Details of the Drug Combinations

General Information of This Drug (ID: DMAI7ZV)

• Drug Name: Diltiazem (DMAI7ZV)
• Synonyms: Acalix; Adizem; Aldizem; Anoheal; Cardil; Cardizem; Citizem; Dilacor; Dilcontin; Dilren; Diltia; Diltiazemum; Dilticard; Diltzac; Dilzen; Endrydil; Viazem; Cardizen LA; Incoril AP; Tiazac Tildiem; Tiazac XC; Adizem (TN); Altiazem (TN); Angiozem (TN); Angizem (TN); Angizem CD (TN); Apo-Diltiaz; Cardizem (Hydrochloride); Cardizem (TN); Cartia XT (TN); Dilacor-XR; Dilatam (TN); Dilatem (TN); Dilcardia (TN); Dilcontin SR (TN); Dilt-cd; Dilta-Hexal; Diltelan (TN); Diltiazem (INN); Diltiazem [INN:BAN]; Diltiazemum [INN-Latin]; Diltime (TN); Dilzem (TN); Dyalec (TN); Filazem (TN); Herben (TN); Nu-Diltiaz; Progor (TN); RG 83606 (Hydrochloride); Surazem (TN); Tiamate (TN); Tiazac (TN); Tiazac XC (TN); Tildiem (TN); Vasmulax (TN); Viazem (TN); Zandil (TN); Zemtrial (TN); D-cis-Diltiazem; MK-793 (Malate); [(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate; Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester; (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester; (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate; (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; (2S,3S)-5-[2-(dimethylamino)ethyl]-2-[4-(methyloxy)phenyl]-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Indication

Angina pectoris; ICD 11: BA40; Status: Approved [1]; Atrial fibrillation; ICD 11: BC81.3; Status: Approved [1]; Hypertension; ICD 11: BA00-BA04; Status: Approved [2]; Malignant essential hypertension; ICD 11: BA00; Status: Approved [1]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

48 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AC265347 + Diltiazem	DC7JKZG	AC265347	DD2 (Cell Line: DD2)	[3]
AC265347 + Diltiazem	DCM53W5	AC265347	Hepatoblastoma (Cell Line: HB3)	[4]
Artemether + Diltiazem	DCZO91N	Artemether	Hepatoblastoma (Cell Line: HB3)	[3]
Atovaquone + Diltiazem	DC62BDB	Atovaquone	DD2 (Cell Line: DD2)	[3]
Azelnidipine + Diltiazem	DCK1H8Z	Azelnidipine	DD2 (Cell Line: DD2)	[3]
Azelnidipine + Diltiazem	DC2YD1Y	Azelnidipine	Hepatoblastoma (Cell Line: HB3)	[3]
Dactinomycin + Diltiazem	DCQUXW8	Dactinomycin	Hepatoblastoma (Cell Line: HB3)	[4]
Dihydroergotamine + Diltiazem	DC4DFEP	Dihydroergotamine	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Diltiazem	DC6Q4R7	Dihydroergotamine	Hepatoblastoma (Cell Line: HB3)	[3]
Diltiazem + Lumefantrine	DCU56LI	Lumefantrine	DD2 (Cell Line: DD2)	[3]
Diltiazem + Azelnidipine	DCLE5H4	Azelnidipine	DD2 (Cell Line: DD2)	[3]
Diltiazem + Marizomib	DC7UBDN	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Diltiazem + KN-62	DCOVDVO	KN-62	DD2 (Cell Line: DD2)	[3]
Diltiazem + Omacetaxine mepesuccinate	DCIMJPF	Omacetaxine mepesuccinate	DD2 (Cell Line: DD2)	[3]
Diltiazem + Lumefantrine	DCAMXE6	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[4]
Diltiazem + KN-62	DC383OH	KN-62	Hepatoblastoma (Cell Line: HB3)	[4]
Diltiazem + Artemisinin	DCJ93EB	Artemisinin	Hepatoblastoma (Cell Line: HB3)	[4]
Diltiazem + Omacetaxine mepesuccinate	DC6B5PM	Omacetaxine mepesuccinate	Hepatoblastoma (Cell Line: HB3)	[4]
Diltiazem + Glipizide	DCCZUOC	Glipizide	Hepatoblastoma (Cell Line: HB3)	[4]
Disopyramide + Diltiazem	DCHIFIT	Disopyramide	DD2 (Cell Line: DD2)	[3]
Disopyramide + Diltiazem	DC767BZ	Disopyramide	Hepatoblastoma (Cell Line: HB3)	[4]
Doxepin + Diltiazem	DCRMSHN	Doxepin	DD2 (Cell Line: DD2)	[3]
Fendiline + Diltiazem	DCA5EWQ	Fendiline	DD2 (Cell Line: DD2)	[3]
Glipizide + Diltiazem	DCILY2K	Glipizide	DD2 (Cell Line: DD2)	[3]
Glipizide + Diltiazem	DC7S214	Glipizide	Hepatoblastoma (Cell Line: HB3)	[4]
KN-62 + Diltiazem	DCVX98A	KN-62	DD2 (Cell Line: DD2)	[3]
KN-62 + Diltiazem	DCVJT4P	KN-62	Hepatoblastoma (Cell Line: HB3)	[4]
Lumefantrine + Diltiazem	DCHY6UK	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
MANOALIDE + Diltiazem	DCFDFW4	MANOALIDE	DD2 (Cell Line: DD2)	[3]
MANOALIDE + Diltiazem	DCGPK6C	MANOALIDE	Hepatoblastoma (Cell Line: HB3)	[4]
Mefloquine + Diltiazem	DCM99AW	Mefloquine	DD2 (Cell Line: DD2)	[3]
Mefloquine + Diltiazem	DC4BX3B	Mefloquine	Hepatoblastoma (Cell Line: HB3)	[3]
Miconazole + Diltiazem	DCCBYN2	Miconazole	DD2 (Cell Line: DD2)	[3]
MK-3207 + Diltiazem	DCZ8KAY	MK-3207	DD2 (Cell Line: DD2)	[3]
MK-3207 + Diltiazem	DCD28DB	MK-3207	Hepatoblastoma (Cell Line: HB3)	[4]
NITD609 + Diltiazem	DCRQWME	NITD609	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Diltiazem	DCI07KO	Omacetaxine mepesuccinate	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Diltiazem	DCHG3XU	Omacetaxine mepesuccinate	Hepatoblastoma (Cell Line: HB3)	[4]
Otilonium bromide + Diltiazem	DCYRZRF	Otilonium bromide	DD2 (Cell Line: DD2)	[3]
Otilonium bromide + Diltiazem	DC5M76P	Otilonium bromide	Hepatoblastoma (Cell Line: HB3)	[3]
Pizotyline + Diltiazem	DCF75CD	Pizotyline	DD2 (Cell Line: DD2)	[3]
Pyrimethamine + Diltiazem	DCWIXUG	Pyrimethamine	Hepatoblastoma (Cell Line: HB3)	[3]
Ritonavir + Diltiazem	DCMSR02	Ritonavir	Hepatoblastoma (Cell Line: HB3)	[3]
Sorafenib + Diltiazem	DCTGKDH	Sorafenib	DD2 (Cell Line: DD2)	[3]
Sorafenib + Diltiazem	DCGQCQJ	Sorafenib	Hepatoblastoma (Cell Line: HB3)	[3]
Thiolactomycin + Diltiazem	DCR535G	Thiolactomycin	DD2 (Cell Line: DD2)	[3]
Thiolactomycin + Diltiazem	DCQE7W0	Thiolactomycin	Hepatoblastoma (Cell Line: HB3)	[4]
Verapamil + Diltiazem	DCJI66A	Verapamil	DD2 (Cell Line: DD2)	[4]

