Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3C5GZ)

Drug Name
FADROZOLE Drug Info
Synonyms
102676-47-1; CGS-16949A; Fadrozole [INN]; Fadrozolum [INN-Latin]; Fadrozol [INN-Spanish]; CHEMBL9298; Fadrozole (INN); 5-p-cyanophenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine; Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo(1,5-a)pyridin-5-yl)-; Fadrozolum; Fadrozol; 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonitrile; Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Cross-matching ID
PubChem CID
59693
ChEBI ID
CHEBI:94355
CAS Number
CAS 102676-47-1
TTD Drug ID
DM3C5GZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anastrozole DMNP60F Breast cancer 2C60-2C65 Approved [7]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [8]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [8]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [9]
Testolactone DMVY4GN Breast cancer 2C60-2C65 Approved [10]
LIAROZOLE DM4OYXE Dermatological disease DA24.Y Phase 2/3 [11]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [12]
BGS-649 DMO4MNQ Endometriosis GA10 Phase 2 [13]
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [11]
FORMESTANE DMWIDJK Breast cancer 2C60-2C65 Withdrawn from market [14]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Fluoxetine DM3PD2C Bipolar depression Approved [29]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [34]
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Drug(s) Targeting Steroid 11-beta-hydroxylase (CYP11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Osilodrostat DMIJC9X Cushing disease 5A70 Approved [15]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [16]
4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol DM6Z5EK Discovery agent N.A. Investigative [17]
4-Indan-(1Z)-ylidenemethyl-pyridine DM25DR7 Discovery agent N.A. Investigative [18]
4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine DMIEMWA Discovery agent N.A. Investigative [17]
4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMY08FE Discovery agent N.A. Investigative [18]
5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine DM2RIHT Discovery agent N.A. Investigative [18]
4-((1H-imidazol-1-yl)methyl)benzonitrile DMFUBRC Discovery agent N.A. Investigative [3]
4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMHDZUO Discovery agent N.A. Investigative [18]
4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine DMQKHXN Discovery agent N.A. Investigative [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [22]
Testosterone DM7HUNW Hot flushes GA30 Approved [22]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [23]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [24]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [24]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [25]
Duloxetine DM9BI7M Depression 6A70-6A7Z Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Ethanol DMDRQZU Chronic pain MG30 Approved [38]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [39]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [42]
Anacetrapib DMP2BFG Arteriosclerosis BD40 Phase 3 [42]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
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Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [44]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [39]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [46]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [47]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [45]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [48]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [49]
Testosterone DM7HUNW Hot flushes GA30 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lanosterol 14-alpha demethylase (CYP51A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [53]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [54]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Leflunomide DMR8ONJ Arthritis FA20 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [58]
Methoxsalen DME8FZ9 Cutaneous T-cell lymphoma 2B01 Approved [59]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [62]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [63]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [66]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [67]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [2]
Steroid 11-beta-hydroxylase (CYP11B1) TTIQUX7 C11B1_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [4]
Cytochrome P450 11B1, mitochondrial (CYP11B1) OTKKL894 C11B1_HUMAN Gene/Protein Processing [4]
Cytochrome P450 11B2, mitochondrial (CYP11B2) OTIOLWYN C11B2_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Regulation of Drug Effects [5]
Lanosterol 14-alpha demethylase (CYP51A1) OTAYHG9C CP51A_HUMAN Gene/Protein Processing [6]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Gene/Protein Processing [4]

References

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63 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
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