Details of the Drug

General Information of Drug (ID: DM2YGNW)

Drug Name
Dactinomycin
Synonyms
Cosmegen; Dactinomicina; Dactinomycine; Dactinomycinum; Meractinomycin; ACT D; ACTINOMYCIN D AMP; Actactinomycin A IV; Actinomycin A IV; Actinomycin Aiv; Actinomycin I; Actinomycin IV; Actinomycin cl; Actinomycin x i; Antibiotic from Streptomyces parvullus; Chounghwamycin B; D Actinomycin; Dactinomycin D; Dactinomyein d; Dilactone actin omycindioic D acid; Dilactone actinomycin D acid; Dilactone actinomycindioic D acid; Lyovac cosmegen; Oncostatin K; Actinomycin 11 cosmegen; Actinomycin 7; Actinomycin C1; Actinomycin I1; Actinomycin X 1; Actinomycin X1; HBF 386; HBF 386 meractinomycin; X 97; AD (VAN); Actinomycin C (sub1); Actinomycin C(sub1); Actinomycin D (JP15); Actinomycin D, sodium deoxyribonucleic acid complex; Actinomycin I (sub1); Actinomycin I(sub 1); Actinomycin I(sub1); Actinomycin-IV; Actinomycindioic D acid, dilactone; Acto-D; COSMEGEN (TN); Dactinomicina [INN-Spanish]; Dactinomycin (USP); Dactinomycin [USAN:BAN]; Dactinomycine [INN-French]; Dactinomycinum [INN-Latin]; NP-005932; Actinomycin D deriv. of 3H-phenoxaocardazine; GNF-PF-1977; Actinomycin-[threo-val-pro-sar-meval]; Actinomyein-theo-val-pro-sar-meval; Actinomycin-(threo-val-pro-sar-meval); O)-(1-oxo-1,2-ethanediyl)]bis(N-methyl)L-valine; PXZ-THR-DVA-PRO-SAR-MVA-THR-DVA-PRO-SAR-MVA; DVA-DPR-SAR-MVA-(c1)DTH-PXZ-(c11)DTH-DVA-DPR-SAR-MVA; 1H-Pyrrolo(2,1-1)-(1,4,7,10,13)oxatetraazacyclohexadecine; 4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Indication
Disease Entry ICD 11 Status REF
Adult kidney Wilms tumor N.A. Approved [1]
Advanced cancer 2A00-2F9Z Approved [1]
Beckwith-Wiedemann syndrome N.A. Approved [1]
Childhood kidney Wilms tumor N.A. Approved [1]
Gestational trophoblastic neoplasia 2F33-2F76 Approved [1]
Hamartoma N.A. Approved [1]
Solid tumour/cancer 2A00-2F9Z Approved [2]
Wilms tumor N.A. Approved [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L01DA01: Dactinomycin
L01DA: Actinomycines
L01D: CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 1255.4
Logarithm of the Partition Coefficient (xlogp) 3.8
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 5
Hydrogen Bond Acceptor Count (hbondacc) 18
ADMET Property
Absorption
The drug is poorly absorbed from gastrointestinal tract []
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [3]
Elimination
10% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 36 hours [4]
Metabolism
The drug is metabolized via the hepatic []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.01195 micromolar/kg/day [5]
Water Solubility
The ability of drug to dissolve in water is measured as 0.5 mg/mL [3]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Cell-mediated cytotoxicity Not Available HYAL1 OT2SJN0X [6]
Chemical Identifiers
Formula
C62H86N12O16
IUPAC Name
2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Canonical SMILES
C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
InChI
InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
InChIKey
RJURFGZVJUQBHK-IIXSONLDSA-N
Cross-matching ID
PubChem CID
457193
ChEBI ID
CHEBI:27666
CAS Number
50-76-0
UNII
1CC1JFE158
DrugBank ID
DB00970
TTD ID
D0P8IV
VARIDT ID
DR01203
ACDINA ID
D00983
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [7]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [8]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [9]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Gene/Protein Processing [11]
All-trans-retinol 13,14-reductase (RETSAT) OTC3AOPX RETST_HUMAN Gene/Protein Processing [11]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Gene/Protein Processing [11]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [11]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [12]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Drug Response [13]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [12]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [14]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Gene/Protein Processing [11]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Gene/Protein Processing [15]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 -3.825 1.9537 -4.9398 25.1663
EW-1 GDSC2 -8.7714 -6.3102 -8.7726 51.8763
ES8 GDSC2 -8.3364 -4.4726 -8.3729 49.2233
HOS GDSC2 -8.3343 -4.8307 -8.3551 49.2048
SK-ES-1 GDSC2 -8.3191 -5.8555 -8.3209 49.1032
HuO9 GDSC2 -8.2929 -5.8398 -8.2947 48.9423
SK-PN-DW GDSC2 -8.0623 -5.3272 -8.0673 47.5323
EW-7 GDSC2 -7.8124 -5.4193 -7.8146 45.9952
EW-12 GDSC2 -7.807 -5.9545 -7.8072 74.6791
ES1 GDSC2 -7.6675 -3.1388 -7.7811 69.1758
EW-11 GDSC2 -7.4973 -4.3453 -7.5165 44.0997
CHSA0011 GDSC2 -7.4765 -3.9209 -7.5149 69.3568
ES7 GDSC2 -7.4663 -3.6981 -7.5187 43.9767
ES5 GDSC2 -7.3361 -5.4661 -7.3366 43.0675
EW-22 GDSC2 -7.2705 -4.1017 -7.2936 42.7209
EW-3 GDSC2 -6.9484 -4.1933 -6.9611 40.7213
SJSA-1 GDSC2 -6.5735 -3.2507 -6.6212 61.7271
CAL-72 GDSC2 -6.4147 -2.264 -6.5592 37.8083
TC-71 GDSC2 -6.3367 -4.7157 -6.3371 36.931
A-673 GDSC2 -6.334 -0.5569 -6.8204 38.1545
CADO-ES1 GDSC2 -6.0139 -3.241 -6.0413 35.0309
EW-18 GDSC2 -5.9953 -4.3478 -5.9961 34.8362
NY GDSC2 -5.9674 -3.0112 -6.0073 34.783
HuO-3N1 GDSC2 -5.9669 -4.0994 -5.9691 34.6663
CHSA0108 GDSC2 -5.9098 -4.6036 -5.9099 56.0719
CAL-78 GDSC2 -5.8734 -4.6788 -5.8734 34.0855
NOS-1 [Human HNSCC] GDSC2 -5.8446 -3.7094 -5.8512 33.9289
EW-13 GDSC2 -5.8248 -0.1269 -6.3817 35.3413
U2OS GDSC2 -5.6872 -2.7506 -5.7346 33.0865
MHH-ES-1 GDSC2 -5.0873 -1.0305 -5.3476 30.0642
ES6 GDSC2 -4.9457 -2.4293 -4.9854 28.5123
EW-16 GDSC2 -4.9312 1.4043 -5.9104 31.2549
MG-63 GDSC2 -4.632 2.7984 -6.1339 30.9891
H-EMC-SS GDSC2 -3.8052 3.791 -5.7007 27.477
CHSA8926 GDSC2 -3.5048 4.7093 -5.8119 27.0217
ES4 GDSC2 -2.899 3.8012 -4.7898 22.3056
U-CH2 GDSC2 -2.1362 10.6642 -7.3917 37.4354
EW-24 GDSC2 -2.0741 5.576 -4.8337 20.5401
SaOS-2 GDSC2 -1.6835 3.4088 -3.4157 14.6262
G-292 clone A141B1 GDSC2 0.0615 6.9396 -3.6383 12.0881
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 165 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 -9.5394 -8.4362 -9.5394 91.4732
MV4-11 GDSC2 -11.742 -10.1169 -11.742 99.0285
BV-173 GDSC2 -11.7372 -9.401 -11.7373 97.5712
SU-DHL-1 GDSC2 -11.3487 -7.2884 -11.3581 91.766
SU-DHL-16 GDSC2 -10.8197 -8.6105 -10.8198 95.3296
OCI-Ly19 GDSC2 -10.7241 -8.0242 -10.7246 93.4548
BONNA-12 GDSC2 -10.7125 -6.591 -10.7271 89.0407
NKM-1 GDSC2 -10.6185 -8.0304 -10.6189 93.3556
RCH-ACV GDSC2 -10.6103 -7.7145 -10.6114 92.3613
SUP-B8 GDSC2 -10.4858 -7.0225 -10.4908 90.0276
RL GDSC2 -10.3837 -7.3169 -10.3858 90.7787
OCI-Ly7 GDSC2 -10.2879 -7.9291 -10.2881 92.5385
CRO-AP2 GDSC2 -10.1819 -6.237 -10.1967 87.0508
NU-DUL-1 GDSC2 -10.0248 -7.6958 -10.0251 91.2316
MC116 GDSC2 -10.0161 -7.259 -10.0173 89.8453
SUP-B15 GDSC2 -9.963 -8.4506 -9.963 59.1947
QIMR-WIL GDSC2 -9.9091 -6.6191 -9.9141 87.5944
CTB-1 GDSC2 -9.747 -5.5775 -9.7732 84.0313
NB4 GDSC2 -9.6932 -5.9303 -9.7075 84.9235
SR GDSC2 -9.6235 -7.9635 -9.6235 57.1104
Farage GDSC2 -9.6033 -7.6112 -9.6034 56.9844
MOLM-13 GDSC2 -9.5803 -7.7731 -9.5804 56.8446
MOLT-16 GDSC2 -9.4712 -7.6811 -9.4712 56.1749
RS4;11 GDSC2 -9.4423 -7.452 -9.4424 55.9964
WSU-NHL GDSC2 -9.4358 -6.6005 -9.438 55.9343
SUP-M2 GDSC2 -9.3874 -7.0456 -9.3879 55.655
MHH-CALL-4 GDSC2 -9.3836 -7.0177 -9.3841 87.0561
HC-1 GDSC2 -9.3586 -7.4909 -9.3586 55.483
CESS GDSC2 -9.3061 -7.6238 -9.3061 55.1612
DB GDSC2 -9.2796 -6.6858 -9.2808 54.9883
SU-DHL-4 GDSC2 -9.2104 -7.5547 -9.2104 87.5722
OCI-AML-2 GDSC2 -9.1686 -7.9998 -9.1686 54.3177
AMO1 GDSC2 -9.0684 -5.1867 -9.0932 53.6277
GDM-1 GDSC2 -8.9387 -6.8211 -8.9389 52.9045
SU-DHL-10 GDSC2 -8.938 -7.3883 -8.938 52.9015
HT GDSC2 -8.8926 -4.248 -8.9647 77.5317
MOLM-16 GDSC2 -8.862 -6.0557 -8.8652 82.0839
MEG-01 GDSC2 -8.8015 -6.7221 -8.8018 52.063
KMS-12-BM GDSC2 -8.7708 -6.5692 -8.7712 51.874
RPMI-8402 GDSC2 -8.7682 -4.9904 -8.7934 78.9159
SIG-M5 GDSC2 -8.7275 -7.6959 -8.7275 84.1833
Jurkat GDSC2 -8.7064 -7.4464 -8.7064 51.4796
P30/OHK GDSC2 -8.7048 -6.1334 -8.7066 51.4667
BC-3 GDSC2 -8.6879 -6.6577 -8.6881 82.442
MY-M12 GDSC2 -8.6801 -6.5178 -8.6805 82.1146
YT GDSC2 -8.653 -6.1321 -8.6546 81.1282
Raji GDSC2 -8.6232 -3.7723 -8.7237 50.9217
ROS-50 GDSC2 -8.585 19.431 -17.7138 56.3181
Jiyoye GDSC2 -8.4977 -4.4713 -8.5395 50.1936
SKM-1 GDSC2 -8.4537 -6.1399 -8.4547 49.9284
LAMA-84 GDSC2 -8.3928 -5.7986 -8.3953 49.5551
TALL-1 [Human adult T-ALL] GDSC2 -8.3748 -5.4851 -8.3806 78.0691
BC-1 GDSC2 -8.37 -5.0899 -8.3835 49.4189
JeKo-1 GDSC2 -8.3247 -5.5809 -8.3288 77.9639
SCC-3 GDSC2 -8.3192 -5.1219 -8.3311 49.1092
VL51 GDSC2 -8.2758 -5.9278 -8.277 48.8367
DEL GDSC2 -8.2675 -5.3076 -8.2749 48.7909
SU-DHL-6 GDSC2 -8.2302 -6.4876 -8.2302 48.5557
LC4-1 GDSC2 -8.2176 -6.4897 -8.2176 48.4784
BALL-1 GDSC2 -8.151 -5.7172 -8.1529 48.0723
OPM-2 GDSC2 -8.0991 -5.028 -8.1098 47.7644
JVM-2 GDSC2 -8.0691 -5.4898 -8.0723 47.5717
Mono-Mac-6 GDSC2 -8.0595 -4.586 -8.083 74.2971
KMOE-2 GDSC2 -8.0438 -4.9034 -8.0566 47.4287
KCL-22 GDSC2 -8.0429 -5.3953 -8.0468 47.4118
Kasumi-1 GDSC2 -8.0378 -5.5174 -8.0405 47.3789
BE-13 GDSC2 -8.0356 -5.3392 -8.0401 47.3679
PL-21 GDSC2 -8.0042 -4.0219 -8.0558 72.8092
EoL-1 GDSC2 -7.9514 -7.0166 -7.9514 46.8442
JSC-1 GDSC2 -7.9473 -4.9481 -7.9575 46.8354
Karpas-299 GDSC2 -7.9434 -4.4976 -7.9676 46.8312
DoHH2 GDSC2 -7.8669 -7.0366 -7.8669 46.3255
NALM-6 GDSC2 -7.8526 -6.0159 -7.8528 46.238
RPMI-6666 GDSC2 -7.7982 -5.6872 -7.799 45.9052
697 GDSC2 -7.7466 -6.6466 -7.7466 45.5866
Loucy GDSC2 -7.7316 -5.0557 -7.7371 45.5065
Reh GDSC2 -7.7188 -6.1075 -7.7189 45.4161
ML-2 GDSC2 -7.7057 -5.3894 -7.7076 45.3401
Ku812 GDSC2 -7.7014 -4.7398 -7.7126 45.3324
JJN-3 GDSC2 -7.6379 -6.8417 -7.6379 44.919
KMS-11 GDSC2 -7.6061 -4.7362 -7.616 71.5636
H9 GDSC2 -7.5932 -5.0829 -7.5971 44.6541
Karpas-1106P GDSC2 -7.5495 -5.3761 -7.5509 44.3801
A3/Kawakami GDSC2 -7.5445 -6.6908 -7.5445 44.346
SU-DHL-5 GDSC2 -7.5 -6.9869 -7.5 44.0723
NCI-H929 GDSC2 -7.4987 -4.2062 -7.5235 44.12
Ramos.2G6.4C10 GDSC2 -7.455 -6.2666 -7.455 43.7961
IM-9 GDSC2 -7.4347 -6.2977 -7.4347 43.6714
MOLT-4 GDSC2 -7.4141 -6.3234 -7.4141 43.5453
RC-K8 GDSC2 -7.3907 -2.9213 -7.5129 43.6483
MN-60 GDSC2 -7.3517 -5.1271 -7.3537 43.1675
BL-41 GDSC2 -7.3454 -5.865 -7.3455 43.1237
PF-382 GDSC2 -7.253 -4.6169 -7.2605 42.576
RPMI-8866 GDSC2 -7.2419 -5.6648 -7.691 8.6014
K-562 GDSC2 -7.2242 -4.6108 -7.2313 42.3982
KY821 GDSC2 -7.1995 -5.3311 -7.2 42.2291
CTV-1 GDSC2 -7.1694 0.225 -7.951 43.3674
L-540 GDSC2 -7.1436 -5.2865 -7.1441 41.8856
L-1236 GDSC2 -7.1117 -4.5323 -7.1189 41.7082
P32/ISH GDSC2 -7.1091 -4.801 -7.1124 41.6819
ALL-SIL GDSC2 -7.0974 -5.3305 -7.0977 41.6016
JVM-3 GDSC2 -7.0336 -5.642 -7.0336 41.2088
P12-Ichikawa GDSC2 -7.0322 -4.7505 -7.0354 41.2096
WSU-DLCL2 GDSC2 -6.9922 -4.9905 -6.9934 66.7004
EB2 GDSC2 -6.8849 -0.4132 -7.4596 41.4919
CML-T1 GDSC2 -6.8798 -5.3867 -6.8799 40.2648
MHH-CALL-2 GDSC2 -6.7939 -5.3258 -6.794 39.7377
CCRF-CEM GDSC2 -6.7786 -4.3979 -6.7842 39.6595
JURL-MK1 GDSC2 -6.7666 -3.7583 -8.1902 10.1431
L-363 GDSC2 -6.6403 -5.2404 -6.6403 38.794
ARH-77 GDSC2 -6.5967 -5.1266 -6.5968 38.5267
RPMI-8226 GDSC2 -6.5945 -5.3253 -6.5945 38.5127
THP-1 GDSC2 -6.5935 -3.5364 -6.6239 62.1403
HAL-01 GDSC2 -6.58 -4.8903 -6.5805 38.4255
U-698-M GDSC2 -6.5521 -4.8483 -6.5526 38.254
Hs 445 GDSC2 -6.547 -5.0815 -6.5471 38.2214
WIL2 NS GDSC2 -6.5372 -4.1167 -6.545 38.1846
Daudi GDSC2 -6.5021 -3.1505 -6.5542 38.0945
Namalwa GDSC2 -6.502 -5.2746 -6.502 37.9449
Karpas-422 GDSC2 -6.4728 -5.2724 -6.4728 37.7658
SUP-HD1 GDSC2 -6.466 -2.9991 -6.5289 37.9033
L-428 GDSC2 -6.4514 -4.3547 -6.4545 37.6439
MHH-PREB-1 GDSC2 -6.444 -2.9253 -6.5126 37.7844
GA-10 GDSC2 -6.4356 -3.7763 -6.451 37.5833
A4/Fukuda GDSC2 -6.4037 -4.3689 -6.4063 37.3494
DND-41 GDSC2 -6.3813 -1.6597 -6.6233 37.8551
NOMO-1 GDSC2 -6.3143 -5.2104 -6.3143 36.7927
KOPN-8 GDSC2 -6.3076 -4.3834 -6.3095 36.7569
P31/FUJ GDSC2 -6.2669 -5.3536 -6.2669 59.6581
OCI-M1 GDSC2 -6.2644 -5.3937 -6.2644 36.4858
MOLT-13 GDSC2 -6.2521 -5.0153 -6.2521 36.4107
SUP-T1 GDSC2 -6.2387 -1.391 -6.5217 37.1023
ST486 GDSC2 -6.2154 -3.6195 -6.2314 36.2332
Karpas-45 GDSC2 -6.1881 -4.5395 -6.1887 36.0192
MM1.S GDSC2 -6.1839 -4.7169 -6.1842 35.9927
KE-37 GDSC2 -6.1628 -5.2227 -6.1628 35.8621
KM-H2 GDSC2 -6.1442 -4.1843 -6.1468 35.7559
Karpas-231 GDSC2 -6.1342 -5.2612 -6.1342 35.6865
HEL GDSC2 -6.131 -4.3328 -6.1323 35.671
SU-DHL-8 GDSC2 -6.1258 -5.046 -6.1258 35.6352
MOLP-8 GDSC2 -6.1132 -4.0191 -6.1176 35.5713
TK [Human B-cell lymphoma] GDSC2 -6.0835 -4.9688 -6.0835 35.3752
OCI-AML-3 GDSC2 -6.0819 -3.6241 -6.0948 35.4048
EM-2 GDSC2 -6.0517 -4.9579 -6.0517 35.1803
MLMA GDSC2 -6.0336 -4.2091 -6.0353 35.0741
TUR GDSC2 -6.0223 -5.3574 -6.0223 34.9999
ALL-PO GDSC2 -5.9974 -4.3227 -5.9983 34.8495
ATN-1 GDSC2 -5.9702 -4.0183 -5.9733 34.6892
HDLM-2 GDSC2 -5.9425 -4.5749 -5.9427 34.5102
VAL GDSC2 -5.9363 -4.4155 -5.9367 34.473
HL-60 GDSC2 -5.8456 -5.2605 -5.8456 33.9148
Karpas-620 GDSC2 -5.8376 -4.4868 -5.8377 33.866
EJM GDSC2 -5.8145 -4.6557 -5.8145 33.7237
KG-1 GDSC2 -5.7289 -3.9221 -5.7312 33.205
DG-75 GDSC2 -5.455 -0.5443 -5.8647 32.7389
NK-92MI GDSC2 -5.3904 -2.8461 -5.4191 50.8397
CA46 GDSC2 -5.3664 2.0805 -6.6292 34.4672
SK-MM-2 GDSC2 -5.3063 -2.6368 -5.3458 30.7252
LP-1 GDSC2 -5.2238 -3.5509 -5.2262 30.1041
GR-ST GDSC2 -5.1693 2.7187 -6.6686 33.9498
HH [Human lymphoma] GDSC2 -4.7416 -1.6569 -4.8573 27.497
ME1 GDSC2 -4.6504 -3.3022 -4.6515 26.5798
U266B1 GDSC2 -4.2759 -2.9509 -4.2776 24.2824
OCI-AML-5 GDSC2 0.0834 4.9547 -8.2332 1.0333
Granta-519 GDSC2 0.4813 12.2423 -5.9479 19.0844
⏷ Show the Full List of 165 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC2 -7.685 -4.4604 -7.7043 71.6762
OACP4 C GDSC2 -6.6963 -4.6709 -6.6981 39.1431
FLO-1 GDSC2 -6.2319 -4.0086 -6.2378 36.3045
KYSE-50 GDSC2 -6.1275 -1.2348 -6.4338 36.4953
KYSE-220 GDSC2 -5.595 0.4207 -6.2953 34.3649
KYAE-1 GDSC2 -5.0162 -0.5071 -5.3956 29.9965