9 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Clarithromycin + Diltiazem	DCDMQ8Y	Clarithromycin	CLARITHROMYCIN/DILTIAZEM [VA Drug Interaction]	[5]
Diltiazem + Amlodipine	DCISQOA	Amlodipine	Hepatitis C	[6]
Diltiazem + Zanubrutinib	DCCJENO	Zanubrutinib	B-cell Malignancies	[7]
Diltiazem + Moxifloxacin	DCGDPFZ	Moxifloxacin	Drug-induced QT Prolongation	[8]
Diltiazem + Darapladib	DCQXK0H	Darapladib	Atherosclerosis	[9]
Fosinopril + Diltiazem	DCRFL2W	Fosinopril	Hypertension	[10]
Tranexamic acid + Diltiazem	DC6AX3J	Tranexamic acid	Hypotension on Induction	[11]
Diltiazem + Oseltamivir	DCYSU14	Oseltamivir	Flu	[12]
Diltiazem + Niclosamide	DC92H2M	Niclosamide	Coronavirus Disease 2019 (COVID-19)	[13]

References

• [1] Diltiazem FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2298).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT02080780) Study to Evaluate the Interaction Potential of Clarithromycin XL on Diltiazem Hydrochloride Cream 2% in Healthy Subjects
• [6] ClinicalTrials.gov (NCT01549496) A Drug Interaction Study of Boceprevir in Combination With Amlodipine or Diltiazem in Healthy Volunteers
• [7] ClinicalTrials.gov (NCT04551963) Interaction Study of Zanubrutinib With Moderate and Strong CYP3A Inhibitors in Participants With B-Cell Malignancies
• [8] ClinicalTrials.gov (NCT02308748) Ability of Late Sodium or Calcium Current Block to Balance the ECG Effects of Potassium Current Block
• [9] ClinicalTrials.gov (NCT01852565) Study to Determine the Effect of Repeated Administration of Diltiazem on the Pharmacokinetics of Darapladib (Sb-480848).
• [10] ClinicalTrials.gov (NCT04467931) ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
• [11] ClinicalTrials.gov (NCT03580590) Efficacy of Oral Diltiazem on the Intraoperative Bleeding in Functional Endoscopic Sinus Surgery
• [12] ClinicalTrials.gov (NCT03212716) Efficiency of Antagonist Drugs of the Cellular Transcriptomic Signature of Influenza A Virus Infection.
• [13] ClinicalTrials.gov (NCT04372082) Hydroxychloroquine or Diltiazem-Niclosamide for the Treatment of COVID-19. U.S. National Institutes of Health.