Details of the Drug Combinations

General Information of This Drug (ID: DMYLOVR)

Drug Name
Aciclovir   DMYLOVR
Synonyms
acyclovir; Acycloguanosine; 59277-89-3; Zovirax; Vipral; Virorax; Wellcome-248U; 9-[(2-Hydroxyethoxy)methyl]guanine; Aciclovirum; Zovir; Aciclovirum [Latin]; Sitavig; Aciclovier; Zyclir; 9-HYROXYETHOXYMETHYLGUANINE; Aciclovirum [INN-Latin]; 2-Amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one; W-248-U; 9-(2-Hydroxyethoxy)methylguanine; Acyclovir-side chain-2-3H; ACYCLOVIR SODIUM; 9-((2-Hydroxyethoxy)methyl)guanine; Acicloftal; Cargosil; BW-248U; UNII-X4HES1O11F; DRG-0008; NSC 645011; CHEBI:2453; CCRIS 1953; Iontophoretic acyclovir
Indication
Disease Entry ICD 11 Status REF
Genital herpes 1A94 Approved [1]
Herpes simplex encephalitis N.A. Approved [2]
Herpes simplex infection 1F00 Approved [3]
Herpes simplex labialis 1F00.01 Approved [4]
Varicella 1E90 Approved [5]
Virus infection 1A24-1D9Z Approved [6]
Herpes simplex virus infection 1F00 Phase 3 [7]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antiviral Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

