Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMW0ZBF)

Drug Name
SULFATE Drug Info
Synonyms
sulfate; Sulfate ion; Sulphate; Sulfate(2-); Sulfate ions; Sulfate (ion); Sulfate radical anion; 14808-79-8; Sulfate dianion; Sulfate anion; UNII-7IS9N8KPMG; tetraoxosulfate(2-); Sulfate anion(2-); 7IS9N8KPMG; Sulfate (7CI,8CI,9CI); SO4(2-); Sulfate-35S; SULFATE STANDARD; Sulfate (S-35); Sulphate Ion; tetraoxosulfate(VI); tetraoxidosulfate(2-); Zirconium Basic sulfate; AC1L1ARH; sulfuric acid, ion(2-); Colistin Sulfate (mixture); CHEMBL183495; CHEBI:16189; CTK0H6976; BDBM26992; QAOWNCQODCNURD-UHFFFAOYSA-L; SO42-; SO4-2; SO4--
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1117
ChEBI ID
CHEBI:16189
CAS Number
CAS 14808-79-8
TTD Drug ID
DMW0ZBF
VARIDT Drug ID
DR00060
INTEDE Drug ID
DR2127

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Sulfate transporter (SLC26A2) DTFSLX5 S26A2_HUMAN Investigative [2]
Sodium/sulfate cotransporter 1 (SLC13A1) DTIZEMV S13A1_HUMAN Investigative [3]
Na(+)/sulfate cotransporter SUT-1 (SLC13A4) DTJZ7W2 S13A4_HUMAN Investigative [4]
Sulfate anion transporter 1 (SLC26A1) DTJ785O S26A1_HUMAN Investigative [5]
Anion exchange transporter (SLC26A7) DTOTME4 S26A7_HUMAN Investigative [6]
Anion exchange transporter (SLC26A6) DTVGOLN S26A6_HUMAN Investigative [7]
Mitochondrial dicarboxylate carrier (SLC25A10) DTJYKDQ DIC_HUMAN Investigative [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Sulfurylase kinase 1 (PAPSS1) DEDG68B PAPS1_HUMAN Investigative [9]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Na(+)/sulfate cotransporter SUT-1 (SLC13A4) DTP SUT1 5.174 5.609 6.022 5.567
Mitochondrial dicarboxylate carrier (SLC25A10) DTP DIC 6.747 5.062 5.44 5.564
Sulfate anion transporter 1 (SLC26A1) DTP SAT1 4.681 4.466 3.567 4.07
Sodium/sulfate cotransporter 1 (SLC13A1) DTP NAS1 2.485 2.433 6.142 2.621
Sulfate transporter (SLC26A2) DTP SLC26A2 3.433 11.126 6.859 8.362
Sulfurylase kinase 1 (PAPSS1) DME PAPSS1 6.385 7.805 8.308 7.549
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Anion exchange transporter (SLC26A6) DTP SLC26A6 1.80E-12 5.81E-01 8.21E-01
Anion exchange transporter (SLC26A7) DTP SLC26A7 3.16E-11 -3.62E-01 -7.55E-01
Na(+)/sulfate cotransporter SUT-1 (SLC13A4) DTP SUT1 2.61E-01 -1.01E-02 -4.53E-02
Mitochondrial dicarboxylate carrier (SLC25A10) DTP DIC 3.82E-09 1.18E-01 2.74E-01
Sulfate anion transporter 1 (SLC26A1) DTP SAT1 5.67E-05 5.64E-02 2.48E-01
Sodium/sulfate cotransporter 1 (SLC13A1) DTP NAS1 1.25E-01 1.66E-02 1.69E-01
Sulfate transporter (SLC26A2) DTP SLC26A2 1.49E-01 -2.01E-01 -2.74E-01
Sulfurylase kinase 1 (PAPSS1) DME PAPSS1 1.43E-01 -1.63E-01 -3.60E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.
2 Regulated transport of sulfate and oxalate by SLC26A2/DTDST. Am J Physiol Cell Physiol. 2010 Jun;298(6):C1363-75.
3 Na+-sulfate cotransporter SLC13A1. Pflugers Arch. 2014 Jan;466(1):131-7.
4 Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice. Cell Res. 2015 Nov;25(11):1273-6.
5 Mutations in SLC26A1 Cause Nephrolithiasis. Am J Hum Genet. 2016 Jun 2;98(6):1228-1234.
6 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.6)
7 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.7)
8 SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Hum Mol Genet. 2018 Feb 1;27(3):499-504.
9 Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains. Biochemistry. 2004 Apr 13;43(14):4356-65.