Details of the Drug Combinations

General Information of This Drug (ID: DMQXTJS)

Drug Name
Eptifibatide   DMQXTJS
Synonyms
Integrelin; Integrilin; Intrifiban; HS-2011; Integrilin (TN); SB-1; Sch-60936; N(6)-amidino-N(2)-(3-mercaptopropionyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(1-6)-disulfide; N(sup 6)-Amidino-N(sup 2)-(3-mercaptopropionyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(1-6)-disulfide; S(1),S(6)-cyclo[N(6)-carbamimidoyl-N(2)-(3-sulfanylpropanoyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide]; L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-prolyl-, cyclic (1-6)-disulfide; L-Cysteinamide,N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-propyl-,cyclic (1-6)-disulfide; [(3R,11S,17S,20S,25aS)-11-(4-carbamimidamidobutyl)-3-carbamoyl-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid; 2-[(3S,6S,12S,20R,23S)-20-carbamoyl-12-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-6-yl]acetic acid; 2-[20-carbamoyl-12-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-6-yl]acetic acid
Indication
Disease Entry ICD 11 Status REF
Acute cardiac ischemic events BA40.Z Approved [1]
Acute coronary syndrome BA41 Approved [2]
Pneumonia CA40 Approved [2]
Therapeutic Class
Anticoagulants
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

53 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Eptifibatide DCBNG8Y Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BHV-0223 + Eptifibatide DCJREEI BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Bortezomib + Eptifibatide DC8LYOI Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Eptifibatide DCAUQZY Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Eptifibatide DCKKPXS Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Efavirenz + Eptifibatide DC11EA6 Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Entacapone + Eptifibatide DC6TA96 Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Epinephrine + Eptifibatide DCSINHW Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Pentostatin DCCX1UM Pentostatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Acetazolamide DC4UXDA Acetazolamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Dantrolene DCV564T Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Imipramine DCKJ3FU Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + PMID28460551-Compound-2 DCX4TO8 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Vinblastine DCCRZYD Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Ramelteon DC42NRW Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Triapine DC9P5FD Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Pepstatin DCOAK4K Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + IT-141 DCXWG7V IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Methylergonovine DC57ZXC Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Metyrosine DC49WNG Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Docetaxel DCDCBH9 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Cilastatin DCCP4ZH Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Daidzin DCPR7OE Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + VR-776 DCIFXMF VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + WAY-100635 DC13XUG WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + BIO-300 DC8JXXN BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Tiagabine DC0SWSC Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Diazoxide DCMUHAT Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Benserazide DCG6SYW Benserazide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Imatinib DCPKSOL Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Methylene blue DC5RAPR Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Leflunomide DCVSUPZ Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Acarbose DC8LD4T Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Mycophenolic acid DCPNKC4 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Mefloquine DCT2C9L Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Cerivastatin DC6GM65 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Atovaquone DC2KM4M Atovaquone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Azatadine DCHES2M Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Everolimus + Eptifibatide DC4VUZL Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Gefitinib + Eptifibatide DC6SQKT Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ibutilide + Eptifibatide DCEC3YB Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Idarubicin + Eptifibatide DCBQ8FP Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Itraconazole + Eptifibatide DC6UV0B Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Levamisole + Eptifibatide DCFPU58 Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maprotiline + Eptifibatide DCYNA97 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Metaxalone + Eptifibatide DCENISS Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Oxyphenbutazone + Eptifibatide DC4C01S Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Paromomycin + Eptifibatide DCWVH9V Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PF-02545920 + Eptifibatide DCS3KNM PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PFK-158 + Eptifibatide DCS0M0G PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Picoplatin + Eptifibatide DC709NT Picoplatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Terazosin + Eptifibatide DCNNMFK Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trimethobenzamide + Eptifibatide DCLMIVU Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 53 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Brilinta + Eptifibatide DCKSI5R Brilinta Acute Coronary Syndrome [4]
Clopidogrel + Eptifibatide DC5PNLP Clopidogrel Acute Coronary Syndrome [5]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6585).
2 Eptifibatide FDA Label
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT01919723) Ticagrelor and Eptifibatide Bolus-Only Versus Ticagrelor and Eptifibatide Bolus Plus Abbreviated Infusion
5 ClinicalTrials.gov (NCT02925923) Crushed Ticagrelor Versus Eptifibatide Bolus + Clopidogrel