Details of the Drug

General Information of Drug (ID: DMPRI8G)

Drug Name
Buprenorphine
Synonyms
Buprel; Buprenex; Buprenophine; Buprenorfina; Buprenorphinum; Probuphine; Temgesic; Buprenorphine Hcl; RX 6029M; Buprenex (TN); Buprenorfina [INN-Spanish]; Buprenorphine [INN:BAN]; Buprenorphinum [INN-Latin]; Subutex (TN); Temgesic (TN); Buprenorphine (JAN/INN); RX-6029-M; Suboxone (TN); [5alpha,7alpha(S)]-17-(Cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol; (-)-buprenorphine; (5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-(methyloxy)-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol; (5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol; 17-Cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl-6-methoxy-6,14-endo-ethanomorphinan-3-ol; 17-cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol; 2-(N-Cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-7alpha-yl)-3,3-dimethyl-2-butanol; 2-(N-cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol; 21-(Cyclopropyl-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 21-cyclopropyl-7alpha-(2-hydroxy-3,3-dimethyl-2-butyl)-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 21-cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 6,14-Ethenomorphinan-7-methanol; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (alphaS,5alpha,7alpha)-(9CI); 6029-M
Indication
Disease Entry ICD 11 Status REF
Opioid dependence 6C43.2Z Approved [1]
Pain MG30-MG3Z Approved [2]
Psychiatric disorder 6E8Z Phase 3 [3]
Migraine 8A80 Phase 2 [4]
Chronic pain MG30 Investigative [1]
Therapeutic Class
Analgesics
Affected Organisms
Humans and other mammals
ATC Code
N02AE01: Buprenorphine
N02AE: Oripavine derivatives
N02A: OPIOIDS
N02: ANALGESICS
N: NERVOUS SYSTEM
N02AE01: Buprenorphine
N02AE: Oripavine derivatives
N02A: OPIOIDS
N02: ANALGESICS
N: NERVOUS SYSTEM
N02AE01: Buprenorphine
N02AE: Oripavine derivatives
N02A: OPIOIDS
N02: ANALGESICS
N: NERVOUS SYSTEM
N07BC01: Buprenorphine
N07BC: Drugs used in opioid dependence
N07B: DRUGS USED IN ADDICTIVE DISORDERS
N07: OTHER NERVOUS SYSTEM DRUGS
N: NERVOUS SYSTEM
N07BC01: Buprenorphine
N07BC: Drugs used in opioid dependence
N07B: DRUGS USED IN ADDICTIVE DISORDERS
N07: OTHER NERVOUS SYSTEM DRUGS
N: NERVOUS SYSTEM
N07BC01: Buprenorphine
N07BC: Drugs used in opioid dependence
N07B: DRUGS USED IN ADDICTIVE DISORDERS
N07: OTHER NERVOUS SYSTEM DRUGS
N: NERVOUS SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 467.6
Logarithm of the Partition Coefficient (xlogp) 5
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 7.651 mcgh/L [5]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 0.780 mcg/L [5]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1.5 h [5]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [6]
Clearance
The drug present in the plasma can be removed from the body at the rate of 19 mL/min/kg [7]
Elimination
It is primarily eliminated via feces (as free forms of buprenorphine and norbuprenorphine) while 10 - 30% of the dose is excreted in urine (as conjugated forms of buprenorphine and norbuprenorphine) []
Half-life
The concentration or amount of drug in body reduced by one-half in 30.75 hours (sublingually adminutesistered buprenorphine/naloxone 2mg/0.5mg) [5]
Metabolism
The drug is metabolized via the cytochrome P450 3A4/3A5-mediated N-dealkylation [5]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.03666 micromolar/kg/day [8]
Unbound Fraction
The unbound fraction of drug in plasma is 0.04% [7]
Vd
The volume of distribution (Vd) of drug is 188-335 L []
Water Solubility
The ability of drug to dissolve in water is measured as 17 mg/mL [6]
Chemical Identifiers
Formula
C29H41NO4
IUPAC Name
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Canonical SMILES
C[C@]([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)(C(C)(C)C)O
InChI
InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1
InChIKey
RMRJXGBAOAMLHD-IHFGGWKQSA-N
Cross-matching ID
PubChem CID
644073
ChEBI ID
CHEBI:3216
CAS Number
52485-79-7
UNII
40D3SCR4GZ
DrugBank ID
DB00921
TTD ID
D06AWE
INTEDE ID
DR0246
ACDINA ID
D00082
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Opioid receptor mu (MOP) TTKWM86 OPRM_HUMAN Agonist [9]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [10]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [11]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [12]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [13]
Cytochrome P450 3A5 (CYP3A5)
Main DME 		DEIBDNY CP3A5_HUMAN Substrate [14]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [15]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [12]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Substrate [16]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Gene/Protein Processing [17]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [17]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Gene/Protein Processing [18]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Gene/Protein Processing [18]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [18]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [18]