OACM5.1 C GDSC2 -4.5899 0.7115 -5.2979 28.4358
ESO-26 GDSC2 -4.2079 0.3041 -4.7489 25.5994
TE-12 GDSC2 -3.2111 6.3215 -6.2777 27.5963
ESO-51 GDSC2 -2.4789 3.3228 -4.1508 19.0986
SK-GT-4 GDSC2 -0.8909 14.6459 -8.2851 27.4111
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 -3.919 3.1396 -5.533 27.2804
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-17 GDSC2 -10.2662 -5.9253 -10.2918 86.2822
CHP-126 GDSC2 -10.0815 -7.4093 -10.0823 90.4701
NB1 GDSC2 -10.0755 120.4897 -69.0367 52.005
MHH-NB-11 GDSC2 -9.4586 -6.8022 -9.4599 86.7422
IMR-5 GDSC2 -9.0215 -6.1621 -9.0247 53.4008
SK-N-MC-IXC GDSC2 -8.4959 -6.5443 -8.4961 80.9137
SJNB-5 GDSC2 -7.7977 -5.155 -7.8025 73.6091
NB(TU)1 GDSC2 -7.3617 -5.7092 -7.3618 43.2235
NB69 GDSC2 -7.3427 -5.1868 -7.3442 43.1109
LA-N-6 GDSC2 -6.8073 -4.6188 -6.8103 64.797
SJNB-10 GDSC2 -6.6989 1.8744 -7.9843 41.6044
SK-N-AS GDSC2 -6.6384 -4.524 -6.6411 38.7904
SJNB-12 GDSC2 -6.4189 -3.0248 -6.4775 60.2622
SK-N-DZ GDSC2 -6.2944 -0.5988 -6.7664 37.8901
SJNB-14 GDSC2 -6.2231 -2.2467 -6.3568 36.6148
Kelly GDSC2 -6.0292 -2.687 -6.099 35.2499
SJNB-13 GDSC2 -5.948 -1.4363 -6.1974 35.2622
SJNB-7 GDSC2 -5.7535 -3.1162 -5.7793 33.428
KP-N-YS GDSC2 -5.4077 -2.3529 -5.4776 50.9803
CHP-212 GDSC2 -5.3927 -0.0448 -5.9339 32.7394
GI-ME-N GDSC2 -4.9935 0.3462 -5.6171 30.5948
TGW GDSC2 -4.8116 -1.3433 -4.9854 28.1088
GOTO GDSC2 -4.5385 3.672 -6.4032 31.4308
SK-N-FI GDSC2 -4.2976 -0.6821 -4.5679 40.8804
SK-N-BE(2)-M17 GDSC2 -3.76 2.2191 -4.9794 25.1205
SiMa GDSC2 -1.5363 10.1933 -6.623 24.7677
SK-N-SH GDSC2 -1.4894 70.0993 -36.5101 47.0817
NH-12 GDSC2 -0.9381 11.2576 -6.6329 23.5995
CHP-134 GDSC2 -0.4662 13.0138 -7.1104 23.9368
KP-N-RT-BM-1 GDSC2 -0.4618 35.1472 -18.1732 42.6414
SJNB-6 GDSC2 -0.2655 15.2857 -8.0788 33.5156
KP-N-YN GDSC2 0.157 9.9794 -5.0791 16.9566
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 -5.8988 -2.2182 -6.0147 34.5859
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-148 GDSC2 -9.6289 -5.8175 -9.645 84.4022
CAL-51 GDSC2 -9.1175 -5.7881 -9.1266 53.9659
HDQ-P1 GDSC2 -8.2601 -5.8238 -8.2619 48.7413
HCC1599 GDSC2 -8.0697 9.843 -12.7393 58.1542
DU4475 GDSC2 -7.5198 -6.2436 -7.5198 44.194
OCUB-M GDSC2 -7.5071 -5.8225 -7.5073 44.1167
Evsa-T GDSC2 -7.4129 -5.9698 -7.4129 43.5378
HCC1806 GDSC2 -7.3819 -4.7223 -7.389 43.3657
MDA-MB-468 GDSC2 -7.1661 -2.9658 -7.2698 42.2612
COLO 824 GDSC2 -6.7602 -3.3585 -6.8078 39.6611
CAMA-1 GDSC2 -6.6864 -3.8638 -6.7044 39.129
MDA-MB-157 GDSC2 -6.6285 -4.9826 -6.6288 38.7224
HCC1569 GDSC2 -6.5339 -3.8501 -6.5489 38.1849
MRK-nu-1 GDSC2 -6.2325 -3.6102 -6.2493 36.3408
CAL-120 GDSC2 -6.1833 -0.8895 -6.573 37.0389
HCC2157 GDSC2 -6.1551 -5.0315 -6.1551 35.8151
UACC-893 GDSC2 -6.1127 0.1933 -6.7895 55.6619
HCC2218 GDSC2 -6.048 -4.4435 -6.0486 57.4426
MDA-MB-231 GDSC2 -5.9824 -3.2246 -6.0097 34.8374
HCC70 GDSC2 -5.9458 -4.8979 -5.9458 34.5299
T-47D GDSC2 -5.8908 -2.1944 -6.0093 34.5447
BT-20 GDSC2 -5.817 -4.6476 -5.817 33.739
HCC1395 GDSC2 -5.8134 -3.4714 -5.8257 55.0099
HCC1187 GDSC2 -5.7224 -5.0005 -5.7224 33.1585
MDA-MB-330 GDSC2 -5.6328 -2.0693 -5.7511 32.9666
HCC1954 GDSC2 -5.5827 -2.4344 -5.6538 32.5177
MDA-MB-415 GDSC2 -5.5805 -1.1231 -5.8635 33.1319
MDA-MB-361 GDSC2 -5.4484 -4.2566 -5.4485 31.4764
MDA-MB-175-VII GDSC2 -5.3543 -0.3552 -5.8048 50.3994
BT-549 GDSC2 -5.3516 -0.7333 -5.7043 31.9489
Hs 578T GDSC2 -5.2431 -0.3323 -5.6898 31.5705
AU565 GDSC2 -5.2367 -3.5707 -5.2391 30.1834
YMB-1-E GDSC2 -5.0031 6.4303 -8.1004 48.6537
MFM-223 GDSC2 -4.9435 -2.9726 -4.9538 28.4078
EFM-192A GDSC2 -4.8443 -2.2238 -4.8969 27.9299
CAL-85-1 GDSC2 -4.2932 1.5594 -5.2836 27.5447
UACC-812 GDSC2 -4.2351 -0.9536 -4.4381 40.0643
EFM-19 GDSC2 -4.2021 -2.7581 -4.2057 23.835
HCC1143 GDSC2 -3.3898 0.9625 -4.0913 21.1642
HCC38 GDSC2 -2.8895 2.1179 -4.0283 19.659
MDA-MB-453 GDSC2 -2.5159 4.145 -4.5712 20.6528
HCC1428 GDSC2 -2.2424 3.2481 -3.8821 17.5877
MCF-7 GDSC2 -1.7836 9.7845 -6.6396 25.3251
ZR-75-30 GDSC2 -1.1884 2.096 -2.3117 9.4014
JIMT-1 GDSC2 -1.066 4.0998 -3.1799 12.4506
HCC1937 GDSC2 -0.919 5.7232 -3.8554 14.6855
MDA-MB-436 GDSC2 -0.3571 7.7698 -4.3972 15.5707
BT-474 GDSC2 -0.222 6.1832 -3.4916 12.0375
HCC1500 GDSC2 -0.0258 9.421 -4.9489 16.8525
HCC1419 GDSC2 0.9442 5.7482 -2.3775 5.9686
BT-483 GDSC2 3.3133 15.68 -5.5333 18.9768
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC2 -9.8787 -7.6851 -9.8788 58.6707
SF126 GDSC2 -9.5669 -1.6089 -10.0912 73.7411
D-423MG GDSC2 -8.5339 -5.37 -8.5434 78.7092
H4 GDSC2 -8.5142 -5.2774 -8.5254 50.297
D-336MG GDSC2 -7.7592 -5.6063 -7.7602 73.9206
SNB-75 GDSC2 -7.7418 -3.1175 -7.8622 69.5571
PFSK-1 GDSC2 -7.7009 -5.6624 -7.7016 45.3079
Daoy GDSC2 -7.6848 -5.8119 -7.6851 45.2078
D-542MG GDSC2 -7.6533 1.8947 -9.0216 61.9908
YKG-1 GDSC2 -7.4984 -3.5 -7.5676 68.7957
D-566MG GDSC2 -7.3915 -5.4309 -7.3922 70.6049
SW1783 GDSC2 -7.2766 -2.4366 -7.4565 65.6916
Hs 683 GDSC2 -7.2449 0.1319 -8.0059 62.0722
Onda 10 GDSC2 -7.1297 -4.2156 -7.1453 67.2177
AM-38 GDSC2 -7.114 -4.6488 -7.1193 41.7173
MOG-G-UVW GDSC2 -7.0257 -2.0863 -7.2428 63.6378
SF539 GDSC2 -7.0138 -4.172 -7.0284 41.1273
D-263MG GDSC2 -6.9601 -4.6377 -6.964 40.769
GaMG GDSC2 -6.7881 -1.2302 -7.153 40.5456
D-392MG GDSC2 -6.7598 -3.8754 -6.7791 39.5829
8-MG-BA GDSC2 -6.6992 -3.987 -6.7132 39.1963
SF295 GDSC2 -6.631 0.4731 -7.4397 58.5464
D-502MG GDSC2 -6.5872 5.6514 -9.3746 55.3825
ONS-76 GDSC2 -6.471 -3.2838 -6.5123 37.874
GB-1 GDSC2 -6.1926 -2.7396 -6.2658 36.2597
GI-1 GDSC2 -6.0415 -2.7874 -6.1025 35.2996
M059J GDSC2 -6.0415 -1.9452 -6.2073 35.5984
LN-18 GDSC2 -6.0093 -5.4663 -6.0093 34.9199
SK-MG-1 GDSC2 -5.9749 -3.1228 -6.0078 34.808
T98G GDSC2 -5.8522 -1.0002 -6.1865 34.9168
D-245MG GDSC2 -5.7585 14.6197 -12.6963 51.195
A-172 GDSC2 -5.7103 1.1745 -6.6698 35.6695
42-MG-BA GDSC2 -5.6195 -2.3811 -5.6983 32.7663
KNS-81-FD GDSC2 -5.3945 10.7964 -10.5198 50.2945
D-247MG GDSC2 -5.0543 7.2229 -8.5141 48.9495
U-118MG GDSC2 -4.8833 1.0739 -5.7406 30.6264
MOG-G-CCM GDSC2 -4.8641 0.7849 -5.62 46.6973
YH-13 GDSC2 -4.863 0.6769 -5.5825 30.1016
SF268 GDSC2 -4.7517 1.3246 -5.6882 30.0836
KS-1 [Human Krukenberg tumour] GDSC2 -4.4156 4.1687 -6.4919 31.3105
Becker GDSC2 -3.8618 3.8953 -5.8047 27.9313
CAS-1 GDSC2 -3.7396 0.4079 -4.2738 22.7273
U-251MG GDSC2 -3.6173 4.2824 -5.7301 27.0715
Onda 11 GDSC2 -3.2896 10.3137 -8.2781 42.3343
KALS-1 GDSC2 -3.1702 3.597 -4.9689 23.5658
SW1088 GDSC2 -2.885 2.9306 -4.3804 20.8769
LN-405 GDSC2 -2.4726 2.8901 -3.9457 18.3537
LN-229 GDSC2 -2.4422 6.3915 -5.5759 23.7502
DBTRG-05MG GDSC2 -1.9781 8.782 -6.3184 24.8748
U-87MG ATCC GDSC2 -1.4767 6.7872 -4.8794 19.4129
DK-MG GDSC2 -0.9264 6.2264 -4.1125 15.6351
KNS-42 GDSC2 -0.7968 10.7867 -6.2768 31.0144
NMC-G1 GDSC2 0.4764 13.6064 -6.6325 28.5302
KINGS-1 GDSC2 1.4939 17.8449 -7.94 22.59
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 -7.6176 -4.0089 -7.6558 44.8704
TGBC24TKB GDSC2 -5.4598 -2.5201 -5.5161 31.7186
TGBC1TKB GDSC2 -0.367 14.229 -7.635 32.9253
