General Information of This Drug (ID: DMXOELT)

Drug Name
Midazolam   DMXOELT
Synonyms
Dazolam; Dormicum; Midanium; Midazolamum; Midosed; Versed; Midazolam Base; Dormicum (TN); Hypnovel (TN); Midacum (TN); Midazolamum [INN-Latin]; Ro 21-3981; Versed (TN); Midazolam (JAN/INN); Midazolam [INN:BAN:JAN]; 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate; 8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride; 8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine; 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
Indication
Disease Entry ICD 11 Status REF
Agitation 6A70.3 Approved [1]
Anxiety N.A. Approved [1]
Irritability MB24 Approved [2]
Pain MG30-MG3Z Approved [1]
Traumatic brain injury NA07.Z Approved [1]
Epilepsy 8A60-8A68 Phase 3 [3]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Hypnotics and Sedatives
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

44 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-492 + Midazolam DCPM3VA ABT-492 VA Drug Interactions [4]
Avapritinib + Midazolam DC2DK5H Avapritinib Gastrointestinal Stromal Tumors [5]
Brigatinib + Midazolam DCTEAXU Brigatinib Carcinoma, Advanced ALK+ or ROS1+Non-Small-Cell Lung, Neoplasm, Advanced ALK+ or ROS1+Solid Tumors [6]
Darapladib + Midazolam DCRCOMN Darapladib Atherosclerosis [7]
Diazepam + Midazolam DCLPAJ9 Diazepam Anxiety Disease [8]
Fentanyl + Midazolam DCAERTR Fentanyl Prostatic Cancer [9]
Fentanyl + Midazolam DCJ3323 Fentanyl Chronic Otitis Media [10]
Fentanyl + Midazolam DCMU52D Fentanyl Cirrhosis [11]
GDC-0032 + Midazolam DC1RFA1 GDC-0032 Solid Cancers [12]
Gilteritinib + Midazolam DCI9R8M Gilteritinib Acute Myeloid Leukemia [13]
Isavuconazole + Midazolam DC6WCDV Isavuconazole Pharmacokinetics of Isavuconazole [14]
Ketamine + Midazolam DC5U3JU Ketamine Bipolar Disorder [15]
Lapatinib + Midazolam DCMTEK5 Lapatinib Neoplasms, Breast [16]
Meperidine + Midazolam DCUPDYO Meperidine Disorders of Gallbladder, Biliary Tract and Pancrease [17]
Midazolam + Remifentanil DCPYZVG Remifentanil Peripheral Arterial Occlusive Disease [18]
Orvepitant + Midazolam DCMF7CS Orvepitant Depressive Disorder [19]
Palovarotene + Midazolam DCEP1AF Palovarotene Fibrodysplasia Ossificans Progressiva [20]
Pretomanid + Midazolam DCJMRR1 Pretomanid Tuberculosis [21]
Prilocaine + Midazolam DCJE108 Prilocaine Other Surgical Procedures [22]
Propofol + Midazolam DCFKA2J Propofol Bronchoscopy [23]
Propofol + Midazolam DCMLHMD Propofol Anesthesia [24]
Propofol + Midazolam DC96GPZ Propofol Biliary Tract Diseases [25]
Propranolol + Midazolam DCTA0ZI Propranolol Extrusion of Tooth [26]
Ridaforolimus + Midazolam DCLOX37 Ridaforolimus Relapsed or Refractory Advanced Cancer [27]
Risdiplam + Midazolam DCGWN5E Risdiplam Spinal Muscular Atrophy [28]
Savolitinib + Midazolam DCSN0CY Savolitinib Solid Tumors [29]
SNDX-275 + Midazolam DCEELVK SNDX-275 Drug Interaction [30]
Tasisulam + Midazolam DC3K89Y Tasisulam Advanced Cancer [31]
VX-970 + Midazolam DCF3FEQ VX-970 Pain [32]
Levetiracetam + Midazolam DCV580E Levetiracetam Status Epilepticus [33]
Magnesium Sulfate + Midazolam DC2TFOG Magnesium Sulfate TBI (Traumatic Brain Injury) [34]
Alfentanil + Midazolam DCG1CV6 Alfentanil Emergence Agitation [35]
Diclofenac + Midazolam DCYXQ29 Diclofenac Postcraniotomy Headache [36]
Fentanyl + Midazolam DC11XZ3 Fentanyl Mechanical Ventilation [37]
Fexofenadine + Midazolam DCRI0V4 Fexofenadine Gout Flare [38]
Hydroxyzine + Midazolam DCI78MB Hydroxyzine Dental Caries in Children [39]
Ketamine + Midazolam DC9944V Ketamine Emergence Agitation [35]
Lidocaine + Midazolam DCOCUWU Lidocaine Critical Illness [40]
Lidocaine + Midazolam DCPKYRT Lidocaine Sedation, Conscious [41]
Midazolam + Remifentanil DCCJYP4 Remifentanil Critical Illness [40]
Midazolam + Etomidate DCTGQ7S Etomidate Congenital Hydronephrosis [42]
Morphine + Midazolam DC2M10U Morphine Inflammatory Disorder of Immune System [43]
Propofol + Midazolam DCNS18O Propofol Congenital Hydronephrosis [42]
Sufentanil + Midazolam DCRJODP Sufentanil Sufentanil [44]
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⏷ Show the Full List of 44 DrugCom(s)

