Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6HM5S)

Drug Name
N1-(2-aminoethyl)ethane-1,2-diamine Drug Info
Synonyms
DIETHYLENETRIAMINE; 111-40-0; Bis(2-aminoethyl)amine; 2,2'-Diaminodiethylamine; Diethylene triamine; Barsamide 115; Epicure T; Ancamine DETA; 1,4,7-Triazaheptane; 2,2'-Iminodiethylamine; N,N-Bis(2-aminoethyl)amine; Aminoethylethandiamine; 3-Azapentane-1,5-diamine; 1,2-Ethanediamine, N-(2-aminoethyl)-; Imino-bis-ethylamine; ChS-P 1; N-(2-Aminoethyl)-1,2-ethanediamine; N-(2-aminoethyl)ethane-1,2-diamine; 1,5-Diamino-3-azapentane; 2,2'-Iminobis(ethanamine); Bis(beta-aminoethyl)amine; 2-(2-Aminoethylamino)ethylamine; Epon 3223
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
8111
ChEBI ID
CHEMBL30629
CAS Number
CAS 111-40-0
TTD Drug ID
DM6HM5S
INTEDE Drug ID
DR2029

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase VI (CA-VI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [3]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [4]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [5]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [6]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [7]
SAR566658 DM6Q295 Solid tumour/cancer 2A00-2F9Z Phase 2 [8]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [6]
SPERMINE DMD4BFY N. A. N. A. Terminated [1]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [6]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [9]
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Drug(s) Targeting Carbonic anhydrase XII (CA-XII)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [3]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [10]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [5]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [6]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [5]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [7]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [6]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [6]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [9]
CATECHIN DMY38SB Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Carbonic anhydrase XIV (CA-XIV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [11]
TRIENTINE DMD2WPG Inborn error of metabolism 5C50-5C59 Approved [1]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [5]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [6]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [5]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [7]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [6]
SPERMINE DMD4BFY N. A. N. A. Terminated [1]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [6]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Carbonic anhydrase (CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [12]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [4]
Quinethazone DMWCOSR Hypertension BA00-BA04 Approved [13]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [5]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [6]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [5]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [7]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [14]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [6]
PMID30074415-Compound-21 DM3NPOU N. A. N. A. Patented [15]
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Drug(s) Targeting Carbonic anhydrase IX (CA-IX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [5]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [6]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [5]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [7]
INDISULAM DM9SX6Y Lymphoma 2A80-2A86 Phase 2 [16]
Girentuximab I-124 DMG3O2Z Renal cell carcinoma 2C90 Phase 2 [17]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [18]
BAY 79-4620 DM14XQN Solid tumour/cancer 2A00-2F9Z Phase 1 [19]
90Y-cG250 DMJR6TC Solid tumour/cancer 2A00-2F9Z Phase 1 [20]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [6]
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Drug(s) Metabolized By Putrescine acetyltransferase (SSAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spermidine DMVJNFI Plaque psoriasis EA90.0 Phase 3 [21]
SPERMINE DMD4BFY N. A. N. A. Terminated [2]
Ethylene diamine DMBULX4 Tuberculosis 1B10-1B1Z Investigative [2]
Propandiamine DMQ9USH N. A. N. A. Investigative [2]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [1]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]
Carbonic anhydrase VI (CA-VI) TTCFSPE CAH6_HUMAN Inhibitor [1]
Carbonic anhydrase XII (CA-XII) TTSYM0R CAH12_HUMAN Inhibitor [1]
Carbonic anhydrase XIV (CA-XIV) TTEYTKG CAH14_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Putrescine acetyltransferase (SSAT1) Main DME DEMWO83 SAT1_HUMAN Substrate [2]

References

1 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22.
2 Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007 Jun 19;46(24):7187-95.
3 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
4 Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54.
5 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
6 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
7 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
8 An Antibody-Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities. Mol Cancer Ther. 2020 Aug;19(8):1660-1669.
9 Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.
10 Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
11 Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.
12 Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6.
13 Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for th... Bioorg Med Chem Lett. 2008 Apr 15;18(8):2567-73.
14 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
15 Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740.
16 Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-assoc... Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23.
17 Potential role of (124)I-girentuximab in the presurgical diagnosis of clear-cell renal cell cancer. Biologics. 2012;6:395-407.
18 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbo... Bioorg Med Chem Lett. 2005 Feb 1;15(3):567-71.
19 Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9. Mol Cancer Ther. 2012 Feb;11(2):340-9.
20 Application of monoclonal antibody G250 recognizing carbonic anhydrase IX in renal cell carcinoma. Int J Mol Sci. 2013 May 29;14(6):11402-23.
21 The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism. J Med Chem. 2011 Jul 14;54(13):4611-8.