Details of the Drug

General Information of Drug (ID: DMXOELT)

Drug Name
Midazolam
Synonyms
Dazolam; Dormicum; Midanium; Midazolamum; Midosed; Versed; Midazolam Base; Dormicum (TN); Hypnovel (TN); Midacum (TN); Midazolamum [INN-Latin]; Ro 21-3981; Versed (TN); Midazolam (JAN/INN); Midazolam [INN:BAN:JAN]; 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate; 8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride; 8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine; 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
Indication
Disease Entry ICD 11 Status REF
Agitation 6A70.3 Approved [1]
Anxiety N.A. Approved [1]
Irritability MB24 Approved [2]
Pain MG30-MG3Z Approved [1]
Traumatic brain injury NA07.Z Approved [1]
Epilepsy 8A60-8A68 Phase 3 [3]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Hypnotics and Sedatives
Affected Organisms
Humans and other mammals
ATC Code
N05CD08: Midazolam
N05CD: Benzodiazepine derivatives
N05C: HYPNOTICS AND SEDATIVES
N05: PSYCHOLEPTICS
N: NERVOUS SYSTEM
N05CD08: Midazolam
N05CD: Benzodiazepine derivatives
N05C: HYPNOTICS AND SEDATIVES
N05: PSYCHOLEPTICS
N: NERVOUS SYSTEM
N05CD08: Midazolam
N05CD: Benzodiazepine derivatives
N05C: HYPNOTICS AND SEDATIVES
N05: PSYCHOLEPTICS
N: NERVOUS SYSTEM
N05CD08: Midazolam
N05CD: Benzodiazepine derivatives
N05C: HYPNOTICS AND SEDATIVES
N05: PSYCHOLEPTICS
N: NERVOUS SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 325.8
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 90 mcg/L [4]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 0.5 h [4]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [5]
Bioavailability
The bioavailability of drug is 90% [4]
Clearance
The total body clearance of drug is 367.3 mL/h/kg []
Elimination
0.5% of drug is excreted via urine []
Half-life
The concentration or amount of drug in body reduced by one-half in 1.8 - 6.4 hours []
Metabolism
The drug is metabolized via the liver [4]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.2557 micromolar/kg/day [6]
Unbound Fraction
The unbound fraction of drug in plasma is 0.017% [7]
Vd
The volume of distribution (Vd) of drug is 2.117 L/kg []
Water Solubility
The ability of drug to dissolve in water is measured as 10.3 mg/mL [5]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Cytokine release syndrome Not Available IL1B OT0DWXXB [8]
Cytokine release syndrome Not Available IL6 OTUOSCCU [8]
Chemical Identifiers
Formula
C18H13ClFN3
IUPAC Name
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
Canonical SMILES
CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F
InChI
InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
InChIKey
DDLIGBOFAVUZHB-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4192
ChEBI ID
CHEBI:6931
CAS Number
59467-70-8
UNII
R60L0SM5BC
DrugBank ID
DB00683
TTD ID
D0U6LM
VARIDT ID
DR00684
INTEDE ID
DR1086
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Translocator protein (TSPO) TTPTXIN TSPO_HUMAN Modulator [9]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [10]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [11]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [12]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [13]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [14]
Cytochrome P450 4B1 (CYP4B1) DEMF740 CP4B1_HUMAN Substrate [14]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [15]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [16]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [17]
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Regulation of Drug Effects [18]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [19]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Biotransformations [20]
Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) OTX4UC3O GBRA6_HUMAN Drug Response [21]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Drug Response [8]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Drug Response [8]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [19]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Midazolam (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Sodium bicarbonate DMMU6BJ Minor Altered absorption of Midazolam due to GI dynamics variation caused by Sodium bicarbonate. Acidosis [5C73] [22]
Ivosidenib DM8S6T7 Moderate Increased metabolism of Midazolam caused by Ivosidenib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [23]
Emapalumab DMZG5WL Moderate Altered metabolism of Midazolam due to Emapalumab alters the formation of CYP450 enzymes. Adaptive immunity immunodeficiency [4A01] [24]
Siltuximab DMGEATB Moderate Altered metabolism of Midazolam due to Siltuximab alters the formation of CYP450 enzymes. Anemia [3A00-3A9Z] [24]
Dronedarone DMA8FS5 Moderate Decreased metabolism of Midazolam caused by Dronedarone mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [25]
Posaconazole DMUL5EW Major Decreased metabolism of Midazolam caused by Posaconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [26]