References

1 Midazolam FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3342).
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 ClinicalTrials.gov (NCT02505997) Study to Evaluate the Effect of Delafloxacin on the Pharmacokinetics of Midazolam in Healthy Subjects
5 ClinicalTrials.gov (NCT04908176) A Drug-drug Interaction Study of Avapritinib and Midazolam
6 ClinicalTrials.gov (NCT03420742) A Phase 1 Drug-Drug Interaction Study Between Brigatinib and the CYP3A Substrate, Midazolam, in Participants With ALK-Positive or ROS1-Positive Solid Tumors
7 ClinicalTrials.gov (NCT01873339) Pharmacokinetic Interaction of Darapladib and CYP 3A4 in Healthy Subjects
8 ClinicalTrials.gov (NCT03165500) Comparative Evaluation of Three Anxiety Control Protocols in Third Molar Extraction
9 ClinicalTrials.gov (NCT01998685) Prothrombotic Factors and Anaesthesia in Prostate Cancer
10 ClinicalTrials.gov (NCT01188551) Dexmedetomidine Versus Fentanyl Following Pressure Equalization Tube Placement
11 ClinicalTrials.gov (NCT00906139) Propofol and Fentanyl Versus Midazolam and Fentanyl for Endoscopy Sedation in Cirrhotic Patients
12 ClinicalTrials.gov (NCT01296555) A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer
13 ClinicalTrials.gov (NCT02014558) Dose Escalation Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of ASP2215 in Patients With Relapsed or Refractory Acute Myeloid Leukemia
14 ClinicalTrials.gov (NCT01406171) Drug Interaction Study of Isavuconazole and Midazolam
15 ClinicalTrials.gov (NCT00947791) Treatment Study of Bipolar Depression
16 ClinicalTrials.gov (NCT00258050) To Examine The Effects Of Lapatinib On Orally And Intravenously Administered Midazolam In Cancer Patients
17 ClinicalTrials.gov (NCT01709422) Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine.
18 ClinicalTrials.gov (NCT02929095) The Effect of Remifentanil-dexmedetomidine Compared With Remifentanil-midazolam on Patient's Satisfaction
19 ClinicalTrials.gov (NCT00511654) 28-day Repeat Dose and Drug Interaction Study With Orvepitant (GW823296)
20 ClinicalTrials.gov (NCT04829773) Study Evaluating the Effect of Food on the Pharmacokinetics of Palovarotene and the Effect of Palovarotene on the Pharmacokinetics of the CYP3A4 Substrate Midazolam in Two Cohorts of Healthy Adult Subjects
21 ClinicalTrials.gov (NCT01768273) Evaluation of the Pharmacokinetic Interaction Between PA-824 and Midazolam
22 ClinicalTrials.gov (NCT01309360) Ultrasound-guided Axillary Plexus Block - Dose Reduction of Prilocaine
23 ClinicalTrials.gov (NCT03406533) Sedation Strategies for Diagnostic Bronchoscopy
24 ClinicalTrials.gov (NCT02536690) Remifentanil and Midazolam on Propofol for Loss of Consciousness
25 ClinicalTrials.gov (NCT01900938) Comparison Between Continuous Infusion and Intermittent Bolus Injection of Propofol for Deep Sedation During ERCP
26 ClinicalTrials.gov (NCT03388957) Oral Propranolol for Reducing Pediatric Dental Patients Anxiety
27 ClinicalTrials.gov (NCT01071304) Effect of Ridaforolimus on the Pharmacokinetics of Midazolam (Study MK-8669-044)
28 ClinicalTrials.gov (NCT03988907) A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants
29 ClinicalTrials.gov (NCT04187456) A Study in Healthy Male Subjects to Understand How Savolitinib When Taken With Midazolam Behaves Inside the Body
30 ClinicalTrials.gov (NCT03187015) A Study to Examine the Effects of Entinostat on Midazolam in Healthy Adult Subjects
31 ClinicalTrials.gov (NCT01209832) A Tasisulam and Midazolam Drug Interaction Study in Cancer Patients
32 ClinicalTrials.gov (NCT05866055) A Phase 1 Dose Escalation Study of VX-973 in Healthy Adults
33 ClinicalTrials.gov (NCT04926844) Effectiveness of Combined Levetiracetam and Midazolam in Generalized Convulsive Status Epilepticus in Children
34 ClinicalTrials.gov (NCT05340803) Sedation of Ventilated Traumatic Brain Injury Patients With Midazolam Alone Versus Combination With Dexmedetomidine or Magnesium Sulfate; Monitored by Ultrasonograghic Optic Nerve Sheath Diameter
35 ClinicalTrials.gov (NCT02022488) Sevoflurane Induced Emergence Agitation
36 ClinicalTrials.gov (NCT01907984) Diclofenac Administered Before Skull Operations Reduces the Severity of Headache After the Intervention
37 ClinicalTrials.gov (NCT02528513) Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients
38 ClinicalTrials.gov (NCT03933007) Relation Between Blood Concentration of Colchicine and Response to Colchicine Treatment in Gout Flare
39 ClinicalTrials.gov (NCT04068948) Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years
40 ClinicalTrials.gov (NCT02635802) the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation
41 ClinicalTrials.gov (NCT02314546) Intranasal Midazolam in Children as a Pre-Operative Sedative
42 ClinicalTrials.gov (NCT02013986) Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children
43 ClinicalTrials.gov (NCT02135055) Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status
44 ClinicalTrials.gov (NCT03901716) Comparison of Sufentanil, Fentanyl and Remifentanil in Combination With Midazolam During Bronchoscopy Under Conscious Sedation