Details of the Drug Combination

General Information of Drug Combination (ID: DC84UHM)

Drug Combination Name
Dactinomycin Dasatinib
Indication
Disease Entry Status REF
Non-small cell lung carcinoma Investigative [1]
Component Drugs Dactinomycin   DM2YGNW Dasatinib   DMJV2EK
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL
High-throughput Screening Result Testing Cell Line: HOP-92
Zero Interaction Potency (ZIP) Score: 3.77
Bliss Independence Score: 6.71
Loewe Additivity Score: 2.72
LHighest Single Agent (HSA) Score: 0.56

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Dactinomycin
Disease Entry ICD 11 Status REF
Adult kidney Wilms tumor N.A. Approved [2]
Advanced cancer 2A00-2F9Z Approved [2]
Beckwith-Wiedemann syndrome N.A. Approved [2]
Childhood kidney Wilms tumor N.A. Approved [2]
Gestational trophoblastic neoplasia 2F33-2F76 Approved [2]
Hamartoma N.A. Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Wilms tumor N.A. Approved [2]
Dactinomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [11]
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Dactinomycin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [12]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [13]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [14]
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Dactinomycin Interacts with 58 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Response To Substance [15]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Increases Expression [8]
Integral membrane protein GPR137B (GPR137B) OT1CINQQ G137B_HUMAN Increases Expression [8]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Increases Expression [8]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Increases Expression [8]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [8]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Increases Expression [8]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Increases Expression [8]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Increases Expression [8]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [8]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [8]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Increases Expression [8]
Large ribosomal subunit protein eL34 (RPL34) OT0U9VMQ RL34_HUMAN Increases Expression [8]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [8]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [8]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [8]
Protein ripply3 (RIPPLY3) OT1HK35I DSCR6_HUMAN Increases Expression [8]
Endonuclease III-like protein 1 (NTHL1) OTPQXPT1 NTH_HUMAN Decreases Expression [8]
Kinesin-like protein KIF1A (KIF1A) OT3JVEGV KIF1A_HUMAN Increases Expression [8]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [8]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [8]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Increases Expression [8]
Immediate early response gene 5 protein (IER5) OTJPTXMD IER5_HUMAN Increases Expression [8]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [8]
All-trans-retinol 13,14-reductase (RETSAT) OTC3AOPX RETST_HUMAN Increases Expression [8]
Interleukin-27 receptor subunit alpha (IL27RA) OTSQBAKI I27RA_HUMAN Increases Expression [8]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Increases Expression [8]
Mitochondria-eating protein (SPATA18) OTOEHTHU MIEAP_HUMAN Increases Expression [8]
Phospholipase ABHD3 (ABHD3) OTH8P977 ABHD3_HUMAN Increases Expression [8]
Homer protein homolog 3 (HOMER3) OTQ6D9X1 HOME3_HUMAN Increases Expression [8]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Increases Expression [8]
Stathmin-3 (STMN3) OT20F289 STMN3_HUMAN Increases Expression [8]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [8]
Fatty acid desaturase 3 (FADS3) OT9RVXGE FADS3_HUMAN Increases Expression [8]
Protein O-mannosyl-transferase 1 (POMT1) OTGQSHL5 POMT1_HUMAN Increases Expression [8]
Tumor protein p53-inducible protein 11 (TP53I11) OTFPDYZU P5I11_HUMAN Decreases Expression [16]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [17]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [18]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Decreases Expression [19]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [19]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [20]
