Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1794O)

Drug Name

Pyrethroids Drug Info

Synonyms

resmethrin; 10453-86-8; Benzofuroline; For-syn; Penncapthrin; Resmethrine; Benzyfuroline; Isathrine; Enforcer; Chryson; Synthrin; Pyresthrin; Premgard; Crossfire; Chrysron; Resmethrin [ANSI]; Resbuthrin; Caswell No. 083E; Bioresmethrine; SB Pennick 1382; Penick 1382; Resmetrina [Portuguese]; ARI-B; Resmethrine [ISO-French]; S.B. Penick 1382; d-trans-Resmethrin; 5-Benzylfurfuryl chrysanthemate; NRDC 104; Bioresmethrin (d trans isomer); CCRIS 2501; HSDB 1516; SBP-1382; OMS-1206; EINECS 233-940-7; FMC 17370; ENT 27474; NIA 17370

Indication

Disease Entry	ICD 11	Status	REF
Pest attack	N.A.	Phase 2	[1]

Cross-matching ID

PubChem CID: 5053
ChEBI ID: CHEMBL8811
CAS Number: CAS 10453-86-8
TTD Drug ID: DM1794O
INTEDE Drug ID: DR1868

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[7]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[8]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[11]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[12]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[13]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[14]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[15]
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Drug(s) Metabolized By Carboxylesterase 3 (CES3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[16]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[17]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[18]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[19]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[20]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[31]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[32]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
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Drug(s) Affected By Parkinson disease protein 7 (PARK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[5]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[40]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[41]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[42]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[43]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[2]
Carboxylesterase 3 (CES3)	DEMI4VE	EST3_HUMAN	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[3]
Nuclear receptor subfamily 1 group I member 3 (NR1I3)	OTS3SGH7	NR1I3_HUMAN	Gene/Protein Processing	[4]
Parkinson disease protein 7 (PARK7)	OT0SKNTG	PARK7_HUMAN	Gene/Protein Processing	[5]

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