Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6ID8P)

Drug Name

NSC-106084 Drug Info

Synonyms

NSC-106084; CHEMBL597113; NSC106084; AC1L6H8Q; CTK7J5419; ZINC1868549; BDBM50308983; {4-[5-bromo-2-(carboxymethoxy)benzoyl]phenoxy}acetic acid; 2-(4-bromo-2-(4-(carboxymethoxy)benzoyl)phenoxy)acetic acid; 2-[4-[5-bromo-2-(carboxymethyloxy)benzoyl]phenoxy]acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 266989
TTD Drug ID: DM6ID8P

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting DNA [cytosine-5]-methyltransferase 3B (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
PMID27376512-Compound-MTC-424	DMGNRZU	N. A.	N. A.	Patented	[2]
PMID27376512-Compound-MTC-427	DMWXEZD	N. A.	N. A.	Patented	[2]
PMID27376512-Compound-MTC-422	DM1MVQD	N. A.	N. A.	Patented	[2]
PMID27376512-Compound-MTC-423	DM9RSDX	N. A.	N. A.	Patented	[2]
(L-)-S-adenosyl-L-homocysteine	DMDUN83	Discovery agent	N.A.	Investigative	[3]
NSC-622445	DME35CB	Discovery agent	N.A.	Investigative	[1]
NSC-622444	DMM5UT9	Discovery agent	N.A.	Investigative	[1]
NSC-138419	DMH684Q	Discovery agent	N.A.	Investigative	[1]
NSC-319745	DMF3G06	Discovery agent	N.A.	Investigative	[1]
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Drug(s) Targeting DNA [cytosine-5]-methyltransferase (DNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[4]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
S-110	DMXY34J	Acute myeloid leukaemia	2A60	Phase 3	[5]
ASTX727	DM4HK8Z	Chronic myelogenous leukaemia	2A20.0	Phase 3	[6]
PMID27376512-Compound-PG-11047	DM5K4YF	N. A.	N. A.	Patented	[2]
PMID27376512-Compound-PG-11048	DM3U7RN	N. A.	N. A.	Patented	[2]
PMID27376512-Compound-MTC-434	DM70CTE	N. A.	N. A.	Patented	[2]
PMID27376512-Compound-CROs	DMBFUTL	N. A.	N. A.	Patented	[2]
(L-)-S-adenosyl-L-homocysteine	DMDUN83	Discovery agent	N.A.	Investigative	[3]
NSC-622445	DME35CB	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA [cytosine-5]-methyltransferase (DNMT)	TTHVCUP	NOUNIPROTAC	Inhibitor	[1]
DNA [cytosine-5]-methyltransferase 3B (DNMT3B)	TT6VZ78	DNM3B_HUMAN	Inhibitor	[1]

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References

1	Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9.
2	DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30.
3	Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6.
4	The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid l... Leukemia. 2009 Jun;23(6):1019-28.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)