UDP-glucuronosyltransferase 1A1 OTH1C8OJ UD11_HUMAN Biotransformations [19]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Opioid dependence
ICD Disease Classification 6C43.2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Opioid receptor mu (MOP) DTT OPRM1 5.94E-01 -0.02 -0.17
Cytochrome P450 2C18 (CYP2C18) DME CYP2C18 7.90E-01 3.72E-02 2.95E-01
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME UGT1A1 1.87E-01 4.98E-02 3.61E-01
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 3.17E-01 -6.95E-02 -2.88E-01
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 5.09E-02 -5.62E-02 -5.19E-01
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 5.64E-01 2.36E-02 1.75E-01
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 7.83E-01 2.32E-03 1.53E-02
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 6.06E-01 -2.42E-02 -1.64E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Buprenorphine
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Oxymorphone DM65AGJ Major Additive hypotensive effects by the combination of Buprenorphine and Oxymorphone. Pain [MG30-MG3Z] [20]
Dezocine DMJDB0Y Major Additive CNS depression effects by the combination of Buprenorphine and Dezocine. Pain [MG30-MG3Z] [20]
Flavoxate DMKV4NL Moderate Additive antimotility effects by the combination of Buprenorphine and Flavoxate. Pain [MG30-MG3Z] [21]
Hydrocodone DMQ2JO5 Major Additive CNS depression effects by the combination of Buprenorphine and Hydrocodone. Pain [MG30-MG3Z] [20]
Ziconotide DMSLJP4 Major Additive CNS depression effects by the combination of Buprenorphine and Ziconotide. Pain [MG30-MG3Z] [22]
Coadministration of a Drug Treating the Disease Different from Buprenorphine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Buprenorphine and Ivosidenib. Acute myeloid leukaemia [2A60] [23]
Midostaurin DMI6E0R Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Midostaurin. Acute myeloid leukaemia [2A60] [24]
Idarubicin DMM0XGL Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Idarubicin. Acute myeloid leukaemia [2A60] [24]
Arn-509 DMT81LZ Moderate Increased metabolism of Buprenorphine caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [20]
Gilteritinib DMTI0ZO Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Gilteritinib. Acute myeloid leukaemia [2A60] [25]
Oliceridine DM6MDCF Major Additive hypotensive effects by the combination of Buprenorphine and Oliceridine. Acute pain [MG31] [20]
Emapalumab DMZG5WL Moderate Altered metabolism of Buprenorphine due to Emapalumab alters the formation of CYP450 enzymes. Adaptive immunity immunodeficiency [4A01] [26]
Rivastigmine DMG629M Moderate Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Rivastigmine. Alzheimer disease [8A20] [24]
Siltuximab DMGEATB Moderate Altered metabolism of Buprenorphine due to Siltuximab alters the formation of CYP450 enzymes. Anemia [3A00-3A9Z] [26]
Ivabradine DM0L594 Major Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Ivabradine. Angina pectoris [BA40] [26]
Nifedipine DMSVOZT Moderate Decreased metabolism of Buprenorphine caused by Nifedipine mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [20]
Bedaquiline DM3906J Major Increased risk of prolong QT interval by the combination of Buprenorphine and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [27]
Chlormezanone DMTWUXR Major Additive CNS depression effects by the combination of Buprenorphine and Chlormezanone. Anxiety disorder [6B00-6B0Z] [22]
Cilostazol DMZMSCT Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Cilostazol. Arterial occlusive disease [BD40] [24]
Posaconazole DMUL5EW Moderate Decreased metabolism of Buprenorphine caused by Posaconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [20]
Levalbuterol DM5YBO1 Moderate Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Levalbuterol. Asthma [CA23] [28]
Pirbuterol DMI5678 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Pirbuterol. Asthma [CA23] [29]
Salbutamol DMN9CWF Moderate Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Salbutamol. Asthma [CA23] [28]
Formoterol DMSOURV Moderate Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Formoterol. Asthma [CA23] [29]
Lisdexamfetamine DM6W8V5 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Lisdexamfetamine. Attention deficit hyperactivity disorder [6A05] [26]
Desipramine DMT2FDC Moderate Additive CNS depression effects by the combination of Buprenorphine and Desipramine. Attention deficit hyperactivity disorder [6A05] [30]
Ofloxacin DM0VQN3 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Ofloxacin. Bacterial infection [1A00-1C4Z] [31]
