General Information of Drug (ID: DM20DXS)

Drug Name
3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione Drug Info
Synonyms CHEMBL25735; 3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
13660221
TTD Drug ID
DM20DXS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anastrozole DMNP60F Breast cancer 2C60-2C65 Approved [2]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [3]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [3]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [4]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [5]
Testolactone DMVY4GN Breast cancer 2C60-2C65 Approved [6]
LIAROZOLE DM4OYXE Dermatological disease DA24.Y Phase 2/3 [7]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [8]
BGS-649 DMO4MNQ Endometriosis GA10 Phase 2 [9]
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [7]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [10]
MK-5684 DMU93NS Prostate cancer 2C82.0 Phase 1/2 [11]
3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione DMD5YKO Discovery agent N.A. Investigative [1]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [1]
Cholesterol desmolase (CYP11A1) TTSYVO6 CP11A_HUMAN Inhibitor [1]

References

1 Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem. 1986 Aug;29(8):1362-9.
2 Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome. J Pediatr Endocrinol Metab. 2002;15 Suppl 3:945-8.
3 Aromatase inhibitors--theoretical concept and present experiences in the treatment of endometriosis. Zentralbl Gynakol. 2003 Jul-Aug;125(7-8):247-51.
4 Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2007 Jul;20(7):1038-45.
5 Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach. J Med Chem. 2005 Nov 17;48(23):7282-9.
6 Aromatase inhibitors for male infertility. J Urol. 2002 Feb;167(2 Pt 1):624-9.
7 Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64.
8 Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. J Med Chem. 2010 Mar 11;53(5):2155-70.
9 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032111)
10 Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma. Cell Immunol. 2000 Nov 25;206(1):7-15.
11 Clinical pipeline report, company report or official report of Merck