Details of the Drug Combination

General Information of Drug Combination (ID: DC25ZRJ)

Drug Combination Name
Hydralazine Flavonoid derivative 1
Indication
Disease Entry Status REF
Chronic myelogenous leukemia Investigative [1]
Component Drugs Hydralazine   DMU8JGH Flavonoid derivative 1   DMCQP0B
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: KBM-7
Zero Interaction Potency (ZIP) Score: 13.52
Bliss Independence Score: 13.52
Loewe Additivity Score: 26.99
LHighest Single Agent (HSA) Score: 27.01

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Hydralazine
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [2]
Hypertension BA00-BA04 Approved [3]
Malignant essential hypertension BA00 Approved [2]
Hydralazine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Membrane copper amine oxidase (AOC3) TT7HC21 AOC3_HUMAN Modulator [4]
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Hydralazine Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
RNA cytidine acetyltransferase (hALP) DEZV4AP NAT10_HUMAN Metabolism [5]
N-acetyltransferase 1 (NAT1) DE7OAB3 ARY1_HUMAN Metabolism [6]
N-acetyltransferase 2 (NAT2) DER7TA0 ARY2_HUMAN Metabolism [6]
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Hydralazine Interacts with 16 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Increases Acetylation [7]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Increases Expression [8]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Increases Expression [8]
Retinoic acid receptor beta (RARB) OT367U3E RARB_HUMAN Decreases Methylation [8]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Increases Expression [8]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Decreases Methylation [8]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Methylation [8]
Bis(5'-adenosyl)-triphosphatase (FHIT) OTGWBSLA FHIT_HUMAN Increases Expression [8]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Increases Expression [8]
Renin (REN) OT52GZR2 RENI_HUMAN Increases Activity [9]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Secretion [10]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [11]
Albumin (ALB) OTVMM513 ALBU_HUMAN Affects Binding [12]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [13]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Secretion [10]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Secretion [10]
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⏷ Show the Full List of 16 DOT(s)
Flavonoid derivative 1 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Signal transducer and activator of transcription 3 (STAT3) TTH8FZW STAT3_HUMAN Inhibitor [19]
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Flavonoid derivative 1 Interacts with 76 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Phosphorylation [20]
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Decreases Activity [21]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [22]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Activity [23]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Decreases Activity [23]
Tumor protein p73 (TP73) OT0LUO47 P73_HUMAN Increases Expression [24]
Prostate stem cell antigen (PSCA) OTQ574EY PSCA_HUMAN Decreases Expression [24]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [24]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Decreases Expression [17]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [25]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [26]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Activity [27]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [25]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Affects Binding [28]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [29]
Catalase (CAT) OTHEBX9R CATA_HUMAN Affects Activity [30]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Decreases Expression [31]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [16]
HLA class II histocompatibility antigen gamma chain (CD74) OTO16X4Q HG2A_HUMAN Decreases Expression [32]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [33]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [27]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [26]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [34]
Fructose-1,6-bisphosphatase 1 (FBP1) OTQBANEP F16P1_HUMAN Decreases Expression [24]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [25]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [35]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [36]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [36]
Pyruvate kinase PKM (PKM) OTLHHMC2 KPYM_HUMAN Increases Activity [37]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [24]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Secretion [38]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [39]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Decreases Activity [27]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Activity [27]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [17]
Cadherin-2 (CDH2) OTH0Y56P CADH2_HUMAN Decreases Expression [36]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [26]
Nuclear receptor subfamily 1 group D member 1 (NR1D1) OTJ38PTB NR1D1_HUMAN Decreases Expression [17]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Activity [40]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [41]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [41]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Expression [26]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [24]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Activity [42]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Expression [16]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Decreases Expression [25]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [25]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [17]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [43]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) OTCLOV90 CDN2C_HUMAN Decreases Expression [24]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [44]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Phosphorylation [44]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [40]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [26]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Decreases Activity [27]
Mitogen-activated protein kinase 10 (MAPK10) OTC46VX1 MK10_HUMAN Increases Phosphorylation [44]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [43]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [44]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [45]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Phosphorylation [38]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [44]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [44]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [39]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Increases Expression [16]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Activity [46]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [47]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [24]
Dehydrogenase/reductase SDR family member 11 (DHRS11) OTU3J0ZL DHR11_HUMAN Decreases Activity [48]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Decreases Activity [47]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Increases Activity [49]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Increases Expression [16]
Tumor protein 63 (TP63) OT0WOOKQ P63_HUMAN Increases Expression [24]
Serine/threonine-protein kinase TBK1 (TBK1) OT1P06NV TBK1_HUMAN Decreases Activity [50]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Affects Activity [33]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Decreases Activity [51]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Response To Substance [39]
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⏷ Show the Full List of 76 DOT(s)

References

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2 Hydralazine FDA Label
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