Proto-oncogene tyrosine-protein kinase ROS (ROS1) OTDSKUGE ROS1_HUMAN Increases Expression [19]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [21]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [22]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [19]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [19]
rRNA 2'-O-methyltransferase fibrillarin (FBL) OTRODIE5 FBRL_HUMAN Affects Localization [23]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Decreases Phosphorylation [24]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [25]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Decreases Expression [19]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [26]
Son of sevenless homolog 1 (SOS1) OTTCWXC3 SOS1_HUMAN Decreases Expression [19]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [19]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Increases Degradation [27]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [28]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [29]
Hyaluronidase-1 (HYAL1) OT2SJN0X HYAL1_HUMAN Increases ADR [30]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) OTPYQX3K C1QBP_HUMAN Decreases Response To Substance [31]
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⏷ Show the Full List of 58 DOT(s)
Indication(s) of Dasatinib
Disease Entry ICD 11 Status REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive N.A. Approved [4]
Brain disease 8C70-8E61 Approved [4]
Central nervous system disease 8A04-8D87 Approved [4]
Chronic myelogenous leukaemia 2A20.0 Approved [5]
Chronic myeloid leukaemia 2A20 Approved [6]
Glioblastoma 2A00 Approved [4]
Leukemia N.A. Approved [4]
Lung cancer 2C25.0 Approved [4]
Non-small-cell lung cancer 2C25.Y Approved [4]
Plasma cell myeloma 2A83.1 Approved [4]
Multiple myeloma 2A83 Phase 2 [5]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [7]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [7]
Dasatinib Interacts with 5 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
LCK tyrosine protein kinase (LCK) TT860QF LCK_HUMAN Inhibitor [35]
Fyn tyrosine protein kinase (FYN) TT2B9KF FYN_HUMAN Inhibitor [35]
Fusion protein Bcr-Abl (Bcr-Abl) TTS7G69 BCR_HUMAN-ABL1_HUMAN Inhibitor [35]
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [35]
HUMAN fusion protein Bcr-Abl (Bcr-Abl) TTE63HY BCR_HUMAN/ABL1_HUMAN Inhibitor [7]
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Dasatinib Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [36]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [37]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [38]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [38]
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Dasatinib Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [39]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [39]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [39]
Dimethylaniline oxidase 3 (FMO3) DEP76YL FMO3_HUMAN Metabolism [40]
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Dasatinib Interacts with 345 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Affects Binding [32]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) OTB6YLFT ENPP3_HUMAN Decreases Expression [32]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Phosphorylation [32]
CD63 antigen (CD63) OT2UGZA9 CD63_HUMAN Decreases Expression [32]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Binding [32]
Tyrosine-protein kinase Tec (TEC) OTU6QJAJ TEC_HUMAN Affects Binding [32]
Tyrosine-protein kinase FRK (FRK) OTEKV1SC FRK_HUMAN Affects Binding [32]
Sialomucin core protein 24 (CD164) OTZ7FIU8 MUC24_HUMAN Decreases Expression [32]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Affects Binding [32]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) OT0ALMEG M3K20_HUMAN Affects Binding [32]
ATP-dependent RNA helicase DDX39A (DDX39A) OT0Z6E1K DX39A_HUMAN Decreases Expression [33]
Cell division cycle 7-related protein kinase (CDC7) OT5133XY CDC7_HUMAN Decreases Expression [33]
Serine/threonine-protein kinase PLK4 (PLK4) OTV8KZDZ PLK4_HUMAN Decreases Expression [33]
