General Information of Drug (ID: DMA6HQJ)

Drug Name
HO/03/03 Drug Info
Synonyms PKC modulator (topical peptide, DU/VU/PU), HealOr
Indication
Disease Entry ICD 11 Status REF
Diabetic foot ulcer BD54 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMA6HQJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug(s) Targeting Protein kinase C (PRKC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Synthetic hypericin DMXU4ON Virus infection 1A24-1D9Z Phase 3 [3]
APH-0812 DM756GE Human immunodeficiency virus-1 infection 1C62 Phase 2 [4]
CYCLOPLATAM DMXR8WN Solid tumour/cancer 2A00-2F9Z Phase 2 [5]
AEB07 DMJVN89 Transplant rejection NE84 Phase 2 [6]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [7]
LXS196 DM65MEL Solid tumour/cancer 2A00-2F9Z Phase 1/2 [8]
SAFINGOL DMBGUDR Psoriasis vulgaris EA90 Phase 1 [9]
GCC-1290K DMJ7WRI Parkinson disease 8A00.0 Phase 1 [10]
AEB701 DM8I4G0 Melanoma 2C30 Phase 1 [11]
Tecadenoson DM9T6MS Atrial fibrillation BC81.3 Discontinued in Phase 3 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Protein kinase C (PRKC) TTYVX59 NOUNIPROTAC Modulator [2]

References

1 ClinicalTrials.gov (NCT00926068) Safety and Efficacy of HO/03/03 10 in the Treatment of Plantar Neuropathic Diabetic Foot Ulcers. U.S. National Institutes of Health.
2 WO patent application no. 2014,0853,81, Pharmaceutical combinations.
3 Characterization of the interaction of hypericin with protein kinase C in U-87 MG human glioma cells. Photochem Photobiol. 2006 May-Jun;82(3):720-8.
4 Targeting the protein kinase C family: are we there yet. Nat Rev Cancer. 2007 Jul;7(7):554-62.
5 Effect of anti-tumor agents cisplatin and cycloplatam on membrane protein kinase C activity in murine T-lymphocytes. Biokhimiia. 1996 Oct;61(10):1866-73.
6 What's next in the pipeline. Am J Transplant. 2008 Oct;8(10):1972-81.
7 Bryostatin-1: a promising compound for neurological disorders. Front Pharmacol. 2023 Jun 7;14:1187411.
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. Int J Oncol. 2009 Dec;35(6):1463-71.
10 Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochem Int. 2009 Jul;54(8):526-34.
11 Changes in Serum Cytokine Profile after AEB071 (Sotrastaurin) or Tacrolimus versus Their Combinations in Rat Heterotopic Cardiac Allografts. J Korean Soc Transplant. 2012 Dec;26(4):248-253.
12 Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001;40(1):55-63.