Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM43GPX)

Drug Name

BVI-007 Drug Info

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Thrombopoietin receptor (MPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[4]
Eltrombopag	DMOGFIX	Thrombocytopenia	3B64	Approved	[5]
Lusutrombopag	DMH6IKO	Thrombocytopenia	3B64	Approved	[6]
AS-1670542	DMV05SW	Thrombocytopenia	3B64	Approved	[3]
LGD-4665	DM9T8A2	Immune thrombocytopenic purpura	3B64.13	Phase 2	[5]
NIP-004	DM0PYEQ	Thrombocytopenia	3B64	Phase 1	[7]
RhTPO	DMCV0BZ	Idiopathic thrombocytopenic purpura	3B64.10	Discontinued in Phase 3	[5]
Totrombopag	DM6SUDC	Thrombocytopenia	3B64	Discontinued in Phase 1	[8]
Promegapoietin	DMS4FG0	Bone marrow transplantation	QB63.6	Terminated	[9]
SB-559457	DM0OLYF	Acute myeloid leukaemia	2A60	Investigative	[3]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Thrombopoietin (THPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
A157	DMFP4FX	Immune thrombocytopenic purpura	3B64.13	IND submitted	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thrombopoietin (THPO)	TTCG5PE	TPO_HUMAN	Inhibitor	[2]
Thrombopoietin receptor (MPL)	TTIHYA4	TPOR_HUMAN	Antagonist	[3]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027040)
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).
4	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
5	Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
6	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
7	A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7.
8	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
9	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10	Clinical pipeline report, company report or official report of Klus Pharma