Details of the Drug

General Information of Drug (ID: DMKECZD)

• Drug Name: Temozolomide
• Synonyms: Methazolastone; Temodal; Temodar; Temozolamide; Temozolodida; Temozolomidum; Essex brand of temozolomide; Scheringbrand of temozolomide; Temozolodida [Spanish]; Temozolomidum [Latin]; M B 39831; MB 39831; Sch 52365; M & B 39831; M&B 39831; M-39831; Sch-52365; Schering-Plough brand of temozolomide; TMZ-Bioshuttle; Temodal (TN); Temodar (TN); Temozolomide [INN:BAN]; M&B-39831; Temozolomide (JAN/USAN/INN); 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide; 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide; 3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide; 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide; 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one; TMZ

Indication

Disease Entry	ICD 11	Status	REF
Adenocarcinoma	2D40	Approved	[1]
Astrocytoma	2A00.0Y	Approved	[1]
Brain disease	8C70-8E61	Approved	[1]
Central nervous system disease	8A04-8D87	Approved	[1]
Cutaneous melanoma	2C30	Approved	[1]
Glioblastoma	2A00	Approved	[1]
Glioblastoma of brain	2A00.00	Approved	[1]
Gliosarcoma	N.A.	Approved	[1]
Grade IV astrocytoma	2A00.0	Approved	[2]
Kidney neoplasm	N.A.	Approved	[1]
Lung cancer	2C25.0	Approved	[1]
Malignant glioma	2A00.0	Approved	[1]
Melanoma	2C30	Approved	[1]
Neuroblastoma	2D11.2	Investigative	[1]

• Therapeutic Class: Anticancer Agents
• Affected Organisms: Humans and other mammals
• ATC Code:
  L01AX03: Temozolomide
  L01AX: Other alkylating agents
  L01A: ALKYLATING AGENTS
  L01: ANTINEOPLASTIC AGENTS
  L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 194.15
  Logarithm of the Partition Coefficient (xlogp); -1.1
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 5
• ADMET Property:
  Absorption AUC: The area under the plot of plasma concentration (AUC) of drug is 23.4 mgh/L [3]
  Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 7.5 mg/L [3]
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 1 h [3]
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [4]
  Bioavailability: 96% of drug becomes completely available to its intended biological destination(s) [5]
  Clearance: The drug present in the plasma can be removed from the body at the rate of 3.6 mL/min/kg [6]
  Elimination: Roughly 38% of administered temozolomide can be recovered over seven days, with 38% in the urine and only 0.8% in the feces [3]
  Half-life: The concentration or amount of drug in body reduced by one-half in 1.8 hours [3]
  Metabolism: The drug is metabolized via the nonenzymatic chemical conversion to the active metabolite [3]
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 25.4585 micromolar/kg/day [7]
  Vd: The volume of distribution (Vd) of drug is 0.4 L/kg [3]
• Chemical Identifiers:
  Formula: C6H6N6O2
  IUPAC Name: 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
  Canonical SMILES: CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
  InChI: InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
  InChIKey: BPEGJWRSRHCHSN-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 5394
  ChEBI ID: CHEBI:72564
  CAS Number: 85622-93-1
  UNII: YF1K15M17Y
  DrugBank ID: DB00853
  TTD ID: D0C8EU
  ACDINA ID: D00660
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Modulator	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(E2-independent) E3 ubiquitin-conjugating enzyme FATS (C10ORF90)	OT6DNZC4	CJ090_HUMAN	Gene/Protein Processing	[9]
(E3-independent) E2 ubiquitin-conjugating enzyme	OTHGS2VA	UBE2O_HUMAN	Gene/Protein Processing	[9]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Gene/Protein Processing	[9]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Gene/Protein Processing	[9]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1)	OT6Z1L2E	PLCH1_HUMAN	Gene/Protein Processing	[9]
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Gene/Protein Processing	[9]
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14)	OT0ETO72	DHB14_HUMAN	Gene/Protein Processing	[9]
182 kDa tankyrase-1-binding protein (TNKS1BP1)	OTBIZECQ	TB182_HUMAN	Gene/Protein Processing	[9]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[9]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Gene/Protein Processing	[9]

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Bone Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
RPMI-3460/CS1	GDSC1; GDSC2	6.4491	9.326	3.8118	3.5253
CAL-72	GDSC1; GDSC2	6.4226	9.2983	3.8088	3.5854
ES1	GDSC1; GDSC2	6.4624	8.8282	4.0406	2.2874
EW-7	GDSC1; GDSC2	6.6725	9.5087	3.8575	2.937
CHSA8926	GDSC1; GDSC2	6.7037	9.2693	3.9785	2.2778
CADO-ES1	GDSC1; GDSC2	6.7194	8.3735	4.3519	0.6512
ES6	GDSC1; GDSC2	6.7247	9.0296	4.0909	1.7134
ES7	GDSC1; GDSC2	6.8198	9.4035	3.9815	2.1173
EW-24	GDSC1; GDSC2	6.8547	8.2457	4.4536	0.2864
EW-3	GDSC1; GDSC2	7.0284	11.7811	3.0359	6.8315
Hs 822.T	CTRP2	7.0972	8.7537	5.4339	1.1106
TC-71	GDSC1; GDSC2	7.1143	13.8874	2.0964	11.717
EW-12	GDSC2	7.1813	8.9813	4.3139	0.4966
EW-1	GDSC1; GDSC2	7.2493	9.7369	4.0528	1.3513
U-CH2	GDSC2	7.2999	9.2611	4.2581	0.5934
HuO-3N1	GDSC1; GDSC2	7.317	9.7595	4.0745	1.2082
ES5	GDSC1; GDSC2	7.3362	9.9826	3.9945	1.5094
EW-13	GDSC1; GDSC2	7.3534	9.0316	4.3621	0.3052
ES8	GDSC1; GDSC2	7.3898	9.1317	4.3403	0.3398
ES4	GDSC1; GDSC2	7.4309	9.3245	4.2868	0.4505
TC71	CTRP2	7.5066	8.7016	5.6492	0.256
EW-22	GDSC1; GDSC2	7.5838	9.6123	4.2419	0.4964
SK-PN-DW	GDSC1; GDSC2	7.5984	9.6382	4.2382	0.4993
SK-N-MC	CTRP2	7.6243	8.677	5.7035	0.1159
NOS-1 [Human HNSCC]	GDSC1; GDSC2	7.6295	9.7078	4.225	0.5192
CHSA0108	GDSC1; GDSC2	7.6437	9.8499	4.1786	0.6392
A-673	GDSC1; GDSC2; CTRP2	7.6609	9.2085	5.5216	0.4839
EW-16	GDSC1; GDSC2	7.7496	10.0506	4.1469	0.6739
U2OS	GDSC1; GDSC2; CTRP2	7.7771	9.9199	5.2892	1.0156
CAL-78	GDSC1; GDSC2; CTRP2	7.8399	9.375	5.5339	0.3433
SW1353	CTRP2	7.8679	9.1682	5.6208	0.1769
CHSA0011	GDSC1; GDSC2	7.9179	10.245	4.1423	0.6018
HuO9	GDSC1; GDSC2	7.9219	10.4272	4.0767	0.7854
EW-18	GDSC1; GDSC2	8	10.1015	4.2253	0.3709
NY	GDSC1; GDSC2	8.01	10.1145	4.2244	0.3693
MG-63	GDSC2; CTRP2	8.0541	10.4935	5.1875	1.204
EW-11	GDSC1; GDSC2	8.1816	10.8886	4.0105	0.8373
H-EMC-SS	GDSC1; GDSC2	8.1929	10.4304	4.181	0.3977
SK-ES-1	GDSC1; GDSC2; CTRP2	8.2803	10.0262	5.4701	0.3083
HOS	GDSC1; GDSC2; CTRP2	8.5626	9.7347	5.6723	0.0338
G-292 clone A141B1	GDSC1; GDSC2; CTRP2	8.6163	10.438	5.4513	0.2429
SJSA-1	GDSC1; GDSC2; CTRP2	8.7546	10.2249	5.5748	0.077
SaOS-2	GDSC1; GDSC2; CTRP2	8.782	11.0628	5.2884	0.478
MHH-ES-1	GDSC1; GDSC2; CTRP2	9.0183	10.4336	5.5947	0.0422
Hs 888.T	CTRP2	9.7138	23.6764	0.0677	16.6802

