Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6FVZW)

• Drug Name: R-dimethindene Drug Info
• Synonyms: CHEMBL564226; UNII-C9Z23T6963; C9Z23T6963; (R)-Dimethindene; Dimetindene, (R)-; (R)-(-)-Dimethindene; ZINC1482162; BDBM50297307; UNII-661FH77Z3P component MVMQESMQSYOVGV-HNNXBMFYSA-N; 1H-Indene-2-ethanamine, N,N-dimethyl-3-((1R)-1-(2-pyridinyl)ethyl)-; 1H-Indene-2-ethanamine, N,N-dimethyl-3-(1-(2-pyridinyl)ethyl)-, (R)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 12963076
  CAS Number: CAS 135821-89-5
  TTD Drug ID: DM6FVZW

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated potassium channel Kv11.1 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VESNARINONE	DMBKX3C	Cardiac failure	BD10-BD13	Approved	[2]
M100907	DM7ZFBA	Sleep-wake disorder	7A00-7B2Z	Phase 3	[3]
HP-184	DMNOMV2	Multiple sclerosis	8A40	Phase 2	[4]
NITD609	DMQHBSX	Malaria	1F40-1F45	Phase 2	[5]
ABT-229	DMN3S1B	Pain	MG30-MG3Z	Phase 2	[6]
ISOQUINE	DMR17YI	Malaria	1F40-1F45	Phase 1	[7]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1	DMC8935	N. A.	N. A.	Patented	[8]
Isoindoline derivative 5	DMIUTQW	N. A.	N. A.	Patented	[9]
Isoindoline derivative 3	DM2MYL9	N. A.	N. A.	Patented	[9]
Isoindoline derivative 4	DMP1NKI	N. A.	N. A.	Patented	[9]

Drug(s) Targeting Muscarinic acetylcholine receptor M1 (CHRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[10]
Fesoterodine fumarate	DM13495	Overactive bladder	GC50.0	Approved	[11]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[12]
Clidinium	DMUMQZ0	Abdominal stomach pain	DD91.4	Approved	[13]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[14]
Oxyphenonium	DMMQHOZ	Visceral spasms	MD81.4	Approved	[15]
Benztropine	DMGZOVN	Parkinson disease	8A00.0	Approved	[16]
Glycopyrrolate	DM2M3ZA	Anaesthesia	9A78.6	Approved	[17]
Pirenzepine	DMP6M1N	Peptic ulcer	DA61	Approved	[18]
Cycrimine	DM8C43Q	Parkinson disease	8A00.0	Approved	[19]

Drug(s) Targeting Histamine H1 receptor (H1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[20]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[21]
Azelastine	DMXTMBJ	Allergic conjunctivitis	9A60.02	Approved	[22]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[23]
Cinnarizine	DM7U5QJ	Meniere disease	AB31.0	Approved	[24]
Diphenhydramine	DMKQTBA	Hyperemesis gravidarum		Approved	[22]
Doxepin	DMPI98T	Anxiety		Approved	[25]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[22]
Epinastine	DMX0K3Q	Allergic conjunctivitis	9A60.02	Approved	[26]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[27]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Inhibitor	[1]
Voltage-gated potassium channel Kv11.1 (KCNH2)	TTQ6VDM	KCNH2_HUMAN	Inhibitor	[1]

References

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• [16] Formulation and biopharmaceutical evaluation of transdermal patch containing benztropine. Int J Pharm. 2008 Jun 5;357(1-2):55-60.
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• [18] Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate. Neurosci Lett. 2009 Aug 14;459(3):127-31.
• [19] Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids. J Chromatogr. 1989 Sep 29;494:135-42.
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• [21] Clinical research of Ibudilast on treating the steroid resistant allergic rhinitis. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan;23(2):63-6.
• [22] Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79.
• [23] Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8.
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• [25] Novel therapeutic usage of low-dose doxepin hydrochloride. Expert Opin Investig Drugs. 2007 Aug;16(8):1295-305.
• [26] Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cell... Mediators Inflamm. 2009;2009:738038.
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