Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5GQD7)

• Drug Name: Metoprine Drug Info
• Synonyms: METOPRINE; Methodichlorophen; DDMP; 7761-45-7; Metoprine [USAN]; BW-197U; TCMDC-123931; NSC-19494; SK 5265; 5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE-2,4-DIAMINE; U 197; NSC7364; U-197; UNII-2L9RKX796Q; Metoprine (USAN); BW 50-197; METOPRINE, METHODICHLOROPHEN; 5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine; NSC 7364; 2,4-Pyrimidinediamine, 5-(3,4-dichlorophenyl)-6-methyl-; NSC 19494; BW50197; BRN 0223622; 5-(3,4-Dichlorphenyl)-6-methyl-2,4-pyrimidindiamin; 2,4-Diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine; MLS002701892; DDMP; BW 197 U; BW 1970; BW 197U; BW 50197; BW 50,197; 2,4-Diamino-5-(3',4'-dichlorophenyl)-6-methyl pyrimidine; Chloroaniline 1

Indication

Disease Entry	ICD 11	Status	REF
Advanced cancer	2A00-2F9Z	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 24466
  CAS Number: CAS 7761-45-7
  TTD Drug ID: DM5GQD7

Molecule-Related Drug Atlas

Drug(s) Targeting Histamine N-methyltransferase (HNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diphenhydramine	DMKQTBA	Hyperemesis gravidarum		Approved	[2]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[5]
(L-)-S-adenosyl-L-homocysteine	DMDUN83	Discovery agent	N.A.	Investigative	[6]
4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE	DM68S9F	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Polypeptide deformylase (PDF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[7]
Meprobamate	DMHM93Y	Anxiety		Approved	[8]
Pralatrexate	DMAO80I	Breast cancer	2C60-2C65	Approved	[9]
Ustekinumab	DMHTYK3	Plaque psoriasis	EA90.0	Approved	[10]
Trimetrexate	DMDEA85	Toxoplasmosis	1F57	Approved	[11]
MCB-3837	DM0R4Z5	Malaria	1F40-1F45	Approved	[8]
Chlorproguanil	DM1IFGT	Malaria	1F40-1F45	Approved	[8]
LY333531	DMGMC8H	Solid tumour/cancer	2A00-2F9Z	Phase 2	[12]
Aminopterin	DMQ9RBV	leukaemia	2A60-2B33	Withdrawn from market	[13]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[6]

Drug(s) Affected By Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]

Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[27]
Bortezomib	DMNO38U	Leukemia		Approved	[4]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[4]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine N-methyltransferase (HNMT)	TT2B6EV	HNMT_HUMAN	Inhibitor	[2]
Polypeptide deformylase (PDF)	TT9SL3Q	DEFM_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)	OTU0FC24	COX41_HUMAN	Gene/Protein Processing	[4]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)	OT5QQB5L	IDH3A_HUMAN	Gene/Protein Processing	[4]

References

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