Nuclear envelope integral membrane protein 1 (NEMP1) OTWN3S47 NEMP1_HUMAN Decreases Expression [33]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [33]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) OTU3TGQ9 RPC7_HUMAN Decreases Expression [33]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [33]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Decreases Expression [33]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [33]
Protein sprouty homolog 2 (SPRY2) OTH0CRCZ SPY2_HUMAN Decreases Expression [33]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [33]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [33]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) OTDVVNS0 EDIL3_HUMAN Increases Expression [33]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Increases Expression [33]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [33]
Tetraspanin-2 (TSPAN2) OTTDPQF1 TSN2_HUMAN Increases Expression [33]
Leupaxin (LPXN) OTUNV3CK LPXN_HUMAN Decreases Expression [33]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [33]
DNA polymerase theta (POLQ) OTBHK0E6 DPOLQ_HUMAN Decreases Expression [33]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [33]
Glypican-4 (GPC4) OTUJ14DW GPC4_HUMAN Increases Expression [33]
Serpin B7 (SERPINB7) OTZ95LR2 SPB7_HUMAN Decreases Expression [33]
Transient receptor potential cation channel subfamily A member 1 (TRPA1) OTRDIR5M TRPA1_HUMAN Decreases Expression [33]
Ribonuclease H2 subunit A (RNASEH2A) OT8G3G7K RNH2A_HUMAN Decreases Expression [33]
Centrosomal protein of 152 kDa (CEP152) OTOKZR9B CE152_HUMAN Decreases Expression [33]
Chromosome-associated kinesin KIF4A (KIF4A) OT3UWL7D KIF4A_HUMAN Decreases Expression [33]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Increases Expression [33]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Increases Expression [33]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Expression [33]
Histone-lysine N-methyltransferase NSD2 (NSD2) OTQ6SW4R NSD2_HUMAN Decreases Expression [33]
Complement C1r subcomponent (C1R) OTA0ZNIU C1R_HUMAN Increases Expression [33]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Increases Expression [33]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Increases Expression [33]
Collagen alpha-1(IV) chain (COL4A1) OTL6D1YE CO4A1_HUMAN Increases Expression [33]
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Increases Expression [33]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [33]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [33]
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Increases Expression [33]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [33]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Decreases Expression [33]
Laminin subunit beta-1 (LAMB1) OT6J9LJR LAMB1_HUMAN Increases Expression [33]
Matrix Gla protein (MGP) OTZWU3FU MGP_HUMAN Increases Expression [33]
Collagen alpha-2(IV) chain (COL4A2) OTJK1LKN CO4A2_HUMAN Increases Expression [33]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Decreases Expression [33]
Histone H2A.Z (H2AZ1) OT3KJJNQ H2AZ_HUMAN Decreases Expression [33]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Decreases Expression [33]
Myb-related protein B (MYBL2) OTZ3JX8Q MYBB_HUMAN Decreases Expression [33]
Histone H1.4 (H1-4) OTQ450A3 H14_HUMAN Decreases Expression [33]
Fibroblast growth factor 5 (FGF5) OTQXGHBY FGF5_HUMAN Decreases Expression [33]
Collagen alpha-1(XI) chain (COL11A1) OTB0DRMS COBA1_HUMAN Increases Expression [33]
Elastin (ELN) OTFSO7PG ELN_HUMAN Increases Expression [33]
Aggrecan core protein (ACAN) OTUOCW8K PGCA_HUMAN Increases Expression [33]
Histone H1.5 (H1-5) OTAN7RD9 H15_HUMAN Decreases Expression [33]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [33]
Biglycan (BGN) OT3AV6IF PGS1_HUMAN Increases Expression [33]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Decreases Expression [33]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Increases Expression [33]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [33]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Decreases Expression [33]
Leiomodin-1 (LMOD1) OTZ2MEMG LMOD1_HUMAN Increases Expression [33]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [33]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [33]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Increases Expression [33]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Decreases Expression [33]
Histone H2B type 1-B (H2BC3) OT1BLFJO H2B1B_HUMAN Decreases Expression [33]
