Details of the Drug Combinations

General Information of This Drug (ID: DM7A8TW)

• Drug Name: Ezetimibe (DM7A8TW)
• Synonyms: Ezedoc; Ezetimib; Ezetrol; Zetia; Zient; Essex brand of ezetimibe; MSD brand of ezetimibe; Merck brand of ezetimibe; SCH58235; Sch 58235; Ezetimibe [USAN:INN]; Inegy (TN); MK-0653; SCH-58235; Schering-Plough brand of ezetimibe; Vytorin (TN); Zetia (TN); Zetia , Ezetrol, Ezetimibe; Ezetimibe (JAN/USAN/INN); (-)-Sch 58235; (1-(4-fluorophenyl)-(3R)-(3-(4-fluorophenyl)-(3S)-hydroxypropyl)-(4S)-(4-hydroxyphenyl)-2-azetidinone); (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3R,4S)-1-(p-Fluorophenyl)-3-((3S)-3-(p-fluorophenyl)-3-hydroxypropyl)-4-(p-hydroxyphenyl)-2-azetidinone; 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-(4-hydroxyphenyl)-2-azetidione; 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone

Indication

Atherosclerosis; ICD 11: BD40; Status: Approved [1]; Hypercholesterolaemia; ICD 11: 5C80.0; Status: Approved [2]; Hyperlipidemia; ICD 11: 5C80.Z; Status: Approved [1]; Hyperlipidemia, familial combined, LPL related; ICD 11: N.A.; Status: Approved [1]; Non-alcoholic fatty liver disease; ICD 11: DB92; Status: Approved [1]; Type-1/2 diabetes; ICD 11: 5A10-5A11; Status: Approved [1]

• Therapeutic Class: Anticholesteremic Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

53 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Ezetimibe	DCQL0BC	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Aciclovir + Ezetimibe	DC6J0OH	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Ezetimibe	DC7K5ET	Amodiaquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Arfolitixorin + Ezetimibe	DCCR9R8	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Artemisinin + Ezetimibe	DCDYC6F	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Ezetimibe	DCMVO8L	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Ezetimibe	DCQJPS1	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Ezetimibe	DCV4VXN	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorzoxazone + Ezetimibe	DCKRV0S	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diazoxide + Ezetimibe	DCPQVWJ	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Epinephrine + Ezetimibe	DCKV1TN	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Triiodothyronine	DCI7L0X	Triiodothyronine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Dantrolene	DCU5A9W	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Ruxolitinib	DCK2Q5D	Ruxolitinib	T-cell leukemia/lymphoma (Cell Line: ED-40515)	[3]
Ezetimibe + Kanamycin	DCAW8W0	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Tindamax	DCLBOSF	Tindamax	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Vinblastine	DCW8SMG	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Acitretin	DC56CPB	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + SCH 727965	DCK0XI2	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Emetine	DC7KZYE	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Docetaxel	DCCH5GE	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Marizomib	DCRM99S	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Ezetimibe + Ciprofibrate	DC8B2SQ	Ciprofibrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + PFK-158	DC2P43O	PFK-158	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Lubiprostone	DCKJ846	Lubiprostone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Tiagabine	DCGLXT6	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Fenoprofen	DCWI59R	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Benserazide	DCZ2NVP	Benserazide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Idarubicin	DC53V20	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
Ezetimibe + Brincidofovir	DCAMLTK	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Sorafenib	DCSGSZD	Sorafenib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Asenapine	DCC9AMB	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Pomalidomide	DC550HZ	Pomalidomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Endoxifen	DCZHYFR	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Mycophenolic acid	DCZRGBK	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Mefloquine	DCURNS1	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Lacosamide	DC0AE8Y	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Doxorubicin	DCHYZ2R	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Auranofin	DC2167M	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Estramustine	DCS4BFD	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Cerivastatin	DCCKCRJ	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Ezetimibe	DCSQUDT	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imatinib + Ezetimibe	DCIQ66Z	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Leflunomide + Ezetimibe	DCE71I1	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Ezetimibe	DCWXIZ5	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Ezetimibe	DCTP6NJ	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methotrexate + Ezetimibe	DCBKP6M	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Moricizine + Ezetimibe	DCN75M1	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pizotyline + Ezetimibe	DCP8EEK	Pizotyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Rifampin + Ezetimibe	DCRNDGM	Rifampin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triapine + Ezetimibe	DCSI221	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Triflupromazine + Ezetimibe	DCLKFVJ	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trihexyphenidyl + Ezetimibe	DCAZJA9	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

14 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bempedoic acid + Ezetimibe	DC6TXZT	Bempedoic acid	High blood cholesterol level	[5]
Ezetimibe + Valsartan	DC1K153	Valsartan	Hypertension	[6]
Ezetimibe + Atorvastatin	DC8HX53	Atorvastatin	Hypercholesterolemia	[7]
Ezetimibe + Cyclosporin A	DCA0W7I	Cyclosporin A	Cholesterol	[8]
Ezetimibe + Fenofibrate	DCD6CCW	Fenofibrate	HIV	[9]
Ezetimibe + Pitavastatin	DCPE8J5	Pitavastatin	Hypercholesterolemia	[10]
Ezetimibe + Rosuvastatin	DCT8XLP	Rosuvastatin	Hypercholesterolemia	[11]
Ezetimibe + Atorvastatin	DCXTST5	Atorvastatin	Hypercholesterolaemia	[12]
Ezetimibe + Atorvastatin	DCD5329	Atorvastatin	Pharmacokinetics	[13]
Simvastatin + Ezetimibe	DC27S5C	Simvastatin	Coronary Heart Disease	[14]
Simvastatin + Ezetimibe	DCEYXLT	Simvastatin	Kidney Disease, Chronic	[15]
Bempedoic acid + Ezetimibe	DCTW8J5	Bempedoic acid	Hypercholesterolemia	[16]
Bempedoic acid + Ezetimibe	DCSUC3R	Bempedoic acid	Hypercholesterolemia	[17]
Ezetimibe + Rosuvastatin	DCNNWGS	Rosuvastatin	Hypercholesterolemia	[18]

References

• [1] Ezetimibe FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6816).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] ClinicalTrials.gov (NCT00738972) Left Ventricular Hypertrophy Reduction With Statins in Hypertensives Patients (MK0653A-168)
• [7] ClinicalTrials.gov (NCT00276484) To Evaluate Ezetimibe Plus Atorvastatin Versus Atorvastatin in Patients With High Cholesterol Not Controlled on Atorvastatin 40 mg (0653-090)
• [8] ClinicalTrials.gov (NCT00653276) MD Ezetimibe Cyclosporine Interaction (0653-057)
• [9] ClinicalTrials.gov (NCT00843661) Coadministration of Ezetimibe With Fenofibrate Versus Pravastatin Monotherapy for the Treatment of Hyperlipidaemia in HIV-infected Patients
• [10] ClinicalTrials.gov (NCT00653913) Evaluation of Potential for Drug Interaction Between SCH 58235 (Ezetimibe) and Pitavastatin (Study P03962)(COMPLETED)
• [11] ClinicalTrials.gov (NCT00653445) Compare the Safety & Efficacy of Rosuvastatin 40mg in Combination With Ezetimibe 10mg
• [12] Efficacy and safety of fenofibric acid in combination with atorvastatin and ezetimibe in patients with mixed dyslipidemia. Am Heart J. 2010 Oct;160(4):759-66.
• [13] ClinicalTrials.gov (NCT00681525) A Multiple-Dose Pharmacokinetic Interaction Study Between ABT-335, Atorvastatin and Ezetimibe
• [14] ClinicalTrials.gov (NCT00481351) Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons
• [15] ClinicalTrials.gov (NCT00125593) Study of Heart and Renal Protection
• [16] ClinicalTrials.gov (NCT03051100) Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg, Ezetimibe 10mg, and Atorvastatin 20 mg Triplet Therapy in Patients With Elevated LDL-C
• [17] ClinicalTrials.gov (NCT03001076) Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility)
• [18] ClinicalTrials.gov (NCT02741245) A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832)