Cancer Drug Sensitivity Data Curated from 218 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MEC1	CTRP2	6.2049	7.7553	5.3188	2.9581
JK1	CTRP2	8.8162	11.0342	5.3128	0.4184
JM1	GDSC1; GDSC2; CTRP2	6.2745	8.5622	4.9717	4.3865
OCI-Ly7	GDSC2	2.1296	5.7983	1.593	30.5532
L-540	GDSC1; GDSC2; CTRP2	3.1879	5.5289	3.0511	19.5005
EoL-1	GDSC1; GDSC2; CTRP2	3.4891	5.3315	3.413	17.2832
JSC-1	GDSC1; GDSC2	3.5042	7.7988	2.1731	21.6266
SIG-M5	GDSC2; CTRP2	3.5098	4.8615	3.4901	18.2083
ATN-1	GDSC1; GDSC2	3.5728	5.0908	3.3969	14.3264
OCI-Ly3	CTRP2	3.6064	5.4258	3.5235	16.5256
HC-1	GDSC1; GDSC2	3.8336	7.5313	2.6199	17.8499
NKM-1	GDSC1; GDSC2	3.9257	6.774	3.0679	14.8373
JVM-3	GDSC1; GDSC2; CTRP2	3.9768	7.538	3.2577	16.4299
MJ	CTRP2	3.9772	10.2614	2.0368	22.5748
QIMR-WIL	GDSC1; GDSC2	4.0549	6.7718	3.1953	13.59
SUP-M2	GDSC1; GDSC2; CTRP2	4.1263	6.2793	3.8826	13.6408
SCC-3	GDSC2	4.2058	6.8804	3.2886	12.4785
WIL2 NS	GDSC1; GDSC2	4.317	7.014	3.3288	11.8444
BONNA-12	GDSC2	4.4212	7.8979	2.9896	13.5899
A4/Fukuda	GDSC1; GDSC2; CTRP2	4.4474	8.2683	3.4268	15.5977
SU-DHL-8	GDSC1; GDSC2; CTRP2	4.5976	7.454	3.9409	12.0991
IM-9	GDSC1; GDSC2	4.6949	7.6801	3.3399	10.5446
KYO-1	CTRP2	4.7745	7.2351	4.2181	10.5417
BC-1	GDSC1; GDSC2	4.7924	9.7959	2.3663	16.1211
VL51	GDSC1; GDSC2	4.8505	8.234	3.1961	10.9722
JVM-2	GDSC1; GDSC2; CTRP2	4.9476	9.1368	3.5103	12.9678
RPMI-8866	GDSC1; GDSC2	4.9699	8.2918	3.2667	10.1831
SKM-1	GDSC1; GDSC2; CTRP2	5.0628	7.5896	4.3542	9.258
Ci-1	CTRP2	5.1615	7.0185	4.7113	8.1406
CRO-AP2	GDSC1; GDSC2	5.228	9.8352	2.705	12.8801
CESS	GDSC1; GDSC2	5.3593	8.4091	3.517	7.5614
MOLM-16	GDSC1; GDSC2; CTRP2	5.3683	8.7861	4.0761	9.6773
SUP-B8	GDSC1; GDSC2	5.5572	8.8311	3.4568	7.4428
HAL-01	GDSC1; GDSC2	5.5601	8.3079	3.7152	5.842
NALM-6	GDSC1; GDSC2; CTRP2	5.5991	7.8955	4.7258	6.4664
CCRF-CEM	GDSC1; GDSC2	5.6239	8.0817	3.87	4.7494
SU-DHL-16	GDSC1; GDSC2	5.6261	7.7169	4.0466	3.6763
SEM	CTRP2	5.7019	8.1586	4.6898	6.3912
SU-DHL-5	GDSC1; GDSC2	5.7181	10.7637	2.6239	12.0505
BL-70	CTRP2	5.7217	6.2584	5.6173	2.7224
DoHH2	GDSC2	5.7233	7.8498	4.0475	3.4746
OCI-AML-2	GDSC1; GDSC2; CTRP2	5.7516	7.6224	4.9998	4.9908
MEG-01	GDSC1; GDSC2	5.7734	8.3838	3.8268	4.6908
KMS-12-BM	GDSC2; CTRP2	5.818	7.935	4.9044	5.2473
KY821	GDSC1; GDSC2	5.8375	9.7439	3.2133	8.2625
MHH-CALL-2	GDSC1; GDSC2	5.862	8.6579	3.7552	4.9352
MY-M12	GDSC2	5.9483	9.5138	3.403	6.8677
P30/OHK	GDSC1; GDSC2	5.9697	8.561	3.8714	4.0324
Karpas-620	GDSC1; GDSC2; CTRP2	6.0048	7.9292	5.0688	4.1781
ALL-SIL	GDSC1; GDSC2; CTRP2	6.0491	9.1354	4.5028	6.4706
Jiyoye	GDSC1; GDSC2	6.069	12.193	2.1811	13.6478
P32/ISH	GDSC1; GDSC2	6.1004	8.9893	3.7539	4.4691
ARH-77	GDSC1; GDSC2	6.1296	8.454	4.0189	2.9054
RC-K8	GDSC1; GDSC2	6.1397	11.0455	2.7945	10.0395
SET-2	CTRP2	6.142	7.1457	5.5729	1.9349
SR	GDSC1; GDSC2; CTRP2	6.1454	9.0446	4.6276	5.7631
MLMA	GDSC1; GDSC2	6.1576	10.2201	3.2066	7.5837
Mono-Mac-6	GDSC1; GDSC2; CTRP2	6.2035	10.5741	3.9107	8.6597
U-937	CTRP2	6.247	9.2327	4.6158	5.6252
KE-97	CTRP2	6.2714	8.8389	4.8316	4.6762
NOMO-1	GDSC1; GDSC2; CTRP2	6.2906	7.9814	5.2726	2.7988
NCO2	CTRP2	6.3056	8.6199	4.9673	4.0477
TK [Human B-cell lymphoma]	GDSC1; GDSC2	6.3143	8.6712	4.0279	2.5661
ALL-PO	GDSC1; GDSC2	6.3377	11.4419	2.7413	9.896
MOLT-4	GDSC1; GDSC2	6.3478	9.2151	3.8022	3.7472
Sc-1	GDSC1	6.361	8.2882	4.2191	1.9119
Loucy	GDSC1; GDSC2	6.3648	12.3992	2.2953	12.3207
H9	GDSC1; GDSC2	6.3774	9.6496	3.6202	4.7255
WSU-NHL	GDSC1; GDSC2	6.3792	13.1644	1.9316	14.2111
Karpas-1106P	GDSC1; GDSC2	6.3895	9.3751	3.7541	3.9455
MV4-11	GDSC1; GDSC2; CTRP2	6.3962	8.6994	4.9975	3.7664
OCI-Ly10	CTRP2	6.4186	9.0689	4.8316	4.4199
Hs 445	GDSC1; GDSC2	6.4406	9.81	3.5851	4.8114
PL-21	GDSC1; GDSC2	6.4491	9.8176	3.5868	4.7864
TUR	GDSC1; GDSC2	6.4619	13.5332	1.811	14.6285
Toledo	CTRP2	6.4927	8.9073	4.9672	3.7325
SU-DHL-6	GDSC1; GDSC2; CTRP2	6.534	9.446	4.7324	4.6389
NK-92MI	GDSC2	6.5975	8.3577	4.3045	0.9196
OCI-AML-3	GDSC1; GDSC2	6.6269	8.238	4.3644	0.6729
ML-2	GDSC1; GDSC2	6.6393	12.0375	2.6616	9.6885
PL21	CTRP2	6.6487	9.5093	4.7861	4.2306
L-1236	GDSC1; GDSC2	6.6487	10.1596	3.5511	4.6367
VAL	GDSC1; GDSC2	6.6489	10.8806	3.217	6.5239
ME1	GDSC1; GDSC2	6.6526	8.7593	4.1677	1.4439
OCI-M1	GDSC1; GDSC2; CTRP2	6.6738	10.4393	4.3469	6.4516
MHH-PREB-1	GDSC1; GDSC2	6.6913	13.0492	2.2099	12.0366
DEL	GDSC1; GDSC2; CTRP2	6.7107	9.4601	4.855	3.8509
LC4-1	GDSC1; GDSC2	6.729	12.541	2.4809	10.4947
Karpas-45	GDSC1; GDSC2	6.7382	9.5701	3.8666	2.7964
P31/FUJ	GDSC1; GDSC2; CTRP2	6.7394	9.9006	4.6603	4.6056
BC-3	GDSC2	6.7429	8.6807	4.2422	1.0402
KOPN-8	GDSC1; GDSC2	6.7902	15.4133	1.1286	17.0933
BL-41	GDSC1; GDSC2; CTRP2	6.8027	8.4498	5.3996	1.549
Ramos.2G6.4C10	GDSC1; GDSC2	6.8146	8.2728	4.4284	0.3656
RPMI-6666	GDSC1; GDSC2; CTRP2	6.824	9.5202	4.9055	3.4752
GR-ST	GDSC1; GDSC2	6.8319	9.3586	4.0067	1.9827
GA-10	GDSC1; GDSC2; CTRP2	6.8449	10.5452	4.4213	5.4231
KMOE-2	GDSC1; GDSC2	6.8506	10.6458	3.4499	4.8545
Mino	CTRP2	6.8685	9.176	5.1007	2.8245
HEL	GDSC1; GDSC2; CTRP2	6.8758	8.5477	5.399	1.466
CTV-1	GDSC1; GDSC2	6.8792	9.3288	4.0429	1.761
HD-MY-Z	CTRP2	6.8817	8.5223	5.4141	1.403
KMS-27	CTRP2	6.899	10.1066	4.6739	4.3052
Farage	GDSC1; GDSC2	6.9158	17.077	0.404	19.8144
U-698-M	GDSC1; GDSC2	6.9182	9.4642	4.0058	1.8874
NU-DHL-1	CTRP2	6.9308	10.269	4.6174	4.4878
CTB-1	GDSC1; GDSC2	6.9556	9.8777	3.8497	2.5895
BALL-1	GDSC1; GDSC2	6.968	8.8564	4.273	0.7502
Karpas-231	GDSC1; GDSC2	6.9727	8.2318	4.5019	0.1543
Karpas-299	GDSC1; GDSC2; CTRP2	7.0093	11.8858	3.8836	7.3704
TF-1	CTRP2	7.0113	9.6263	4.981	3.1276
KG-1	GDSC1; GDSC2	7.0215	8.7793	4.3244	0.5516
P12-Ichikawa	GDSC1; GDSC2; CTRP2	7.0547	8.8627	5.3616	1.4083
DB	GDSC1; GDSC2; CTRP2	7.0845	9.6426	5.0207	2.858
JURL-MK1	GDSC1; GDSC2; CTRP2	7.114	8.9864	5.3402	1.4238
ST486	GDSC1; GDSC2; CTRP2	7.1171	9.8508	4.9437	3.1361
MOLT-16	GDSC1; GDSC2; CTRP2	7.1224	11.0001	4.3973	5.0974
MN-60	GDSC1; GDSC2	7.1287	9.168	4.2222	0.8134
Namalwa	GDSC1; GDSC2; CTRP2	7.1306	10.6535	4.5702	4.3865
NB4	GDSC1; GDSC2; CTRP2	7.1481	8.5463	5.5495	0.689
EB2	GDSC1; GDSC2	7.1481	8.8102	4.3632	0.3825
MOLT-3	CTRP2	7.176	8.4871	5.5876	0.5561
AML-193	CTRP2	7.201	10.3557	4.7597	3.533
JJN-3	GDSC1; GDSC2; CTRP2	7.2047	9.4848	5.168	1.9553
SU-DHL-1	GDSC2; CTRP2	7.2169	8.1989	5.7187	0.2085
YT	GDSC1; GDSC2	7.2209	8.9559	4.3388	0.412
REC-1	CTRP2	7.2487	11.3095	4.3354	5.1632
DG-75	GDSC1; GDSC2	7.2671	9.9982	3.9556	1.7399
697	GDSC1; GDSC2; CTRP2	7.2897	9.6843	5.1277	2.0101
BE-13	GDSC1; GDSC2	7.3096	9.243	4.2688	0.5576
K-562	GDSC1; GDSC2; CTRP2	7.3228	9.037	5.4313	0.9909
LAMA-84	GDSC1; GDSC2; CTRP2	7.3355	11.629	4.241	5.4178
A3/Kawakami	GDSC1; GDSC2; CTRP2	7.3604	8.5214	5.6567	0.2803
Hs 611.T	CTRP2	7.3747	10.9904	4.5728	4.0395
KMS-21-BM	CTRP2	7.3817	9.2533	5.3697	1.0726
HL-60	GDSC1; GDSC2; CTRP2	7.3978	9.4304	5.3019	1.3786
KHM-1B	CTRP2	7.4062	9.4127	5.314	1.2351
NU-DUL-1	GDSC1; GDSC2; CTRP2	7.4768	9.1948	5.4422	0.7736
EHEB	GDSC1; CTRP2	7.5183	9.9265	5.1505	1.691
LP-1	GDSC1; GDSC2; CTRP2	7.5262	9.7119	5.2486	1.3474
EB1	CTRP2	7.5536	9.9709	5.1505	1.6569
M-07e	CTRP2	7.5543	11.7389	4.3358	4.7349
WSU-DLCL2	GDSC1; GDSC2; CTRP2	7.5589	10.4451	4.9414	2.401
MC116	GDSC1; GDSC2; CTRP2	7.5757	8.2237	5.8392	0.0109
Pfeiffer	CTRP2	7.5799	9.0993	5.5285	0.4747
KO52	CTRP2	7.5927	8.85	5.629	0.2648
SU-DHL-4	GDSC1; GDSC2; CTRP2	7.5966	17.1591	1.7217	14.7473
SU-DHL-10	GDSC1; GDSC2; CTRP2	7.6403	8.5108	5.7663	0.0466
CMK	GDSC1; CTRP2	7.6539	8.9884	5.6023	0.2762
HT	GDSC1; GDSC2; CTRP2	7.6585	8.8414	5.658	0.1746
Karpas-422	GDSC1; GDSC2; CTRP2	7.7312	14.4429	3.1544	9.1672
OCI-AML-5	GDSC1; GDSC2; CTRP2	7.7584	10.2506	5.1395	1.5067
Ku812	GDSC1; GDSC2; CTRP2	7.7625	10.951	4.8319	2.5815
KM-H2	GDSC1; GDSC2; CTRP2	7.7676	12.4561	4.1359	5.2365
AMO1	GDSC1; GDSC2; CTRP2	7.7749	13.5702	3.6078	7.3138
CA46	GDSC1; GDSC2; CTRP2	7.7931	11.8187	4.4519	3.9743
RS4;11	GDSC1; GDSC2; CTRP2	7.802	12.0893	4.3311	4.4295
KMS-26	CTRP2	7.8196	8.8418	5.7168	0.0675
MOLT-13	GDSC1; GDSC2; CTRP2	7.8233	9.4303	5.506	0.4103
PF-382	GDSC1; GDSC2; CTRP2	7.8234	10.2032	5.1936	1.2763
OCI-Ly19	GDSC1; GDSC2; CTRP2	7.8298	9.5574	5.4598	0.5147
Raji	GDSC1; GDSC2; CTRP2	7.8515	9.1951	5.6048	0.2068
BV-173	GDSC1; GDSC2; CTRP2	7.8695	10.9533	4.8923	2.2527
THP-1	GDSC1; GDSC2; CTRP2	7.8907	9.6135	5.4646	0.4737
HEL 92.1.7	CTRP2	7.8974	8.8137	5.7529	0.0349
HPB-ALL	CTRP2	7.9135	9.3435	5.5751	0.2387
Reh	GDSC1; GDSC2; CTRP2	7.9228	9.3546	5.5748	0.2364
KE-37	GDSC1; GDSC2; CTRP2	7.9288	9.2002	5.6323	0.1457
Jurkat	GDSC1; GDSC2; CTRP2	7.9406	9.6964	5.4541	0.4744
MM1.S	GDSC2; CTRP2	7.9871	9.4811	5.5538	0.253
RL	GDSC1; GDSC2; CTRP2	8.0329	9.3388	5.622	0.1473
HDLM-2	GDSC1; GDSC2; CTRP2	8.0479	10.7313	5.0849	1.4418
KMM-1	CTRP2	8.0506	10.3209	5.2566	0.9228
KMS-34	CTRP2	8.0517	9.2599	5.6562	0.0939
KMS-18	CTRP2	8.1121	9.4891	5.5985	0.1514
RCH-ACV	GDSC1; GDSC2; CTRP2	8.1342	10.5163	5.2168	0.9811
EM-2	GDSC1; GDSC2; CTRP2	8.1716	9.6112	5.5776	0.1666
OPM-2	GDSC1; GDSC2; CTRP2	8.1744	9.8343	5.4985	0.2916
CML-T1	GDSC1; GDSC2; CTRP2	8.1748	9.4221	5.6443	0.0876
KCL-22	GDSC1; GDSC2; CTRP2	8.1819	9.9196	5.4701	0.3418
P3HR-1	CTRP2	8.1958	11.0728	5.016	1.5421
MOLM-13	GDSC1; GDSC2; CTRP2	8.1969	9.9528	5.4639	0.3485
NCI-H929	GDSC1; GDSC2; CTRP2	8.2014	9.8402	5.507	0.2682
EJM	GDSC1; GDSC2; CTRP2	8.2191	9.721	5.5565	0.1853
HH [Human lymphoma]	GDSC1; GDSC2; CTRP2	8.2231	10.8326	5.1299	1.2592
Kasumi-1	GDSC1; GDSC2; CTRP2	8.2316	9.6285	5.5936	0.1336
SK-MM-2	GDSC1; GDSC2; CTRP2	8.2354	9.9215	5.4907	0.286
RPMI-8226	GDSC1; GDSC2; CTRP2	8.2395	10.993	5.0715	1.3357
MHH-CALL-4	GDSC2; CTRP2	8.2842	9.7795	5.5601	0.1657
Kasumi-2	CTRP2	8.3175	9.7313	5.589	0.1235
KMS-11	GDSC1; GDSC2; CTRP2	8.318	10.2051	5.4192	0.3917
RPMI-8402	GDSC1; GDSC2; CTRP2	8.3254	10.1428	5.4453	0.3389
Peer	CTRP2	8.3278	9.5531	5.6532	0.0614
L-363	GDSC1; GDSC2; CTRP2	8.3438	9.5064	5.6742	0.0454
KMS-20	CTRP2	8.3701	15.1058	3.2746	7.773
MHH-CALL-3	CTRP2	8.3714	10.7522	5.2318	0.7972
SUP-T11	CTRP2	8.3744	9.7852	5.5909	0.1121
MOTN-1	CTRP2	8.3896	9.9516	5.5386	0.1844
ME1	CTRP2	8.411	9.9827	5.5356	0.1712
Daudi	GDSC1; GDSC2; CTRP2	8.4213	9.7648	5.6144	0.0888
SUP-B15	GDSC2; CTRP2	8.4937	10.0065	5.5574	0.1385
MOLP-8	GDSC1; GDSC2; CTRP2	8.4949	10.3671	5.4301	0.3343
MOLP-2	CTRP2	8.5256	10.1938	5.5038	0.189
L-428	GDSC1; GDSC2; CTRP2	8.5448	10.434	5.4252	0.3045
TALL-1 [Human adult T-ALL]	GDSC2; CTRP2	8.546	10.8352	5.2761	0.6021
Granta-519	GDSC1; GDSC2; CTRP2	8.555	10.3755	5.4503	0.2605
ROS-50	GDSC1; GDSC2	8.6285	17.7388	1.2639	12.7185
F-36P	CTRP2	8.6969	16.5501	2.8038	9.1027
MOLM-6	CTRP2	8.6991	10.2927	5.5324	0.1227
SUP-HD1	GDSC1; GDSC2; CTRP2	8.7136	10.4577	5.4806	0.1801
HuT 78	CTRP2	8.726	13.0205	4.4563	2.9414
SUP-T1	GDSC1; GDSC2; CTRP2	8.7532	10.9679	5.312	0.4422
GDM-1	GDSC1; GDSC2; CTRP2	8.94	10.634	5.501	0.1187
Ri-1	CTRP2	9.2179	11.4252	5.3269	0.2784
Mono-Mac-1	CTRP2	9.3979	11.5279	5.3573	0.2
DND-41	GDSC1; GDSC2; CTRP2	9.6286	17.3673	3.018	7.1204
JeKo-1	GDSC1; GDSC2; CTRP2	9.8923	16.2642	3.673	4.8388
U266B1	GDSC1; GDSC2; CTRP2	10.5316	18.1457	3.1976	5.5064

Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TE15	CTRP2	6.877	11.3251	4.0617	7.3567
TE8	CTRP2	8.1565	9.8178	5.4975	0.2992
TE-5	GDSC1; GDSC2; CTRP2	6.162	7.2372	5.543	1.8912
TE-15	GDSC1; GDSC2	6.279	11.2985	2.7698	9.8645
EC-GI-10	GDSC1; GDSC2; CTRP2	6.4216	11.6896	3.5296	9.8385
T.T	GDSC1; GDSC2	6.805	8.7773	4.2321	1.0263
KYSE-510	GDSC1; GDSC2; CTRP2	6.8158	8.7737	5.2566	2.085
TE-6	GDSC1; GDSC2	6.9791	13.5615	2.161	11.6678
OE21	GDSC1; GDSC2; CTRP2	7.0781	9.7527	4.9647	2.8879
OE19	GDSC1; GDSC2; CTRP2	7.2603	8.5192	5.6139	0.4319
KYSE-270	GDSC1; GDSC2	7.6322	9.5044	4.2991	0.3421
TE-8	GDSC1; GDSC2	7.6699	10.1001	4.0957	0.8771
KYSE-450	GDSC1; GDSC2; CTRP2	7.7377	8.9272	5.6574	0.1546
COLO 680N	GDSC1; GDSC2; CTRP2	7.8488	9.4076	5.5253	0.3576
KYSE-30	CTRP2	7.8878	10.8758	4.9369	2.0781
TE-14	CTRP2	7.9192	13.43	3.7729	6.4578
TE-11	GDSC1; GDSC2; CTRP2	7.9575	13.2589	3.8798	6.4216
OE33	GDSC1; GDSC2; CTRP2	8.0737	10.1798	5.324	0.7259
KYSE-140	GDSC2; CTRP2	8.0796	10.2075	5.3156	0.7443
KYSE-70	GDSC1; GDSC2; CTRP2	8.1323	9.7298	5.5201	0.2667
TE-9	GDSC1; GDSC2; CTRP2	8.1492	9.5126	5.6039	0.1368
TE-4	GDSC1; GDSC2; CTRP2	8.3003	10.0106	5.4837	0.2783
KYSE-520	GDSC1; GDSC2; CTRP2	8.4445	10.6288	5.3119	0.5672
KYSE-150	GDSC1; GDSC2; CTRP2	8.4752	9.8023	5.6203	0.0713
TE-1	GDSC1; GDSC2; CTRP2	8.6402	10.2938	5.5109	0.1568
KYSE-180	GDSC1; GDSC2; CTRP2	8.7652	10.4238	5.511	0.135
KYSE-410	GDSC2; CTRP2	9.0781	10.67	5.5367	0.0728
TE-10	GDSC1; GDSC2; CTRP2	9.1154	10.705	5.5378	0.0686