Replication factor C subunit 4 (RFC4) OTWALD2R RFC4_HUMAN Decreases Expression [33]
Replication factor C subunit 2 (RFC2) OTJ9N6BD RFC2_HUMAN Decreases Expression [33]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Increases Expression [33]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Increases Expression [33]
Myosin-11 (MYH11) OTVNVWY3 MYH11_HUMAN Increases Expression [33]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Increases Expression [33]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [33]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Decreases Expression [33]
Pre-B-cell leukemia transcription factor 1 (PBX1) OTORABGO PBX1_HUMAN Increases Expression [33]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [33]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [33]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Increases Expression [33]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [33]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [33]
Condensin-2 complex subunit D3 (NCAPD3) OTOZY2UL CNDD3_HUMAN Decreases Expression [33]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [33]
Glutathione S-transferase Mu 5 (GSTM5) OTMMBFY8 GSTM5_HUMAN Increases Expression [33]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [33]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [33]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [33]
DNA primase large subunit (PRIM2) OTGT0KTF PRI2_HUMAN Decreases Expression [33]
Thrombospondin-3 (THBS3) OTDKMUBD TSP3_HUMAN Increases Expression [33]
Selenoprotein P (SELENOP) OT02B8IR SEPP1_HUMAN Increases Expression [33]
Kinetochore-associated protein 1 (KNTC1) OTI2OOFN KNTC1_HUMAN Decreases Expression [33]
Ras association domain-containing protein 2 (RASSF2) OT2JHDO4 RASF2_HUMAN Increases Expression [33]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Decreases Expression [33]
Lumican (LUM) OTSRC874 LUM_HUMAN Increases Expression [33]
Calponin-1 (CNN1) OTVPG39Z CNN1_HUMAN Increases Expression [33]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [33]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [33]
Microfibril-associated glycoprotein 4 (MFAP4) OT5W64QY MFAP4_HUMAN Increases Expression [33]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Decreases Expression [33]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Decreases Expression [33]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Increases Expression [33]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Increases Expression [33]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Increases Expression [33]
Actin, alpha cardiac muscle 1 (ACTC1) OTJU04B1 ACTC_HUMAN Increases Expression [33]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Increases Expression [33]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Increases Expression [33]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [33]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Decreases Expression [33]
Histone H1.1 (H1-1) OTSS815G H11_HUMAN Decreases Expression [33]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Increases Expression [33]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Increases Expression [33]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [33]
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) OTA0UNHM ECH1_HUMAN Increases Expression [33]
MAL-like protein (MALL) OTKGZ89D MALL_HUMAN Decreases Expression [33]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [33]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [33]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Decreases Expression [33]
Limbic system-associated membrane protein (LSAMP) OTYXVQX2 LSAMP_HUMAN Increases Expression [33]
Four and a half LIM domains protein 1 (FHL1) OTN535SU FHL1_HUMAN Increases Expression [33]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) OT6KFNMS CAC1C_HUMAN Increases Expression [33]
DNA polymerase alpha subunit B (POLA2) OTTWQ73N DPOA2_HUMAN Decreases Expression [33]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) OTKUW1WT PDE3A_HUMAN Increases Expression [33]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Decreases Expression [33]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [33]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [33]
