General Information of Drug (ID: DM43GPX)

Drug Name
BVI-007 Drug Info
Indication
Disease Entry ICD 11 Status REF
Myocardial infarction BA41-BA43 Phase 1 [1]
Thrombotic stroke 8B20 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DM43GPX

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [4]
Eltrombopag DMOGFIX Thrombocytopenia 3B64 Approved [5]
Lusutrombopag DMH6IKO Thrombocytopenia 3B64 Approved [6]
AS-1670542 DMV05SW Thrombocytopenia 3B64 Approved [3]
LGD-4665 DM9T8A2 Immune thrombocytopenic purpura 3B64.13 Phase 2 [5]
NIP-004 DM0PYEQ Thrombocytopenia 3B64 Phase 1 [7]
RhTPO DMCV0BZ Idiopathic thrombocytopenic purpura 3B64.10 Discontinued in Phase 3 [5]
Totrombopag DM6SUDC Thrombocytopenia 3B64 Discontinued in Phase 1 [8]
Promegapoietin DMS4FG0 Bone marrow transplantation QB63.6 Terminated [9]
N. A. N. A. [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Thrombopoietin (THPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
A157 DMFP4FX Immune thrombocytopenic purpura 3B64.13 IND submitted [10]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thrombopoietin (THPO) TTCG5PE TPO_HUMAN Inhibitor [2]
Thrombopoietin receptor (MPL) TTIHYA4 TPOR_HUMAN Antagonist [3]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027040)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).
4 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
5 Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
6 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
7 A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7.
8 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
9 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10 Clinical pipeline report, company report or official report of Klus Pharma