Dalfopristin DM4LTKV Moderate Decreased metabolism of Midazolam caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [27]
Clarithromycin DM4M1SG Moderate Decreased metabolism of Midazolam caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [26]
Troleandomycin DMUZNIG Moderate Decreased metabolism of Midazolam caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [28]
Telithromycin DMZ4P3A Major Decreased metabolism of Midazolam caused by Telithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [29]
Erdafitinib DMI782S Moderate Increased metabolism of Midazolam caused by Erdafitinib mediated induction of CYP450 enzyme. Bladder cancer [2C94] [30]
Lapatinib DM3BH1Y Moderate Decreased metabolism of Midazolam caused by Lapatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [31]
Tucatinib DMBESUA Major Decreased metabolism of Midazolam caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [32]
Palbociclib DMD7L94 Moderate Decreased metabolism of Midazolam caused by Palbociclib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [33]
Atorvastatin DMF28YC Moderate Decreased metabolism of Midazolam caused by Atorvastatin mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [34]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Midazolam and Olopatadine. Conjunctiva disorder [9A60] [35]
Propofol DMB4OLE Moderate Additive cardiorespiratory depression effects by the combination of Midazolam and Propofol. Corneal disease [9A76-9A78] [36]
Alfentanil DMVO0UB Moderate Decreased metabolism of Midazolam caused by Alfentanil mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [37]
Mifepristone DMGZQEF Major Decreased metabolism of Midazolam caused by Mifepristone mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [38]
Lumacaftor DMCLWDJ Major Increased metabolism of Midazolam caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [26]
Ivacaftor DMZC1HS Moderate Decreased clearance of Midazolam due to the transporter inhibition by Ivacaftor. Cystic fibrosis [CA25] [39]
Ethanol DMDRQZU Moderate Additive CNS depression effects by the combination of Midazolam and Ethanol. Cystitis [GC00] [40]
MK-8228 DMOB58Q Moderate Decreased metabolism of Midazolam caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [41]
Nefazodone DM4ZS8M Moderate Decreased metabolism of Midazolam caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [42]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Midazolam and Esketamine. Depression [6A70-6A7Z] [26]
SODIUM CITRATE DMHPD2Y Minor Altered absorption of Midazolam due to GI dynamics variation caused by SODIUM CITRATE. Discovery agent [N.A.] [22]
Oxcarbazepine DM5PU6O Moderate Increased metabolism of Midazolam caused by Oxcarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [43]
Cenobamate DM8KLU9 Moderate Increased metabolism of Midazolam caused by Cenobamate mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [44]
Stiripentol DMMSDOY Moderate Decreased metabolism of Midazolam caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [45]
Fosphenytoin DMOX3LB Moderate Increased metabolism of Midazolam caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [46]
Rufinamide DMWE60C Moderate Increased metabolism of Midazolam caused by Rufinamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [24]
Tazemetostat DMWP1BH Moderate Increased metabolism of Midazolam caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [47]
Itraconazole DMCR1MV Major Decreased metabolism of Midazolam caused by Itraconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [32]
Ketoconazole DMPZI3Q Major Decreased metabolism of Midazolam caused by Ketoconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [32]
Boceprevir DMBSHMF Major Decreased metabolism of Midazolam caused by Boceprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [48]
Simeprevir DMLUA9D Moderate Decreased metabolism of Midazolam caused by Simeprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [49]
Telaprevir DMMRV29 Major Decreased metabolism of Midazolam caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [48]
Rifampin DMA8J1G Minor Increased metabolism of Midazolam caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [50]
Rifapentine DMCHV4I Moderate Increased metabolism of Midazolam caused by Rifapentine mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [51]
Delavirdine DM3NF5G Major Decreased metabolism of Midazolam caused by Delavirdine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [52]
Fosamprenavir DM4W9B3 Major Decreased metabolism of Midazolam caused by Fosamprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [53]
Saquinavir DMG814N Major Decreased metabolism of Midazolam caused by Saquinavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [53]
Didanosine DMI2QPE Minor Altered absorption of Midazolam due to GI dynamics variation caused by Didanosine. Human immunodeficiency virus disease [1C60-1C62] [22]
Amprenavir DMLMXE0 Major Decreased metabolism of Midazolam caused by Amprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [53]