Condensin complex subunit 1 (NCAPD2) OT8VGE2O CND1_HUMAN Decreases Expression [33]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Decreases Expression [33]
SCL-interrupting locus protein (STIL) OT9799VN STIL_HUMAN Decreases Expression [33]
Pachytene checkpoint protein 2 homolog (TRIP13) OTFM3TI9 PCH2_HUMAN Decreases Expression [33]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Increases Expression [33]
Neuronal regeneration-related protein (NREP) OT2AZPKK NREP_HUMAN Increases Expression [33]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [33]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2) OTJ8LX4N PCKGM_HUMAN Increases Expression [33]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Increases Expression [33]
Flap endonuclease GEN homolog 1 (GEN1) OT1XFQXF GEN_HUMAN Decreases Expression [33]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2) OTCH86VF AL1L2_HUMAN Increases Expression [33]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) OTOBICRD SVEP1_HUMAN Increases Expression [33]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Increases Expression [33]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [33]
Centromere protein W (CENPW) OTZL05QN CENPW_HUMAN Decreases Expression [33]
Shugoshin 1 (SGO1) OTIP6IRN SGO1_HUMAN Decreases Expression [33]
Probable E3 ubiquitin-protein ligase HERC4 (HERC4) OTU4DSDE HERC4_HUMAN Decreases Expression [33]
Testis-expressed protein 30 (TEX30) OT87WEPQ TEX30_HUMAN Decreases Expression [33]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Increases Expression [33]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [33]
Protein FAM72D (FAM72D) OTCQVOXB FA72D_HUMAN Decreases Expression [33]
Repulsive guidance molecule B (RGMB) OT2DROYU RGMB_HUMAN Decreases Expression [33]
STEAP family member 1B (STEAP1B) OTZJDFWK STEAL_HUMAN Decreases Expression [33]
Mis18-binding protein 1 (MIS18BP1) OT41T0FB M18BP_HUMAN Decreases Expression [33]
Mitochondrial fission regulator 2 (MTFR2) OTLOR68D MTFR2_HUMAN Decreases Expression [33]
Rho GTPase-activating protein 11A (ARHGAP11A) OTVQCFVP RHGBA_HUMAN Decreases Expression [33]
E3 ubiquitin-protein ligase RFWD3 (RFWD3) OTDUULBQ RFWD3_HUMAN Decreases Expression [33]
Podocan-like protein 1 (PODNL1) OTL72ES9 PONL1_HUMAN Increases Expression [33]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [33]
Neutral cholesterol ester hydrolase 1 (NCEH1) OTZ66CKX NCEH1_HUMAN Decreases Expression [33]
Fidgetin-like protein 1 (FIGNL1) OTKII63K FIGL1_HUMAN Decreases Expression [33]
ATPase family AAA domain-containing protein 2 (ATAD2) OT8MCRNY ATAD2_HUMAN Decreases Expression [33]
Serine protease FAM111B (FAM111B) OT9IQ9NV F111B_HUMAN Decreases Expression [33]
Protein FAM180A (FAM180A) OTKQ7XUG F180A_HUMAN Decreases Expression [33]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Increases Expression [33]
Plexin domain-containing protein 2 (PLXDC2) OTS1FUV6 PXDC2_HUMAN Increases Expression [33]
ALK and LTK ligand 1 (ALKAL1) OTZGAZ79 ALKL1_HUMAN Increases Expression [33]
Protein MMS22-like (MMS22L) OTJI0HM9 MMS22_HUMAN Decreases Expression [33]
Centrosomal protein of 128 kDa (CEP128) OT922YCJ CE128_HUMAN Decreases Expression [33]
DNA-binding protein RFX8 (RFX8) OT27SFGQ RFX8_HUMAN Decreases Expression [33]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Decreases Expression [33]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [33]
Treslin (TICRR) OT2HKWOC TICRR_HUMAN Decreases Expression [33]
MAM domain-containing protein 2 (MAMDC2) OT4GICNY MAMC2_HUMAN Increases Expression [33]
LisH domain-containing protein ARMC9 (ARMC9) OT0MZER2 ARMC9_HUMAN Increases Expression [33]
Rho GTPase-activating protein 22 (ARHGAP22) OTXUQEFL RHG22_HUMAN Decreases Expression [33]
Podocan (PODN) OTV3P7P5 PODN_HUMAN Increases Expression [33]
Schlafen family member 11 (SLFN11) OTJWFPMY SLN11_HUMAN Decreases Expression [33]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Increases Expression [33]
Alpha-protein kinase 2 (ALPK2) OTWZZDQ9 ALPK2_HUMAN Increases Expression [33]
Myopalladin (MYPN) OTHTOFDU MYPN_HUMAN Decreases Expression [33]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3) OT89V4N5 MARH3_HUMAN Decreases Expression [33]
Ras GTPase-activating-like protein IQGAP3 (IQGAP3) OT4RZV2M IQGA3_HUMAN Decreases Expression [33]
