Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3UZ95)

Drug Name

Bisoprolol Drug Info

Synonyms

Bisocor; Bisoprololum; Cardicor; Concor; Detensiel; Emconcor; Emcor; Euradal; Isoten; Monocor; Soloc; Soprol; Zebeta; Bisoprolol fumerate; Bisoprolol hemifumarate; Bisoprololum [Latin]; CL-297939; Concor (TN); Concore (TN); EMD-33512; Monocor (TN); Zebeta (TN); Bisoprolol (USAN/INN); Bisoprolol [USAN:BAN:INN]; EMD-33-512; (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol; (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol; 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol; 1-[(1-methylethyl)amino]-3-({4-[({2-[(1-methylethyl)oxy]ethyl}oxy)methyl]phenyl}oxy)propan-2-ol; 1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1]
Malignant essential hypertension	BA00	Approved	[2]

Therapeutic Class

Antihypertensive Agents

Cross-matching ID

PubChem CID: 2405
ChEBI ID: CHEMBL645
CAS Number: CAS 66722-44-9
TTD Drug ID: DM3UZ95
INTEDE Drug ID: DR0216
ACDINA Drug ID: D00072

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[8]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[9]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[10]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[11]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[11]
Metoprolol	DMOJ0V6	Acute coronary syndrome	BA41	Approved	[11]
Timolol	DM3NXRU	High blood pressure	BA00	Approved	[12]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[13]
Betaxolol	DM6EUL5	Hypertension	BA00-BA04	Approved	[14]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[15]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[17]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[17]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[24]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[26]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[28]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[29]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[30]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[31]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[32]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[33]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[37]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[38]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[43]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[44]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[45]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[46]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[47]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[48]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[49]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[50]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[51]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[49]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Antagonist	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)^{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Regulation of Drug Effects	[6]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[7]

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References

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2	Bisoprolol FDA Label
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