Dalfopristin DM4LTKV Moderate Decreased metabolism of Buprenorphine caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [20]
Clarithromycin DM4M1SG Moderate Decreased metabolism of Buprenorphine caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [20]
Sulfamethoxazole DMB08GE Minor Increased risk of prolong QT interval by the combination of Buprenorphine and Sulfamethoxazole. Bacterial infection [1A00-1C4Z] [24]
Sparfloxacin DMB4HCT Major Increased risk of prolong QT interval by the combination of Buprenorphine and Sparfloxacin. Bacterial infection [1A00-1C4Z] [31]
Gemifloxacin DMHT34O Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Gemifloxacin. Bacterial infection [1A00-1C4Z] [31]
Norfloxacin DMIZ6W2 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Norfloxacin. Bacterial infection [1A00-1C4Z] [31]
Levofloxacin DMS60RB Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Levofloxacin. Bacterial infection [1A00-1C4Z] [31]
Troleandomycin DMUZNIG Moderate Decreased metabolism of Buprenorphine caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [20]
Lomefloxacin DMVRH9C Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Lomefloxacin. Bacterial infection [1A00-1C4Z] [24]
Retigabine DMGNYIH Major Additive CNS depression effects by the combination of Buprenorphine and Retigabine. Behcet disease [4A62] [22]
Cariprazine DMJYDVK Major Additive CNS depression effects by the combination of Buprenorphine and Cariprazine. Bipolar disorder [6A60] [22]
Pexidartinib DMS2J0Z Moderate Increased metabolism of Buprenorphine caused by Pexidartinib mediated induction of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [20]
Eribulin DM1DX4Q Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Eribulin. Breast cancer [2C60-2C6Y] [24]
Lapatinib DM3BH1Y Moderate Decreased metabolism of Buprenorphine caused by Lapatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [20]
Tucatinib DMBESUA Moderate Decreased metabolism of Buprenorphine caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [20]
Bosutinib DMTI8YE Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Bosutinib. Breast cancer [2C60-2C6Y] [26]
PF-04449913 DMSB068 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [32]
Olodaterol DM62B78 Moderate Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Olodaterol. Chronic obstructive pulmonary disease [CA22] [29]
Vilanterol DMF5EK1 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Vilanterol. Chronic obstructive pulmonary disease [CA22] [28]
Salmeterol DMIEU69 Moderate Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Salmeterol. Chronic obstructive pulmonary disease [CA22] [29]
Indacaterol DMQJHR7 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Indacaterol. Chronic obstructive pulmonary disease [CA22] [29]
Arformoterol DMYM974 Moderate Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Arformoterol. Chronic obstructive pulmonary disease [CA22] [29]
Dihydrocodeine DMB0FWL Major Additive hypotensive effects by the combination of Buprenorphine and Dihydrocodeine. Chronic pain [MG30] [20]
Levetiracetam DMTGDN8 Major Additive CNS depression effects by the combination of Buprenorphine and Levetiracetam. Chronic pain [MG30] [22]
Levomilnacipran DMV26S8 Moderate Additive CNS depression effects by the combination of Buprenorphine and Levomilnacipran. Chronic pain [MG30] [30]
Isoproterenol DMK7MEY Moderate Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Isoproterenol. Conduction disorder [BC63] [28]
Sevoflurane DMC9O43 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Sevoflurane. Corneal disease [9A76-9A78] [24]
Probucol DMVZQ2M Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Probucol. Coronary atherosclerosis [BA80] [24]
Pasireotide DMHM7JS Major Increased risk of prolong QT interval by the combination of Buprenorphine and Pasireotide. Cushing syndrome [5A70] [24]
Osilodrostat DMIJC9X Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Osilodrostat. Cushing syndrome [5A70] [26]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Buprenorphine caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [20]
MK-8228 DMOB58Q Moderate Decreased metabolism of Buprenorphine caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [20]
Sertraline DM0FB1J Moderate Additive CNS depression effects by the combination of Buprenorphine and Sertraline. Depression [6A70-6A7Z] [30]
Cyclobenzaprine DM1YBRM Major Additive CNS depression effects by the combination of Buprenorphine and Cyclobenzaprine. Depression [6A70-6A7Z] [22]
Vilazodone DM4LECQ Moderate Additive CNS depression effects by the combination of Buprenorphine and Vilazodone. Depression [6A70-6A7Z] [30]
Nefazodone DM4ZS8M Moderate Decreased metabolism of Buprenorphine caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [20]