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC2 -6.7655 -3.9866 -6.7809 39.607
ESS-1 GDSC2 -6.3872 -2.9382 -6.4518 37.4261
RL95-2 GDSC2 -6.2009 -4.4849 -6.2017 36.0986
MFE-319 GDSC2 -6.0718 -1.6512 -6.2904 35.9273
EN GDSC2 -5.7963 -5.0529 -5.7963 33.6118
KLE GDSC2 -3.0205 6.4587 -6.1592 26.8081
MFE-296 GDSC2 -2.6889 3.0799 -4.2494 19.9451
MFE-280 GDSC2 -1.995 3.906 -3.9525 17.2823
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-140 GDSC2 -8.5263 -4.3019 -8.5795 76.1055
ACHN GDSC2 -7.8413 -3.6276 -7.9158 46.2778
KTCTL-21 GDSC2 -7.803 -2.5308 -8.0065 68.7979
BFTC-909 GDSC2 -7.4405 -4.1529 -7.466 43.7657
769-P GDSC2 -7.261 -3.8044 -7.2988 42.6966
CAL-54 GDSC2 -7.1389 -0.1603 -7.8063 43.047
KTCTL-13 GDSC2 -6.5121 -3.0228 -6.5752 61.024
RXF 393L GDSC2 -6.4806 -2.0045 -6.6698 38.3214
SW13 GDSC2 -6.4088 -4.9993 -6.4089 37.3732
786-O GDSC2 -6.1664 1.0724 -7.1289 38.2216
BB65-RCC GDSC2 -5.9727 3.984 -8.0304 53.3508
HA7-RCC GDSC2 -5.9654 -2.6408 -6.0363 34.8624
LB996-RCC GDSC2 -5.9548 -0.2837 -6.4798 36.0253
UO-31 GDSC2 -5.9092 -2.3718 -6.0063 55.5318
Caki-1 GDSC2 -5.8521 2.6548 -7.3684 53.114
LB2241-RCC GDSC2 -5.5334 -0.5921 -5.9379 51.8453
A-704 GDSC2 -5.4053 -2.7079 -5.4438 31.3297
KTCTL-195 GDSC2 -5.0774 -0.5508 -5.451 30.3499
NCC010 GDSC2 -4.7962 -2.0971 -4.8589 27.6659
KTCTL-1M GDSC2 -4.7358 -0.7695 -5.0245 44.9821
LB1047-RCC GDSC2 -4.6655 -2.4751 -4.6907 43.6796
KMRC-20 GDSC2 -4.4505 0.86 -5.1979 27.7236
SN12C GDSC2 -3.7663 1.6772 -4.7675 24.4452
KTCTL-26A GDSC2 -3.4059 2.2331 -4.6144 36.013
OS-RC-2 GDSC2 -3.1948 3.2785 -4.8507 23.238
A-498 GDSC2 -3.0336 2.9157 -4.525 21.7405
SW156 GDSC2 -2.8129 5.3537 -5.4321 35.7221
RCC10RGB GDSC2 -2.2551 2.5771 -3.5846 16.539
TK-10 GDSC2 -1.8475 5.4362 -4.5538 19.0902
KMRC-1 GDSC2 -1.6103 4.2774 -3.7673 24.8383
NCC021 GDSC2 -1.2179 8.2989 -5.4 29.8048
VMRC-RCW GDSC2 -1.0827 3.3306 -2.8153 17.9423
VMRC-RCZ GDSC2 0.2666 5.4757 -2.7461 8.3829
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 GDSC2 -8.2323 -3.3116 -8.3595 48.6422
RKO GDSC2 -7.6739 -5.2046 -7.6771 45.1476
GP5d GDSC2 -7.4843 -5.3865 -7.4854 43.9791
COLO 320HSR GDSC2 -7.3023 -5.4972 -7.3026 42.8597
KM12 GDSC2 -7.0721 -0.788 -7.5668 42.4148
LS411N GDSC2 -7.0115 -1.5702 -7.3234 41.7485
SW48 GDSC2 -6.945 -2.4147 -7.1047 41.0487
HCC2998 GDSC2 -6.8725 -3.1147 -6.9452 40.4099
SNU-407 GDSC2 -6.8307 -3.1509 -6.8981 40.1422
NCI-H508 GDSC2 -6.7894 -1.2174 -7.1572 61.0995
SW620 GDSC2 -6.5863 -3.1036 -6.6461 38.6303
LoVo GDSC2 -6.5802 2.4457 -8.0664 41.2929
DiFi GDSC2 -6.5623 -3.1554 -6.6167 38.469
HT-29 GDSC2 -6.4711 -1.9663 -6.6658 38.2777
HCT 116 GDSC2 -6.4668 -4.1343 -6.4733 37.7486
LS513 GDSC2 -6.4331 -3.6209 -7.9835 7.8844
COLO205 GDSC2 -6.2649 -2.0102 -6.4369 36.9722
HT-55 GDSC2 -6.1406 -2.3596 -6.2538 36.0552
HCT 15 GDSC2 -6.0467 -1.9288 -6.2156 35.6387
LS180 GDSC2 -6.0211 -3.1104 -6.0565 35.0991
MDST8 GDSC2 -5.9656 -0.6347 -6.3985 35.8554
SNU-81 GDSC2 -5.9432 -2.1312 -6.0741 34.9006
NCI-H716 GDSC2 -5.8642 -1.5547 -6.0839 34.6723
SK-CO-1 GDSC2 -5.7417 -2.3588 -5.8303 33.5444
SW837 GDSC2 -5.5504 -0.9098 -5.8788 33.0805
HT115 GDSC2 -5.5176 -3.3289 -5.5284 31.9339
SNU-C1 GDSC2 -5.2612 -1.0794 -5.526 31.1376
SNU-283 GDSC2 -5.2461 -2.7393 -5.2762 49.429
RCM-1 [Human ESC] GDSC2 -5.033 0.6108 -5.7452 31.0897
SW1463 GDSC2 -5.0208 0.7195 -5.7679 31.1188
SNU-C2B GDSC2 -4.8022 0.3389 -5.4066 29.3911
CW-2 GDSC2 -4.771 -2.0154 -4.8413 27.5351
CCK-81 GDSC2 -4.4963 -0.2622 -4.8941 26.8922
C2BBe1 GDSC2 -3.375 5.7859 -6.1842 27.7466
NCI-H747 GDSC2 -3.1156 3.0364 -4.6622 22.41
T84 GDSC2 -2.8157 0.6795 -3.3702 17.1594
SW948 GDSC2 -2.6417 0.8673 -3.2547 16.303
CaR-1 GDSC2 -2.4551 1.8095 -3.4462 16.5163
CL-11 GDSC2 -2.3099 3.8129 -4.2134 18.9278
SNU-C5 GDSC2 -2.0476 5.3129 -4.6809 19.9643
SNU-61 GDSC2 -1.7014 3.1377 -3.3027 14.2447
LS1034 GDSC2 -1.3574 6.8712 -4.8141 18.9478
LS123 GDSC2 -1.3372 9.1397 -5.9233 22.4087
SW626 GDSC2 -1.1454 9.4777 -5.9238 22.0237
SW1116 GDSC2 -1.0531 5.7014 -3.9627 15.3413
SW1417 GDSC2 -0.9797 6.3119 -4.2018 16.0596
COLO 678 GDSC2 -0.3401 8.9503 -4.9732 17.5027
SNU-1040 GDSC2 0.0587 3.4999 -7.7403 0.2158
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 -3.5992 3.2102 -5.2339 25.5107
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC2 -7.5748 -5.0613 -7.5788 44.5415
SNU-423 GDSC2 -6.9385 -3.8492 -6.9637 40.6935
SK-HEP-1 GDSC2 -6.2133 -1.9241 -6.3955 36.6866
Hep 3B2.1-7 GDSC2 -5.9828 -4.4558 -5.9832 34.7585
JHH-1 GDSC2 -5.9322 -5.4767 -5.9322 34.4465
HLE GDSC2 -5.9225 -2.7007 -5.9855 34.5763
JHH-2 GDSC2 -5.6354 -2.399 -5.7132 32.8611
JHH-6 GDSC2 -5.3125 0.5756 -6.0375 32.7761
JHH-4 GDSC2 -5.1068 0.4385 -5.7696 31.3849
SNU-387 GDSC2 -4.547 0.7296 -5.2575 28.1867
Huh-7 GDSC2 -3.4748 0.6225 -4.0602 21.2857
Hep-G2/C3A GDSC2 -1.6103 3.8351 -3.5521 14.9749
JHH-7 GDSC2 -1.5496 6.105 -4.6082 18.6435
HuH-1 GDSC2 -0.974 4.2954 -3.1943 12.3224
SNU-449 GDSC2 1.0042 4.9102 -1.9324 4.2363
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 183 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H460 GDSC2 -12.5217 -4.3952 -12.7853 85.1642
COR-L303 GDSC2 -8.7868 -0.9559 -9.3948 70.0768
NCI-H2171 GDSC2 -8.7076 -6.3202 -8.7085 81.8654
NCI-H292 GDSC2 -8.6964 -5.5068 -8.7054 79.8825
RERF-LC-MS GDSC2 -8.6428 -4.9298 -8.6672 78.187
A-427 GDSC2 -8.348 -6.1119 -8.3488 49.2799
NCI-H2110 GDSC2 -8.3339 -3.4926 -8.4471 73.3457
NCI-H838 GDSC2 -8.2843 -5.8348 -8.2861 78.1951
SBC-1 GDSC2 -8.2827 -4.7341 -8.3059 75.8885
A-549 GDSC2 -8.1237 -2.7812 -8.3127 48.0449
NCI-H1648 GDSC2 -8.0202 -1.7985 -8.3711 68.5274
NCI-H1963 GDSC2 -8.001 -5.6612 -8.0026 47.1516
LB647-SCLC GDSC2 -7.9774 -5.5772 -7.9793 75.5836
CAL-12T GDSC2 -7.9631 -1.757 -8.3176 68.194
COR-L23 GDSC2 -7.9495 -4.0542 -7.9968 46.8967
HARA [Human squamous cell lung carcinoma] GDSC2 -7.8706 -4.9938 -7.8788 46.363
NCI-H209 GDSC2 -7.8593 -5.0616 -7.8661 46.2916
NCI-H1437 GDSC2 -7.851 -4.4399 -7.8752 72.7297
NCI-H322M GDSC2 -7.8303 -3.1373 -7.9537 46.2714
EMC-BAC-2 GDSC2 -7.8229 -4.7579 -7.8357 46.0788
NCI-H1993 GDSC2 -7.7473 -5.8284 -7.7477 45.592
NCI-H446 GDSC2 -7.6984 -4.3669 -7.7216 45.336
CPC-N GDSC2 -7.695 -5.3964 -7.6968 45.2739
NCI-H1975 GDSC2 -7.5923 -5.0557 -7.5966 44.6497
COR-L321 GDSC2 -7.5712 -6.6498 -7.5712 72.7405
RERF-LC-KJ GDSC2 -7.5272 -6.7339 -7.5272 44.2396
NCI-H2081 GDSC2 -7.5187 1.33 -8.682 62.0135
NCI-H748 GDSC2 -7.3932 -5.0363 -7.3961 70.274
NCI-H23 GDSC2 -7.3862 -4.7658 -7.3926 43.3903
NCI-H1581 GDSC2 -7.3821 -3.4296 -7.4518 43.4995
NCI-H2170 GDSC2 -7.3652 -4.3289 -7.382 43.2861
LXF 289 GDSC2 -7.3256 -4.7907 -7.3309 43.0159
HCC366 GDSC2 -7.2726 -5.5323 -7.2728 42.6768
DMS 273 GDSC2 -7.23 -3.5539 -7.283 42.5413
EPLC-272H GDSC2 -7.1363 -4.3379 -7.1484 41.8722
HCC33 GDSC2 -7.0105 -1.7035 -7.2959 63.0404
NCI-H647 GDSC2 -6.9662 -4.4179 -6.9737 66.0676
RERF-LC-Sq1 GDSC2 -6.9552 -3.2095 -7.0234 40.9027
NCI-H1781 GDSC2 -6.9538 -2.5071 -7.101 41.0741
Lu-134-A GDSC2 -6.933 1.507 -8.1077 59.2333