Condensin-2 complex subunit G2 (NCAPG2) OTZYENKO CNDG2_HUMAN Decreases Expression [33]
GAS2-like protein 3 (GAS2L3) OTWPVI29 GA2L3_HUMAN Decreases Expression [33]
Histone H2A type 2-B (H2AC21) OTH7W2NJ H2A2B_HUMAN Decreases Expression [33]
Pleckstrin homology domain-containing family H member 2 (PLEKHH2) OT3TK3NN PKHH2_HUMAN Increases Expression [33]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Increases Expression [33]
CD302 antigen (CD302) OTX580VU CD302_HUMAN Increases Expression [33]
Spindle and kinetochore-associated protein 3 (SKA3) OTLHEVJD SKA3_HUMAN Decreases Expression [33]
DNA damage-induced apoptosis suppressor protein (DDIAS) OTTGG2PM DDIAS_HUMAN Decreases Expression [33]
Cytoskeleton-associated protein 2-like (CKAP2L) OT4T73GG CKP2L_HUMAN Decreases Expression [33]
Fanconi anemia group M protein (FANCM) OTNJG99Z FANCM_HUMAN Decreases Expression [33]
Lung adenoma susceptibility protein 2 (C18ORF54) OT4WJKTF LAS2_HUMAN Decreases Expression [33]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Decreases Expression [33]
Retinol dehydrogenase 10 (RDH10) OTL9FSGF RDH10_HUMAN Increases Expression [33]
Centromere protein L (CENPL) OT7P006B CENPL_HUMAN Decreases Expression [33]
Rho GTPase-activating protein 18 (ARHGAP18) OTYMJP6H RHG18_HUMAN Decreases Expression [33]
T-complex protein 11-like protein 2 (TCP11L2) OTTIZO7B T11L2_HUMAN Increases Expression [33]
Aminopeptidase O (AOPEP) OT0MMANL AMPO_HUMAN Increases Expression [33]
Junction-mediating and -regulatory protein (JMY) OTH5FFVK JMY_HUMAN Increases Expression [33]
Holliday junction recognition protein (HJURP) OTWMV16B HJURP_HUMAN Decreases Expression [33]
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1) OTVXEF85 MDGA1_HUMAN Increases Expression [33]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Increases Expression [33]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [33]
Protein CIP2A (CIP2A) OTVS2GXA CIP2A_HUMAN Decreases Expression [33]
Sodium-dependent phosphate transporter 1 (SLC20A1) OTC3D894 S20A1_HUMAN Decreases Expression [33]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [33]
Basic helix-loop-helix ARNT-like protein 2 (BMAL2) OTIBDGQC BMAL2_HUMAN Decreases Expression [33]
Centromere protein I (CENPI) OTWRIMZ3 CENPI_HUMAN Decreases Expression [33]
Hyaluronan synthase 2 (HAS2) OTTD3PAL HYAS2_HUMAN Decreases Expression [33]
Neogenin (NEO1) OTGJ1997 NEO1_HUMAN Increases Expression [33]
Histone H2B type 1-H (H2BC9) OTQ9XX72 H2B1H_HUMAN Decreases Expression [33]
F-box only protein 32 (FBXO32) OTUE978R FBX32_HUMAN Increases Expression [33]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [33]
Transcription factor E2F7 (E2F7) OTWW358N E2F7_HUMAN Decreases Expression [33]
Spindle and kinetochore-associated protein 1 (SKA1) OTDYJ12A SKA1_HUMAN Decreases Expression [33]
Mdm2-binding protein (MTBP) OTWLCW9C MTBP_HUMAN Decreases Expression [33]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Decreases Expression [33]
Serine/threonine-protein kinase greatwall (MASTL) OTQ7YKK5 GWL_HUMAN Decreases Expression [33]
Centromere protein N (CENPN) OTRO7XPD CENPN_HUMAN Decreases Expression [33]
Proline-rich protein 11 (PRR11) OT2JJ08Z PRR11_HUMAN Decreases Expression [33]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Decreases Expression [33]
Leucine-rich repeat protein 1 (LRR1) OTSWDXVY LLR1_HUMAN Decreases Expression [33]
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1) OT5TS6P7 PCMD1_HUMAN Increases Expression [33]
Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) OTB71I02 DCBD2_HUMAN Decreases Expression [33]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [33]
ATPase family AAA domain-containing protein 5 (ATAD5) OTI8ABKF ATAD5_HUMAN Decreases Expression [33]
Hemicentin-1 (HMCN1) OTLZAS0P HMCN1_HUMAN Increases Expression [33]
Hyaluronan and proteoglycan link protein 3 (HAPLN3) OTB853Z1 HPLN3_HUMAN Increases Expression [33]
Cell division cycle-associated protein 3 (CDCA3) OTUI8QK3 CDCA3_HUMAN Decreases Expression [33]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Decreases Expression [33]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [33]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Increases Expression [33]
Histone H2B type 1-M (H2BC14) OTSDZZZY H2B1M_HUMAN Decreases Expression [33]