Vortioxetine DM6F1PU Moderate Additive CNS depression effects by the combination of Buprenorphine and Vortioxetine. Depression [6A70-6A7Z] [30]
Milnacipran DMBFE74 Moderate Additive CNS depression effects by the combination of Buprenorphine and Milnacipran. Depression [6A70-6A7Z] [30]
Escitalopram DMFK9HG Major Increased risk of prolong QT interval by the combination of Buprenorphine and Escitalopram. Depression [6A70-6A7Z] [24]
Desvenlafaxine DMHD4PE Moderate Additive serotonergic effects by the combination of Buprenorphine and Desvenlafaxine. Depression [6A70-6A7Z] [30]
OPC-34712 DMHG57U Major Additive CNS depression effects by the combination of Buprenorphine and OPC-34712. Depression [6A70-6A7Z] [22]
Clomipramine DMINRKW Moderate Additive CNS depression effects by the combination of Buprenorphine and Clomipramine. Depression [6A70-6A7Z] [30]
Doxepin DMPI98T Moderate Additive CNS depression effects by the combination of Buprenorphine and Doxepin. Depression [6A70-6A7Z] [30]
Maprotiline DMPWB7T Moderate Additive CNS depression effects by the combination of Buprenorphine and Maprotiline. Depression [6A70-6A7Z] [30]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Buprenorphine and Esketamine. Depression [6A70-6A7Z] [33]
Mepenzolate DM8YU2F Moderate Additive antimotility effects by the combination of Buprenorphine and Mepenzolate. Digestive system disease [DE2Z] [21]
5-hydroxy-L-tryptophan DMDWZGJ Moderate Additive serotonergic effects by the combination of Buprenorphine and 5-hydroxy-L-tryptophan. Discovery agent [N.A.] [30]
Oxybutynine DMJPBAX Moderate Additive antimotility effects by the combination of Buprenorphine and Oxybutynine. Discovery agent [N.A.] [21]
Heroin diacetylmorphine DMDBWHY Major Additive CNS depression effects by the combination of Buprenorphine and Heroin diacetylmorphine. Dissociative neurological symptom disorder [6B60] [34]
Tetrabenazine DMYWQ0O Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [24]
Deutetrabenazine DMUPFLI Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Deutetrabenazine. Dystonic disorder [8A02] [35]
Ingrezza DMVPLNC Moderate Additive CNS depression effects by the combination of Buprenorphine and Ingrezza. Dystonic disorder [8A02] [36]
Felbamate DM1V5ZS Major Additive CNS depression effects by the combination of Buprenorphine and Felbamate. Epilepsy/seizure [8A61-8A6Z] [22]
Methsuximide DM6L5VO Major Additive CNS depression effects by the combination of Buprenorphine and Methsuximide. Epilepsy/seizure [8A61-8A6Z] [22]
Gabapentin DM6T924 Major Additive CNS depression effects by the combination of Buprenorphine and Gabapentin. Epilepsy/seizure [8A61-8A6Z] [22]
Cenobamate DM8KLU9 Major Additive CNS depression effects by the combination of Buprenorphine and Cenobamate. Epilepsy/seizure [8A61-8A6Z] [22]
Phenacemide DMOHS9P Major Additive CNS depression effects by the combination of Buprenorphine and Phenacemide. Epilepsy/seizure [8A61-8A6Z] [22]
Fosphenytoin DMOX3LB Major Increased metabolism of Buprenorphine caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [37]
Brivaracetam DMSEPK8 Major Additive CNS depression effects by the combination of Buprenorphine and Brivaracetam. Epilepsy/seizure [8A61-8A6Z] [22]
Clonazepam DMTO13J Major Additive CNS depression effects by the combination of Buprenorphine and Clonazepam. Epilepsy/seizure [8A61-8A6Z] [22]
Rufinamide DMWE60C Major Additive CNS depression effects by the combination of Buprenorphine and Rufinamide. Epilepsy/seizure [8A61-8A6Z] [22]
Phenobarbital DMXZOCG Major Additive CNS depression effects by the combination of Buprenorphine and Phenobarbital. Epilepsy/seizure [8A61-8A6Z] [37]
Vigabatrin DMYT0OG Major Additive CNS depression effects by the combination of Buprenorphine and Vigabatrin. Epilepsy/seizure [8A61-8A6Z] [22]
Eslicarbazepine DMZREFQ Major Additive CNS depression effects by the combination of Buprenorphine and Eslicarbazepine. Epilepsy/seizure [8A61-8A6Z] [22]
Cannabidiol DM0659E Major Additive CNS depression effects by the combination of Buprenorphine and Cannabidiol. Epileptic encephalopathy [8A62] [22]
Dantrolene DM1D8XY Major Additive CNS depression effects by the combination of Buprenorphine and Dantrolene. Fever [MG26] [22]
Tazemetostat DMWP1BH Moderate Increased metabolism of Buprenorphine caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [38]
Solifenacin DMG592Q Moderate Additive antimotility effects by the combination of Buprenorphine and Solifenacin. Functional bladder disorder [GC50] [21]
Tolterodine DMSHPW8 Moderate Additive antimotility effects by the combination of Buprenorphine and Tolterodine. Functional bladder disorder [GC50] [21]
Itraconazole DMCR1MV Moderate Decreased metabolism of Buprenorphine caused by Itraconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [20]
Miconazole DMPMYE8 Moderate Decreased metabolism of Buprenorphine caused by Miconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [20]