NCI-H211 GDSC2 -6.9039 -5.3659 -6.904 40.4128
NCI-H510A GDSC2 -6.8601 -5.3336 -6.8602 65.5619
NCI-H1734 GDSC2 -6.8359 -5.2546 -6.8361 65.3097
NCI-H2009 GDSC2 -6.82 -0.9389 -7.255 60.9791
NCI-H841 GDSC2 -6.8107 -4.2328 -6.82 39.8672
NCI-H847 GDSC2 -6.7937 -4.2769 -6.8017 64.4533
HCC827 GDSC2 -6.7529 -0.0885 -7.4054 40.8872
NCI-H1436 GDSC2 -6.7248 -5.3966 -6.7249 64.2374
NCI-H1792 GDSC2 -6.7083 -3.5553 -6.7415 39.3052
NCI-H2795 GDSC2 -6.6893 -2.5994 -6.8071 39.407
NCI-H2122 GDSC2 -6.6708 -3.5416 -6.7034 39.0736
ChaGo-K-1 GDSC2 -6.6243 -4.3188 -6.6294 62.9542
NCI-H290 GDSC2 -6.6009 -3.7338 -6.6219 62.3614
LC-2/ad GDSC2 -6.5987 2.2577 -8.0162 57.0981
NCI-H1341 GDSC2 -6.5847 3.239 -8.376 56.4667
NCI-H1105 GDSC2 -6.5552 -4.0359 -6.5652 62.166
HCC78 GDSC2 -6.55 -2.4591 -6.6769 38.5844
EMC-BAC-1 GDSC2 -6.5028 -3.4867 -6.5329 61.3294
SBC-3 GDSC2 -6.4309 -3.8578 -6.4436 37.5463
NCI-H69 GDSC2 -6.422 -2.926 -6.4894 60.2085
NCI-H1155 GDSC2 -6.4012 -5.0247 -6.4013 37.3263
NCI-H1651 GDSC2 -6.3656 -2.1548 -6.5227 37.5436
Ms-1 GDSC2 -6.3533 -4.6346 -6.354 37.0342
NCI-H146 GDSC2 -6.3252 -3.3026 -6.3598 59.6639
IST-SL1 GDSC2 -6.3171 -4.0885 -6.3226 59.9882
NCI-H1563 GDSC2 -6.234 -4.3637 -6.2356 36.3044
NCI-H1048 GDSC2 -6.2306 -5.2398 -6.2306 36.2787
LCLC-97TM1 GDSC2 -6.2043 -2.5574 -6.2975 36.388
NCI-H3255 GDSC2 -6.1726 -1.1404 -6.5035 36.8281
Lu-99A GDSC2 -6.1682 0.2668 -6.8721 37.6843
NCI-H1703 GDSC2 -6.1555 -3.2885 -6.185 58.1485
COR-L311 GDSC2 -6.1377 -4.9394 -6.1377 35.7081
PaCa-3 GDSC2 -6.135 -2.291 -6.2568 57.3927
NCI-H1876 GDSC2 -6.0572 -3.3989 -6.0781 35.2773
NCI-H2291 GDSC2 -6.0388 2.7869 -7.6186 54.0549
LC-1/sq GDSC2 -5.999 -3.6669 -6.009 34.887
HOP-62 GDSC2 -5.985 -1.6682 -6.1935 35.3738
COR-L279 GDSC2 -5.975 -3.8866 -5.98 56.6526
DMS 53 GDSC2 -5.9599 -0.7017 -6.3754 35.7766
NCI-H810 GDSC2 -5.9531 -4.0131 -5.9561 34.5837
SBC-5 GDSC2 -5.8933 -5.0211 -5.8933 34.2078
ABC-1 GDSC2 -5.8811 -4.872 -5.8811 34.1329
UMC-11 GDSC2 -5.8788 -3.1073 -5.9093 34.2111
NCI-H2029 GDSC2 -5.8769 -5.1578 -5.8769 34.1071
NCI-H2818 GDSC2 -5.8748 -2.3364 -5.9741 34.3907
DMS 114 GDSC2 -5.8748 -2.2783 -5.9814 34.4122
NCI-H82 GDSC2 -5.8636 -4.3116 -5.8642 34.0271
NCI-H2373 GDSC2 -5.8477 -0.7094 -6.2511 35.0758
SHP-77 GDSC2 -5.8241 -4.0166 -5.8261 33.7887
LOU-NH91 GDSC2 -5.7883 -2.1882 -5.9009 33.901
PC-14 GDSC2 -5.717 -2.9004 -5.7545 33.2394
NCI-H1770 GDSC2 -5.7137 -0.9685 -6.043 53.3596
IST-SL2 GDSC2 -5.7062 -4.3188 -5.7064 33.0595
NCI-H1568 GDSC2 -5.5923 -3.1227 -5.6127 32.422
NCI-H596 GDSC2 -5.5779 0.4683 -6.2916 34.2997
BEN GDSC2 -5.5607 0.1017 -6.1602 51.9209
NCI-H1623 GDSC2 -5.4875 -4.1089 -5.4878 31.7168
NCI-H520 GDSC2 -5.4756 -0.8248 -5.8174 32.6673
Lu-65 GDSC2 -5.2197 2.5501 -6.655 34.0723
NCI-H2030 GDSC2 -5.1583 0.2545 -5.768 48.8764
NCI-H2810 GDSC2 -5.0218 -1.2102 -5.2387 29.5299
NCI-H1299 GDSC2 -4.9972 -0.462 -5.3866 29.912
NCI-H1944 GDSC2 -4.9668 -0.1994 -5.425 29.9376
HCC44 GDSC2 -4.9657 -0.1704 -5.432 29.9557
NCI-H3122 GDSC2 -4.8514 0.0438 -5.3696 29.4238
SW1271 GDSC2 -4.7922 1.7545 -5.8913 30.7873
NCI-H661 GDSC2 -4.7554 -0.8193 -5.0341 28.0953
NCI-H1869 GDSC2 -4.7323 -1.345 -4.8994 27.6018
COLO 668 GDSC2 -4.73 -0.4506 -5.0981 28.2215
NCI-H1755 GDSC2 -4.6674 -1.8603 -4.7499 26.9373
EKVX GDSC2 -4.6483 0.6893 -5.3537 28.7776
NCI-H64 GDSC2 -4.6356 1.1467 -5.499 45.0569
NCI-H524 GDSC2 -4.6175 -1.7607 -4.7096 26.6613
KNS-62 GDSC2 -4.5934 -1.6106 -4.7054 26.5758
NCI-H522 GDSC2 -4.5359 -0.954 -4.7649 26.595
NCI-H2804 GDSC2 -4.5203 0.538 -5.1645 27.8192
NCI-H1650 GDSC2 -4.5 0.8668 -5.2538 28.0396
NCI-H835 GDSC2 -4.4913 9.7861 -9.1648 47.0198
LCLC-103H GDSC2 -4.4506 0.0749 -4.9419 26.9131
NCI-H2023 GDSC2 -4.2922 0.6621 -4.9585 26.5145
NCI-H2085 GDSC2 -4.2886 4.34 -6.4374 30.8187
NCI-H2087 GDSC2 -4.2546 0.5649 -4.885 26.1718
NCI-H1666 GDSC2 -4.1823 4.7489 -6.5116 30.7171
NCI-H2869 GDSC2 -4.1377 0.5033 -4.7376 25.3649
NCI-H2803 GDSC2 -3.9899 -0.8971 -4.1838 23.1354
NCI-H526 GDSC2 -3.951 -1.482 -4.0366 22.5499
NCI-H2228 GDSC2 -3.8731 2.9994 -5.4254 26.8298
NCI-H1688 GDSC2 -3.8267 2.0544 -4.9824 39.2882
NCI-H358 GDSC2 -3.7644 3.421 -5.4959 26.756
NCI-H2369 GDSC2 -3.4146 0.8454 -4.0749 21.1741
LK-2 GDSC2 -3.3991 1.6223 -4.3564 22.0946
NCI-H727 GDSC2 -3.2784 -0.0551 -3.625 19.2781
EBC-1 GDSC2 -3.1874 1.8129 -4.2107 21.0468
NCI-H2141 GDSC2 -3.1369 1.1482 -3.8912 19.8097
NCI-H2731 GDSC2 -3.1166 2.501 -4.4283 21.6167
NCI-H2227 GDSC2 -2.9258 3.8444 -4.8364 22.5263
COR-L105 GDSC2 -2.9256 6.0864 -5.8899 25.8159
DMS 79 GDSC2 -2.9091 2.0865 -4.0352 19.7318
NCI-H1355 GDSC2 -2.8928 2.0656 -4.0094 19.6007
Calu-6 GDSC2 -2.864 7.413 -6.4691 27.2758
NCI-H1915 GDSC2 -2.6959 4.0564 -4.7065 21.5377
NCI-H650 GDSC2 -2.6427 6.4579 -5.7978 24.8789
NCI-H1693 GDSC2 -2.6292 2.9632 -4.1364 19.4043
NCI-H1694 GDSC2 -2.3655 4.0657 -4.387 19.6662
NCI-H2172 GDSC2 -2.3627 1.7755 -3.3361 25.7084
NCI-H2722 GDSC2 -2.1573 4.9053 -4.5876 19.8886
NCI-H1435 GDSC2 -2.1473 2.0039 -3.2165 14.9426
NCI-H1793 GDSC2 -2.074 7.7346 -5.8896 23.8651
NCI-H513 GDSC2 -2.0032 5.9136 -4.9318 20.7113
NCI-H740 GDSC2 -1.9482 24.2526 -13.9895 43.1078
HOP-92 GDSC2 -1.9107 3.4372 -3.6474 15.9824
Calu-3 GDSC2 -1.7995 4.3947 -4.0019 17.0313
SK-MES-1 GDSC2 -1.7468 4.544 -4.0247 16.9998
NCI-H2595 GDSC2 -1.7383 4.7051 -4.0953 17.2359
NCI-H2066 GDSC2 -1.6011 1.1499 -2.2801 16.6876
NCI-H1092 GDSC2 -1.3163 4.0337 -3.3753 13.6969
NCI-H1573 GDSC2 -1.0672 2.4949 -2.3912 15.3874
NCI-H2347 GDSC2 -1.0281 10.5832 -6.3736 31.9391
COR-L88 GDSC2 -0.9319 8.2603 -5.1314 28.0092
HCC15 GDSC2 -0.9172 13.0075 -7.489 25.7003
NCI-H1836 GDSC2 -0.7296 8.6134 -5.1337 27.3862
NCI-H250 GDSC2 -0.7193 8.5353 -5.0859 18.5863
COR-L32 GDSC2 -0.6134 12.8104 -7.1325 32.5287
VMRC-LCD GDSC2 -0.4549 4.7926 -2.9908 10.561
SK-LU-1 GDSC2 -0.4013 6.2918 -3.6952 13.1181
NCI-H2196 GDSC2 -0.3904 16.1922 -8.6361 34.7699
NCI-H2591 GDSC2 -0.2257 8.4038 -4.6049 16.0521
NCI-H345 GDSC2 -0.1421 8.012 -4.34 14.9804
NCI-H720 GDSC2 -0.1398 6.673 -3.6688 12.5512
NCI-H2461 GDSC2 -0.069 14.4593 -7.5028 24.1728
Lu-135 GDSC2 -0.0268 9.6751 -5.0767 17.274
NCI-H2342 GDSC2 0.0121 7.9998 -4.2078 21.5638
Lu-139 GDSC2 0.0692 5.4582 -8.422 1.517
NCI-H2135 GDSC2 0.2129 6.8163 -3.4557 11.1529
NCI-H196 GDSC2 0.2275 7.2745 -3.6726 11.9318
NCI-H226 GDSC2 0.2521 8.9575 -4.4923 14.8204
SW1573 GDSC2 0.2908 8.7517 -4.3587 14.2899
IA-LM GDSC2 0.3622 5.6055 -2.7366 8.1935
Lu-165 GDSC2 0.4236 12.7284 -6.2367 20.0165
NCI-H1838 GDSC2 0.4238 10.0026 -4.8766 23.1445
NCI-H2405 GDSC2 0.7137 6.9585 -3.1392 9.1652
NCI-H2444 GDSC2 0.7415 6.9906 -3.1342 14.3583
NCI-H441 GDSC2 1.1636 11.5045 -5.0473 15.1728
⏷ Show the Full List of 183 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 -5.9997 -2.5985 -6.0768 35.0905
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-11 GDSC2 -9.4432 -5.1372 -9.4801 81.869
KYSE-180 GDSC2 -8.5172 -3.3749 -8.6542 50.299
KYSE-150 GDSC2 -8.0334 1.0401 -9.1454 64.3991
TE-10 GDSC2 -7.5246 -2.6267 -7.6941 67.4568
