Details of the Drug Combinations

General Information of This Drug (ID: DM053KT)

Drug Name
Aprepitant   DM053KT
Synonyms
Aprepitant [USAN]; L 754030; MK 0869; Emend (TN); L-754030; MK-0869; ONO-7436; Aprepitant (JAN/USAN/INN); MK-869, L-754030, Emend, Aprepitant; 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-Delta(2)-1,2,4-triazolin-5-one; 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-delta(sup 2)-1,2,4-triazolin-5-one; 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one; 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one; 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Nausea MD90 Approved [2]
Vomiting MD90 Approved [3]
Solid tumour/cancer 2A00-2F9Z Phase 3 [4]
Therapeutic Class
Antiemetics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

93 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Aliskiren + Aprepitant DCE00KL Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Amodiaquine + Aprepitant DCFGXQ7 Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Anamorelin + Aprepitant DC8HP6G Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Kanamycin DCS6NP9 Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Citalopram DCPQ2RY Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Tindamax DCQYWU1 Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Dihydroergotamine DCB2BMM Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Miglustat DCI6RFE Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Fomepizole DCJ59L3 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Everolimus DC4MCYT Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Pepstatin DC3KG1W Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Metyrosine DC8SDVJ Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Testosterone cypionate DCZFRQF Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + ETHISTERONE DC1BL8I ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Aminosalicylic acid DC9BLWY Aminosalicylic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Etonogestrel DCOOOLQ Etonogestrel Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + GINKGOLIDE A DCXTX8N GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Fenoprofen DCIB91I Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Idarubicin DC3ZQN2 Idarubicin Glioblastoma? (Cell Line: T98G) [5]
Aprepitant + BRL-15572 DC45U9Y BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Probenecid DCLO32N Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Darunavir DCHH953 Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Linagliptin DC2SDHB Linagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Acamprosate DCQYMLN Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Topotecan DCKZVEY Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Trimethobenzamide DCDBENO Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Oxyphenbutazone DCILR52 Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Novobiocin DCF886S Novobiocin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Cisatracurium DCAICUT Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Zileuton DCOKQ3F Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Olmesartan medoxomil DC2TWQL Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Auranofin DC5VV3J Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Estramustine DC55GK6 Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Raltegravir DC0GG2V Raltegravir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Aprepitant + Cilostazol DCZT6GP Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Artemisinin + Aprepitant DCMRXTC Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
AS-1949490 + Aprepitant DCDAL3O AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Asenapine + Aprepitant DCADRQL Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Azatadine + Aprepitant DCRZHZ2 Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Baclofen + Aprepitant DC16T3Y Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Benserazide + Aprepitant DC14UFI Benserazide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
BIO-300 + Aprepitant DCGP7KO BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Bortezomib + Aprepitant DCMNO4G Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Brincidofovir + Aprepitant DC66O5L Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Bumetanide + Aprepitant DCXD7AF Bumetanide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Cefmenoxime + Aprepitant DC07ZLP Cefmenoxime Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Chlorambucil + Aprepitant DC256RW Chlorambucil Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Chlormezanone + Aprepitant DC0AFQ4 Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Cilastatin + Aprepitant DCWZEW0 Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Daidzin + Aprepitant DCREOQC Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Diethylcarbamazine + Aprepitant DCCYUMX Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Doxorubicin + Aprepitant DCVFHMR Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Enalaprilat + Aprepitant DCCJ69R Enalaprilat Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Endoxifen + Aprepitant DCGOIR0 Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Epinephrine + Aprepitant DC8JRP8 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Fibrates + Aprepitant DCVU7IQ Fibrates Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Galantamine + Aprepitant DCCHHGD Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Gefitinib + Aprepitant DCJMO95 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
GSK2194069 + Aprepitant DCNX1YX GSK2194069 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Hydroxychloroquine + Aprepitant DCJ81NL Hydroxychloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Imatinib + Aprepitant DCBVQP7 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
K-134 + Aprepitant DCTV8G1 K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Leflunomide + Aprepitant DCCEV8J Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Maprotiline + Aprepitant DCFCJOV Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mebendazole + Aprepitant DCQR284 Mebendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mebutamate + Aprepitant DC1L73R Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mefloquine + Aprepitant DCEAOY5 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Metaxalone + Aprepitant DCC9XPP Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Nitisinone + Aprepitant DC2CB1U Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Oseltamivir + Aprepitant DCPJQT0 Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Pazopanib + Aprepitant DC589T8 Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