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Pancreas Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
N2a-PK1	CTRP2	8.6027	10.0489	5.5814	0.089
PaTu 8988t	GDSC1; GDSC2; CTRP2	6.6243	7.946	4.6061	0.3238
PaTu 8988s	CTRP2	7.0234	8.8569	5.346	1.4984
PL4	GDSC1; GDSC2	7.4398	9.019	4.3982	0.2095
HPAC	GDSC2; CTRP2	7.4761	9.3315	5.3849	0.9479
L3.3	CTRP2	7.5126	8.8914	5.5799	0.3845
MZ-PC-1	GDSC1; GDSC2	7.5229	10.2015	3.9926	1.3528
MIA PaCa-2	GDSC1; GDSC2; CTRP2	7.6291	8.9782	5.596	0.3206
Panc 02.03	GDSC1; GDSC2; CTRP2	7.6651	8.9083	4.6495	0.0423
YAPC	GDSC1; GDSC2; CTRP2	7.7036	8.7959	5.6911	0.1156
KP-1N	GDSC1; GDSC2	7.7101	9.7963	4.2243	0.4849
SNU-213	CTRP2	7.7454	9.1023	5.597	0.2539
PaTu 8902	GDSC1; GDSC2; CTRP2	7.8161	9.0463	5.6446	0.1544
SUIT-2	GDSC1; GDSC2; CTRP2	7.8659	9.0788	5.6517	0.1332
DAN-G	GDSC2; CTRP2	7.892	9.362	5.5598	0.2731
KP-2	GDSC1; GDSC2; CTRP2	7.9189	9.3438	5.5771	0.2509
SW1990	GDSC1; GDSC2; CTRP2	7.9508	11.0723	4.8852	2.3603
SU.86.86	GDSC1; GDSC2; CTRP2	7.9547	9.1995	5.642	0.1274
KP-4	GDSC1; GDSC2; CTRP2	7.9869	9.3743	5.5923	0.1897
Hs 766T	GDSC1; GDSC2; CTRP2	8.0485	9.4993	5.571	0.2065
BxPC-3	GDSC1; GDSC2; CTRP2	8.1111	10.2776	5.3021	0.7616
PK-45H	CTRP2	8.188	10.2305	5.3549	0.5883
TCC-Pan2	CTRP2	8.2199	9.5399	5.62	0.1056
Panc 03.27	GDSC1; GDSC2; CTRP2	8.262	9.9575	5.488	0.3034
Panc 05.04	CTRP2	8.2845	9.7355	5.5756	0.1456
PSN1	GDSC1; GDSC2; CTRP2	8.3306	10.1811	5.4332	0.3865
QGP-1	GDSC1; GDSC2; CTRP2	8.3605	9.8877	5.5503	0.1625
CFPAC-1	GDSC1; GDSC2; CTRP2	8.3878	9.8329	5.5793	0.1225
HPAF-II	GDSC1; GDSC2; CTRP2	8.4392	10.2473	5.4519	0.2908
HuP-T4	GDSC2; CTRP2	8.4537	10.1542	5.4909	0.2243
Panc 10.05	GDSC1; GDSC2; CTRP2	8.534	10.5972	5.361	0.4265
Capan-1	GDSC2; CTRP2	8.5542	10.0122	5.5769	0.1069
HuP-T3	GDSC1; GDSC2; CTRP2	8.7009	10.7338	5.3773	0.3647
Panc 04.03	GDSC2; CTRP2	8.711	10.2378	5.5553	0.106
AsPC-1	GDSC1; GDSC2; CTRP2	8.7827	11.4134	5.1552	0.8286
Panc 08.13	GDSC1; GDSC2; CTRP2	8.794	10.765	5.4019	0.2725
SNU-410	CTRP2	8.878	10.7807	5.4279	0.2147
PK-59	CTRP2	8.9964	10.5794	5.5391	0.0791
Capan-2	GDSC1; GDSC2; CTRP2	9.0132	10.6648	5.5162	0.0955
KP-3	GDSC1; GDSC2; CTRP2	9.2943	11.4496	5.3468	0.2337

Cancer Drug Sensitivity Data Curated from 76 Cell Line(s) in Skin Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SH4	CTRP2	13.095	31.2426	-1.2749	15.8404
G-mel	GDSC1; GDSC2	5.1292	8.2165	3.4335	8.6925
LB2518-MEL	GDSC1; GDSC2	5.914	8.0271	4.0848	2.9028
MMAc-SF	GDSC1; GDSC2	6.1937	7.9238	4.2878	1.4083
DJM-1	GDSC1; GDSC2	6.2517	8.6718	3.9919	2.8566
RPMI-7951	GDSC2	6.3567	11.4286	2.761	9.7413
MZ-MEL-7	GDSC1; GDSC2	6.365	11.3118	2.8231	9.3675
GAK	GDSC1; GDSC2	6.3881	7.9888	4.3558	0.8993
A101D	GDSC1; GDSC2; CTRP2	6.3918	7.6965	4.6029	0.4503
HMCB	CTRP2	6.4141	7.3195	4.7514	0.1124
Hs 938.T	GDSC1; GDSC2	6.4598	8.4381	4.206	1.4816
COLO 679	GDSC1; GDSC2	6.646	8.5737	4.2403	1.1363
LB373-MEL-D	GDSC1; GDSC2	6.6866	7.7599	4.562	0.1266
COLO 783	GDSC1; GDSC2	6.7387	8.1008	4.4613	0.3158
SH-4	GDSC1; GDSC2	6.7761	9.1675	4.0589	1.803
MZ-MEL-2	GDSC1; GDSC2	6.8846	9.1671	4.1122	1.4478
M14	GDSC1; GDSC2	6.9309	13.3616	2.2243	11.4393
CP66-MEL	GDSC1; GDSC2	6.9375	8.5243	4.3849	0.423
A2058	GDSC2; CTRP2	6.9479	7.9887	4.7118	0.0651
451Lu	GDSC1; GDSC2	7.0012	8.4863	4.4233	0.2993
VMRC-MELG	GDSC1; GDSC2	7.0545	8.8222	4.3218	0.5409
G-361	GDSC1; GDSC2; CTRP2	7.0715	8.5073	5.5269	0.8214
IST-MEL1	GDSC1; GDSC2	7.1035	8.9675	4.2876	0.6163
CP50-MEL-B	GDSC1; GDSC2	7.1127	8.6701	4.4	0.3098
SK-MEL-28	GDSC1; GDSC2; CTRP2	7.1444	8.132	5.7138	0.2485
A-431	GDSC1; GDSC2	7.1762	14.4993	1.8448	12.8578
UACC-257	GDSC1; GDSC2; CTRP2	7.22	8.7643	5.4942	0.8056
LOX-IMVI	GDSC1; GDSC2; CTRP2	7.2577	9.7183	5.0931	2.1747
WM1552C	GDSC1; GDSC2	7.2678	8.8818	4.3831	0.2905
CHL-1	GDSC1; GDSC2	7.2902	8.9956	4.3511	0.3532
WM35	GDSC1; GDSC2	7.319	9.2341	4.2758	0.5329
SK-MEL-24	GDSC1; GDSC2; CTRP2	7.3521	9.1178	5.4121	1.0315
WM266-4	CTRP2	7.3728	8.4021	5.7062	0.1911
IGR-39	CTRP2	7.4164	8.7496	5.593	0.4305
SK-MEL-2	GDSC1; GDSC2; CTRP2	7.4262	8.3581	5.7423	0.1146
HMV-II	GDSC1; GDSC2	7.454	9.9604	4.0566	1.1657
SK-MEL-3	GDSC1; GDSC2; CTRP2	7.4542	8.7466	5.6105	0.3665
Hs 936.T	CTRP2	7.4997	8.8609	5.5861	0.3763
Hs 294T	CTRP2	7.5275	10.362	4.9605	2.5402
Hs 688(A).T	CTRP2	7.5629	15.1142	2.7044	11.1804
WM278	GDSC1; GDSC2	7.6328	9.5835	4.2711	0.4041
IGR-1	GDSC2; CTRP2	7.6739	9.1078	5.5657	0.344
SK-MEL-30	GDSC1; GDSC2; CTRP2	7.6902	8.5634	5.7658	0.0418
Hs 944.T	CTRP2	7.6989	10.597	4.9543	2.2053
WM115	GDSC1; GDSC2; CTRP2	7.7014	8.9507	5.6351	0.2149
Hs 940.T	GDSC1; GDSC2; CTRP2	7.749	9.7099	5.362	0.8211
SK-MEL-5	GDSC1; GDSC2; CTRP2	7.7639	9.0885	5.6094	0.2253
Hs 934.T	CTRP2	7.8281	9.3758	5.5287	0.359
Mel JuSo	GDSC1; GDSC2; CTRP2	7.8309	10.5183	5.0623	1.7006
Hs 839.T	CTRP2	7.8463	8.7734	5.749	0.0419
COLO 800	GDSC1; GDSC2; CTRP2	7.8558	9.8725	5.3465	0.7957
WT2-iPS	GDSC1; GDSC2; CTRP2	7.8959	10.317	5.1825	1.3471
SK-MEL-1	GDSC1; GDSC2; CTRP2	7.9102	9.3019	5.589	0.2161
A-388	GDSC1; GDSC2	7.9141	10.2541	4.1376	0.6164
CJM [Human melanoma]	CTRP2	7.9436	9.3198	5.5954	0.211
UACC-62	GDSC1; GDSC2; CTRP2	7.965	9.0957	5.6816	0.0811
RVH-421	GDSC1; GDSC2; CTRP2	7.9997	9.2797	5.6306	0.1428
WM1799	CTRP2	8.0256	9.115	5.6962	0.0602
A-375	GDSC1; GDSC2; CTRP2	8.0694	9.5313	5.5675	0.2064
IGR-37	GDSC1; GDSC2; CTRP2	8.0867	9.2662	5.6664	0.0788
IPC-298	GDSC1; GDSC2; CTRP2	8.1134	9.3566	5.645	0.0961
Hs 852.T	CTRP2	8.1176	9.7112	5.5212	0.2694
MDA-MB-435S	CTRP2	8.1495	9.419	5.6364	0.0994
K029AX	CTRP2	8.1618	9.3207	5.6741	0.0628
Mel Ho	GDSC1; GDSC2; CTRP2	8.1766	9.6384	5.5699	0.1762
COLO 792	GDSC1; GDSC2; CTRP2	8.1878	9.7869	5.521	0.267
WM88	CTRP2	8.2056	12.7345	4.2829	4.4255
SK-MEL-31	GDSC1; GDSC2; CTRP2	8.2679	9.6522	5.5985	0.1213
WM793	GDSC1; GDSC2; CTRP2	8.2931	9.7806	5.563	0.1599
MeWo	GDSC1; GDSC2; CTRP2	8.3999	9.7321	5.6179	0.0883
HT-144	GDSC1; GDSC2; CTRP2	8.4552	9.6527	5.6634	0.0465
WM983B	CTRP2	8.5108	10.6001	5.3504	0.4905
COLO 829	GDSC1; GDSC2; CTRP2	8.5158	10.2574	5.4776	0.2286
Hs 895.T	CTRP2	8.5843	9.863	5.6373	0.0527
Malme-3M	CTRP2	9.1995	23.346	-0.1386	18.0162
EquiPSC Line K2	GDSC1; GDSC2	6.9087	10.1518	3.705	3.3906

Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
KYSE-220	GDSC1; GDSC2	5.8282	9.9872	3.0876	9.0402
HCE-4	GDSC1; GDSC2	6.4844	8.5698	4.163	1.6549
OACM5.1 C	GDSC1; GDSC2	6.8623	10.6693	3.4461	4.8555
SK-GT-4	GDSC1; GDSC2	6.8629	9.7523	3.8547	2.6866
ESO-51	GDSC1; GDSC2	6.9967	8.9708	4.2413	0.8403
OACP4 C	GDSC1; GDSC2	7.07	9.923	3.8896	2.2547
FLO-1	GDSC1; GDSC2	7.2878	10.05	3.9443	1.7676
TE-12	GDSC1; GDSC2	7.4964	10.6229	3.8098	2.1423
ESO-26	GDSC1; GDSC2	7.517	9.3484	4.3112	0.3574
KYAE-1	GDSC1; GDSC2	7.5355	9.1803	4.3769	0.221
KYSE-50	GDSC1; GDSC2	7.6119	9.4393	4.3145	0.3168

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
COLO 684	GDSC1; GDSC2; CTRP2	8.596	14.6579	3.633	6.545

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Autonomic Ganglia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CHP-212	GDSC1; GDSC2; CTRP2	5.7083	10.7153	3.4233	12.5088
KP-N-YN	GDSC1; GDSC2; CTRP2	6.033	8.5027	4.8057	5.6162
GI-ME-N	GDSC1; GDSC2	6.2107	12.3328	2.2165	13.112
KP-N-RT-BM-1	GDSC2	6.241	8.4609	4.08	2.3993
SJNB-17	GDSC1; GDSC2	6.4066	8.3883	4.2001	1.5713
SJNB-13	GDSC1; GDSC2	6.5031	8.5951	4.1618	1.638
SK-N-MC-IXC	GDSC1; GDSC2	6.5535	7.8738	4.4713	0.3771
CHP-134	GDSC2	6.7082	8.0072	4.4832	0.2753
SJNB-6	GDSC2	6.7256	8.764	4.2007	1.2264
SJNB-7	GDSC1; GDSC2	6.7418	8.5329	4.3	0.8189
TGW	GDSC1; GDSC2	6.759	8.6597	4.2579	0.9646
NB(TU)1	GDSC1; GDSC2	6.7933	8.7038	4.2559	0.9438
LA-N-6	GDSC1; GDSC2	6.8245	8.9911	4.1553	1.3229
SJNB-10	GDSC1; GDSC2	6.8956	8.6563	4.3187	0.6455
GOTO	GDSC1; GDSC2	6.9798	9.321	4.0948	1.4282
IMR-5	GDSC1; GDSC2	7.0474	8.7587	4.3425	0.4851
NH-6	CTRP2	7.0543	8.7817	5.3976	1.3746
KP-N-YS	GDSC2	7.0788	9.4834	4.0756	1.4141
IMR-32	CTRP2	7.0987	8.1347	5.693	0.3425
NH-12	GDSC2	7.1081	8.711	4.3836	0.3498
SJNB-5	GDSC1; GDSC2	7.2123	8.9297	4.3449	0.4004
SK-N-BE(2)-M17	GDSC1; GDSC2	7.2202	8.8712	4.369	0.3392
SJNB-14	GDSC1; GDSC2	7.2276	8.9513	4.343	0.3984
NB69	GDSC2	7.3459	9.4094	4.2216	0.6771
SJNB-12	GDSC1; GDSC2	7.4246	11.2069	3.525	3.5869
SiMa	GDSC1; GDSC2	7.4361	9.7842	4.1172	0.9613
SK-N-DZ	GDSC1; GDSC2; CTRP2	7.6714	8.8936	5.6441	0.2081
SK-N-SH	GDSC1; GDSC2; CTRP2	7.6879	9.6912	4.3877	0.3766
CHP-126	GDSC1; GDSC2; CTRP2	7.9077	9.476	5.5239	0.3373
KP-N-SI9s	CTRP2	7.9384	9.9196	5.3658	0.6935
NB1	GDSC1; GDSC2; CTRP2	8.0054	9.1513	5.6769	0.08
Kelly	GDSC1; GDSC2; CTRP2	8.0292	9.2145	5.6637	0.0896
SK-N-FI	GDSC1; GDSC2; CTRP2	8.1263	9.4609	5.6136	0.1389
SK-N-AS	GDSC1; GDSC2; CTRP2	8.2202	9.8729	5.5025	0.2903
MHH-NB-11	GDSC2; CTRP2	8.4092	10.065	5.5059	0.2132
SK-N-BE(2)	CTRP2	8.6986	10.9776	5.2861	0.515

Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuCC-T1	GDSC1; GDSC2	5.9224	8.7718	3.7411	4.8952
HuH-28	CTRP2	7.7811	9.1766	5.5839	0.2661
SNU-1079	CTRP2	7.7995	9.7483	5.3704	0.765
SNU-1196	CTRP2	8.1982	9.4324	5.649	0.08
SNU-478	CTRP2	8.2364	9.6589	5.5848	0.1436
SNU-869	CTRP2	8.4498	10.036	5.5312	0.1813
SNU-308	CTRP2	8.461	9.8958	5.5838	0.1061

Cancer Drug Sensitivity Data Curated from 89 Cell Line(s) in Breast Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MDA-MB-157	GDSC1; GDSC2; CTRP2	6.4917	8.7312	5.0531	3.3787
BT-20	GDSC1; GDSC2; CTRP2	6.5021	7.6007	5.6066	1.2046
HCC2157	GDSC1; GDSC2	6.5111	8.5659	4.1781	1.5472
Hs 578T	GDSC1; GDSC2; CTRP2	6.6689	11.55	3.7932	8.3109
HDQ-P1	GDSC1; GDSC2	6.6953	8.9723	4.1002	1.6979
MFM-223	GDSC1; GDSC2	6.7435	8.0682	4.4748	0.28
OCUB-M	GDSC1; GDSC2	6.7628	8.8129	4.1984	1.1963
KPL-1	CTRP2	6.8516	7.5852	5.7984	0.19
HCC70	GDSC1; GDSC2	6.9545	9.1408	4.1556	1.1961
HCC38	GDSC1; GDSC2; CTRP2	7.0228	8.5729	5.4723	1.0483
HCC1569	GDSC1; GDSC2	7.0534	11.197	3.3195	5.2112
UACC-893	GDSC1; GDSC2	7.0595	9.4397	4.0842	1.3917
MDA-MB-436	GDSC1; GDSC2	7.0645	12.3662	2.7855	8.1166
MRK-nu-1	GDSC1; GDSC2	7.0824	8.4138	4.4786	0.165
DU4475	GDSC1; GDSC2; CTRP2	7.1428	8.7693	5.4518	1.008
MDA-MB-175-VII	GDSC1; GDSC2	7.1568	8.699	4.4063	0.2789
HCC1599	GDSC2	7.2092	8.8392	4.3762	0.3258
MDA-MB-330	GDSC1; GDSC2	7.2555	9.6343	4.0963	1.1712
EFM-19	GDSC1; GDSC2	7.2807	10.8057	3.6219	3.2841
HCC1187	GDSC1; GDSC2	7.2895	8.9456	4.3687	0.3128
Evsa-T	GDSC1; GDSC2	7.3478	8.7211	4.4674	0.1246
BT-483	GDSC1; GDSC2	7.352	8.7326	4.465	0.127
YMB-1-E	GDSC2	7.3681	9.6748	4.13	0.9647
Hs 578Bst	CTRP2	7.4454	8.5924	5.665	0.2298
MDA-MB-361	GDSC1; GDSC2; CTRP2	7.5425	10.0263	5.1198	1.7747
CAL-120	GDSC1; GDSC2; CTRP2	7.5552	9.2219	5.4685	0.6465
HCC1419	GDSC1; GDSC2; CTRP2	7.591	9.046	5.5541	0.4376
HCC202	GDSC1; CTRP2	7.7061	10.2783	5.0993	1.6892
HCC2218	GDSC1; GDSC2; CTRP2	7.7076	9.8061	5.3022	1.0276
HMC-1-8	CTRP2	7.7406	8.7011	5.7369	0.0595
ZR-75-30	GDSC1; GDSC2; CTRP2	7.7617	9.3365	5.5157	0.447
ZR-75-1	CTRP2	7.812	9.031	5.6485	0.1497
COLO 824	GDSC1; GDSC2	7.8372	9.6345	4.3286	0.2244
BT-474	GDSC1; GDSC2; CTRP2	8.0364	9.5777	5.538	0.2654
CAL-51	GDSC1; GDSC2; CTRP2	8.0696	9.5083	5.5759	0.1935
CAMA-1	GDSC1; GDSC2; CTRP2	8.116	14.9361	3.1841	8.4797
MCF-7	GDSC1; GDSC2; CTRP2	8.1225	10.2968	5.2997	0.7616
HCC1428	GDSC1; GDSC2; CTRP2	8.1252	9.3331	5.6571	0.0822
JIMT-1	GDSC1; GDSC2; CTRP2	8.1253	9.396	5.6357	0.1041
MDA-MB-415	GDSC1; GDSC2; CTRP2	8.1283	9.793	5.4954	0.3126
CAL-148	GDSC2; CTRP2	8.1305	9.5254	5.5926	0.1553
MDA-MB-453	GDSC1; GDSC2; CTRP2	8.1322	9.5882	5.5711	0.1851
UACC-812	GDSC2; CTRP2	8.2552	10.1744	5.4049	0.4786
HCC1500	GDSC1; GDSC2; CTRP2	8.2975	9.6057	5.625	0.0891
SK-BR-3	CTRP2	8.3635	10.375	5.3742	0.466
BT-549	GDSC1; GDSC2; CTRP2	8.3971	10.2722	5.4262	0.35
HCC1937	GDSC1; GDSC2; CTRP2	8.3981	10.0799	5.4964	0.2303
MDA-MB-468	GDSC1; GDSC2; CTRP2	8.416	10.1452	5.4798	0.2514
EFM-192A	GDSC1; GDSC2; CTRP2	8.4391	9.8806	5.5812	0.1204
HCC1954	GDSC1; GDSC2; CTRP2	8.584	10.0382	5.5785	0.094
HCC1806	GDSC1; GDSC2; CTRP2	8.5867	10.2211	5.5167	0.1599
MDA-MB-231	GDSC1; GDSC2; CTRP2	8.6731	10.3891	5.4897	0.1766
CAL-85-1	GDSC1; GDSC2; CTRP2	8.7265	15.7708	3.1936	8.1301
T-47D	GDSC1; GDSC2; CTRP2	8.8669	10.6929	5.4545	0.1824
HCC1143	GDSC1; GDSC2; CTRP2	8.9196	10.8928	5.4038	0.2387
HCC1395	GDSC1; GDSC2; CTRP2	9.0173	10.8206	5.4646	0.1442
AU565	GDSC2; CTRP2	9.3075	11.0356	5.4931	0.082
BT 145	CTRP2	3.4965	7.2564	2.8592	19.2858
BT164	CTRP2	6.1502	9.7729	4.2676	7.2658
BT 112	CTRP2	6.185	8.608	4.8778	4.6389
BT 245	CTRP2	6.9955	10.3867	4.6057	4.4394
BT 139	CTRP2	7.0852	8.3912	5.5829	0.6339
BT 482	CTRP2	7.2001	8.528	5.5824	0.5548
BT 498	CTRP2	7.2209	11.1169	4.409	4.9064
BT 504	CTRP2	7.2337	8.9688	5.414	1.0538
BT 330	CTRP2	7.3194	9.0773	5.4124	0.9859
BT 444	CTRP2	7.5083	21.7475	-0.623	22.0536
BT 416	CTRP2	7.5305	9.0704	5.5178	0.529
BT 286	CTRP2	7.5717	14.4914	3.0162	9.9565
BT 320	CTRP2	7.6145	8.8048	5.6542	0.1936
BT 232	CTRP2	7.6531	16.7057	1.9878	13.7048
BT 333	CTRP2	7.6875	9.4478	5.4392	0.6457
BT 340	CTRP2	7.69	9.2908	5.5023	0.4823
BT 172	CTRP2	7.7578	16.9915	1.9249	13.7578
BT 179	CTRP2	7.8082	8.8876	5.6971	0.0891
BT 231	CTRP2	7.8301	9.7365	5.3893	0.6947
BT 440	CTRP2	7.8842	9.2123	5.6112	0.1874
BT 428	CTRP2	7.8932	9.6284	5.4599	0.4833
BT 422	CTRP2	7.9238	9.1683	5.6416	0.1342
BT 216	CTRP2	7.9302	9.7899	5.4133	0.577
BT147	CTRP2	7.9319	9.5436	5.5085	0.3593
BT 159	CTRP2	7.959	10.439	5.1631	1.2658
BT 239	CTRP2	7.9689	9.0889	5.6853	0.077
BT 228	CTRP2	7.9907	9.4305	5.5736	0.2183
BT 224	CTRP2	7.9982	9.388	5.5917	0.1877
BT 131	CTRP2	8.0588	13.8117	3.684	6.6146
BT 359	CTRP2	8.1327	9.3931	5.6393	0.099
BT 271	CTRP2	8.3071	18.1633	1.7516	13.489
BT 328	CTRP2	8.324	9.6146	5.6312	0.0799

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-38	CTRP2	7.7877	8.6918	5.7562	0.0393

Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Central Nervous System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
D-423MG	GDSC1; GDSC2	5.8744	9.9432	3.1424	8.6026
GI-1	GDSC1; GDSC2	5.9296	10.0546	3.1275	8.5637
D-245MG	GDSC2	6.1692	11.2927	2.6951	10.5435
LN-405	GDSC1; GDSC2	6.4275	8.7811	4.0421	2.328
D-263MG	GDSC1; GDSC2	6.4957	7.8831	4.4442	0.4921
AM-38	GDSC1; GDSC2	6.5333	9.8903	3.6048	4.5352
SW1783	GDSC1; GDSC2; CTRP2	6.6075	9.3685	4.8251	4.4415
LNZTA3WT4	GDSC1; GDSC2	6.6498	8.6014	4.2309	1.1721
M059J	GDSC1; GDSC2	6.7372	11.3185	3.0679	7.2003
D-542MG	GDSC1; GDSC2	6.7777	8.1662	4.4527	0.3203
MOG-G-UVW	GDSC1; GDSC2	6.8193	9.6375	3.881	2.6125
D-247MG	GDSC1; GDSC2	6.8225	9.2334	4.0545	1.7709
CCF-STTG1	CTRP2	6.8395	8.2988	5.4906	1.168
8-MG-BA	GDSC1; GDSC2; CTRP2	6.928	12.3449	2.8194	7.2201
SNU-466	CTRP2	6.9351	8.0893	5.6342	0.5895
D-336MG	GDSC1; GDSC2	6.9508	11.4842	3.1254	6.4768
GMS-10	CTRP2	6.9758	8.558	4.5211	0.3672
KINGS-1	GDSC1; GDSC2	6.9981	8.9342	4.256	0.7877
M059K	CTRP2	7.0183	8.7613	4.4623	0.4878
SNU-489	CTRP2	7.0267	8.1992	5.6337	0.5237
KNS-81-FD	GDSC1; GDSC2	7.1367	9.4188	4.128	1.1518
H4	GDSC1; GDSC2	7.1975	9.0213	4.3057	0.5113
D-392MG	GDSC1; GDSC2	7.2094	9.4626	4.1432	1.0358
D-502MG	GDSC1; GDSC2	7.2096	9.8916	3.9717	1.7284
SK-MG-1	GDSC1; GDSC2	7.2225	8.9719	4.3336	0.4246
Onda 10	GDSC1; GDSC2	7.2332	8.8953	4.3653	0.3427
KS-1 [Human Krukenberg tumour]	GDSC1; GDSC2	7.2564	12.1288	3.0154	6.5364
YH-13	GDSC1; GDSC2; CTRP2	7.2656	8.6861	4.586	0.1579
Hs 683	GDSC1; GDSC2; CTRP2	7.3319	8.6749	5.5846	0.5023
MOG-G-CCM	GDSC1; GDSC2	7.3653	10.0906	3.9645	1.6061
KNS-81	CTRP2	7.3658	8.4708	5.678	0.2337
Daoy	GDSC1; GDSC2; CTRP2	7.374	9.6035	5.2127	1.6143
PFSK-1	GDSC2	7.3989	9.4856	4.2148	0.6671
D-566MG	GDSC1; GDSC2	7.4137	9.6366	4.1641	0.818
SNU-1105	CTRP2	7.472	8.5684	5.6845	0.1849
LN-18	GDSC1; GDSC2; CTRP2	7.4939	8.3996	5.7526	0.0804
SNU-738	CTRP2	7.51	8.8999	5.5755	0.3962
SF295	GDSC1; GDSC2; CTRP2	7.6055	10.5617	4.916	2.4435
U-118MG	GDSC1; GDSC2; CTRP2	7.7259	9.1299	5.5789	0.2958
Onda 11	GDSC1; GDSC2	7.7484	9.837	4.2244	0.4683
SNU-201	CTRP2	7.7565	9.0574	5.6178	0.213
SNU-626	CTRP2	7.8272	9.0651	5.6421	0.1553
TM-31	CTRP2	7.8306	9.0407	5.652	0.1509
A-172	GDSC1; GDSC2; CTRP2	7.8467	11.5845	4.5933	3.3724
KNS-60	CTRP2	7.8521	8.7909	5.7451	0.0411
D283 Med	GDSC1; GDSC2; CTRP2	7.8521	9.3374	5.5529	0.3225
CAS-1	GDSC1; GDSC2; CTRP2	7.8772	9.2721	5.5869	0.2295
U-87MG ATCC	GDSC1; GDSC2; CTRP2	7.8923	8.923	5.7147	0.0602
U-251MG	GDSC1; GDSC2; CTRP2	7.9123	9.9573	5.3388	0.7818
DK-MG	GDSC1; GDSC2; CTRP2	7.9134	9.1448	5.6461	0.1306
GB-1	GDSC1; GDSC2; CTRP2	7.9447	9.5943	5.4947	0.3829
NMC-G1	GDSC1; GDSC2; CTRP2	7.9461	9.5532	5.5108	0.3491
SF126	GDSC1; GDSC2; CTRP2	8.0255	9.344	5.6175	0.1446
SNB-75	GDSC1; GDSC2; CTRP2	8.09	10.4978	5.2032	1.0497
GOS-3	CTRP2	8.1912	10.6451	5.1914	1.091
ONS-76	GDSC1; GDSC2; CTRP2	8.2138	9.6505	5.5794	0.155
KG-1-C	CTRP2	8.2269	9.3581	5.6838	0.0491
YKG-1	GDSC1; GDSC2; CTRP2	8.2362	9.665	5.5826	0.1572
T98G	GDSC1; GDSC2; CTRP2	8.3331	9.9176	5.5296	0.1969
Becker	GDSC1; GDSC2; CTRP2	8.4191	10.4024	5.3868	0.4182
GaMG	GDSC1; GDSC2; CTRP2	8.442	10.0933	5.5082	0.202
KNS-42	GDSC1; GDSC2; CTRP2	8.4856	9.8113	5.6209	0.0749
LN-229	GDSC1; GDSC2; CTRP2	8.5072	9.8399	5.6188	0.0691
SW1088	GDSC1; GDSC2; CTRP2	8.6464	10.3586	5.4906	0.1809
DBTRG-05MG	GDSC1; GDSC2; CTRP2	8.6517	10.0936	5.5834	0.0815
42-MG-BA	GDSC1; GDSC2; CTRP2	8.8965	14.1959	4.0287	4.2863
KALS-1	GDSC1; GDSC2; CTRP2	8.9422	11.3668	5.2403	0.5136
SF268	GDSC1; GDSC2; CTRP2	8.9947	11.1169	5.3524	0.2964
SF539	GDSC1; GDSC2; CTRP2	10.2723	18.7503	2.7735	7.2386

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TGBC1TKB	GDSC1; GDSC2	6.8219	8.2621	4.4352	0.3449
ETK-1	GDSC1; GDSC2	7.055	9.2495	4.1581	1.1035
TGBC24TKB	GDSC1; GDSC2	7.4339	9.3475	4.2796	0.4674

Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Endometrium Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JHUEM-3	CTRP2	6.344	9.0591	4.7789	4.7684
HEC-6	CTRP2	7.4271	8.6551	5.6339	0.3011
JHUEM-7	CTRP2	7.6613	10.08	5.1615	1.5193
MFE-280	GDSC1; GDSC2	7.6872	10.1212	4.0949	0.8685
HEC-59	CTRP2	7.7737	9.1465	5.592	0.2535
RL95-2	GDSC1; GDSC2; CTRP2	7.841	9.0946	5.6368	0.1597
HEC-265	CTRP2	7.8774	9.0791	5.6558	0.1255
JHUEM-1	CTRP2	7.9091	8.8466	5.746	0.0384
HEC-151	CTRP2	7.922	9.1962	5.6312	0.1487
HEC-1-B	CTRP2	8.0397	9.611	5.5271	0.284
EN	GDSC1; GDSC2; CTRP2	8.0444	9.7319	5.4842	0.3651
HEC-251	CTRP2	8.1884	9.5375	5.6095	0.1227
HEC-108	CTRP2	8.1942	9.3296	5.6822	0.0533
MFE-319	GDSC1; GDSC2; CTRP2	8.2279	9.6038	5.6008	0.135
HEC-1-A	CTRP2	8.3309	14.3514	3.6069	6.5484
JHUEM-2	CTRP2	8.3862	9.9853	5.5255	0.1904
ESS-1	GDSC1; GDSC2; CTRP2	8.4403	9.845	5.5938	0.1066
EFE-184	CTRP2	8.5737	9.927	5.6124	0.067
AN3-CA	GDSC1; GDSC2; CTRP2	8.6996	10.5404	5.4462	0.2298
MFE-296	GDSC1; GDSC2; CTRP2	8.7057	10.3935	5.5	0.1577
HEC-50B	CTRP2	8.7856	10.7899	5.3898	0.2938
KLE	GDSC1; GDSC2; CTRP2	8.8125	10.7543	5.4128	0.2513
Ishikawa (Heraklio) 02 ER-	CTRP2	7.3759	8.3316	5.7328	0.1326

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Kidney Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TUHR14TKB	CTRP2	0.986	3.4105	-2.7464	1.0659
KTCTL-140	GDSC1; GDSC2	5.9145	10.077	3.1059	8.728
A-704	GDSC1; GDSC2	6.6985	8.3147	4.3655	0.6194
SN12C	GDSC1; GDSC2	6.8527	9.4596	3.9747	2.1103
SW13	GDSC1; GDSC2	6.9332	8.811	4.2755	0.7656
KTCTL-26A	GDSC1; GDSC2	6.9551	9.8938	3.8425	2.6257
KTCTL-1M	GDSC1; GDSC2	7.1415	9.2313	4.2033	0.8698
KTCTL-13	GDSC1; GDSC2	7.1725	9.4923	4.1151	1.1718
NCC010	GDSC1; GDSC2	7.1837	9.3778	4.1649	0.9758
Caki-2	CTRP2	7.1871	8.4262	4.6472	0.0962
BB65-RCC	GDSC1; GDSC2	7.2606	9.1542	4.2819	0.5458
LB996-RCC	GDSC1; GDSC2	7.3744	9.508	4.1963	0.739
KTCTL-21	GDSC1; GDSC2	7.4039	9.7694	4.109	1.0132
LB2241-RCC	GDSC1; GDSC2	7.411	9.708	4.1357	0.9149
SW156	GDSC1; GDSC2	7.4605	9.8801	4.0907	1.0367
UO-31	GDSC1; GDSC2; CTRP2	7.483	12.4718	3.9363	6.4286
NCC021	GDSC1; GDSC2	7.5225	9.295	4.3321	0.3103
KTCTL-195	GDSC1; GDSC2	7.5525	9.1877	4.3805	0.2105
HA7-RCC	GDSC1; GDSC2	7.663	9.7082	4.2379	0.4715
TUHR4TKB	CTRP2	7.6852	8.9372	5.6336	0.2075
TUHR10TKB	CTRP2	7.695	8.7711	5.6966	0.1103
TK-10	GDSC1; GDSC2	7.7686	9.8959	4.2109	0.4928
RXF 393L	GDSC1; GDSC2	7.7911	10.2325	4.096	0.802
RCC10RGB	GDSC1; GDSC2; CTRP2	7.9232	9.2909	5.5979	0.198
A-498	GDSC1; GDSC2; CTRP2	7.958	9.3308	5.5969	0.2043
LB1047-RCC	GDSC1; GDSC2	7.9699	9.9484	4.2679	0.2961
KMRC-1	GDSC2; CTRP2	8.0575	9.2938	5.6466	0.1033
SNU-1272	CTRP2	8.1071	9.6022	5.5565	0.2136
KMRC-3	CTRP2	8.1278	10.1352	5.3656	0.5925
VMRC-RCW	GDSC2; CTRP2	8.2336	9.886	5.5029	0.2655
BFTC-909	GDSC1; GDSC2; CTRP2	8.3187	9.9551	5.5108	0.2288
769-P	GDSC1; GDSC2; CTRP2	8.4027	9.8895	5.5651	0.1361
786-O	GDSC1; GDSC2; CTRP2	8.4439	10.1623	5.4843	0.2544
KMRC-2	CTRP2	8.4921	9.61	5.6897	0.0295
OS-RC-2	GDSC1; GDSC2; CTRP2	8.5697	9.9347	5.6085	0.0705
KMRC-20	GDSC1; GDSC2; CTRP2	8.6814	9.8998	5.6577	0.0316
VMRC-RCZ	GDSC1; GDSC2; CTRP2	8.7056	10.089	5.6034	0.0653
ACHN	GDSC1; GDSC2; CTRP2	8.7561	10.3207	5.543	0.1041
Caki-1	GDSC1; GDSC2; CTRP2	8.7617	10.4882	5.4875	0.1743
CAL-54	GDSC1; GDSC2; CTRP2	8.7929	10.3718	5.5385	0.111

Cancer Drug Sensitivity Data Curated from 59 Cell Line(s) in Large Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
GP2d	CTRP2	5.9167	7.5027	5.2062	3.7776
SNU-283	GDSC2	5.9471	8.4142	3.9258	3.7583
SNU-1040	GDSC1	6.2833	8.2964	4.1751	2.3015
SK-CO-1	GDSC1; GDSC2; CTRP2	6.433	9.055	4.8494	4.3209
COLO 320HSR	GDSC1; GDSC2	6.7532	11.4122	3.0341	7.3601
SNU-175	GDSC2	7.0053	9.0354	4.22	0.9106
GP5d	GDSC1; GDSC2	7.0894	8.8323	4.3321	0.4926
HCT 15	GDSC1; GDSC2; CTRP2	7.1047	8.8109	5.4129	1.2633
SW1417	GDSC1; GDSC2; CTRP2	7.1128	10.1579	4.7954	3.7704
SW1116	GDSC1; GDSC2	7.113	8.9158	4.3107	0.5414
SNU-81	GDSC1; GDSC2	7.1132	12.1307	2.9263	7.2787
LS1034	GDSC1; GDSC2; CTRP2	7.2494	8.5636	5.5912	0.4988
COLO 678	GDSC1; GDSC2; CTRP2	7.2864	9.9714	4.9941	2.7009
DLD-1	CTRP2	7.3376	16.7278	1.7385	15.1311
CaR-1	GDSC1; GDSC2	7.3623	8.985	4.3818	0.262
HCC2998	GDSC1; GDSC2	7.3946	9.1616	4.3314	0.3579
SW837	GDSC1; GDSC2	7.5137	9.5389	4.2412	0.5313
SNU-1033	CTRP2	7.5296	10.9982	4.6688	3.4653
OUMS-23	CTRP2	7.6127	8.87	5.6296	0.2384
MDST8	GDSC1; GDSC2; CTRP2	7.6512	8.7204	5.6982	0.1172
SNU-C4	CTRP2	7.7068	8.836	5.6781	0.1322
HCC-56	CTRP2	7.7166	8.7921	5.6971	0.1131
HT115	GDSC1; GDSC2; CTRP2	7.7665	8.7093	5.7431	0.0512
SW626	GDSC1; GDSC2	7.7815	9.8883	4.2187	0.4684
NCI-H747	GDSC1; GDSC2	7.8241	9.7272	4.2917	0.2944
NCI-H508	GDSC1; GDSC2; CTRP2	7.8566	9.4087	5.5281	0.3486
LS123	GDSC1; GDSC2; CTRP2	7.8623	9.3098	5.5672	0.2694
SNU-503	CTRP2	7.8832	9.3473	5.5617	0.2928
HT-55	GDSC2; CTRP2	7.9254	9.3732	5.5689	0.2458
RCM-1 [Human ESC]	GDSC1; GDSC2; CTRP2	7.9441	9.2199	5.631	0.144
HCT 116	GDSC1; GDSC2; CTRP2	7.9458	9.3105	5.5995	0.1893
SNU-C2B	GDSC1; GDSC2	8.0008	16.5939	1.3971	13.3048
COLO205	GDSC1; GDSC2; CTRP2	8.0038	9.362	5.6031	0.1694
DiFi	GDSC1; GDSC2	8.0157	10.2385	4.1826	0.4592
CL-11	GDSC1; GDSC2; CTRP2	8.0444	10.0236	5.3724	0.6186
SNU-61	GDSC1; GDSC2; CTRP2	8.0511	9.6676	5.5108	0.3104
LS411N	GDSC1; GDSC2; CTRP2	8.059	9.4219	5.6025	0.1576
SNU-C1	GDSC1; GDSC2; CTRP2	8.0637	9.5722	5.5506	0.2528
SW1463	GDSC1; GDSC2; CTRP2	8.1353	9.5021	5.6025	0.1413
HCT 8	CTRP2	8.1778	9.3738	5.6617	0.0713
SW48	GDSC1; GDSC2; CTRP2	8.2286	10.2048	5.3822	0.5063
LS180	GDSC1; GDSC2; CTRP2	8.235	9.6875	5.5742	0.1574
LS513	GDSC1; GDSC2; CTRP2	8.2446	9.4976	5.6431	0.0794
HT-29	GDSC1; GDSC2; CTRP2	8.251	9.4104	5.6746	0.0533
CCK-81	GDSC1; GDSC2; CTRP2	8.3006	10.1051	5.4492	0.34
COLO201	CTRP2	8.3171	9.9549	5.5103	0.23
RKO	GDSC1; GDSC2; CTRP2	8.3642	10.4652	5.3403	0.5395
KM12	GDSC1; GDSC2; CTRP2	8.3786	10.1606	5.4597	0.2956
SNU-C2A	CTRP2	8.4814	10.6429	5.322	0.5285
SW620	GDSC1; GDSC2; CTRP2	8.5713	10.5968	5.3761	0.3839
C2BBe1	GDSC1; GDSC2; CTRP2	8.6088	10.4256	5.4528	0.2424
NCI-H716	GDSC1; GDSC2; CTRP2	8.7056	10.4061	5.4956	0.163
CW-2	GDSC1; GDSC2; CTRP2	8.7064	10.3892	5.5018	0.1555
SNU-C5	GDSC1; GDSC2; CTRP2	8.7206	10.4288	5.4932	0.1631
SNU-407	GDSC1; GDSC2; CTRP2	8.8594	10.6549	5.4651	0.171
SW948	GDSC1; GDSC2; CTRP2	8.9105	18.6069	1.9615	12.5832
LoVo	GDSC1; GDSC2; CTRP2	8.9747	10.5498	5.5415	0.0795
T84	GDSC1; GDSC2; CTRP2	8.9748	10.9658	5.3986	0.2333
COLO 320	CTRP2	9.5098	11.9193	5.2613	0.3035

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MO-T	GDSC1; GDSC2	6.1775	8.5665	3.9962	2.9524

Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Liver Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Hep-G2/C3A	GDSC1; GDSC2	6.2009	7.7493	4.3644	1.0462
JHH-1	GDSC1; GDSC2; CTRP2	6.5658	7.476	4.752	0.0801
JHH-4	GDSC1; GDSC2; CTRP2	6.9723	8.8002	5.3415	1.5714
JHH-6	GDSC1; GDSC2; CTRP2	7.1887	7.9241	5.807	0.0772
HLE	GDSC1; GDSC2	7.327	9.3629	4.2312	0.6586
Huh-7	GDSC1; GDSC2	7.3994	8.8398	4.4452	0.1452
HuH-1	GDSC1; GDSC2; CTRP2	7.4093	8.8201	4.5913	0.1229
SNU-886	CTRP2	7.4945	9.4115	5.3606	1.0099
JHH-7	GDSC1; GDSC2	7.5371	11.9115	3.2776	4.6899
SNU-423	GDSC1; GDSC2; CTRP2	7.6008	9.1009	5.5371	0.4758
SNU-475	CTRP2	7.6567	8.9093	5.6326	0.2344
Hep 3B2.1-7	GDSC1; GDSC2; CTRP2	7.8636	9.1407	5.629	0.1657
SK-HEP-1	GDSC1; GDSC2; CTRP2	7.9707	9.2687	5.6237	0.1481
JHH-5	CTRP2	7.9959	9.6816	5.483	0.4153
Hep-G2	CTRP2	8.0192	9.306	5.6285	0.1317
JHH-2	GDSC1; GDSC2; CTRP2	8.2058	9.8004	5.5231	0.2577
SNU-449	GDSC1; GDSC2; CTRP2	8.2605	11.7345	4.7649	2.3182
SNU-182	CTRP2	8.271	10.0427	5.4604	0.3292
SNU-387	GDSC1; GDSC2; CTRP2	8.3009	10.1757	5.4232	0.419
SNU-878	CTRP2	8.3249	9.9615	5.5109	0.227
HuH-6	CTRP2	8.3699	10.5716	5.3018	0.6253
HLF	CTRP2	8.4294	9.8115	5.6014	0.1004
Li-7	CTRP2	8.4822	10.1044	5.5192	0.1778
SNU-398	GDSC1; GDSC2; CTRP2	8.5626	10.405	5.4426	0.2706
PLC/PRF/5	CTRP2	8.7724	9.995	5.6566	0.0295

Cancer Drug Sensitivity Data Curated from 221 Cell Line(s) in Lung Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
LC-1F	CTRP2	-0.1922	18.0268	-10.5093	34.8505
NCI-H1184	CTRP2	4.9738	11.5844	2.3384	17.5809
NCI-H510A	GDSC2	5.3632	7.6593	3.89	5.2266
NCI-H250	GDSC2	5.5706	7.8237	3.9577	4.3318
NCI-H345	GDSC1; GDSC2	5.7482	6.58	4.6245	0.3909
NCI-H146	GDSC1; GDSC2	5.8443	7.8711	4.114	2.8598
VMRC-LCD	GDSC1; GDSC2; CTRP2	5.9875	6.7796	5.6284	1.8615
NCI-H1341	GDSC1; GDSC2; CTRP2	6.0632	6.9583	5.603	1.9539
NCI-H187	GDSC1	6.0796	8.018	4.1858	2.5889
NCI-H2803	GDSC1; GDSC2	6.0985	8.9545	3.7691	4.3845
NCI-H1568	GDSC1; GDSC2; CTRP2	6.1144	7.8134	5.2175	3.5905
UMC-11	GDSC1; GDSC2	6.1601	8.6003	3.9706	3.1237
NCI-H1836	GDSC1; GDSC2	6.198	8.5128	4.0323	2.7213
NCI-H2227	GDSC1; GDSC2	6.2617	13.5398	1.6609	15.8603
NCI-H209	GDSC1; GDSC2	6.2628	10.3728	3.2047	7.3703
NCI-H2444	GDSC1; GDSC2	6.302	7.5032	4.5071	0.4117
COR-L32	GDSC1; GDSC2	6.317	8.6275	4.0487	2.452
NCI-H1770	GDSC1; GDSC2	6.3391	7.7463	4.4296	0.6525
NCI-H1304	GDSC1	6.3804	8.232	4.2525	1.6897
COR-L321	GDSC1; GDSC2	6.3876	8.4563	4.1614	1.7811
NCI-H64	GDSC2	6.3977	9.0355	3.9128	3.0562
LB647-SCLC	GDSC1; GDSC2	6.4233	8.1834	4.2935	1.1276
IST-SL1	GDSC1; GDSC2	6.4241	8.3966	4.2054	1.5254
NCI-H2196	GDSC2; CTRP2	6.4298	8.1381	5.2987	2.6467
T3M-10	CTRP2	6.4469	8.0503	5.3539	2.2115
NCI-H847	GDSC1; GDSC2	6.4765	8.709	4.0996	1.9717
COR-L95	GDSC1; GDSC2; CTRP2	6.489	8.0274	5.3945	2.1305
COR-L23	GDSC1; GDSC2	6.4901	9.8566	3.594	4.6721
NCI-H1781	GDSC1; GDSC2	6.5022	8.1012	4.3629	0.7731
NCI-H2369	GDSC1; GDSC2	6.5127	8.1578	4.3453	0.8319
NCI-H82	GDSC1; GDSC2	6.5241	8.4134	4.2477	1.2245
NCI-H720	GDSC1; GDSC2	6.5709	7.9003	4.4685	0.3761
Lu-135	GDSC1; GDSC2	6.5806	11.386	2.9336	8.2765
SBC-1	GDSC1; GDSC2	6.5813	11.3346	2.9585	8.1331
Lu-165	GDSC1; GDSC2	6.6228	8.1044	4.4135	0.5114
NCI-H810	GDSC1; GDSC2; CTRP2	6.6479	12.1983	3.4548	9.7399
LK-2	GDSC1; GDSC2	6.649	11.865	2.7507	9.1688
ChaGo-K-1	GDSC1; GDSC2; CTRP2	6.6512	8.8572	5.106	2.9157
NCI-H1436	GDSC1; GDSC2	6.6809	8.1152	4.4332	0.4189
Lu-134-A	GDSC1; GDSC2	6.7253	13.7602	1.8889	13.6252
NCI-H3255	GDSC1; GDSC2	6.7423	15.1296	1.2327	16.7371
DV-90	CTRP2	6.7483	9.3188	4.9503	3.4049
NCI-H2722	GDSC1; GDSC2	6.8048	8.7052	4.2605	0.9169
NCI-H2810	GDSC1; GDSC2	6.8151	9.5664	3.9095	2.4757
COR-L311	GDSC2	6.8376	8.6608	4.2922	0.7755
NCI-H748	GDSC2	6.857	9.9208	3.778	3.0857
LC-2/ad	GDSC1; GDSC2	6.8609	8.6081	4.3224	0.6558
NCI-H2141	GDSC1; GDSC2	6.8614	9.1107	4.1241	1.4195
COLO 668	GDSC1; GDSC2	6.8638	9.1279	4.1183	1.4425
BEN	GDSC1; GDSC2; CTRP2	6.8773	7.9102	5.6802	0.4916
NCI-H1876	GDSC1; GDSC2	6.8937	10.3064	3.628	3.8195
NCI-H2461	GDSC1; GDSC2	6.8956	11.1733	3.2351	5.9661
CPC-N	GDSC1; GDSC2	6.8969	8.7615	4.279	0.7794
NCI-H524	GDSC1; GDSC2	6.9164	8.845	4.2551	0.85
Lu-99A	GDSC1; GDSC2	6.9286	9.7394	3.8948	2.4025
NCI-H2029	GDSC1; GDSC2	6.9446	8.2041	4.5014	0.1622
RERF-LC-KJ	GDSC1; GDSC2	6.9477	8.3838	4.4396	0.2827
NCI-H1993	GDSC1; GDSC2	6.951	8.6843	4.3311	0.5719
HCC4006	CTRP2	6.9632	8.9785	5.2541	2.0527
NCI-H290	GDSC1; GDSC2	6.9741	10.0233	3.7968	2.8289
NCI-H2731	GDSC1; GDSC2	6.9833	9.3664	4.078	1.4966
RERF-LC-Sq1	GDSC1; GDSC2	6.9946	10.3096	3.683	3.3808
NCI-H1648	GDSC1; GDSC2	6.9959	9.6098	3.9838	1.9015
NCI-H596	GDSC1; GDSC2	6.9961	8.8007	4.306	0.6234
RERF-LC-Ad1	CTRP2	7.0051	7.9158	5.7372	0.2594
HCC33	GDSC2	7.0376	8.4956	4.4337	0.2632
NCI-H2795	GDSC1; GDSC2	7.0386	9.403	4.0892	1.3952
Lu-139	GDSC1; GDSC2	7.0517	8.6451	4.3856	0.3686
NCI-H2373	GDSC1; GDSC2	7.058	9.0902	4.2217	0.8653
Ms-1	GDSC1; GDSC2	7.0679	8.9059	4.296	0.6113
NCI-H1734	GDSC2; CTRP2	7.069	10.044	4.8205	3.4702
NCI-H1975	GDSC1; GDSC2	7.0711	8.8881	4.3041	0.5847
LK2	CTRP2	7.0727	7.8244	5.7989	0.1101
NCI-H2818	GDSC1; GDSC2	7.0753	13.5434	2.2347	11.0806
NCI-H835	GDSC1; GDSC2	7.1027	12.7247	2.6415	8.8542
NCI-H2171	GDSC2; CTRP2	7.1062	8.5695	5.5184	0.8809
NCI-H513	GDSC1; GDSC2	7.1182	9.5355	4.073	1.3881
EMC-BAC-2	GDSC1; GDSC2	7.1385	9.8939	3.9361	1.9613
SBC-3	GDSC1; GDSC2	7.1473	9.1149	4.2502	0.7078
NCI-H2135	GDSC1; GDSC2	7.1518	8.4569	4.4884	0.1346
NCI-H740	GDSC2	7.1753	10.812	3.5618	3.7488
NCI-H1437	GDSC1; GDSC2	7.1767	8.8379	4.3643	0.3679
NCI-H1048	GDSC1; GDSC2	7.1977	9.1312	4.265	0.6307
IST-SL2	GDSC1; GDSC2	7.2003	11.2271	3.3916	4.6044
NCI-H2009	GDSC1; GDSC2	7.2162	9.8972	3.9725	1.7179
NCI-H1092	GDSC1; GDSC2; CTRP2	7.2236	9.0974	5.3525	1.3663
PaCa-3	GDSC1; GDSC2	7.2449	13.1241	2.545	9.097
NCI-H1963	GDSC2	7.2597	9.8695	4.0044	1.5398
NCI-H2081	GDSC1; GDSC2; CTRP2	7.2806	10.1792	4.894	2.9055
A-427	GDSC1; GDSC2	7.3031	9.506	4.1671	0.882
MOR/CPR	CTRP2	7.3216	8.2371	5.746	0.1265
Sq-1	CTRP2	7.333	8.6983	5.5758	0.4902
COR-L303	GDSC2	7.3513	8.7702	4.452	0.1455
SBC-5	GDSC1; GDSC2; CTRP2	7.4125	8.6766	5.6196	0.3398
NCI-H1688	GDSC1; GDSC2	7.47	9.1522	4.3629	0.2655
NCI-H460	GDSC1; GDSC2; CTRP2	7.5148	8.7517	5.6339	0.2657
NCI-H1573	GDSC1; GDSC2; CTRP2	7.5527	8.9122	5.5891	0.3452
LC-1/sq	GDSC1; GDSC2	7.58	9.8292	4.1604	0.728
LCLC-103H	GDSC1; GDSC2; CTRP2	7.584	10.0008	5.154	1.6158
SW1573	GDSC1; GDSC2	7.5864	9.9678	4.1109	0.8811
NCI-H322M	GDSC1; GDSC2	7.6028	10.0222	4.097	0.916
NCI-H2347	GDSC1; GDSC2	7.6124	9.4523	4.3101	0.3257
ABC-1	GDSC1; GDSC2	7.6144	9.7644	4.1984	0.5984
NCI-H2804	GDSC1; GDSC2	7.6167	10.2232	4.0257	1.1543
HCC2108	CTRP2	7.6338	10.1396	5.1205	1.6842
IA-LM	GDSC1; GDSC2; CTRP2	7.651	9.1238	5.55	0.3889
NCI-H2066	GDSC1; GDSC2	7.661	9.3058	4.3786	0.1872
NCI-H2595	GDSC1; GDSC2	7.6894	9.5838	4.2923	0.3366
NCI-H1563	GDSC1; GDSC2; CTRP2	7.69	9.1674	5.5498	0.3717
EMC-BAC-1	GDSC1; GDSC2	7.6964	10.3358	4.0167	1.1274
NCI-H3122	GDSC1; GDSC2	7.6974	9.8548	4.1981	0.5583
NCI-H23	GDSC1; GDSC2; CTRP2	7.6979	9.8932	5.2607	1.1641
SK-LU-1	GDSC1; GDSC2; CTRP2	7.6983	11.0108	4.7667	2.8931
NCI-H2869	GDSC1; GDSC2	7.7129	9.6551	4.2759	0.3634
DMS 53	GDSC1; GDSC2; CTRP2	7.7298	15.1627	2.8022	10.538
Calu-3	GDSC1; GDSC2; CTRP2	7.7547	13.2994	3.7243	6.8812
Lu-65	GDSC1; GDSC2; CTRP2	7.7662	9.7929	5.3364	0.8836
NCI-H226	GDSC1; GDSC2; CTRP2	7.7854	8.9772	5.6576	0.143
HCC1438	CTRP2	7.7994	10.2902	5.1441	1.4561
DMS 79	GDSC1; GDSC2; CTRP2	7.8238	9.8149	5.3548	0.7929
NCI-H2126	CTRP2	7.8505	9.0519	5.6554	0.1315
NCI-H69	GDSC1; GDSC2; CTRP2	7.8904	10.5838	5.0658	1.6359
NCI-H1395	CTRP2	7.9024	11.3398	4.738	2.9791
NCI-H2591	GDSC1; GDSC2	7.9026	9.8434	4.2799	0.2935
NCI-H841	GDSC1; GDSC2; CTRP2	7.9099	9.944	5.343	0.7717
NCI-H889	CTRP2	7.9194	9.7729	5.4152	0.578
LCLC-97TM1	GDSC1; GDSC2; CTRP2	7.9391	10.1092	5.2898	0.9015
HCC1588	CTRP2	7.9478	9.3712	5.5784	0.2228
DMS 114	GDSC1; GDSC2; CTRP2	7.9597	11.5906	4.6582	3.004
SHP-77	GDSC1; GDSC2; CTRP2	7.9782	9.2674	5.6269	0.1422
COR-L88	GDSC1; GDSC2; CTRP2	7.9805	10.0464	5.3345	0.752
LC-1/sq-SF	CTRP2	7.9833	9.1178	5.6805	0.0796
CAL-12T	GDSC1; GDSC2; CTRP2	7.9918	9.8983	5.3981	0.5824
NCI-H526	GDSC1; GDSC2; CTRP2	7.9946	9.2201	5.6494	0.1109
NCI-H1694	GDSC1; GDSC2; CTRP2	8.0061	9.5464	5.5375	0.2761
Calu-6	GDSC1; GDSC2; CTRP2	8.032	9.73	5.4798	0.3789
NCI-H1793	GDSC1; GDSC2; CTRP2	8.0383	9.843	5.4396	0.4627
COR-L279	GDSC1; GDSC2; CTRP2	8.0935	9.5151	5.5824	0.1779
PC-14	GDSC1; GDSC2; CTRP2	8.1008	9.8463	5.4644	0.3834
NCI-H196	GDSC1; GDSC2; CTRP2	8.1212	9.4624	5.6112	0.1332
NCI-H650	GDSC1; GDSC2; CTRP2	8.1238	9.7617	5.5052	0.2961
NCI-H520	GDSC1; GDSC2; CTRP2	8.1274	9.6479	5.5479	0.2218
NCI-H2106	CTRP2	8.1394	10.0233	5.4136	0.4758
NCI-H1703	GDSC1; GDSC2; CTRP2	8.1548	12.6443	4.2934	4.447
NCI-H522	GDSC1; GDSC2; CTRP2	8.1652	12.4475	4.3901	4.045
NCI-H441	GDSC1; GDSC2; CTRP2	8.1722	9.7278	5.5364	0.2279
RERF-LC-Ad2	CTRP2	8.1803	9.5035	5.6183	0.114
HCC1195	CTRP2	8.1804	9.6364	5.572	0.1724
NCI-H838	GDSC1; GDSC2; CTRP2	8.1843	9.2416	5.7081	0.0401
HCC827	GDSC1; GDSC2; CTRP2	8.1906	9.8342	5.505	0.2751
RERF-LC-MS	GDSC1; GDSC2; CTRP2	8.1914	9.8077	5.5149	0.2577
NCI-H1435	GDSC1; GDSC2; CTRP2	8.2373	9.8162	5.5295	0.2212
SW1271	GDSC1; GDSC2; CTRP2	8.2418	9.8013	5.5365	0.2092
NCI-H2122	GDSC1; GDSC2; CTRP2	8.2525	9.6869	5.5809	0.1453
NCI-H446	GDSC1; GDSC2; CTRP2	8.2542	10.0044	5.4678	0.3212
Calu-1	CTRP2	8.2748	10.1292	5.4299	0.3865
LOU-NH91	GDSC1; GDSC2; CTRP2	8.2777	9.5022	5.6531	0.0669
NCI-H2170	GDSC1; GDSC2; CTRP2	8.2819	10.172	5.4168	0.4102
NCI-H1755	GDSC1; GDSC2; CTRP2	8.2843	9.949	5.4998	0.2559
KNS-62	GDSC1; GDSC2; CTRP2	8.3154	10.0816	5.4637	0.3085
NCI-H1155	GDSC1; GDSC2; CTRP2	8.3195	9.5423	5.654	0.0617
DMS 273	GDSC1; GDSC2; CTRP2	8.3313	9.9019	5.5345	0.2045
NCI-H661	GDSC1; GDSC2; CTRP2	8.3341	10.6291	5.2636	0.7368
LUDLU-1	CTRP2	8.3397	17.3432	2.1748	12.6997
NCI-H1299	GDSC1; GDSC2; CTRP2	8.3415	9.9822	5.5098	0.2244
HCC78	GDSC1; GDSC2; CTRP2	8.3476	9.7924	5.5788	0.13
NCI-H2286	CTRP2	8.3628	9.8484	5.5649	0.1437
NCI-H2172	GDSC1; GDSC2; CTRP2	8.3685	9.5507	5.6679	0.0474
SK-MES-1	GDSC1; GDSC2; CTRP2	8.3806	10.1195	5.4754	0.2884
NCI-H1581	GDSC1; GDSC2; CTRP2	8.3856	9.7407	5.61	0.0912
NCI-H1666	GDSC1; GDSC2; CTRP2	8.392	10.3252	5.4045	0.3931
HARA [Human squamous cell lung carcinoma]	GDSC1; GDSC2; CTRP2	8.4166	9.9542	5.5476	0.1546
HCC95	CTRP2	8.4172	10.0551	5.5124	0.2017
NCI-H2291	GDSC1; GDSC2; CTRP2	8.425	10.9678	5.1705	0.9275
NCI-H1915	GDSC1; GDSC2; CTRP2	8.4542	9.7365	5.6352	0.0667
NCI-H2023	GDSC1; GDSC2; CTRP2	8.4823	10.0649	5.533	0.1599
NCI-H1693	GDSC1; GDSC2; CTRP2	8.5195	10.3191	5.457	0.2788
NCI-H1869	GDSC1; GDSC2; CTRP2	8.5217	10.3359	5.4518	0.2672
Lu-99	CTRP2	8.5256	9.8489	5.6221	0.0647
NCI-H1838	GDSC1; GDSC2; CTRP2	8.5593	10.5123	5.4024	0.3397
NCI-H2342	GDSC1; GDSC2; CTRP2	8.5594	10.2087	5.5111	0.1723
NCI-H1339	CTRP2	8.5622	10.4008	5.444	0.2884
COLO 699	CTRP2	8.571	10.2072	5.5158	0.164
NCI-H1651	GDSC1; GDSC2; CTRP2	8.5721	10.2709	5.4939	0.1923
NCI-H1944	GDSC1; GDSC2; CTRP2	8.5986	10.2569	5.5085	0.1801
NCI-H211	GDSC1; GDSC2; CTRP2	8.6391	10.1714	5.5526	0.1112
NCI-H1373	CTRP2	8.6656	10.4018	5.4825	0.1874
EBC-1	GDSC1; GDSC2; CTRP2	8.672	10.3028	5.5193	0.1414
HOP-62	GDSC1; GDSC2; CTRP2	8.6847	10.4917	5.4579	0.2167
HCC2279	CTRP2	8.6873	10.399	5.4915	0.1716
HCC1833	CTRP2	8.7018	10.6351	5.4133	0.2792
NCI-H1792	GDSC1; GDSC2; CTRP2	8.7035	10.3993	5.4972	0.1614
HCC2935	CTRP2	8.7144	10.2751	5.5438	0.109
HOP-92	GDSC1; GDSC2; CTRP2	8.7203	15.0644	3.5216	6.373
NCI-H292	GDSC1; GDSC2; CTRP2	8.7326	13.4065	4.2888	3.5238
NCI-H2030	GDSC1; GDSC2; CTRP2	8.733	10.3802	5.5144	0.1365
RERF-LC-A1	CTRP2	8.758	9.9248	5.6747	0.0213
NCI-H322	CTRP2	8.7701	10.4278	5.5113	0.1437
NCI-H2087	GDSC1; GDSC2; CTRP2	8.7778	10.487	5.4937	0.1521
HCC15	GDSC1; GDSC2; CTRP2	8.7831	10.4461	5.5097	0.1335
LXF 289	GDSC1; GDSC2; CTRP2	8.8106	10.3718	5.5447	0.0955
HCC44	GDSC1; GDSC2; CTRP2	8.8388	10.7873	5.4109	0.2476
DMS 454	CTRP2	8.8453	15.5273	3.3844	6.7319
HCC1171	CTRP2	8.8594	10.4913	5.5213	0.1105
NCI-H1355	GDSC1; GDSC2; CTRP2	8.874	10.7342	5.4427	0.196
NCI-H2228	GDSC2; CTRP2	8.9377	10.7207	5.4705	0.1508
EPLC-272H	GDSC1; GDSC2; CTRP2	8.949	10.674	5.4906	0.1278
NCI-H358	GDSC1; GDSC2; CTRP2	8.9776	10.7621	5.4706	0.1442
NCI-H2405	GDSC1; GDSC2; CTRP2	8.9817	10.8795	5.4314	0.1887
HCC366	GDSC1; GDSC2; CTRP2	9.0106	10.5716	5.5465	0.0722
NCI-H727	GDSC1; GDSC2; CTRP2	9.0474	10.5755	5.5577	0.0614
NCI-H2085	GDSC1; GDSC2; CTRP2	9.0769	10.9002	5.4586	0.1412
NCI-H1105	GDSC1; GDSC2; CTRP2	9.089	17.8622	2.4396	10.54
NCI-H2110	GDSC1; GDSC2; CTRP2	9.1042	11.8004	5.1442	0.697
A-549	GDSC1; GDSC2; CTRP2	9.1324	10.6113	5.5744	0.0454
NCI-H1623	GDSC1; GDSC2; CTRP2	9.2252	10.9094	5.5071	0.0799
EKVX	GDSC1; GDSC2; CTRP2	9.2618	11.627	5.2715	0.3522
NCI-H1650	GDSC2; CTRP2	9.4943	10.984	5.5723	0.0278
COR-L105	GDSC1; GDSC2; CTRP2	9.6023	11.6205	5.3983	0.1352
NCI-H647	GDSC1; GDSC2; CTRP2	9.6614	17.1604	3.1334	6.6684
Hs 888.Lu	CTRP2	7.9807	10.6265	5.0948	1.5729

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CBTCi002-A	GDSC1; GDSC2	7.4878	12.749	2.8709	6.9115

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
P-STS	CTRP2	5.9553	6.9882	5.4963	2.4819
H-STS	CTRP2	6.3277	7.6167	5.48	1.8783
SYO-1	CTRP2	8.3017	10.1268	5.4416	0.3539

Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Aska-SS	CTRP2	7.3326	16.2554	1.9687	14.3163
Yamato-SS	CTRP2	8.2695	9.6451	5.6015	0.1176
VA-ES-BJ	GDSC1; GDSC2	6.138	7.7633	4.3272	1.2871
STS-0421	GDSC1; GDSC2	6.3759	9.5602	3.6607	4.4972
SW684	GDSC1; GDSC2	6.5559	7.748	4.518	0.2545
Rh30	GDSC1; GDSC2	6.7618	9.0899	4.0842	1.7025
BT-12	CTRP2	7.0188	7.6743	5.832	0.0744
TE 617.T	CTRP2	7.0228	9.1594	5.2071	2.1684
MFH-ino	GDSC1; GDSC2	7.0477	8.8307	4.3159	0.5622
EW-8	GDSC1; GDSC2	7.2404	15.4874	1.4125	14.7949
Hs 729.T	CTRP2	7.2576	9.2392	5.3088	1.4942
Hs 633.T	GDSC1; GDSC2	7.2832	8.7452	4.4364	0.1852
SW872	GDSC1; GDSC2	7.2855	8.9177	4.377	0.2973
MES-SA	GDSC1; GDSC2; CTRP2	7.7366	8.7425	5.7214	0.0803
HT-1080	GDSC1; GDSC2; CTRP2	7.7523	8.9685	5.6482	0.1771
BT-16	CTRP2	7.7622	8.9156	5.6707	0.1301
Rh18	GDSC1; CTRP2	7.7957	9.3548	5.5231	0.3845
KYM-1	GDSC1; GDSC2; CTRP2	8.0102	9.7731	5.4544	0.4423
SW982	GDSC1; GDSC2; CTRP2	8.0227	9.3143	5.6269	0.133
Tm87-16	CTRP2	8.0738	9.7499	5.4894	0.3434
TE 441.T	GDSC2; CTRP2	8.0869	9.2885	5.6589	0.0923
Rh41	GDSC1; GDSC2; CTRP2	8.1942	10.0757	5.4168	0.4455
TTC-709	CTRP2	8.1978	10.1691	5.3827	0.519
SK-UT-1	GDSC1; GDSC2; CTRP2	8.2127	11.7618	4.7265	2.4972
RKN	GDSC1; GDSC2; CTRP2	8.326	9.5747	5.6454	0.0677
G-401	GDSC1; GDSC2; CTRP2	8.5326	10.9957	5.2081	0.8274
SK-LMS-1	GDSC1; GDSC2; CTRP2	8.5938	10.6762	5.3559	0.4454
RD	GDSC1; GDSC2; CTRP2	9.0496	10.9271	5.4395	0.1665
G-402	GDSC1; GDSC2; CTRP2	9.199	11.6157	5.2512	0.4349
A-204	GDSC1; GDSC2; CTRP2	9.3792	11.8933	5.2207	0.4025
GCT	GDSC1; GDSC2; CTRP2	10.1586	19.2323	2.4823	8.3792

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
U-CH1	CTRP2	8.1212	9.5177	5.5919	0.1583

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Ovary Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
2004	CTRP2	8.2103	10.899	5.0962	1.2822
ES-2	GDSC1; GDSC2	5.7756	8.2724	3.8814	4.3582
SNU-8	CTRP2	6.42	7.5514	5.5763	1.35
JHOM-1	CTRP2	6.4695	7.886	5.4493	1.7904
EFO-21	GDSC1; GDSC2; CTRP2	6.6371	8.6531	5.1949	2.5759
OVKATE	GDSC1; GDSC2	7.0344	8.8276	4.3116	0.5829
JHOS-4	GDSC1; GDSC2	7.2614	9.8184	4.0257	1.4501
OVCAR-3	GDSC1; GDSC2	7.3668	9.355	4.2503	0.5802
EFO-27	GDSC1; GDSC2; CTRP2	7.3865	12.0893	4.0542	6.0959
OV56	GDSC1; GDSC2; CTRP2	7.4044	8.6072	5.6426	0.3137
OV7	CTRP2	7.431	9.3814	5.3406	1.2093
HEY A8	CTRP2	7.4731	10.0114	5.087	1.9618
OAW42	GDSC1; GDSC2; CTRP2	7.5797	8.6608	5.6926	0.1521
Caov-4	GDSC1; GDSC2	7.6014	9.8358	4.1667	0.6968
TYK-nu	GDSC1; GDSC2; CTRP2	7.7117	12.365	4.1423	5.2864
TOV-21G	GDSC1; GDSC2; CTRP2	7.7311	8.9088	5.6615	0.1614
OVISE	GDSC1; GDSC2; CTRP2	7.7562	8.7293	5.7328	0.0612
ES2	CTRP2	7.8145	8.9094	5.6919	0.0938
FU-OV-1	GDSC1; GDSC2; CTRP2	7.9646	10.4037	5.1807	1.2072
DOV13	GDSC1; GDSC2; CTRP2	7.9791	9.375	5.5891	0.1967
Caov-3	GDSC2; CTRP2	7.9871	9.2664	5.6306	0.1355
COV434	CTRP2	7.9971	12.6613	4.1873	4.7391
COV644	CTRP2	8.0032	9.3153	5.6194	0.1469
COV362	CTRP2	8.2486	10.2784	5.3625	0.5416
ONCO-DG-1	CTRP2	8.291	9.6674	5.6016	0.114
JHOS-2	GDSC1; GDSC2; CTRP2	8.3146	9.9847	5.4986	0.2677
SK-OV-3	GDSC1; GDSC2; CTRP2	8.3334	9.8016	5.5704	0.1425
SNU-119	CTRP2	8.4282	10.0724	5.5104	0.202
IGROV-1	GDSC1; GDSC2; CTRP2	8.4361	10.2877	5.4359	0.3194
A2780	GDSC1; GDSC2; CTRP2	8.4911	13.5715	4.0717	4.5815
Kuramochi	GDSC1; GDSC2; CTRP2	8.5357	10.3378	5.4564	0.256
OVSAHO	CTRP2	8.5934	9.9674	5.6057	0.0701
TOV-112D	GDSC1; GDSC2; CTRP2	8.6029	11.0049	5.2352	0.7192
SNU-840	CTRP2	8.6224	10.1357	5.5589	0.1074
OVCAR-5	GDSC1; GDSC2; CTRP2	8.6439	10.1568	5.5593	0.104
OC 314	GDSC1; GDSC2; CTRP2	8.6594	9.8229	5.6755	0.0252
MCAS	CTRP2	8.672	10.2648	5.5323	0.127
OV-90	GDSC1; GDSC2; CTRP2	8.7628	10.4553	5.4993	0.1484
OVK18	GDSC1; GDSC2; CTRP2	8.7707	10.1747	5.597	0.0593
JHOC-5	CTRP2	8.8145	10.0583	5.6499	0.0282
RMG-I	GDSC1; GDSC2; CTRP2	8.8637	10.6603	5.4647	0.1706
OVCAR-4	GDSC1; GDSC2; CTRP2	8.8782	10.6115	5.4868	0.1428
OAW28	GDSC1; GDSC2; CTRP2	8.9301	10.699	5.4753	0.1468
OVTOKO	GDSC1; GDSC2; CTRP2	8.9927	10.9116	5.4242	0.1956
OVCAR-8	GDSC1; GDSC2; CTRP2	9.2513	10.7187	5.5787	0.0364

Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
IST-Mes1	GDSC1; GDSC2; CTRP2	7.9928	10.6397	4.1584	0.7703
MPP 89	GDSC1; GDSC2; CTRP2	8.0915	9.9502	5.4212	0.5157
ACC-MESO-1	CTRP2	8.1962	9.4918	5.628	0.1009
JL-1	CTRP2	8.3476	9.6669	5.6218	0.0854
NCI-H2052	GDSC2; CTRP2	8.4406	9.9601	5.5543	0.1418
NCI-H2452	GDSC1; GDSC2; CTRP2	8.4554	10.9704	5.1834	0.8756
MSTO-211H	GDSC2; CTRP2	8.49	10.5294	5.3683	0.4283
NCI-H28	GDSC1; GDSC2; CTRP2	8.5166	10.0315	5.557	0.1256

Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
PaCa-3	CTRP2	6.3122	7.314	5.6165	1.3427
NCI-H660	GDSC2; CTRP2	7.0369	8.5293	5.4991	0.9438
LNCaP clone FGC	GDSC1; GDSC2	7.3749	9.8024	4.0835	1.1279
PC-3	GDSC1; GDSC2	7.7205	10.1823	4.0857	0.8774
DU145	GDSC1; GDSC2; CTRP2	7.8309	9.3245	5.5491	0.3392
VCaP	GDSC1; GDSC2; CTRP2	8.0948	9.4717	5.5983	0.1669
22Rv1	GDSC1; GDSC2; CTRP2	8.5121	10.2618	5.4746	0.2341

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-15	CTRP2	7.2154	8.6139	5.5546	0.6251
A-253	GDSC1; GDSC2; CTRP2	8.432	10.7739	5.2503	0.7715

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuTu 80	GDSC1; GDSC2	6.5385	8.7456	4.1163	1.8127

Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Stomach Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SCH	GDSC1; GDSC2	5.4705	10.0492	2.789	11.7242
TMK-1	GDSC1; GDSC2	6.01	11.3094	2.5719	11.6245
HuG1-N	CTRP2	6.3504	18.8016	-0.0811	23.8898
MKN45	GDSC1; GDSC2; CTRP2	6.4611	11.187	3.8116	8.6004
RF-48	GDSC1; GDSC2	6.6069	9.0269	4.0317	2.1396
OCUM-1	GDSC1; GDSC2	6.7498	8.8152	4.1914	1.2425
NUGC-4	GDSC1; GDSC2; CTRP2	6.9247	9.5479	4.9608	3.1095
SNU-16	GDSC1; GDSC2; CTRP2	6.9501	8.576	5.43	1.365
GCIY	GDSC2	7.0453	9.6375	3.9966	1.7898
GSS	CTRP2	7.0564	9.3835	5.124	2.2962
SK-GT-2	GDSC1; GDSC2	7.1964	9.7966	4.0041	1.602
GSU	CTRP2	7.2412	8.03	5.7892	0.0838
RERF-GC-1B	GDSC1; GDSC2	7.3404	11.1512	3.5036	3.812
HSC-39	GDSC1; GDSC2	7.3474	9.0866	4.3403	0.3558
SNU-216	CTRP2	7.442	10.3858	4.8983	2.6942
TGBC11TKB	GDSC1; GDSC2	7.5304	9.5203	4.2545	0.4884
SNU-620	CTRP2	7.5467	12.9743	3.7375	7.1316
SH-10-TC	CTRP2	7.6168	8.8395	5.6424	0.2134
MKN28	GDSC2	7.7117	9.9186	4.1804	0.5993
ECC10	GDSC1; GDSC2; CTRP2	7.7315	9.2313	5.5431	0.3686
SNU-5	GDSC1; GDSC2; CTRP2	7.7529	9.2538	5.5435	0.3586
SNU-668	CTRP2	7.7622	8.9592	5.6553	0.1518
Hs 746.T	GDSC1; GDSC2; CTRP2	7.8002	10.6681	4.9799	2.1621
Fu97	GDSC1; GDSC2; CTRP2	7.9166	10.1	5.2828	0.9367
MKN7	GDSC1; GDSC2; CTRP2	7.9322	9.5175	5.5184	0.339
MKN1	GDSC1; GDSC2; CTRP2	7.9354	9.2016	5.6342	0.1416
ECC12	GDSC2; CTRP2	7.9455	8.9356	5.7287	0.0439
SNU-1	GDSC1; GDSC2; CTRP2	7.9645	13.624	3.7107	7.119
HGC-27	GDSC1; GDSC2; CTRP2	7.9847	11.291	4.8072	2.4386
IM95	GDSC2; CTRP2	8.054	9.9636	5.4	0.5468
23132/87	GDSC1; GDSC2; CTRP2	8.1158	9.3897	5.6344	0.107
SNU-601	CTRP2	8.1584	9.5239	5.6034	0.1357
LMSU	CTRP2	8.1963	13.3959	3.9699	5.7131
SNU-719	CTRP2	8.26	9.9547	5.4883	0.2827
KATO III	GDSC1; GDSC2; CTRP2	8.2831	9.9583	5.496	0.282
AGS	GDSC2; CTRP2	8.3632	9.618	5.6436	0.0651
NUGC-3	GDSC1; GDSC2; CTRP2	8.4578	10.0683	5.5229	0.1781
MKN74	CTRP2	9.063	11.0386	5.4056	0.2051
NCI-N87	GDSC1; GDSC2; CTRP2	9.1892	11.0856	5.4349	0.1485
KE-39	CTRP2	9.4042	11.6952	5.3011	0.2715
SNG-M	GDSC1; GDSC2; CTRP2	7.5526	9.2214	5.4675	0.6509
SNU-685	CTRP2	7.8074	9.2242	5.5768	0.2703
SNU-1077	CTRP2	8.5023	10.2789	5.4649	0.2517

Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
ASH-3	GDSC1; GDSC2	6.0228	7.6355	4.322	1.4564
K5	GDSC1; GDSC2	6.4565	10.6314	3.2102	6.9401
WRO	GDSC1; GDSC2	6.6405	8.5986	4.2277	1.1947
KMH-2	GDSC1; GDSC2	6.6881	9.1947	4.0023	2.1803
IHH-4	GDSC1; GDSC2	6.6972	8.001	4.4812	0.2845
FTC-238	CTRP2	6.9511	8.5783	4.5034	0.4191
ML-1 [Human leukemia]	GDSC1; GDSC2; CTRP2	7.2403	9.4141	5.221	1.7218
BHT-101	GDSC1; GDSC2; CTRP2	7.449	9.4903	5.3033	1.2332
B-CPAP	GDSC1; GDSC2; CTRP2	7.7547	9.5485	5.4298	0.6313
CGTH-W-1	GDSC1; GDSC2; CTRP2	7.795	9.487	5.4719	0.5029
HTC-C3	GDSC1; GDSC2	7.9009	9.9881	4.2283	0.3993
CAL-62	GDSC1; GDSC2; CTRP2	7.9057	9.6964	5.439	0.5268
FTC-133	GDSC1; GDSC2; CTRP2	7.9602	9.4617	5.5503	0.2679
8305C	GDSC1; GDSC2; CTRP2	8.2853	10.0672	5.4571	0.3305
8505C	GDSC1; GDSC2; CTRP2	8.292	10.2459	5.3932	0.4552
SW579	CTRP2	8.3819	9.4853	5.6939	0.034
TT	GDSC1; GDSC2; CTRP2	8.3906	9.6773	5.6332	0.0704
TT2609-C02	GDSC1; GDSC2; CTRP2	8.648	10.2698	5.522	0.153

Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Upper Aerodigestive Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
KOSC-2	GDSC1; GDSC2	5.6875	8.9737	3.4816	6.9803
KON	GDSC1; GDSC2	5.8401	8.5833	3.7762	4.8551
OSC-19	GDSC1; GDSC2	5.9499	8.6746	3.8052	4.4603
PCI-06A	GDSC1; GDSC2	6.0631	10.4053	3.0515	8.7106
HO-1-N-1	GDSC1; GDSC2	6.1767	8.2094	4.1553	2.0971
BICR 10	GDSC1; GDSC2	6.5177	8.2947	4.2929	1.0381
JHU-029	GDSC1; GDSC2	6.5569	10.7583	3.2155	6.7104
PE/CA-PJ34 (clone C12)	CTRP2	6.5778	7.9157	5.5072	1.5169
CAL-27	GDSC1; GDSC2; CTRP2	6.7571	8.3307	4.516	0.4832
BB49-HNC	GDSC1; GDSC2	6.8064	9.57	3.9033	2.5176
BB30-HNC	GDSC1; GDSC2	6.8219	8.7825	4.2377	0.9901
SKN-3	GDSC1; GDSC2	6.8381	10.6661	3.4332	4.9674
JHU-022	GDSC1; GDSC2	6.8491	9.3918	4.0015	1.9874
HSC-3	GDSC1; GDSC2; CTRP2	6.8638	9.1477	5.111	2.5952
HO-1-u-1	GDSC1; GDSC2	6.9089	9.2196	4.1024	1.4656
PE/CA-PJ15	GDSC1; GDSC2; CTRP2	7.0232	9.3751	5.1069	2.5814
PCI-30	GDSC1; GDSC2	7.0382	9.1511	4.1893	0.9985
PCI-15A	GDSC1; GDSC2	7.0555	8.8725	4.3035	0.5956
OSC-20	GDSC1; GDSC2	7.0767	12.6247	2.6718	8.7401
NCI-H3118	GDSC1; GDSC2	7.0847	10.1382	3.8057	2.6406
SAS	GDSC1; GDSC2	7.0962	9.2259	4.1857	0.9666
PE/CA-PJ49	CTRP2	7.0965	9.2929	5.1907	2.1417
BICR 78	GDSC1; GDSC2	7.1121	9.5943	4.0464	1.505
JHU-011	GDSC2	7.1329	13.7882	2.1564	11.3687
DOK	GDSC1; GDSC2	7.1477	10.0048	3.8945	2.1417
SCC-15	GDSC1; GDSC2	7.1746	10.3763	3.7508	2.7953
UPCI-SCC-090	GDSC1; GDSC2	7.1997	10.2265	3.8274	2.3949
Ca9-22	GDSC1; GDSC2	7.2966	9.8338	4.0358	1.3775
PCI-04B	GDSC1; GDSC2	7.3934	14.9092	1.7955	12.6462
SAT [Human HNSCC]	GDSC1; GDSC2	7.4136	13.1096	2.6588	8.1721
BICR 22	GDSC1; GDSC2; CTRP2	7.466	9.8822	5.1407	1.9087
LB771-HNC	GDSC1; GDSC2	7.5427	9.6076	4.2275	0.5541
HSC-4	GDSC1; GDSC2; CTRP2	7.605	9.0593	5.555	0.3987
FaDu	GDSC2; CTRP2	7.6621	9.3577	5.4634	0.6403
PE/CA-PJ41 (clone D2)	CTRP2	7.6652	10.218	5.1034	1.8406
HSC-2	GDSC1; GDSC2; CTRP2	7.6663	9.014	5.5978	0.3013
PCI-38	GDSC1	7.7695	9.6716	4.2911	0.3893
BICR 6	CTRP2	7.8292	8.8946	5.7022	0.0804
SNU-1076	CTRP2	7.8392	9.2933	5.564	0.2835
CAL-33	GDSC1; GDSC2; CTRP2	7.8738	11.223	4.774	2.6732
Detroit 562	GDSC1; GDSC2; CTRP2	7.9244	9.4156	5.553	0.2748
SCC-4	GDSC1; GDSC2; CTRP2	7.9696	9.5856	5.5083	0.3451
SNU-899	CTRP2	8.0194	9.0949	5.7008	0.0572
YD-10B	CTRP2	8.1338	9.3714	5.6471	0.0908
BICR 18	CTRP2	8.1373	10.1612	5.3597	0.6466
YD-8	CTRP2	8.164	9.7986	5.5075	0.2789
SNU-1214	CTRP2	8.2105	10.1813	5.3834	0.5116
SNU-46	CTRP2	8.3168	10.1078	5.4547	0.3244
BICR 56	CTRP2	8.3921	9.6751	5.6345	0.0692
BICR 31	GDSC2; CTRP2	8.4469	9.9775	5.5505	0.156
SCC-25	GDSC1; GDSC2; CTRP2	8.4682	10.1166	5.5097	0.1938
BHY	GDSC1; GDSC2; CTRP2	8.482	9.9912	5.5585	0.1297
SCC-9	GDSC1; GDSC2; CTRP2	8.5582	10.3832	5.4488	0.2814
SNU-1041	CTRP2	8.7392	10.3987	5.5103	0.14
SNU-1066	CTRP2	9.152	10.8016	5.518	0.0791
BICR 16	CTRP2	10.4245	21.9065	1.3992	11.6715

Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urinary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
647V	GDSC1; GDSC2; CTRP2	5.0979	7.2997	4.5214	9.1283
5637	GDSC1; GDSC2; CTRP2	6.3381	8.4009	5.1011	3.4329
CAL-29	GDSC1; GDSC2	6.6397	8.5118	4.2623	1.0512
SCaBER	CTRP2	6.7728	9.0133	4.2481	1.3246
SW780	GDSC1; GDSC2	6.8458	8.6377	4.3046	0.7261
JMSU-1	CTRP2	6.8949	8.3018	5.5209	1.0025
BC-3C	CTRP2	7.2561	9.332	5.2668	1.6549
639V	GDSC1; GDSC2; CTRP2	7.2727	8.2224	5.7324	0.1633
BFTC-905	GDSC1; GDSC2; CTRP2	7.3745	8.737	5.5793	0.4574
253J-BV	CTRP2	7.8563	9.3348	5.5556	0.2936
KU-19-19	GDSC1; GDSC2; CTRP2	7.8659	9.2359	5.5956	0.2179
U-BLC1	CTRP2	8.0702	12.6723	4.2281	4.4917
RT-4	GDSC1; GDSC2; CTRP2	8.1005	9.6643	5.5316	0.2567
T24	GDSC1; GDSC2; CTRP2	8.1087	11.5775	4.7499	2.704
RT-112	GDSC1; GDSC2; CTRP2	8.1664	9.3545	5.6643	0.0705
253J	CTRP2	8.1821	9.4297	5.6443	0.0867
HT-1376	GDSC1; GDSC2; CTRP2	8.1994	9.7576	5.536	0.2211
UM-UC-3	GDSC1; GDSC2; CTRP2	8.2124	9.4998	5.6311	0.0953
UM-UC-1	CTRP2	8.23	10.1025	5.4215	0.4521
HT-1197	GDSC1; GDSC2; CTRP2	8.2651	9.5889	5.6193	0.1067
TCCSUP	GDSC1; GDSC2; CTRP2	8.3107	9.5561	5.6463	0.0686
J82	GDSC1; GDSC2; CTRP2	8.3114	10.0789	5.4632	0.3108
KMBC-2	CTRP2	8.3514	10.2249	5.4253	0.3675
SW1710	GDSC1; GDSC2; CTRP2	8.4846	10.1266	5.5123	0.1865
VM-CUB-1	CTRP2	8.5158	10.262	5.476	0.2311

Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NT2-D1	GDSC1; GDSC2	3.2286	8.6475	1.5034	26.1368
SiSo	GDSC1; GDSC2	5.7412	8.7252	3.6404	5.8883
JAR	GDSC1; GDSC2	5.81	9.2215	3.448	6.9042
NEC8	GDSC2	5.9704	13.6871	1.3685	18.0022
CAL-39	GDSC1; GDSC2	6.2248	8.7968	3.9196	3.2993
SKG-IIIa	GDSC1; GDSC2	6.3702	8.8789	3.9671	2.8064
SiHa	GDSC1; GDSC2	6.4082	8.1431	4.3027	1.1031
OMC-1 [Human cervical carcinoma]	GDSC1; GDSC2	6.4532	8.2153	4.2947	1.0925
HEY	GDSC1; GDSC2	6.4595	8.8267	4.0396	2.2964
TC-YIK	GDSC1; GDSC2	6.6785	10.6542	3.3413	5.763
DSH1	GDSC1; GDSC2	6.6911	8.5762	4.2602	1.0138
SKN	GDSC1; GDSC2	6.7301	8.8318	4.1753	1.3304
PA-1	GDSC2	6.8063	8.758	4.2403	0.9932
C-33 A	GDSC1; GDSC2	6.8704	9.3585	4.0261	1.8478
LB831-BLC	GDSC1; GDSC2	6.8768	9.1054	4.1336	1.3638
C-4-I	GDSC2	6.9641	8.6277	4.3575	0.4861
DoTc2 4510	GDSC1; GDSC2	6.9751	8.6519	4.3529	0.4933
NCC-IT	GDSC2	6.9774	8.7836	4.3047	0.6391
JEG-3	GDSC1; GDSC2	7.0053	8.4139	4.4505	0.2392
KGN	GDSC1; GDSC2	7.0561	9.5105	4.0539	1.5275
HEC-1	GDSC1; GDSC2	7.094	8.4053	4.4856	0.1514
HT-3	GDSC1; GDSC2	7.1227	9.7766	3.9769	1.7952
SW954	GDSC1; GDSC2	7.1362	9.0906	4.2548	0.7
BPH-1	GDSC1; GDSC2	7.1892	11.3349	3.3367	4.9143
Ca Ski	GDSC1; GDSC2	7.1906	11.4905	3.2673	5.2851
MS751	GDSC1; GDSC2	7.1938	9.0052	4.3101	0.5008
SW962	GDSC1; GDSC2	7.2147	8.9175	4.3502	0.3861
OVCA433	GDSC1; GDSC2	7.3025	9.155	4.2982	0.4798
SW756	GDSC1; GDSC2	7.365	16.6615	0.9308	16.6677
OV17R	GDSC1; GDSC2	7.5134	9.4868	4.26	0.4817
JHOS-3	GDSC1; GDSC2	7.555	9.558	4.2504	0.4877
ME-180	GDSC1; GDSC2	7.5962	16.6253	1.1093	15.4052
HeLa	GDSC1; GDSC2; CTRP2	7.6097	8.8385	5.64	0.2202
OVCA420	GDSC1; GDSC2	7.6192	17.3578	0.7713	16.7945
PEO1	GDSC1; GDSC2	7.6262	9.6275	4.2528	0.4504
PWR-1E	GDSC1; GDSC2	7.7689	9.4347	4.3727	0.1725
OVMIU	GDSC1; GDSC2	8.1228	10.4691	4.1407	0.5148
UWB1.289	GDSC1; GDSC2	8.1967	10.9126	4.0077	0.8371
ACC-OV7	GDSC1; GDSC2	8.4784	21.6563	-0.7104	20.4357

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Temozolomide (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Remdesivir	DMBFZ6L	Moderate	Increased risk of hepatotoxicity by the combination of Temozolomide and Remdesivir.	1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]	[10]
Bedaquiline	DM3906J	Moderate	Increased risk of hepatotoxicity by the combination of Temozolomide and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[11]
Roflumilast	DMPGHY8	Moderate	Additive immunosuppressive effects by the combination of Temozolomide and Roflumilast.	Asthma [CA23]	[12]
Ofloxacin	DM0VQN3	Minor	Decreased absorption of Temozolomide due to intestinal mucosa variation caused by Ofloxacin.	Bacterial infection [1A00-1C4Z]	[13]
Sparfloxacin	DMB4HCT	Minor	Decreased absorption of Temozolomide due to intestinal mucosa variation caused by Sparfloxacin.	Bacterial infection [1A00-1C4Z]	[13]
Gemifloxacin	DMHT34O	Minor	Decreased absorption of Temozolomide due to intestinal mucosa variation caused by Gemifloxacin.	Bacterial infection [1A00-1C4Z]	[13]
Norfloxacin	DMIZ6W2	Minor	Decreased absorption of Temozolomide due to intestinal mucosa variation caused by Norfloxacin.	Bacterial infection [1A00-1C4Z]	[13]
ABT-492	DMJFD2I	Minor	Decreased absorption of Temozolomide due to intestinal mucosa variation caused by ABT-492.	Bacterial infection [1A00-1C4Z]	[13]
Levofloxacin	DMS60RB	Minor	Decreased absorption of Temozolomide due to intestinal mucosa variation caused by Levofloxacin.	Bacterial infection [1A00-1C4Z]	[13]
Lomefloxacin	DMVRH9C	Minor	Decreased absorption of Temozolomide due to intestinal mucosa variation caused by Lomefloxacin.	Bacterial infection [1A00-1C4Z]	[13]
Pexidartinib	DMS2J0Z	Major	Increased risk of hepatotoxicity by the combination of Temozolomide and Pexidartinib.	Bone/articular cartilage neoplasm [2F7B]	[14]
Cannabidiol	DM0659E	Moderate	Increased risk of hepatotoxicity by the combination of Temozolomide and Cannabidiol.	Epileptic encephalopathy [8A62]	[12]
Brentuximab vedotin	DMWLC57	Moderate	Increased risk of hepatotoxicity by the combination of Temozolomide and Brentuximab vedotin.	Hodgkin lymphoma [2B30]	[15]
Mipomersen	DMGSRN1	Major	Increased risk of hepatotoxicity by the combination of Temozolomide and Mipomersen.	Hyper-lipoproteinaemia [5C80]	[16]
Teriflunomide	DMQ2FKJ	Major	Additive immunosuppressive effects by the combination of Temozolomide and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[17]
BMS-201038	DMQTAGO	Major	Increased risk of hepatotoxicity by the combination of Temozolomide and BMS-201038.	Hyper-lipoproteinaemia [5C80]	[18]
Denosumab	DMNI0KO	Moderate	Additive immunosuppressive effects by the combination of Temozolomide and Denosumab.	Low bone mass disorder [FB83]	[19]
Calaspargase pegol	DMQZBXI	Moderate	Increased risk of hepatotoxicity by the combination of Temozolomide and Calaspargase pegol.	Malignant haematopoietic neoplasm [2B33]	[20]
Idelalisib	DM602WT	Moderate	Increased risk of hepatotoxicity by the combination of Temozolomide and Idelalisib.	Mature B-cell leukaemia [2A82]	[21]
Thalidomide	DM70BU5	Major	Additive thrombogenic effects by the combination of Temozolomide and Thalidomide.	Multiple myeloma [2A83]	[22]
Tecfidera	DM2OVDT	Moderate	Additive immunosuppressive effects by the combination of Temozolomide and Tecfidera.	Multiple sclerosis [8A40]	[23]
Siponimod	DM2R86O	Major	Additive immunosuppressive effects by the combination of Temozolomide and Siponimod.	Multiple sclerosis [8A40]	[10]
Fingolimod	DM5JVAN	Major	Additive immunosuppressive effects by the combination of Temozolomide and Fingolimod.	Multiple sclerosis [8A40]	[24]
Ocrelizumab	DMEZ2KH	Moderate	Additive immunosuppressive effects by the combination of Temozolomide and Ocrelizumab.	Multiple sclerosis [8A40]	[25]
Ozanimod	DMT6AM2	Major	Additive immunosuppressive effects by the combination of Temozolomide and Ozanimod.	Multiple sclerosis [8A40]	[12]
Omacetaxine mepesuccinate	DMPU2WX	Moderate	Additive myelosuppressive effects by the combination of Temozolomide and Omacetaxine mepesuccinate.	Myeloproliferative neoplasm [2A20]	[26]
Gatifloxacin	DMSL679	Minor	Decreased absorption of Temozolomide due to intestinal mucosa variation caused by Gatifloxacin.	Respiratory infection [CA07-CA4Z]	[13]
Canakinumab	DM8HLO5	Moderate	Additive immunosuppressive effects by the combination of Temozolomide and Canakinumab.	Rheumatoid arthritis [FA20]	[27]
Golimumab	DMHZV7X	Major	Additive immunosuppressive effects by the combination of Temozolomide and Golimumab.	Rheumatoid arthritis [FA20]	[28]
Anthrax vaccine	DM9GSWY	Moderate	Antagonize the effect of Temozolomide when combined with Anthrax vaccine.	Sepsis [1G40-1G41]	[29]
Trabectedin	DMG3Y89	Moderate	Increased risk of hepatotoxicity by the combination of Temozolomide and Trabectedin.	Solid tumour/cancer [2A00-2F9Z]	[12]
Azathioprine	DMMZSXQ	Moderate	Additive myelosuppressive effects by the combination of Temozolomide and Azathioprine.	Transplant rejection [NE84]	[10]
Ganciclovir	DM1MBYQ	Moderate	Additive myelosuppressive effects by the combination of Temozolomide and Ganciclovir.	Virus infection [1A24-1D9Z]	[10]
Valganciclovir	DMS2IUH	Moderate	Additive myelosuppressive effects by the combination of Temozolomide and Valganciclovir.	Virus infection [1A24-1D9Z]	[10]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Allura red AC dye	E00338	33258	Colorant
D&C red no. 28	E00491	6097185	Colorant
FD&C blue no. 1	E00263	19700	Colorant
FD&C blue no. 2	E00446	2723854	Colorant
Hydrazine yellow	E00409	164825	Colorant
Isopropyl alcohol	E00070	3776	Antimicrobial preservative; Solvent
Kyselina citronova	E00014	311	Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Mannitol	E00103	6251	Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
methylparaben	E00149	7456	Antimicrobial preservative
Propyl 4-hydroxybenzoate	E00141	7175	Antimicrobial preservative
Propylparaben sodium	E00567	23679044	Antimicrobial preservative
Quinoline yellow WS	E00309	24671	Colorant
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sodium methylparaben	E00543	23663626	Antimicrobial preservative
Stearic acid	E00079	5281	Emulsifying agent; Solubilizing agent; Viscosity-controlling agent; lubricant
Sunset yellow FCF	E00255	17730	Colorant
Ammonia	E00007	222	Alkalizing agent
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Butyl alcohol	E00011	263	Flavoring agent; Solvent
Carmellose sodium	E00625	Not Available	Disintegrant
Eisenoxyd	E00585	56841934	Colorant
FD&C red no. 3	E00629	Not Available	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Ferrosoferric oxide	E00231	14789	Colorant
Isobutyl alcohol	E00130	6560	Flavoring agent; Solvent
Lithol rubin BCA	E00607	135423095	Colorant
Magnesium stearate	E00208	11177	lubricant
Potassium hydroxide	E00233	14797	Alkalizing agent
Propylene glycol	E00040	1030	Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium hydroxide	E00234	14798	Alkalizing agent
Tartaric acid	E00029	875	Acidulant; Complexing agent; Flavoring agent
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Water	E00035	962	Solvent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Temozolomide 5 mg capsule	5 mg	Oral Capsule	Oral
Temozolomide 140 mg capsule	140 mg	Oral Capsule	Oral
Temozolomide 180 mg capsule	180 mg	Oral Capsule	Oral
Temozolomide 20 mg capsule	20 mg	Oral Capsule	Oral
Temozolomide 100 mg capsule	100 mg	Oral Capsule	Oral
Temozolomide 250 mg capsule	250 mg	Oral Capsule	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

• [1] Temozolomide FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7301).
• [3] FDA Approved Drug Products: TEMODAR (temozolomide) capsules and injection
• [4] BDDCS applied to over 900 drugs
• [5] Critical Evaluation of Human Oral Bioavailability for Pharmaceutical Drugs by Using Various Cheminformatics Approaches
• [6] Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
• [7] Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
• [8] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [9] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
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• [25] Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
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• [27] Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
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• [29] CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]