Ketoconazole DMPZI3Q Moderate Decreased metabolism of Buprenorphine caused by Ketoconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [20]
Sunitinib DMCBJSR Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Sunitinib. Gastrointestinal stromal tumour [2B5B] [24]
Sulfinpyrazone DMEV954 Moderate Increased metabolism of Buprenorphine caused by Sulfinpyrazone mediated induction of CYP450 enzyme. Gout [FA25] [20]
Telaprevir DMMRV29 Moderate Decreased metabolism of Buprenorphine caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [20]
Isoniazid DM5JVS3 Moderate Decreased metabolism of Buprenorphine caused by Isoniazid mediated inhibition of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [20]
Rifapentine DMCHV4I Moderate Increased metabolism of Buprenorphine caused by Rifapentine mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [20]
Fosamprenavir DM4W9B3 Moderate Decreased metabolism of Buprenorphine caused by Fosamprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [20]
Fostemsavir DM50ILT Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [39]
Cobicistat DM6L4H2 Moderate Decreased metabolism of Buprenorphine caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [20]
Saquinavir DMG814N Major Increased risk of prolong QT interval by the combination of Buprenorphine and Saquinavir. Human immunodeficiency virus disease [1C60-1C62] [40]
Etravirine DMGV8QU Moderate Increased metabolism of Buprenorphine caused by Etravirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [41]
Rilpivirine DMJ0QOW Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [24]
Darunavir DMN3GCH Moderate Decreased metabolism of Buprenorphine caused by Darunavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [20]
Atazanavir DMSYRBX Moderate Decreased metabolism of Buprenorphine caused by Atazanavir mediated inhibition of UGT. Human immunodeficiency virus disease [1C60-1C62] [42]
BMS-201038 DMQTAGO Moderate Decreased metabolism of Buprenorphine caused by BMS-201038 mediated inhibition of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [20]
Belladonna DM2RBWK Moderate Additive antimotility effects by the combination of Buprenorphine and Belladonna. Infectious gastroenteritis/colitis [1A40] [21]
Berotralstat DMWA2DZ Moderate Decreased metabolism of Buprenorphine caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [20]
Suvorexant DM0E6S3 Major Additive CNS depression effects by the combination of Buprenorphine and Suvorexant. Insomnia [7A00-7A0Z] [22]
Amobarbital DM0GQ8N Major Additive CNS depression effects by the combination of Buprenorphine and Amobarbital. Insomnia [7A00-7A0Z] [22]
Ramelteon DM7IW9J Major Additive CNS depression effects by the combination of Buprenorphine and Ramelteon. Insomnia [7A00-7A0Z] [22]
Zaleplon DMGFWSM Major Additive CNS depression effects by the combination of Buprenorphine and Zaleplon. Insomnia [7A00-7A0Z] [22]
Tasimelteon DMLOQ1V Major Additive CNS depression effects by the combination of Buprenorphine and Tasimelteon. Insomnia [7A00-7A0Z] [22]
Paraldehyde DMOC1BX Major Additive CNS depression effects by the combination of Buprenorphine and Paraldehyde. Insomnia [7A00-7A0Z] [22]
ITI-007 DMUQ1DO Major Additive CNS depression effects by the combination of Buprenorphine and ITI-007. Insomnia [7A00-7A0Z] [22]
Quazepam DMY4D87 Major Additive CNS depression effects by the combination of Buprenorphine and Quazepam. Insomnia [7A00-7A0Z] [22]
Estazolam DMZGXUM Major Additive CNS depression effects by the combination of Buprenorphine and Estazolam. Insomnia [7A00-7A0Z] [22]
Polyethylene glycol DM4I1JP Moderate Increased risk of lowers seizure threshold by the combination of Buprenorphine and Polyethylene glycol. Irritable bowel syndrome [DD91] [24]
Remimazolam DMLVSYX Major Additive CNS depression effects by the combination of Buprenorphine and Remimazolam. Labour/delivery anaesthesia complication [JB0C] [22]
Crizotinib DM4F29C Major Increased risk of prolong QT interval by the combination of Buprenorphine and Crizotinib. Lung cancer [2C25] [43]
PF-06463922 DMKM7EW Moderate Increased metabolism of Buprenorphine caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [20]
Selpercatinib DMZR15V Major Increased risk of prolong QT interval by the combination of Buprenorphine and Selpercatinib. Lung cancer [2C25] [26]
Lumefantrine DM29GAD Major Increased risk of prolong QT interval by the combination of Buprenorphine and Lumefantrine. Malaria [1F40-1F45] [33]
Halofantrine DMOMK1V Major Increased risk of prolong QT interval by the combination of Buprenorphine and Halofantrine. Malaria [1F40-1F45] [44]
Hydroxychloroquine DMSIVND Major Increased risk of prolong QT interval by the combination of Buprenorphine and Hydroxychloroquine. Malaria [1F40-1F45] [45]
