Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4IF32)

• Drug Name: Pyrazinamide Drug Info
• Synonyms: Aldinamid; Aldinamide; Braccopiral; Corsazinmid; Dipimide; Eprazin; Farmizina; Isopas; Lynamide; Novamid; Pezetamid; Pharozinamide; Piraldina; Pirazimida; Pirazinamid; Pirazinamida; Pirazinamide; Prazina; Pyrafat; Pyramide; Pyrazide; Pyrazinamdie; Pyrazinamidum; Pyrazineamide; Pyrazinecarboxamide; Rozide; Tebrazid; Tebrazio; Tisamid; Unipyranamide; Zinamide; Zinastat; P ezetamid; Pirazinamide [DCIT]; Pyrazine carboxamide; Pyrazine carboxylamide; Pyrazinecarboxylic acid amide; Pyrazinoic acid am ide; Pyrazinoic acid amide; DRG 0124; MK 56; P 7136; Pyrazinamide BP 2000; T 165; AZT + Pyrazinamide combination; D-50; Pirazinamida [INN-Spanish]; Pms-Pyrazinamide; Pyrazinamide (TN); Pyrazinamidum [INN-Latin]; D-50 (VAN); Pyrazinamide [INN:BAN:JAN]; Pyrazine-2-carboxamide; Pyrazinamide (JP15/USP/INN); Pyrazinoic acid amide, Pezetamid, Pyrafat, Zinamide, Tebrazid, Pyrafat, Pyrazinamide; 2-Carbamylpyrazine; 2-carbamyl pyrazine

Indication

Disease Entry	ICD 11	Status	REF
Meningeal tuberculosis		Approved	[1]
Mycobacterium infection	1B10-1B21	Approved	[2]
Pulmonary tuberculosis	1B10.Z	Approved	[1]

• Therapeutic Class: Antitubercular Agents
• Cross-matching ID:
  PubChem CID: 1046
  ChEBI ID: CHEBI:45285
  CAS Number: CAS 98-96-4
  TTD Drug ID: DM4IF32
  INTEDE Drug ID: DR1372
  ACDINA Drug ID: D00570

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Fatty acid synthetase I (Bact inhA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[8]
Ethionamide	DM8K3EI	Pulmonary tuberculosis	1B10.Z	Approved	[9]
Prothionamide	DMX0EZJ	Tuberculosis	1B10-1B1Z	Approved	[9]
AFN-1720	DM6AJKC	Bacterial infection	1A00-1C4Z	Phase 2	[10]
MMV00/0053	DMF27BS	Malaria	1F40-1F45	Terminated	[11]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[12]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[12]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[13]
4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole	DMX681M	Discovery agent	N.A.	Investigative	[12]
Indole Naphthyridinone	DMB4ZNW	Discovery agent	N.A.	Investigative	[12]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[14]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[15]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[18]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[20]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[15]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[22]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[23]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[24]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[20]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[29]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[30]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[31]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[38]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[33]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[47]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[48]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[51]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[52]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[53]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[56]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[33]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Selenium	DM25CGV	N. A.	N. A.	Approved	[59]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[60]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[38]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[61]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[47]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[61]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[67]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[70]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[33]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[57]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[76]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[77]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[78]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[81]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[82]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[83]

Drug(s) Affected By Solute carrier family 22 member 12 (SLC22A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]
Oxypurinol	DMURH4X	Heart failure	BD10-BD13	Phase 2/3	[87]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[88]
Erythropoietin	DM3R8YL	Periventricular leukomalacia		Investigative	[84]
[3H]estrone-3-sulphate	DMGPF0N	Discovery agent	N.A.	Investigative	[89]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[33]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[38]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Fatty acid synthetase I (Bact inhA)	TTVTX4N	INHA_MYCTU	Inhibitor	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[4]
Nicotinamidase (pncA)	DERQS6E	B0VA03_ACIBY	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[6]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Gene/Protein Processing	[6]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)	OTAFHAVI	ATF6A_HUMAN	Gene/Protein Processing	[6]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Gene/Protein Processing	[6]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Gene/Protein Processing	[6]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Post-Translational Modifications	[6]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Post-Translational Modifications	[6]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Gene/Protein Processing	[6]
Solute carrier family 22 member 12 (SLC22A12)	OT72ZAWS	S22AC_HUMAN	Gene/Protein Processing	[7]
X-box-binding protein 1	OTJYCREE	XBP1_HUMAN	Gene/Protein Processing	[6]

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