Darunavir DMN3GCH Major Decreased metabolism of Midazolam caused by Darunavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [53]
Atazanavir DMSYRBX Major Decreased metabolism of Midazolam caused by Atazanavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [53]
Conivaptan DM1V329 Major Decreased metabolism of Midazolam caused by Conivaptan mediated inhibition of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [54]
Probenecid DMMFWOJ Minor Decreased metabolism of Midazolam caused by Probenecid. Inborn purine/pyrimidine/nucleotide metabolism error [5C55] [55]
Lesinurad DMUR64T Moderate Increased metabolism of Midazolam caused by Lesinurad mediated induction of CYP450 enzyme. Inborn purine/pyrimidine/nucleotide metabolism error [5C55] [56]
Berotralstat DMWA2DZ Moderate Decreased metabolism of Midazolam caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [57]
Glycerol phenylbutyrate DMDGRQO Moderate Increased metabolism of Midazolam caused by Glycerol phenylbutyrate mediated induction of CYP450 enzyme. Liver disease [DB90-DB9Z] [24]
Crizotinib DM4F29C Moderate Decreased metabolism of Midazolam caused by Crizotinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [58]
Brigatinib DM7W94S Moderate Increased metabolism of Midazolam caused by Brigatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [59]
Ceritinib DMB920Z Major Decreased metabolism of Midazolam caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [32]
PF-06463922 DMKM7EW Moderate Increased metabolism of Midazolam caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [60]
Osimertinib DMRJLAT Moderate Increased metabolism of Midazolam caused by Osimertinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [24]
Selpercatinib DMZR15V Moderate Decreased metabolism of Midazolam caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [24]
Idelalisib DM602WT Major Decreased metabolism of Midazolam caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [32]
IPI-145 DMWA24P Moderate Decreased metabolism of Midazolam caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [61]
Vemurafenib DM62UG5 Minor Increased metabolism of Midazolam caused by Vemurafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [26]
LGX818 DMNQXV8 Moderate Increased metabolism of Midazolam caused by LGX818 mediated induction of CYP450 enzyme. Melanoma [2C30] [62]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Midazolam caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [24]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Midazolam and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [63]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Midazolam and Lasmiditan. Migraine [8A80] [64]
Exjade DMHPRWG Moderate Decreased metabolism of Midazolam caused by Exjade mediated inhibition of CYP450 enzyme. Mineral absorption/transport disorder [5C64] [65]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Midazolam and Flibanserin. Mood disorder [6A60-6E23] [66]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Midazolam and Thalidomide. Multiple myeloma [2A83] [67]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Midazolam caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [24]
Dasatinib DMJV2EK Moderate Decreased metabolism of Midazolam caused by Dasatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [68]
Modafinil DMYILBE Moderate Increased metabolism of Midazolam caused by Modafinil mediated induction of CYP450 enzyme. Narcolepsy [7A20] [26]
Teduglutide DMYOAKS Moderate Altered absorption of Midazolam caused by Teduglutide. Neonatal malabsorption syndrome [KB89] [69]
Levomethadyl Acetate DM06HG5 Major Additive CNS depression effects by the combination of Midazolam and Levomethadyl Acetate. Opioid use disorder [6C43] [66]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Midazolam and Apraclonidine. Optic nerve disorder [9C40] [70]
Olaparib DM8QB1D Moderate Decreased metabolism of Midazolam caused by Olaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [26]
Rucaparib DM9PVX8 Moderate Decreased metabolism of Midazolam caused by Rucaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [71]
Abametapir DM2RX0I Moderate Decreased metabolism of Midazolam caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [72]
Ranitidine DM0GUSX Moderate Increased metabolism of Midazolam caused by Ranitidine mediated induction of CYP450 enzyme. Peptic ulcer [DA61] [73]
Lonafarnib DMGM2Z6 Major Decreased metabolism of Midazolam caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [74]
Enzalutamide DMGL19D Moderate Increased metabolism of Midazolam caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [26]
Ustekinumab DMHTYK3 Moderate Altered metabolism of Midazolam due to Ustekinumab alters the formation of CYP450 enzymes. Psoriasis [EA90] [24]
Ixekizumab DMXW92T Moderate Altered metabolism of Midazolam due to Ixekizumab alters the formation of CYP450 enzymes. Psoriasis [EA90] [24]