Primaquine DMWQ16I Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Primaquine. Malaria [1F40-1F45] [24]
Inotuzumab ozogamicin DMAC130 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Inotuzumab ozogamicin. Malignant haematopoietic neoplasm [2B33] [26]
Idelalisib DM602WT Moderate Decreased metabolism of Buprenorphine caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [20]
IPI-145 DMWA24P Moderate Decreased metabolism of Buprenorphine caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [20]
Arsenic trioxide DM61TA4 Major Increased risk of prolong QT interval by the combination of Buprenorphine and Arsenic trioxide. Mature B-cell lymphoma [2A85] [46]
Vemurafenib DM62UG5 Major Increased risk of prolong QT interval by the combination of Buprenorphine and Vemurafenib. Melanoma [2C30] [24]
LGX818 DMNQXV8 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and LGX818. Melanoma [2C30] [24]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Buprenorphine caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [20]
Danazol DML8KTN Moderate Decreased metabolism of Buprenorphine caused by Danazol mediated inhibition of CYP450 enzyme. Menstrual cycle bleeding disorder [GA20] [20]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Buprenorphine and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [47]
Frovatriptan DM7RE8P Moderate Additive CNS depression effects by the combination of Buprenorphine and Frovatriptan. Migraine [8A80] [30]
Rizatriptan DMDJMA3 Moderate Additive CNS depression effects by the combination of Buprenorphine and Rizatriptan. Migraine [8A80] [30]
Naratriptan DMO50U2 Moderate Additive CNS depression effects by the combination of Buprenorphine and Naratriptan. Migraine [8A80] [30]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Buprenorphine and Lasmiditan. Migraine [8A80] [48]
Exjade DMHPRWG Moderate Increased metabolism of Buprenorphine caused by Exjade mediated induction of CYP450 enzyme. Mineral absorption/transport disorder [5C64] [20]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Buprenorphine and Flibanserin. Mood disorder [6A60-6E23] [49]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Buprenorphine and Thalidomide. Multiple myeloma [2A83] [50]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Siponimod. Multiple sclerosis [8A40] [33]
Fingolimod DM5JVAN Major Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Fingolimod. Multiple sclerosis [8A40] [24]
Ozanimod DMT6AM2 Major Increased risk of ventricular arrhythmias by the combination of Buprenorphine and Ozanimod. Multiple sclerosis [8A40] [51]
Romidepsin DMT5GNL Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Romidepsin. Mycosis fungoides [2B01] [24]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Buprenorphine caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [20]
Dasatinib DMJV2EK Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Dasatinib. Myeloproliferative neoplasm [2A20] [24]
Prasugrel DM7MT6E Moderate Altered absorption of Buprenorphine due to GI dynamics variation caused by Prasugrel. Myocardial infarction [BA41-BA43] [52]
Metoclopramide DMFA5MY Moderate Additive CNS depression effects by the combination of Buprenorphine and Metoclopramide. Nausea/vomiting [MD90] [53]
E-2007 DMJDYNQ Major Additive CNS depression effects by the combination of Buprenorphine and E-2007. Neuropathy [8C0Z] [22]
Bupropion DM5PCS7 Major Increased risk of lowers seizure threshold by the combination of Buprenorphine and Bupropion. Nicotine use disorder [6C4A] [54]
Entrectinib DMMPTLH Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Entrectinib. Non-small cell lung cancer [2C25] [24]
Sibutramine DMFJTDI Moderate Additive CNS depression effects by the combination of Buprenorphine and Sibutramine. Obesity [5B80-5B81] [30]
Dexfenfluramine DMJ7YDS Moderate Additive serotonergic effects by the combination of Buprenorphine and Dexfenfluramine. Obesity [5B80-5B81] [30]
Levomethadyl Acetate DM06HG5 Major Increased risk of prolong QT interval by the combination of Buprenorphine and Levomethadyl Acetate. Opioid use disorder [6C43] [26]
Lofexidine DM1WXA6 Moderate Additive hypotensive effects by the combination of Buprenorphine and Lofexidine. Opioid use disorder [6C43] [24]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Buprenorphine and Apraclonidine. Optic nerve disorder [9C40] [55]
Rucaparib DM9PVX8 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Rucaparib. Ovarian cancer [2C73] [24]
Triclabendazole DMPWGBR Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Triclabendazole. Parasitic worm infestation [1F90] [24]
Pimavanserin DMR7IVC Major Additive CNS depression effects by the combination of Buprenorphine and Pimavanserin. Parkinsonism [8A00] [22]
Orphenadrine DMW542E Major Additive CNS depression effects by the combination of Buprenorphine and Orphenadrine. Parkinsonism [8A00] [22]
