Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5QFT4)

• Drug Name: Declopramide Drug Info
• Synonyms: IBD therapy, Active Biotech; Inflammatory bowel disease therapy, Active Biotech; OXi-104; IMO-B project, Active Biotech; 3-CPA; 3-chloroprocainamide

Indication

Disease Entry	ICD 11	Status	REF
Inflammatory bowel disease	DD72	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 70177
  CAS Number: CAS 891-60-1
  TTD Drug ID: DM5QFT4

Molecule-Related Drug Atlas

Drug(s) Targeting Muscarinic acetylcholine receptor M1 (CHRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[4]
Fesoterodine fumarate	DM13495	Overactive bladder	GC50.0	Approved	[5]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[6]
Clidinium	DMUMQZ0	Abdominal stomach pain	DD91.4	Approved	[7]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[8]
Oxyphenonium	DMMQHOZ	Visceral spasms	MD81.4	Approved	[9]
Benztropine	DMGZOVN	Parkinson disease	8A00.0	Approved	[10]
Glycopyrrolate	DM2M3ZA	Anaesthesia	9A78.6	Approved	[11]
Pirenzepine	DMP6M1N	Peptic ulcer	DA61	Approved	[12]
Cycrimine	DM8C43Q	Parkinson disease	8A00.0	Approved	[13]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[14]
Haloperidol	DM96SE0	Delirium		Approved	[15]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[16]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[17]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[18]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[19]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[20]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[21]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[22]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[23]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[24]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[27]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[30]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[31]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[32]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[33]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Modulator	[2]
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[3]

References

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