KYSE-140 GDSC2 -7.1847 -5.5578 -7.1848 42.1367
KYSE-510 GDSC2 -6.8876 -1.6046 -7.1822 40.9876
KYSE-450 GDSC2 -6.2993 -4.2808 -6.302 36.7087
OE33 GDSC2 -6.2897 -0.0067 -6.9235 38.2256
TE-8 GDSC2 -6.265 -4.4986 -6.266 36.493
EC-GI-10 GDSC2 -6.2332 -4.4783 -6.2342 36.2975
TE-6 GDSC2 -6.1863 -3.1759 -6.2237 36.1178
TE-4 GDSC2 -6.0137 -4.6319 -6.0139 34.9473
KYSE-270 GDSC2 -5.9401 -2.953 -5.983 34.6243
TE-1 GDSC2 -5.9155 -3.0088 -5.9535 34.4587
OE21 GDSC2 -5.9077 -3.3174 -5.9282 34.3583
TE-9 GDSC2 -5.3898 -4.1725 -5.3899 31.1165
T.T GDSC2 -5.1913 -1.8859 -5.3051 48.9448
KYSE-70 GDSC2 -4.2798 -0.3979 -4.6207 25.3878
KYSE-520 GDSC2 -3.5892 5.8941 -6.4453 28.9865
TE-5 GDSC2 -3.5227 1.8704 -4.587 23.1984
KYSE-410 GDSC2 -3.091 8.5758 -7.2467 29.7334
OE19 GDSC2 -2.4322 2.5899 -3.7686 17.6225
TE-15 GDSC2 -0.5367 9.6619 -10.4454 9.6322
COLO 680N GDSC2 -0.5229 8.1687 -4.7359 17.0471
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC2 -8.136 -5.2398 -8.143 47.9859
JHOS-2 GDSC2 -7.5271 -3.4679 -7.6004 68.9212
OVCAR-8 GDSC2 -7.4432 -4.1447 -7.4691 43.7833
OVK18 GDSC2 -7.4237 -5.1229 -7.4261 43.6103
JHOS-4 GDSC2 -7.3893 -3.5882 -7.4465 68.2305
TOV-21G GDSC2 -6.6223 -0.6747 -7.1047 39.8202
IGROV-1 GDSC2 -6.3748 -2.8111 -6.4507 37.3816
RMG-I GDSC2 -6.3127 -2.6097 -6.4064 59.0657
TOV-112D GDSC2 -6.1322 -4.3196 -6.1337 35.679
DOV13 GDSC2 -6.0713 -1.1361 -6.3943 36.2018
OC 314 GDSC2 -5.9852 -2.3848 -6.0854 56.1923
TYK-nu GDSC2 -5.9092 1.2954 -6.9269 36.915
OVISE GDSC2 -5.8673 0.3323 -6.5643 35.939
Caov-3 GDSC2 -5.8133 0.5317 -6.5679 53.5575
OVCAR-3 GDSC2 -5.7913 -1.0728 -6.1039 34.4905
Caov-4 GDSC2 -5.4513 -3.3736 -5.4596 51.4587
ES-2 GDSC2 -4.6771 2.9583 -6.2471 31.422
OVCAR-4 GDSC2 -4.229 -0.0967 -4.6494 25.3357
OAW42 GDSC2 -3.815 -0.0138 -4.2225 22.765
EFO-27 GDSC2 -3.2586 3.5129 -5.0204 23.9551
FU-OV-1 GDSC2 -2.9942 5.3559 -5.6093 36.9299
OV56 GDSC2 -2.9598 6.3846 -6.0655 26.4001
OAW28 GDSC2 -2.809 1.5195 -3.6925 18.2731
OV-90 GDSC2 -2.0488 3.5598 -3.8394 16.9925
OVTOKO GDSC2 -1.871 11.4978 -7.5677 27.7761
SK-OV-3 GDSC2 -1.74 5.4154 -4.4439 18.4764
EFO-21 GDSC2 -1.6017 5.4173 -4.3172 17.737
Kuramochi GDSC2 -1.4469 5.415 -4.1745 16.9053
OVCAR-5 GDSC2 -1.4357 10.8426 -6.8575 25.1726
OVKATE GDSC2 1.0965 9.0465 -3.883 17.2143
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuP-T3 GDSC2 -7.3731 -3.5214 -7.4348 43.4292
DAN-G GDSC2 -7.3111 -4.7974 -7.3162 42.9265
PaTu 8988t GDSC2 -6.8693 -0.689 -7.3705 41.274
KP-4 GDSC2 -6.6372 -1.889 -6.8581 39.3395
KP-1N GDSC2 -6.3337 -1.5144 -6.5999 37.6296
PL4 GDSC2 -6.2383 -2.0825 -6.3971 36.7753
BxPC-3 GDSC2 -6.1788 -4.8462 -6.1789 35.9609
Capan-1 GDSC2 -5.9898 -2.8728 -6.0411 34.9542
HPAF-II GDSC2 -5.8677 0.7821 -6.708 36.2819
KP-2 GDSC2 -5.7324 -3.9508 -5.7344 33.2258
CFPAC-1 GDSC2 -5.0629 1.6167 -6.1299 32.2568
HuP-T4 GDSC2 -5.0623 -3.5168 -5.064 29.1104
MIA PaCa-2 GDSC2 -4.8481 -0.7396 -5.154 28.7464
PSN1 GDSC2 -4.5881 0.3521 -5.1779 28.0572
Panc 02.03 GDSC2 -4.4339 3.2103 -6.098 30.3251
Panc 08.13 GDSC2 -4.1723 -0.3121 -4.5266 24.7743
SUIT-2 GDSC2 -4.1614 1.0636 -4.9581 26.1461
YAPC GDSC2 -3.5918 2.1343 -4.7678 23.9827
QGP-1 GDSC2 -3.3937 3.6985 -5.2408 25.0036
Hs 766T GDSC2 -3.263 7.9159 -7.0906 40.7982
HPAC GDSC2 -2.753 8.1583 -6.7264 27.6848
PaTu 8902 GDSC2 -2.5646 4.698 -4.88 21.8102
Panc 03.27 GDSC2 -2.353 9.212 -6.8719 37.2119
SW1990 GDSC2 -1.8906 8.974 -6.3343 34.5466
KP-3 GDSC2 -1.5209 5.2572 -4.1644 17.0231
Panc 10.05 GDSC2 -1.4136 7.6886 -5.2698 20.5606
Panc 04.03 GDSC2 -1.3245 6.2803 -4.4917 26.9541
SU.86.86 GDSC2 -1.1075 8.8571 -5.5814 20.9184
Capan-2 GDSC2 -0.8717 4.6234 -3.2665 12.3957
MZ-PC-1 GDSC2 0.4281 11.6136 -5.6767 25.9106
AsPC-1 GDSC2 1.137 7.0178 -2.8584 7.4929
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC2 -4.5209 -0.3279 -4.9028 26.9912
NCI-H2452 GDSC2 -4.4266 0.0057 -4.895 42.5984
MSTO-211H GDSC2 -4.2274 0.9381 -4.9842 26.4144
NCI-H2052 GDSC2 -2.9213 2.8773 -4.3935 21.0115
IST-Mes1 GDSC2 -2.6029 5.1654 -5.1394 22.7501
NCI-H28 GDSC2 -2.4667 5.6093 -5.2214 22.6979
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 -7.874 -5.5714 -7.8755 46.3718
22Rv1 GDSC2 -7.1966 -4.6328 -7.2031 42.2275
VCaP GDSC2 -5.9175 -3.7467 -5.9243 34.3769
DU145 GDSC2 -2.3417 2.6756 -3.7164 17.2203
PC-3 GDSC2 -0.8041 9.0756 -5.4283 19.8468
NCI-H660 GDSC2 0.6486 6.4347 -2.9295 13.4816
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 -6.6295 -4.1302 -6.6384 38.7542
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-MEL-2 GDSC2 -10.1798 -5.8807 -10.205 85.9723
DJM-1 GDSC2 -10.0622 -5.0151 -10.1274 83.1965
A-431 GDSC2 -9.8405 -4.0861 -9.9752 80.1324
SK-MEL-28 GDSC2 -9.323 -2.2744 -9.6891 74.3769
A-388 GDSC2 -9.2434 -2.9375 -9.4889 75.5862
IPC-298 GDSC2 -8.8826 -0.6768 -9.57 69.9251
A101D GDSC2 -8.8702 -7.1152 -8.8702 52.4852
IGR-1 GDSC2 -8.5597 -5.9703 -8.5619 50.578
SK-MEL-30 GDSC2 -8.3389 -2.5318 -8.5819 71.3273
LOX-IMVI GDSC2 -8.3283 -6.7704 -8.3283 49.1579
HT-144 GDSC2 -8.0906 -3.5702 -8.1828 47.7856
RPMI-7951 GDSC2 -7.9974 -2.6428 -8.1979 47.3241
Hs 938.T GDSC2 -7.7797 -5.1412 -7.7846 73.4559
VMRC-MELG GDSC2 -7.6665 -5.3901 -7.6682 72.9145
CP50-MEL-B GDSC2 -7.5978 -4.1339 -7.6287 70.5295
COLO 679 GDSC2 -7.3375 -4.9322 -7.3411 43.0845
Mel Ho GDSC2 -7.2702 -4.8585 -7.2741 69.0624
IGR-37 GDSC2 -7.155 -4.3242 -7.1678 41.9884
SH-4 GDSC2 -6.9867 -3.7089 -7.0205 41.0109
G-mel GDSC2 -6.982 -4.9112 -6.9836 40.897
CHL-1 GDSC2 -6.9471 -4.6697 -6.9506 40.6878
COLO 792 GDSC2 -6.8778 -5.2239 -6.878 40.2529
M14 GDSC2 -6.8701 -4.2162 -6.8807 40.2352
MZ-MEL-7 GDSC2 -6.8567 -4.7806 -6.8586 65.3384
A-375 GDSC2 -6.8383 -4.8842 -6.8395 40.0132
COLO 783 GDSC2 -6.8183 -5.4925 -6.8183 65.1725
MMAc-SF GDSC2 -6.7449 -4.8612 -6.7459 64.3233
COLO 800 GDSC2 -6.7248 -3.7632 -6.7479 63.4402
Mel JuSo GDSC2 -6.6575 -3.4886 -6.6927 38.9994
LB373-MEL-D GDSC2 -6.6463 -5.7391 -6.6463 63.4647
RVH-421 GDSC2 -6.581 -5.4737 -6.581 62.8075
GAK GDSC2 -6.5448 -5.033 -6.545 38.2081
HMV-II GDSC2 -6.5173 -3.7098 -6.5371 38.097
Hs 940.T GDSC2 -6.3781 0.3239 -7.1183 57.2137
A2058 GDSC2 -6.3762 -4.8392 -6.3764 37.1732
G-361 GDSC2 -6.3556 -5.1059 -6.3556 37.0461
SK-MEL-5 GDSC2 -6.1732 -5.4526 -6.1732 35.9262
WM793 GDSC2 -6.1602 -5.248 -6.1602 35.8464
UACC-62 GDSC2 -6.1228 -5.4519 -6.1228 35.6166
SK-MEL-2 GDSC2 -6.1163 -5.0259 -6.1163 35.5769
WM35 GDSC2 -6.1127 -4.8467 -6.1128 35.5551
451Lu GDSC2 -6.1091 -2.0005 -6.2712 56.9973
SK-MEL-31 GDSC2 -6.031 -1.647 -6.2471 56.1631
WM1552C GDSC2 -6.0135 -4.1912 -6.0153 34.951
UACC-257 GDSC2 -5.8845 -3.9825 -5.8873 34.1623
LB2518-MEL GDSC2 -5.8304 -3.8506 -5.8343 55.2335
SK-MEL-3 GDSC2 -5.8262 -3.7869 -5.8311 55.1847
CP66-MEL GDSC2 -4.7307 -3.4035 -4.7316 27.0721
MeWo GDSC2 -4.6289 -1.6371 -4.7395 43.5746
WM278 GDSC2 -4.5982 -1.6121 -4.7103 26.606
SK-MEL-1 GDSC2 -4.0594 0.0704 -4.5143 39.2522
IST-MEL1 GDSC2 -3.9659 3.7962 -5.8673 41.8991
WT2-iPS GDSC2 -3.1473 2.5057 -4.462 21.8092
COLO 829 GDSC2 -3.1138 1.669 -4.0742 20.3857
SK-MEL-24 GDSC2 -1.635 7.8392 -5.5425 21.8783