Abametapir DM2RX0I Moderate Decreased metabolism of Buprenorphine caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [56]
Methylscopolamine DM5VWOB Moderate Additive antimotility effects by the combination of Buprenorphine and Methylscopolamine. Peptic ulcer [DA61] [21]
Famotidine DMRL3AB Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Famotidine. Peptic ulcer [DA61] [33]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Buprenorphine and Macimorelin. Pituitary gland disorder [5A60-5A61] [57]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of Buprenorphine and Lefamulin. Pneumonia [CA40] [58]
Lonafarnib DMGM2Z6 Moderate Decreased metabolism of Buprenorphine caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [20]
Degarelix DM3O8QY Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Degarelix. Prostate cancer [2C82] [26]
ABIRATERONE DM8V75C Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and ABIRATERONE. Prostate cancer [2C82] [26]
Enzalutamide DMGL19D Moderate Increased metabolism of Buprenorphine caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [20]
Relugolix DMK7IWL Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Relugolix. Prostate cancer [2C82] [26]
Bicalutamide DMZMSPF Moderate Decreased metabolism of Buprenorphine caused by Bicalutamide mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [20]
Ustekinumab DMHTYK3 Moderate Altered metabolism of Buprenorphine due to Ustekinumab alters the formation of CYP450 enzymes. Psoriasis [EA90] [26]
Ixekizumab DMXW92T Moderate Altered metabolism of Buprenorphine due to Ixekizumab alters the formation of CYP450 enzymes. Psoriasis [EA90] [26]
Temsirolimus DMS104F Moderate Increased plasma concentrations of Buprenorphine and Temsirolimus due to competitive inhibition of the same metabolic pathway. Renal cell carcinoma [2C90] [59]
Gatifloxacin DMSL679 Major Increased risk of prolong QT interval by the combination of Buprenorphine and Gatifloxacin. Respiratory infection [CA07-CA4Z] [60]
Tocilizumab DM7J6OR Moderate Altered metabolism of Buprenorphine due to Tocilizumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [26]
Canakinumab DM8HLO5 Moderate Altered metabolism of Buprenorphine due to Canakinumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [26]
Rilonacept DMGLUQS Moderate Altered metabolism of Buprenorphine due to Rilonacept alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [26]
Golimumab DMHZV7X Moderate Altered metabolism of Buprenorphine due to Golimumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [26]
Dexamethasone DMMWZET Moderate Increased metabolism of Buprenorphine caused by Dexamethasone mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [20]
Sarilumab DMOGNXY Moderate Altered metabolism of Buprenorphine due to Sarilumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [26]
Quetiapine DM1N62C Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Quetiapine. Schizophrenia [6A20] [24]
Aripiprazole DM3NUMH Major Additive CNS depression effects by the combination of Buprenorphine and Aripiprazole. Schizophrenia [6A20] [22]
Iloperidone DM6AUFY Major Increased risk of prolong QT interval by the combination of Buprenorphine and Iloperidone. Schizophrenia [6A20] [24]
Paliperidone DM7NPJS Major Additive CNS depression effects by the combination of Buprenorphine and Paliperidone. Schizophrenia [6A20] [22]
Molindone DMAH70G Major Additive CNS depression effects by the combination of Buprenorphine and Molindone. Schizophrenia [6A20] [22]
Thiothixene DMDINC4 Major Additive CNS depression effects by the combination of Buprenorphine and Thiothixene. Schizophrenia [6A20] [22]
Amisulpride DMSJVAM Major Increased risk of prolong QT interval by the combination of Buprenorphine and Amisulpride. Schizophrenia [6A20] [61]
Asenapine DMSQZE2 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Asenapine. Schizophrenia [6A20] [24]
Pimozide DMW83TP Major Increased risk of prolong QT interval by the combination of Buprenorphine and Pimozide. Schizophrenia [6A20] [26]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Buprenorphine caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [20]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Buprenorphine caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [26]
Larotrectinib DM26CQR Moderate Decreased metabolism of Buprenorphine caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [20]
Armodafinil DMGB035 Minor Increased metabolism of Buprenorphine caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [62]
LEE011 DMMX75K Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and LEE011. Solid tumour/cancer [2A00-2F9Z] [24]
Vandetanib DMRICNP Major Increased risk of prolong QT interval by the combination of Buprenorphine and Vandetanib. Solid tumour/cancer [2A00-2F9Z] [24]
