Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTNZVQWX)

• DOT Name: Histidine-rich carboxyl terminus protein 1 (HRCT1)
• Gene Name: HRCT1
• Related Disease: Cardiovascular disease
• UniProt ID: HRCT1_HUMAN
• Pfam ID: PF15758
• Sequence:
  MLGLLGSTALVGWITGAAVAVLLLLLLLATCLFHGRQDCDVERNRTAAGGNRVRRAQPWP
  FRRRGHLGIFHHHRHPGHVSHVPNVGLHHHHHPRHTPHHLHHHHHPHRHHPRHAR

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Cardiovascular disease	DIS2IQDX	Strong	Genetic Variation	[1]

9 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Ciclosporin	DMAZJFX	Approved	Ciclosporin decreases the expression of Histidine-rich carboxyl terminus protein 1 (HRCT1).	[2]
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Histidine-rich carboxyl terminus protein 1 (HRCT1).	[3]
Cupric Sulfate	DMP0NFQ	Approved	Cupric Sulfate decreases the expression of Histidine-rich carboxyl terminus protein 1 (HRCT1).	[4]
Temozolomide	DMKECZD	Approved	Temozolomide increases the expression of Histidine-rich carboxyl terminus protein 1 (HRCT1).	[5]
Calcitriol	DM8ZVJ7	Approved	Calcitriol increases the expression of Histidine-rich carboxyl terminus protein 1 (HRCT1).	[6]
Testosterone	DM7HUNW	Approved	Testosterone increases the expression of Histidine-rich carboxyl terminus protein 1 (HRCT1).	[6]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the expression of Histidine-rich carboxyl terminus protein 1 (HRCT1).	[7]
(+)-JQ1	DM1CZSJ	Phase 1	(+)-JQ1 decreases the expression of Histidine-rich carboxyl terminus protein 1 (HRCT1).	[8]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the expression of Histidine-rich carboxyl terminus protein 1 (HRCT1).	[9]

References

• [1] Leveraging Polygenic Functional Enrichment to Improve GWAS Power.Am J Hum Genet. 2019 Jan 3;104(1):65-75. doi: 10.1016/j.ajhg.2018.11.008. Epub 2018 Dec 27.
• [2] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [3] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [4] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [5] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [6] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [7] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [8] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [9] Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.