WM115 GDSC2 -0.5276 4.7401 -3.0263 10.8298
EquiPSC Line K2 GDSC2 -7.3508 -2.7263 -7.495 66.5952
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 -8.0418 -5.8155 -8.0428 47.4007
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-402 GDSC2 -9.1059 -5.1614 -9.1326 53.8476
TE 441.T GDSC2 -8.8594 -6.16 -8.8617 82.33
STS-0421 GDSC2 -8.4135 -1.832 -8.7907 70.2706
MES-SA GDSC2 -8.3757 -6.2715 -8.3761 49.4495
KYM-1 GDSC2 -7.4217 -4.3283 -7.4397 43.6345
G-401 GDSC2 -7.1731 -4.3426 -7.1857 42.0989
Hs 633.T GDSC2 -7.0603 -3.1003 -7.1441 65.254
Rh30 GDSC2 -7.0548 -3.6584 -7.094 41.4406
EW-8 GDSC2 -6.5786 -3.2781 -6.6245 38.5455
Rh41 GDSC2 -6.2267 -4.8241 -6.2268 36.2548
SW872 GDSC2 -5.9913 -0.9295 -6.3544 35.8276
HT-1080 GDSC2 -5.92 -2.0642 -6.0588 34.7817
MFH-ino GDSC2 -5.8976 1.995 -7.1662 53.5679
SW982 GDSC2 -5.8248 0.7609 -6.6545 36.0128
SK-UT-1 GDSC2 -5.7336 -1.5485 -5.9439 33.8517
VA-ES-BJ GDSC2 -5.6454 0.3022 -6.3132 34.5748
GCT GDSC2 -4.8568 -1.1497 -5.072 28.5153
SK-LMS-1 GDSC2 -4.5679 4.4176 -6.7574 32.3926
A-204 GDSC2 -4.3034 1.0752 -5.1152 27.0453
RD GDSC2 -3.4755 3.0836 -5.0515 24.6082
SW684 GDSC2 0.678 11.2309 -5.2876 16.7343
RKN GDSC2 3.7899 15.0992 -4.9339 11.144
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AGS GDSC2 -8.996 -5.4639 -9.0105 53.2162
TMK-1 GDSC2 -8.3636 -3.0445 -8.5323 72.5034
23132/87 GDSC2 -8.264 -2.6277 -8.4861 48.8627
SNU-16 GDSC2 -7.7614 -4.8606 -7.7708 72.8783
HSC-39 GDSC2 -7.6713 -3.079 -7.7919 69.0884
Fu97 GDSC2 -7.2232 -2.2162 -7.4337 65.0384
SCH GDSC2 -7.2171 -4.4878 -7.2267 68.2309
IM95 GDSC2 -7.1399 -4.3127 -7.1527 41.8961
RF-48 GDSC2 -6.9694 -2.6677 -7.0965 41.124
MKN45 GDSC2 -6.9469 0.9578 -7.938 42.4712
NUGC-3 GDSC2 -6.791 -4.434 -6.7962 39.7345
SK-GT-2 GDSC2 -6.5681 -3.5088 -6.5991 38.4403
SNU-5 GDSC2 -6.4314 -2.4957 -6.5459 37.8311
RERF-GC-1B GDSC2 -6.3549 -3.8497 -6.3663 37.0758
MKN28 GDSC2 -6.2582 -1.1683 -6.5904 37.3422
ECC10 GDSC2 -6.2205 -4.8819 -6.2206 36.2169
HGC-27 GDSC2 -6.0999 -5.4085 -6.0999 35.4762
SNU-1 GDSC2 -6.0695 -2.6189 -6.1483 35.5229
MKN7 GDSC2 -5.9405 3.334 -7.731 53.3784
OCUM-1 GDSC2 -5.6278 1.6748 -6.7585 35.6061
NCI-N87 GDSC2 -5.164 1.2147 -6.0933 32.4674
GCIY GDSC2 -5.0966 -0.3887 -5.5146 30.6008
Hs 746.T GDSC2 -4.8481 2.3382 -6.1769 31.7376
ECC12 GDSC2 -4.7481 -3.445 -4.7488 44.4203
TGBC11TKB GDSC2 -3.6313 -1.7078 -3.6703 33.4034
NUGC-4 GDSC2 -1.5969 6.5237 -4.8578 19.5915
MKN1 GDSC2 -1.345 9.5524 -6.1356 23.0384
KATO III GDSC2 -1.0989 8.9127 -5.6018 20.9638
SNG-M GDSC2 -8.2691 -5.2057 -8.2784 48.802
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-62 GDSC2 -9.1231 -5.4485 -9.1404 53.9752
KMH-2 GDSC2 -8.6166 -6.0025 -8.6188 80.6267
K5 GDSC2 -8.3739 -5.3422 -8.3819 49.4411
IHH-4 GDSC2 -7.8039 -5.2895 -7.8072 45.9455
ASH-3 GDSC2 -7.7782 -5.4051 -7.7804 45.7856
HTC-C3 GDSC2 -7.3114 -5.331 -7.3122 42.9168
BHT-101 GDSC2 -6.97 -4.0263 -6.9886 40.8696
FTC-133 GDSC2 -5.9786 -0.1207 -6.5514 36.2831
8305C GDSC2 -5.8328 -4.4441 -5.833 33.8366
B-CPAP GDSC2 -5.4732 -0.1667 -5.9868 33.142
ML-1 [Human leukemia] GDSC2 -5.4244 -1.7881 -5.5695 51.0907
8505C GDSC2 -3.7682 2.025 -4.9087 24.9128
TT2609-C02 GDSC2 -1.2357 5.9812 -4.2641 16.7922
CGTH-W-1 GDSC2 -0.1029 5.6454 -3.1251 16.5915
TT GDSC2 0.6985 2.8677 -1.1679 3.0151
WRO GDSC2 1.6526 13.9023 -5.863 16.9288
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-15A GDSC2 -10.4008 -6.3968 -10.4151 87.959
KON GDSC2 -10.0295 -5.7679 -10.0553 85.3043
JHU-011 GDSC2 -9.9746 -5.1336 -10.029 83.3268
OSC-19 GDSC2 -9.126 -4.7751 -9.1719 79.7908
BB30-HNC GDSC2 -8.9425 -4.9335 -8.9746 79.509
KOSC-2 GDSC2 -8.6079 -2.881 -8.8163 73.1781
JHU-029 GDSC2 -8.2667 -5.0041 -8.2808 76.3949
PCI-06A GDSC2 -8.1924 -1.2935 -8.6667 68.399
HSC-3 GDSC2 -8.0879 -6.2132 -8.0881 47.6826
DOK GDSC2 -7.9169 -5.6179 -7.9184 46.6352
BICR 22 GDSC2 -7.7671 -4.4708 -7.7879 45.7511
HO-1-N-1 GDSC2 -7.7632 -5.5673 -7.7643 45.691
SKN-3 GDSC2 -7.7263 -2.58 -7.9168 45.738
PCI-04B GDSC2 -7.7244 -5.8139 -7.7247 45.451
FaDu GDSC2 -7.6327 -4.3829 -7.6537 44.9309
CAL-33 GDSC2 -7.5103 -3.4486 -7.5845 44.2833
BICR 78 GDSC2 -7.3641 -4.5468 -7.3746 43.2646
BB49-HNC GDSC2 -7.3382 -4.5534 -7.3481 43.1042
SCC-15 GDSC2 -7.1631 -4.8567 -7.1662 42.0128
Ca9-22 GDSC2 -7.0121 -4.8348 -7.0144 41.0835
HSC-4 GDSC2 -7.0089 -5.0259 -7.01 41.0606
SAS GDSC2 -6.9908 -4.169 -7.005 40.9853
BICR 31 GDSC2 -6.9509 -4.8274 -6.953 66.2304
NCI-H3118 GDSC2 -6.8799 -4.5417 -6.8844 40.2783
HO-1-u-1 GDSC2 -6.7945 -2.2496 -6.9681 62.3219
PCI-30 GDSC2 -6.6757 1.5615 -7.8484 57.9414
HSC-2 GDSC2 -6.4135 -5.3993 -6.4135 37.4016
UPCI-SCC-090 GDSC2 -6.2883 -4.2935 -6.2908 36.6404
CAL-27 GDSC2 -6.0858 -5.3798 -6.0858 35.3897
BICR 10 GDSC2 -6.0377 -1.2471 -6.3336 35.9288
Detroit 562 GDSC2 -6.0371 -3.2358 -6.0656 35.1765
SAT [Human HNSCC] GDSC2 -5.7813 -3.3027 -5.799 33.5742
BHY GDSC2 -5.6571 -4.2093 -5.6575 53.5347
SCC-4 GDSC2 -5.6261 -0.7579 -5.9976 33.6599
SCC-25 GDSC2 -5.2991 -3.4282 -5.304 49.9464
LB771-HNC GDSC2 -4.6905 -2.735 -4.7035 26.8625
PE/CA-PJ15 GDSC2 -4.6431 3.0676 -6.2567 45.955
OSC-20 GDSC2 -4.2019 2.1413 -5.4137 27.6908
SCC-9 GDSC2 -3.5617 1.3695 -4.4296 22.7712
JHU-022 GDSC2 -2.514 6.2943 -5.5967 23.9783
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC2 -8.4428 -5.8158 -8.4455 49.8618
KU-19-19 GDSC2 -8.1445 -5.4642 -8.1485 48.0347
5637 GDSC2 -7.4432 -2.6766 -7.6003 44.0214
UM-UC-3 GDSC2 -7.3408 -0.4251 -7.9539 63.2104
SW1710 GDSC2 -6.5545 -3.2677 -6.6002 38.3974
639V GDSC2 -6.3269 -5.2526 -6.3269 36.8698
RT-112 GDSC2 -6.1855 -4.2107 -6.1882 36.0098
CAL-29 GDSC2 -6.0561 -2.6141 -6.1347 35.4403
RT-4 GDSC2 -6.0409 -4.8816 -6.0409 35.1137
647V GDSC2 -5.8499 -1.4106 -6.0962 34.6601
HT-1197 GDSC2 -5.2103 1.2783 -6.1659 32.8059
T24 GDSC2 -4.7439 0.4437 -5.3766 45.5988
HT-1376 GDSC2 -3.6731 -2.0069 -3.6912 33.7192
TCCSUP GDSC2 -2.5354 2.1298 -3.6685 17.5106
SW780 GDSC2 -2.3209 4.9688 -4.7743 20.8945
J82 GDSC2 1.4323 8.8824 -3.5566 9.6321
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JAR GDSC2 -9.8892 -6.3666 -9.8974 86.7705
NT2-D1 GDSC2 -9.8604 -4.5736 -9.95 81.4825
OVCA433 GDSC2 -8.9144 3.2432 -10.8674 64.8588
KGN GDSC2 -8.7022 -3.867 -8.7978 75.8246
SW954 GDSC2 -8.6287 -3.902 -8.7174 75.6005
NEC8 GDSC2 -8.5178 -6.8644 -8.5179 50.3219
TC-YIK GDSC2 -8.4549 -5.886 -8.4571 49.9355
PA-1 GDSC2 -8.2454 -5.9489 -8.2464 48.6501
C-33 A GDSC2 -7.7989 -3.8055 -7.8574 46.0014
BPH-1 GDSC2 -7.7583 -4.4346 -7.7803 45.6996
Ca Ski GDSC2 -7.7163 -5.5107 -7.7176 45.4036
ACC-OV7 GDSC2 -7.5043 -3.7526 -7.5545 69.2628
OMC-1 [Human cervical carcinoma] GDSC2 -7.3739 0.8412 -8.3644 61.8969
CAL-39 GDSC2 -7.3205 -4.7243 -7.3268 42.9872
C-4-I GDSC2 -7.0512 -5.2151 -7.0518 41.3188
UWB1.289 GDSC2 -7.0453 -2.6814 -7.1755 64.5749
JEG-3 GDSC2 -6.805 -4.3016 -6.8127 64.5713
SiSo GDSC2 -6.7741 -1.6404 -7.0521 40.2829
HeLa GDSC2 -6.6988 -4.7697 -6.7 39.1569
OVMIU GDSC2 -6.5676 -2.1693 -6.737 38.7976
ME-180 GDSC2 -6.4002 -1.573 -6.6604 38.0136
