNCMAEKRETVLIETQLKACASFIRTRLLLQFTQPQQTSFALERNLRTQQEIEDK
MKGFSFKEDTLLLIAEVMGEDIPEKIKDEVHPEVKCVGSVALTALVTVSSEEFEDKWFRK
IKDHFCPFENQFHTEIQILA

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
6 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Ciclosporin DMAZJFX Approved Ciclosporin increases the expression of Uncharacterized protein C8orf76 (C8ORF76). [1]
Hydrogen peroxide DM1NG5W Approved Hydrogen peroxide affects the expression of Uncharacterized protein C8orf76 (C8ORF76). [2]
Menadione DMSJDTY Approved Menadione affects the expression of Uncharacterized protein C8orf76 (C8ORF76). [2]
SNDX-275 DMH7W9X Phase 3 SNDX-275 decreases the expression of Uncharacterized protein C8orf76 (C8ORF76). [3]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the expression of Uncharacterized protein C8orf76 (C8ORF76). [1]
Trichostatin A DM9C8NX Investigative Trichostatin A decreases the expression of Uncharacterized protein C8orf76 (C8ORF76). [4]
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⏷ Show the Full List of 6 Drug(s)

References

1 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
2 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
3 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
4 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.