93 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole + Aciclovir DC9KP77 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Acamprosate + Aciclovir DCVHPKT Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Dantrolene DCV62LL Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Diethylcarbamazine DCBEUQY Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + GYKI-52466 DCD23RF GYKI-52466 Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Tacrine DCJ7VQD Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Vinblastine DCDNBMK Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Mephenytoin DC5QWDY Mephenytoin Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Pazopanib HCl DCMZ18O Pazopanib HCl Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Ezetimibe DC6J0OH Ezetimibe Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Methylergonovine DCRQ4CR Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Isosorbide dinitrate DCGTSAB Isosorbide dinitrate Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Metyrosine DCEF2MQ Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Docetaxel DCGBHWJ Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Sulfinpyrazone DCP40UN Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Pazopanib DCYW2DT Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Nizatidine DCBHW4Y Nizatidine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Mecamylamine DC0GDMJ Mecamylamine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Pentamidine DCCGJR1 Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Triflupromazine DC35DLQ Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + PF-02545920 DCHF1HD PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Trazodone DCSBRRS Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Pargyline DCOEDBQ Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Idarubicin DC6641V Idarubicin Glioblastoma? (Cell Line: T98G) [8]
Aciclovir + Cefmenoxime DCFBEBE Cefmenoxime Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Trimethobenzamide DC4TMC1 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Leflunomide DCDMBGZ Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Brincidofovir DCV1AU4 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Asenapine DCJJXPY Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Naltrexone DCRORYY Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Silver sulfadiazine DCEMG26 Silver sulfadiazine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Testolactone DCE7ZCH Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Auranofin DC77Z7N Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + AS-1949490 DCYDNN0 AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aciclovir + Tetracycline DC0GIZ0 Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Aliskiren + Aciclovir DC3T340 Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Anamorelin + Aciclovir DCHIGHJ Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Atenolol + Aciclovir DCS21IQ Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
BIO-300 + Aciclovir DCE1261 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Brincidofovir + Aciclovir DCEAZ3H Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Cerivastatin + Aciclovir DCM2G7B Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Chloroquine + Aciclovir DCYKV2W Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Cinacalcet + Aciclovir DCRRSOC Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Cytarabine + Aciclovir DCH1NHO Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Diphenidol + Aciclovir DCOSKLK Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Doxorubicin + Aciclovir DC2LQNH Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Emetine + Aciclovir DCAHQW1 Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Endoxifen + Aciclovir DCIBYTV Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Entacapone + Aciclovir DCH815B Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Ethinyl estradiol + Aciclovir DCJY9F3 Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
ETHISTERONE + Aciclovir DCDEEUP ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Etomidate + Aciclovir DCCPP53 Etomidate Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Fenoprofen + Aciclovir DCWSURE Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Fibrates + Aciclovir DCZX4KE Fibrates Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Fomepizole + Aciclovir DCZJ3UE Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Gefitinib + Aciclovir DCPTZA6 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Ginsenoside Rb1 + Aciclovir DC85I2U Ginsenoside Rb1 Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Hyodeoxycholic acid + Aciclovir DC0OHIN Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Imatinib + Aciclovir DC9BYKU Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Isoproterenol + Aciclovir DC26LCR Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
IT-141 + Aciclovir DCZ5R5L IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Kanamycin + Aciclovir DCOM9UO Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
L-165041 + Aciclovir DC3F77P L-165041 Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Lacosamide + Aciclovir DCICNUA Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Lefaxin + Aciclovir DCYW2PV Lefaxin Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
LY03004 + Aciclovir DCBQHFP LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Maprotiline + Aciclovir DCB22DG Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Meclofenamic acid + Aciclovir DCI9Z1I Meclofenamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Mefloquine + Aciclovir DCO9JL1 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Metformin + Aciclovir DC34BDD Metformin Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Methylene blue + Aciclovir DCUSYR3 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Miglustat + Aciclovir DCYTT30 Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Mycophenolic acid + Aciclovir DCHQCZT Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Oseltamivir + Aciclovir DC8I14E Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Paromomycin + Aciclovir DCAD12T Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Pentamidine + Aciclovir DCHDOYV Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Pepstatin + Aciclovir DC29OI6 Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Pinacidil + Aciclovir DCU6ASJ Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Pizotyline + Aciclovir DCM02BB Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
PMID28460551-Compound-2 + Aciclovir DCLM74N PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Quinine + Aciclovir DCR4TPP Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Ramelteon + Aciclovir DCM9CHA Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Rufinamide + Aciclovir DCL1ACS Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Sorafenib + Aciclovir DCTXLMT Sorafenib Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Spironolactone + Aciclovir DCL6B98 Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Testosterone + Aciclovir DCR1OKS Testosterone Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Tiagabine + Aciclovir DCX6IRO Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Topotecan + Aciclovir DC9LRSK Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [9]
Triapine + Aciclovir DCTMF6K Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [9]
Triiodothyronine + Aciclovir DC7ZB82 Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Trioxsalen + Aciclovir DCPRAAY Trioxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Tropisetron + Aciclovir DCHM31F Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
Zaleplon + Aciclovir DCNLE0X Zaleplon Chronic myelogenous leukemia (Cell Line: KBM-7) [8]
------------------------------------------------------------------------------------
⏷ Show the Full List of 93 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Tobramycin + Aciclovir DC1AOQH Tobramycin Corneal Ulcer [10]
Bortezomib + Aciclovir DCLECW6 Bortezomib Non-Small Cell Lung Cancer [11]
------------------------------------------------------------------------------------

References

1 Genital herpes. BMJ Clin Evid. 2011 Apr 15;2011:1603.
2 Management of suspected viral encephalitis in adults--Association of British Neurologists and British Infection Association National Guidelines. J Infect. 2012 Apr;64(4):347-73.
3 Prevention and management of genital herpes simplex infection during pregnancy and delivery: Guidelines from the French College of Gynaecologists and Obstetricians (CNGOF). Eur J Obstet Gynecol Reprod Biol. 2018 May;224:93-101.
4 Interventions for prevention of herpes simplex labialis (cold sores on the lips). Cochrane Database Syst Rev. 2015 Aug 7;2015(8):CD010095.
5 Neonatal varicella. Arch Dis Child. 2023 Oct 31:archdischild-2022-324820.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4829).
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
8 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
9 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
10 ClinicalTrials.gov (NCT05313828) Effect of Various Treatment Modalities on Dendritic Vial Ulcer
11 ClinicalTrials.gov (NCT01833143) Bortezomib in KRAS-Mutant Non-Small Cell Lung Cancer in Never Smokers or Those With KRAS G12D