Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3FXMA)

Drug Name

Naloxone Drug Info

Synonyms

Nalone; Nalossone; Naloxona; Naloxonum; Narcan; Narcanti; Narcon; DBL Naloxone; Nalossone [DCIT]; Naloxone HCl; EN 1530base; DBL Naloxone (TN); L-Naloxone; N-Allylnoroxymorphone; Nalone (TN); Naloxona [INN-Spanish]; Naloxone (INN); Naloxone [INN:BAN]; Naloxonum [INN-Latin]; Narcan (TN); Narcanti (TN); N-Allyl-noroxymorphone; L-N-Allyl-14-hydroxynordihydromorphinone; L-N-Allyl-7,8-dihydro-14-hydroxynormorphinone; N-Allyl-4,5alpha-epoxy-3,14-dihydroxy-6-morphinanon; Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-(8CI); Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-(9CI); (-)-N-allyl-14-hydroxynordihydroxymorphinan-6-one; (-)-Naloxone; (5alpha)-3,14-dihydroxy-17-prop-2-en-1-yl-4,5-epoxymorphinan-6-one; (5alpha)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one; 1-N-Allyl-14-hydroxynordihydromorphinone; 1-N-Allyl-7,8-dihydro-14-hydroxynormorphinone; 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furanone; 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5(6H)-one; 17-Allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one; 17-Allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one; 17-allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one; 3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5alpha-epoxymorphinan-6-one

Indication

Disease Entry	ICD 11	Status	REF
Narcotic depression	6A7Z	Approved	[1]
Pain	MG30-MG3Z	Approved	[2]
Pruritus	EC90	Phase 3	[3]
Respiratory depression	MD11.5	Phase 3	[4]
Opioid dependence	6C43.2Z	Phase 1	[4]

Therapeutic Class

Antinarcotic Agents

Cross-matching ID

PubChem CID: 5284596
ChEBI ID: CHEMBL80
CAS Number: CAS 465-65-6
TTD Drug ID: DM3FXMA
VARIDT Drug ID: DR00698

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Opioid receptor mu (MOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[12]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[13]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[14]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[15]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[16]
Alfentanil	DMVO0UB	Anaesthesia	9A78.6	Approved	[17]
Naloxegol	DML0B41	Opioid-induced constipation	DB32.1	Approved	[18]
Eluxadoline	DMYZ0P1	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[19]
Nalfurafine hcl	DMA9DHW	Uremic pruritus	EC90.10	Approved	[20]
Oxycodone	DMXLKHV	Osteoarthritis	FA00-FA05	Approved	[21]
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Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[22]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[23]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[24]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[25]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[26]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[27]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[28]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[29]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[30]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[31]
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Drug(s) Affected By Natriuretic peptides A (NPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[32]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[35]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[36]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[40]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[41]
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Drug(s) Affected By Vasopressin-neurophysin 2-copeptin (AVP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Oxprenolol	DM51OQW	Anxiety		Approved	[43]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[45]
Luvox	DMJKROX	Anxiety disorder	6B00-6B0Z	Approved	[46]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[47]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[11]
Chlorpropamide	DMPHZQE	Non-insulin dependent diabetes	5A11	Approved	[48]
Indomethacin	DMSC4A7	Bursitis		Approved	[49]
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Drug(s) Affected By Pro-opiomelanocortin (POMC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[50]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[51]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[52]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[53]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[54]
Triamcinolone	DM98IXF	Acute adrenal insufficiency		Approved	[55]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[56]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[57]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[58]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[59]
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Drug(s) Affected By Lutropin subunit beta (LHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[60]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[63]
Alprazolam	DMC7XDN	Anxiety		Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[61]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[6]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[65]
Ganirelix	DMGMB30	Ovulation dysfunction	5A80	Approved	[66]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor mu (MOP)	TTKWM86	OPRM_HUMAN	Antagonist	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Lutropin subunit beta (LHB)	OT5GBOVJ	LSHB_HUMAN	Gene/Protein Processing	[6]
Natriuretic peptides A (NPPA)	OTMQNTNX	ANF_HUMAN	Gene/Protein Processing	[7]
Pro-opiomelanocortin (POMC)	OTV41F7T	COLI_HUMAN	Gene/Protein Processing	[8]
Renin (REN)	OT52GZR2	RENI_HUMAN	Gene/Protein Processing	[9]
UDP-glucuronosyltransferase 2B7	OT2Q71VQ	UD2B7_HUMAN	Biotransformations	[10]
Vasopressin-neurophysin 2-copeptin (AVP)	OTAVZ76K	NEU2_HUMAN	Protein Interaction/Cellular Processes	[11]

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References

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