Condensin complex subunit 3 (NCAPG) OT1AI9EO CND3_HUMAN Decreases Expression [33]
Mitochondrial genome maintenance exonuclease 1 (MGME1) OTC5LPXX MGME1_HUMAN Decreases Expression [33]
Synaptotagmin-15 (SYT15) OT7Q088G SYT15_HUMAN Increases Expression [33]
Hephaestin (HEPH) OTZ2F15Z HEPH_HUMAN Increases Expression [33]
DNA replication complex GINS protein SLD5 (GINS4) OTCVOO3S SLD5_HUMAN Decreases Expression [33]
Centromere protein K (CENPK) OTKPUF8K CENPK_HUMAN Decreases Expression [33]
Protein PIMREG (PIMREG) OTKC8T3E PIMRE_HUMAN Decreases Expression [33]
Nucleoporin NDC1 (NDC1) OTF2GQC1 NDC1_HUMAN Decreases Expression [33]
Centromere protein O (CENPO) OTXAH83Y CENPO_HUMAN Decreases Expression [33]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [33]
TIMELESS-interacting protein (TIPIN) OT9PZHXV TIPIN_HUMAN Decreases Expression [33]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [33]
Meiotic nuclear division protein 1 homolog (MND1) OTS87F3H MND1_HUMAN Decreases Expression [33]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [33]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [33]
Transmembrane 6 superfamily member 1 (TM6SF1) OTQR4I2N TM6S1_HUMAN Increases Expression [33]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Increases Expression [33]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [33]
Centromere protein H (CENPH) OTPOO9LK CENPH_HUMAN Decreases Expression [33]
Kinetochore-associated protein DSN1 homolog (DSN1) OTHROI0H DSN1_HUMAN Decreases Expression [33]
Uncharacterized protein C1orf198 (C1ORF198) OTK3L4G7 CA198_HUMAN Increases Expression [33]
Golgi-associated plant pathogenesis-related protein 1 (GLIPR2) OTFTH6ZY GAPR1_HUMAN Increases Expression [33]
Very long chain fatty acid elongase 6 (ELOVL6) OTB26UJJ ELOV6_HUMAN Decreases Expression [33]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Increases Expression [33]
Gremlin-2 (GREM2) OTE91EWT GREM2_HUMAN Increases Expression [33]
Metal transporter CNNM2 (CNNM2) OTZHO8WU CNNM2_HUMAN Increases Expression [33]
Protein ECT2 (ECT2) OTQDUCT6 ECT2_HUMAN Decreases Expression [33]
Claspin (CLSPN) OTZZXNDK CLSPN_HUMAN Decreases Expression [33]
Mineralization regulator ANKH (ANKH) OTCN25R5 ANKH_HUMAN Increases Expression [33]
Ribonucleoprotein PTB-binding 2 (RAVER2) OT0MDL7K RAVR2_HUMAN Increases Expression [33]
Neurexin-3-beta (NRXN3) OTJ0I7HJ NRX3B_HUMAN Increases Expression [33]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [33]
Phospholipid scramblase 4 (PLSCR4) OT2AMYLY PLS4_HUMAN Increases Expression [33]
Lymphoid-specific helicase (HELLS) OTVVV668 HELLS_HUMAN Decreases Expression [33]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM) OTALLHT1 FIRRM_HUMAN Decreases Expression [33]
Protein diaphanous homolog 3 (DIAPH3) OTPOT23F DIAP3_HUMAN Decreases Expression [33]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [33]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Increases Expression [33]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Decreases Expression [33]
Histone chaperone ASF1B (ASF1B) OTKXX12I ASF1B_HUMAN Decreases Expression [33]
PCNA-interacting partner (PARPBP) OTPZDGW7 PARI_HUMAN Decreases Expression [33]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [33]
Dapper homolog 1 (DACT1) OT19Z704 DACT1_HUMAN Increases Expression [33]
Protein Mis18-alpha (MIS18A) OTD80K5X MS18A_HUMAN Decreases Expression [33]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Decreases Expression [33]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Decreases Expression [33]
LIM and cysteine-rich domains protein 1 (LMCD1) OT3AWE8O LMCD1_HUMAN Increases Expression [33]
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) OT1PAIN0 CACO1_HUMAN Increases Expression [33]
Homologous-pairing protein 2 homolog (PSMC3IP) OT9UB5UO HOP2_HUMAN Decreases Expression [33]
Fibulin-5 (FBLN5) OTLVNZ8U FBLN5_HUMAN Increases Expression [33]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B) OTHLNI51 ABC3B_HUMAN Decreases Expression [33]
STEAP1 protein (STEAP1) OTJMW5R9 STEA1_HUMAN Decreases Expression [33]
DNA helicase MCM8 (MCM8) OTC93H3S MCM8_HUMAN Decreases Expression [33]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [33]
Angiopoietin-related protein 2 (ANGPTL2) OTB6JG41 ANGL2_HUMAN Increases Expression [33]