JHOS-3 GDSC2 -6.3102 8.9611 -10.5671 53.4651
DoTc2 4510 GDSC2 -6.2496 -5.0364 -6.2497 36.3955
DSH1 GDSC2 -6.2322 -2.8317 -6.2987 36.483
LB831-BLC GDSC2 -6.1129 -3.9681 -6.118 35.5714
MS751 GDSC2 -6.0694 -4.8051 -6.0695 35.289
HT-3 GDSC2 -6.0459 -4.3834 -6.0467 35.1468
SiHa GDSC2 -5.9524 -2.0074 -6.102 35.0103
NCC-IT GDSC2 -5.8331 -5.0032 -5.8331 55.3055
HEC-1 GDSC2 -5.164 0.932 -5.995 32.1981
OVCA420 GDSC2 -4.8344 -2.1786 -4.8909 27.881
HEY GDSC2 -4.7589 -0.0649 -5.2367 28.7399
SKN GDSC2 -3.735 2.966 -5.2681 25.9747
OV17R GDSC2 -3.4198 4.1672 -5.4789 38.4921
SKG-IIIa GDSC2 -3.3853 1.4153 -4.2597 21.7282
SW962 GDSC2 -3.3737 3.7889 -5.2611 37.7415
PWR-1E GDSC2 -2.695 4.7744 -5.0429 22.6535
PEO1 GDSC2 -0.4618 8.1953 -4.6976 16.8028
SW756 GDSC2 0.1306 11.8232 -6.0216 19.9111
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Dactinomycin (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Dactinomycin and Roflumilast. Asthma [CA23] [16]
Ofloxacin DM0VQN3 Minor Decreased absorption of Dactinomycin due to intestinal mucosa variation caused by Ofloxacin. Bacterial infection [1A00-1C4Z] [17]
Sparfloxacin DMB4HCT Minor Decreased absorption of Dactinomycin due to intestinal mucosa variation caused by Sparfloxacin. Bacterial infection [1A00-1C4Z] [17]
Gemifloxacin DMHT34O Minor Decreased absorption of Dactinomycin due to intestinal mucosa variation caused by Gemifloxacin. Bacterial infection [1A00-1C4Z] [17]
Norfloxacin DMIZ6W2 Minor Decreased absorption of Dactinomycin due to intestinal mucosa variation caused by Norfloxacin. Bacterial infection [1A00-1C4Z] [17]
ABT-492 DMJFD2I Minor Decreased absorption of Dactinomycin due to intestinal mucosa variation caused by ABT-492. Bacterial infection [1A00-1C4Z] [17]
Levofloxacin DMS60RB Minor Decreased absorption of Dactinomycin due to intestinal mucosa variation caused by Levofloxacin. Bacterial infection [1A00-1C4Z] [17]
Lomefloxacin DMVRH9C Minor Decreased absorption of Dactinomycin due to intestinal mucosa variation caused by Lomefloxacin. Bacterial infection [1A00-1C4Z] [17]
Teriflunomide DMQ2FKJ Major Additive immunosuppressive effects by the combination of Dactinomycin and Teriflunomide. Hyper-lipoproteinaemia [5C80] [18]
Denosumab DMNI0KO Moderate Additive myelosuppressive effects by the combination of Dactinomycin and Denosumab. Low bone mass disorder [FB83] [19]
Thalidomide DM70BU5 Major Additive thrombogenic effects by the combination of Dactinomycin and Thalidomide. Multiple myeloma [2A83] [20]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Dactinomycin and Tecfidera. Multiple sclerosis [8A40] [21]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Dactinomycin and Siponimod. Multiple sclerosis [8A40] [22]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Dactinomycin and Fingolimod. Multiple sclerosis [8A40] [23]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Dactinomycin and Ocrelizumab. Multiple sclerosis [8A40] [24]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Dactinomycin and Ozanimod. Multiple sclerosis [8A40] [16]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive immunosuppressive effects by the combination of Dactinomycin and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [25]
Gatifloxacin DMSL679 Minor Decreased absorption of Dactinomycin due to intestinal mucosa variation caused by Gatifloxacin. Respiratory infection [CA07-CA4Z] [17]
Canakinumab DM8HLO5 Moderate Additive immunosuppressive effects by the combination of Dactinomycin and Canakinumab. Rheumatoid arthritis [FA20] [26]
Rilonacept DMGLUQS Moderate Additive immunosuppressive effects by the combination of Dactinomycin and Rilonacept. Rheumatoid arthritis [FA20] [26]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Dactinomycin and Golimumab. Rheumatoid arthritis [FA20] [27]
Leflunomide DMR8ONJ Major Additive immunosuppressive effects by the combination of Dactinomycin and Leflunomide. Rheumatoid arthritis [FA20] [18]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Dactinomycin when combined with Anthrax vaccine. Sepsis [1G40-1G41] [28]
Fostamatinib DM6AUHV Moderate Decreased clearance of Dactinomycin due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [29]
Azathioprine DMMZSXQ Moderate Additive myelosuppressive effects by the combination of Dactinomycin and Azathioprine. Transplant rejection [NE84] [22]
Ganciclovir DM1MBYQ Moderate Additive myelosuppressive effects by the combination of Dactinomycin and Ganciclovir. Virus infection [1A24-1D9Z] [22]
⏷ Show the Full List of 26 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Mannitol E00103 6251 Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Water E00035 962 Solvent
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Dactinomycin 0.5mg/1ml lyophilized powder 0.5mg/1ml Lyophilized Powder Intravenous
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Dactinomycin FDA Label
2 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 050682.
3 BDDCS applied to over 900 drugs
4 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
6 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
7 Structural studies of atom-specific anticancer drugs acting on DNA. Pharmacol Ther. 1999 Sep;83(3):181-215.
8 Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution. Cancer Res. 1995 Nov 15;55(22):5342-7.
9 Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol. 2003 Jan;63(1):65-72.
10 Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia. 2005 Feb;46(2):224-35.
11 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
12 Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes. Anticancer Drugs. 2007 Aug;18(7):763-72. doi: 10.1097/CAD.0b013e3280adc905.
13 Establishment and characterization of new cellular lymphoma model expressing transgenic human MDR1. Leuk Res. 2005 Apr;29(4):407-14. doi: 10.1016/j.leukres.2004.09.001.
14 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
15 Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells. Clin Cancer Res. 2001 Feb;7(2):407-14.
16 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
17 Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42. [PMID: 2373666]
18 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
19 Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
20 Bennett CL, Nebeker JR, Samore MH, et al "The Research on Adverse Drug Events and Reports (RADAR) project." JAMA 293 (2005): 2131-40. [PMID: 15870417]
21 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
22 Cerner Multum, Inc. "Australian Product Information.".
23 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
24 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
25 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
26 Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
27 Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
28 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
29 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.