Triptorelin DMTK4LS Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Triptorelin. Solid tumour/cancer [2A00-2F9Z] [26]
Doxorubicin DMVP5YE Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Doxorubicin. Solid tumour/cancer [2A00-2F9Z] [24]
Pitolisant DM8RFNJ Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Pitolisant. Somnolence [MG42] [26]
Telavancin DM58VQX Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Telavancin. Staphylococcal/streptococcal disease [1B5Y] [24]
Fostamatinib DM6AUHV Moderate Decreased metabolism of Buprenorphine caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [63]
Brilinta DMBR01X Moderate Decreased metabolism of Buprenorphine caused by Brilinta mediated inhibition of CYP450 enzyme. Thrombosis [DB61-GB90] [20]
Lenvatinib DMB1IU4 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Lenvatinib. Thyroid cancer [2D10] [24]
Cabozantinib DMIYDT4 Major Increased risk of prolong QT interval by the combination of Buprenorphine and Cabozantinib. Thyroid cancer [2D10] [26]
Papaverine DMCA9QP Major Increased risk of prolong QT interval by the combination of Buprenorphine and Papaverine. Tonus and reflex abnormality [MB47] [64]
Elagolix DMB2C0E Moderate Increased metabolism of Buprenorphine caused by Elagolix mediated induction of CYP450 enzyme. Uterine fibroid [2E86] [20]
Procainamide DMNMXR8 Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Procainamide. Ventricular tachyarrhythmia [BC71] [24]
Propafenone DMPIBJK Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Propafenone. Ventricular tachyarrhythmia [BC71] [24]
Flecainide DMSQDLE Moderate Increased risk of prolong QT interval by the combination of Buprenorphine and Flecainide. Ventricular tachyarrhythmia [BC71] [24]
Amiodarone DMUTEX3 Moderate Decreased metabolism of Buprenorphine caused by Amiodarone mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [24]
⏷ Show the Full List of 214 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Acesulfame E00341 36573 Flavoring agent
Hydrochloric acid E00015 313 Acidulant
Kyselina citronova E00014 311 Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Maltitol E00423 493591 Binding agent; Coating agent; Diluent; Flavoring agent
Mannitol E00103 6251 Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Sodium citrate anhydrous E00102 6224 Alkalizing agent; Buffering agent; Complexing agent; Emulsifying agent
Sodium stearyl fumarate E00545 23665634 lubricant
Sunset yellow FCF E00255 17730 Colorant
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Butylhydroxyanisole E00308 24667 Antimicrobial preservative; Antioxidant
Crospovidone E00626 Not Available Disintegrant
Dextrose anhydrous E00394 107526 Binding agent; Diluent; Flavoring agent; Tonicity agent
Hypromellose E00634 Not Available Coating agent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 4000 E00654 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium citrate dihydrate E00369 71474 Alkalizing agent; Buffering agent; Complexing agent; Emulsifying agent
Vinylpyrrolidone E00668 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Water E00035 962 Solvent
Pregelatinized starch E00674 Not Available Binding agent; Diluent; Disintegrant
⏷ Show the Full List of 22 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Buprenorphine 2 mg tablet 2 mg Sublingual Tablet Oral
Buprenorphine 8 mg tablet 8 mg Sublingual Tablet Oral
Buprenorphine Hydrochloride eq 0.5mg base film eq 0.5mg base Film Buccal; Sublingual
Buprenorphine Hydrochloride eq 2mg base film eq 2mg base Film Buccal; Sublingual
Buprenorphine Hydrochloride eq 2mg base tablet eq 2mg base Tablet Sublingual
Buprenorphine Hydrochloride eq 0.3mg base/ml injectable eq 0.3mg base/ml Injectable Injection
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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47 Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
48 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
49 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
50 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
51 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
52 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
53 Product Information. Reglan (metoclopramide). Wyeth-Ayerst Laboratories, Philadelphia, PA.
54 Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
55 Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
56 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
57 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
58 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
59 Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
60 Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
61 Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
62 Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
63 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
64 Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]