Protein HEG homolog 1 (HEG1) OT3CUXA7 HEG1_HUMAN Increases Expression [33]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [33]
Synaptopodin-2 (SYNPO2) OTC3U0YH SYNP2_HUMAN Increases Expression [33]
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) OT953SV2 ATS5_HUMAN Increases Expression [33]
Protein timeless homolog (TIMELESS) OTD8DCBJ TIM_HUMAN Decreases Expression [33]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Increases Expression [33]
Exonuclease 1 (EXO1) OTI87RS5 EXO1_HUMAN Decreases Expression [33]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Increases Expression [33]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [33]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [33]
Serine/threonine-protein kinase 38-like (STK38L) OTI00JVW ST38L_HUMAN Increases Expression [33]
Small kinetochore-associated protein (KNSTRN) OTYA7UXS SKAP_HUMAN Decreases Expression [33]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Decreases Expression [33]
Carboxypeptidase Q (CPQ) OTTNZNLD CBPQ_HUMAN Increases Expression [33]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Decreases Expression [33]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1) OTMRW5U5 IRAG1_HUMAN Increases Expression [33]
Adenylate kinase isoenzyme 5 (AK5) OTTGXLOT KAD5_HUMAN Decreases Expression [33]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [41]
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) OTFBFPV4 ADAS_HUMAN Increases Expression [42]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [42]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Phosphorylation [42]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [42]
cAMP-regulated phosphoprotein 19 (ARPP19) OTZS3IT6 ARP19_HUMAN Increases Expression [42]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Increases Expression [43]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [44]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [43]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Activity [45]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Decreases Activity [34]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Phosphorylation [46]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [47]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Activity [48]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [47]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Decreases Phosphorylation [49]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Decreases Expression [47]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Activity [48]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [47]
C-C motif chemokine 1 (CCL1) OT23NON8 CCL1_HUMAN Decreases Expression [47]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [34]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [34]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [50]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Decreases Phosphorylation [49]
Crk-like protein (CRKL) OTOYSD1R CRKL_HUMAN Decreases Phosphorylation [51]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [50]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Decreases Phosphorylation [52]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [47]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [34]
Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1) OTF91GTL FIP1_HUMAN Decreases Phosphorylation [53]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Phosphorylation [54]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) OTYRXD2T PMYT1_HUMAN Decreases Activity [55]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [29]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Affects Localization [44]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) OTK3EJFD NSDHL_HUMAN Decreases Response To Substance [56]
------------------------------------------------------------------------------------
⏷ Show the Full List of 345 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Carcinoma DCZQ2DI RXF 393 Investigative [57]
Adenocarcinoma DC73NE6 OVCAR3 Investigative [1]
Cutaneous melanoma DC8GMZP SK-MEL-28 Investigative [1]
------------------------------------------------------------------------------------

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57 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165