Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM27WCE)

Drug Name
NEUROTENSIN Drug Info
Synonyms
CHEMBL407196; 55508-42-4; 58889-67-1; Neurotensin (ox); (D-Tyr11)neurotensin; Neurotensin 1-13; 11-Tyr-neurotensin; Neurotensin, tyr(11)-; Neurotensin, tyrosine(11)-; GTPL1579; Neurotensin, > MolPort-016-581-032; Neurotensin (ox), 11-D-tyrosine-; MFCD00076678; BDBM50130880; NCGC00167274-01; NT(1-13); 889N671; pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu; pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
25077406
ChEBI ID
CHEBI:7542
CAS Number
CAS 39379-15-2
TTD Drug ID
DM27WCE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Neurotensin receptor type 1 (NTSR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclinertant DMBIO6E Inflammatory bowel disease DD72 Phase 2/3 [6]
ABS-212 DMZ52P6 Pain MG30-MG3Z Terminated [7]
CGX-1160 DMADYF7 Acute or chronic pain MG30-MG31 Terminated [8]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G Discovery agent N.A. Investigative [9]
JMV458 DMC1ARG Discovery agent N.A. Investigative [10]
Neurotensin(8-13) DMOBU62 N. A. N. A. Investigative [11]
JMV449 DME9GF8 Discovery agent N.A. Investigative [12]
SR48527 DMUHQS9 Discovery agent N.A. Investigative [13]
HBN-2 DM5VDU2 Neurological disorder 6B60 Investigative [14]
[3H]meclinertant DMEX6GT Discovery agent N.A. Investigative [13]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [15]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [17]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [18]
Isoflavone DM7U58J N. A. N. A. Phase 4 [19]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [20]
Hexadecanoic acid DMWUXDZ Discovery agent N.A. Investigative [21]
⏷ Show the Full List of 17 Drug(s)
Drug(s) Affected By Neurotensin receptor type 2 (NTSR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [20]
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [22]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Verapamil DMA7PEW Angina pectoris BA40 Approved [24]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [24]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [31]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [34]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [39]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fos-related antigen 1 (FOSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [43]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [47]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [48]
Leflunomide DMR8ONJ Arthritis FA20 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor JunB (JUNB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [22]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [53]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [54]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [56]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [57]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Gefitinib DM15F0X Colon adenocarcinoma Approved [58]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [65]
Selenium DM25CGV N. A. N. A. Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [67]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [72]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [73]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [74]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [75]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [76]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [77]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [78]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [79]
Epinephrine DM3KJBC Acute asthma CA23 Approved [80]
Chlorthalidone DM4DMBT Edema MG29 Approved [81]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neurotensin receptor type 1 (NTSR1) TTTUMEP NTR1_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Gene/Protein Processing [3]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [3]
Neurotensin receptor type 1 (NTSR1) OTTJUTE3 NTR1_HUMAN Protein Interaction/Cellular Processes [4]
Neurotensin receptor type 2 (NTSR2) OTQ4WS0O NTR2_HUMAN Protein Interaction/Cellular Processes [4]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Gene/Protein Processing [3]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [3]
Renin (REN) OT52GZR2 RENI_HUMAN Drug Response [5]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Gene/Protein Processing [3]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Gene/Protein Processing [3]

References

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