PF-02545920 + Aprepitant DCNTHD3 PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Phenprocoumon + Aprepitant DCA1DL1 Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Phensuximide + Aprepitant DCZ2OPN Phensuximide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Picoplatin + Aprepitant DCM71OI Picoplatin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Pinacidil + Aprepitant DCYQ7BJ Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Pizotyline + Aprepitant DCFT33A Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Pomalidomide + Aprepitant DCB0SI1 Pomalidomide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Rifampin + Aprepitant DCQ7IFP Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
SCH 727965 + Aprepitant DCLVVJ2 SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Spironolactone + Aprepitant DCDOO5M Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Tacrine + Aprepitant DCJF0RF Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Tamoxifen + Aprepitant DCRZ7K3 Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Terameprocol + Aprepitant DC424FF Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Tetracycline + Aprepitant DCP3HOI Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Tiagabine + Aprepitant DCK4T6M Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Tolvaptan + Aprepitant DCBI9QL Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Tranexamic acid + Aprepitant DC25KG4 Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Triapine + Aprepitant DC0TOD9 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Triflupromazine + Aprepitant DCVDP0T Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Trimethobenzamide + Aprepitant DC6CWSZ Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
WAY-100635 + Aprepitant DC7RCAD WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Zaleplon + Aprepitant DC3CHIK Zaleplon Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
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⏷ Show the Full List of 93 DrugCom(s)
19 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Aprepitant + Dexamethasone DC5Z165 Dexamethasone Cancer [7]
Aprepitant + Desloratadine DC9H6TV Desloratadine Pruritus [8]
Aprepitant + Oxycodone DCJ12PH Oxycodone Narcotic Abuse [9]
Aprepitant + Dexamethasone DCX0H9M Dexamethasone Nausea [10]
Aprepitant + Ondansetron DC3WL60 Ondansetron Nausea [11]
Aprepitant + Ondansetron DC8N8TH Ondansetron Hematologic Diseases [12]
Aprepitant + Palonosetron DCMQ9DD Palonosetron Leukemia [13]
Aprepitant + Palonosetron DCP2LMK Palonosetron Postoperative Nausea and Vomiting [14]
Aprepitant + Ramosetron DCPF48D Ramosetron Postoperative Nausea and Vomiting [14]
Aprepitant + Dexamethasone DCYX8UN Dexamethasone Nausea [15]
Aprepitant + Dexamethasone DCLDEDP Dexamethasone Myeloma, Plasma-Cell [16]
Aprepitant + Dexamethasone DCW8R42 Dexamethasone Chemotherapy-induced Nausea and Vomiting [17]
Aprepitant + Olanzapine DCKOO1K Olanzapine Chemotherapy Induced Nausea and Vomiting [18]
Aprepitant + Dexamethasone DC44ZMX Dexamethasone Chemotherapy-induced Nausea and Vomiting [19]
Aprepitant + Dexamethasone DC562VS Dexamethasone Chemotherapy-induced Nausea and Vomiting [20]
Aprepitant + Dexamethasone DC91BX6 Dexamethasone Chemotherapy-induced Nausea and Vomiting (CINV) [21]
Aprepitant + Dexamethasone DCIZP75 Dexamethasone Chemotherapy-Induced Nausea and Vomiting (CINV) [22]
Aprepitant + Dexamethasone DCSH5XJ Dexamethasone Chemotherapy-induced Nausea and Vomiting [19]
Aprepitant + Dexamethasone DCIQIMI Dexamethasone Postoperative Nausea and Vomiting (PONV) [23]
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⏷ Show the Full List of 19 DrugCom(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3490).
3 Aprepitant FDA Label
4 ClinicalTrials.gov (NCT00571168) Efficacy and Safety of Aprepitant in Subjects With Multiple Myeloma During and After High-dose Chemotherapy. U.S. National Institutes of Health.
5 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
7 ClinicalTrials.gov (NCT00248547) Aprepitant in Preventing Nausea and Vomiting in Patients Who Are Undergoing a Stem Cell Transplant
8 ClinicalTrials.gov (NCT04399148) Influence of Antipruritics on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.
9 ClinicalTrials.gov (NCT00999544) Aprepitant Effects on Oxycodone Response
10 ClinicalTrials.gov (NCT00314743) Efficacy & Safety of the Oral Neurokinin-1 Antagonist, Aprepitant, in Combo With Ondansetron & Dexamethasone in Patients Undergoing Auto Peripheral Blood Stem Cell Transplantation
11 ClinicalTrials.gov (NCT01450826) Emend and Ondansetron Compared to Ondansetron Alone to Prevent CINV in Glioma Patients Receiving Temozolomide
12 ClinicalTrials.gov (NCT00954941) Ondansetron Versus Aprepitant Plus Ondansetron for Emesis
13 ClinicalTrials.gov (NCT00415103) AMENO-2: Aprepitant Plus Palonosetron Versus Granisetron in the Prevention of Nausea and the Emesis Induced by Chemotherapy in Patients Treated With Haematopoietic Progenitors
14 ClinicalTrials.gov (NCT02597907) Postoperative Nausea and Vomiting: Ramosetron Plus Aprepitant vs Palonosetron Plus Aprepitant
15 ClinicalTrials.gov (NCT00835965) Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and Vomiting (PONV) After Elective Laparoscopic Surgeries
16 ClinicalTrials.gov (NCT00600353) Multi-day Doses in Prevention of Nausea and Emesis
17 ClinicalTrials.gov (NCT03237611) Low Dose Aprepitant for Patients Receiving Carboplatin
18 ClinicalTrials.gov (NCT02097823) Pilot Study of Olanzapine and Aprepitant to Prevent Nausea and Vomiting in Children Receiving Chemotherapy
19 ClinicalTrials.gov (NCT02484911) Aprepitant ,Olanzapine,Palonosetron and Dexamethasone for the Prevention of Chemotherapy-induced Nausea and Vomiting
20 ClinicalTrials.gov (NCT03219710) "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)"
21 ClinicalTrials.gov (NCT04912271) Granisetron Transdermal Patch for Prophylaxis of Delayed CINV
22 ClinicalTrials.gov (NCT00619359) Evaluation of Fosaprepitant (MK0517) in Single Dose Schedule (0517-017)
23 ClinicalTrials.gov (NCT01474915) Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting