Details of the Drug-Related molecule(s) Interaction Atlas

Aphidicolin Drug Info

bis(hydroxymethyl)-dimethyl-[ ]diol; AC1LA8KN; 8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,9R,11bS)-

Cross-matching ID

PubChem CID

457964

ChEBI ID

CHEBI:2766

CAS Number

CAS 38966-21-1

TTD Drug ID

DM71C6D

General Information of Drug (ID: DM71C6D)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[7]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[8]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[9]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[7]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[10]
Penciclovir	DMOUMDV	Herpes simplex labialis	1F00.01	Approved	[11]
Famciclovir	DMJHLSD	Meniere disease	AB31.0	Approved	[12]
Valacyclovir Hydrochloride	DM5I1CE	Herpes simplex virus infection	1F00	Approved	[7]
Foscavir	DM9KJLZ	Cytomegalovirus retinitis	9B72.00	Approved	[10]
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Drug(s) Affected By DNA polymerase alpha catalytic subunit (POLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[20]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[22]
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Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[30]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[31]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
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Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[34]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[5]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[44]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[5]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[47]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[48]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30)	TTIU7X1	DPOL_HHV11	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Gene/Protein Processing	[2]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Gene/Protein Processing	[3]
DNA repair protein XRCC4	OT4SXOIZ	XRCC4_HUMAN	Drug Response	[4]
Retinoic acid receptor RXR-alpha (RXRA)	OTP1TBDM	RXRA_HUMAN	Gene/Protein Processing	[2]
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)	OTJ8UM8O	TNR8_HUMAN	Gene/Protein Processing	[5]

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