Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7V58G)

• Drug Name: MG149 Drug Info
• Synonyms: MG-149; MG 149

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 49864204
  TTD Drug ID: DM7V58G

Molecule-Related Drug Atlas

Drug(s) Targeting Histone acetyltransferase KAT6B (KAT6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
garcinol	DM6B9ZG	Discovery agent	N.A.	Investigative	[4]
SGC-CBP30	DMTLRGZ	Discovery agent	N.A.	Investigative	[5]
anacardic acid	DMAS5BI	Discovery agent	N.A.	Investigative	[6]
I-CBP112	DMQX3W6	Discovery agent	N.A.	Investigative	[7]
C646	DMCOQKH	Discovery agent	N.A.	Investigative	[8]

Drug(s) Affected By C-X-C motif chemokine 13 (CXCL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[9]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[10]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[12]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[13]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[14]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[9]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[15]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[24]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[25]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[28]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[33]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[31]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone acetyltransferase KAT6B (KAT6B)	TTH4VJL	KAT6B_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-X-C motif chemokine 13 (CXCL13)	OT2AT4N8	CXL13_HUMAN	Gene/Protein Processing	[3]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Gene/Protein Processing	[3]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[3]

References

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