Temsirolimus DMS104F Moderate Increased plasma concentrations of Midazolam and Temsirolimus due to competitive inhibition of the same metabolic pathway. Renal cell carcinoma [2C90] [75]
Tocilizumab DM7J6OR Moderate Altered metabolism of Midazolam due to Tocilizumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [24]
Canakinumab DM8HLO5 Moderate Altered metabolism of Midazolam due to Canakinumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [24]
Rilonacept DMGLUQS Moderate Altered metabolism of Midazolam due to Rilonacept alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [24]
Golimumab DMHZV7X Moderate Altered metabolism of Midazolam due to Golimumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [24]
Sarilumab DMOGNXY Moderate Altered metabolism of Midazolam due to Sarilumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [24]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Midazolam caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [76]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Midazolam caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [24]
Larotrectinib DM26CQR Moderate Decreased metabolism of Midazolam caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [26]
Armodafinil DMGB035 Moderate Increased metabolism of Midazolam caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [26]
LEE011 DMMX75K Moderate Decreased metabolism of Midazolam caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [77]
Pitolisant DM8RFNJ Moderate Increased metabolism of Midazolam caused by Pitolisant mediated induction of CYP450 enzyme. Somnolence [MG42] [24]
Fostamatinib DM6AUHV Moderate Decreased clearance of Midazolam due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [78]
Brilinta DMBR01X Moderate Decreased metabolism of Midazolam caused by Brilinta mediated inhibition of CYP450 enzyme. Thrombosis [DB61-GB90] [24]
Tizanidine DMR2IQ4 Moderate Additive CNS depression effects by the combination of Midazolam and Tizanidine. Tonus and reflex abnormality [MB47] [79]
Sirolimus DMGW1ID Moderate Increased plasma concentrations of Midazolam and Sirolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [75]
Tacrolimus DMZ7XNQ Moderate Increased plasma concentrations of Midazolam and Tacrolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [75]
Amiodarone DMUTEX3 Minor Potentiate the pharmacologic effects by the combination of Midazolam and Amiodarone. Ventricular tachyarrhythmia [BC71] [80]
⏷ Show the Full List of 99 DDI Information of This Drug

References

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39 Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
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41 Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
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43 Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
44 Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
45 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
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47 Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
48 Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
49 Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
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51 Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
52 Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
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54 Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
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56 Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
57 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
58 Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
59 Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
60 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
61 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
62 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
63 Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
64 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
65 Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
66 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
67 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
68 Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
69 Product Information. Gattex (teduglutide). NPS Pharmaceuticals, Bedminster, NJ.
70 Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
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72 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
73 Product Information. Zantac (ranitidine). Glaxo Wellcome, Research Triangle Park, NC.
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75 Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
76 Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
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78 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
79 Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
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