Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAC8TP)

Drug Name
TFMPP Drug Info
Synonyms
1-[3-(Trifluoromethyl)phenyl]piperazine; 15532-75-9; 1-(3-(Trifluoromethyl)phenyl)piperazine; 1-(3-Trifluoromethylphenyl)piperazine; N-(3-trifluoromethylphenyl)piperazine; 3-trifluoromethylphenylpiperazine; Legal E [Street Name]; Piperazine, 1-[3-(trifluoromethyl)phenyl]-; UNII-25R3ONU51C; 1-(m-trifluoromethylphenyl)piperazine; 1-(3-Trifluoromethyl-phenyl)-piperazine; EINECS 239-574-4; N-(alpha,alpha,alpha-trifluoro-m-tolyl)piperazine; NSC 128882; N-(alpha,alpha,alpha-Trifluoro-3-tolyl)piperazine; 3-trifluoromethylphenylpiperazine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4296
ChEBI ID
CHEBI:83536
CAS Number
CAS 15532-75-9
TTD Drug ID
DMAC8TP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting 5-HT 1B receptor (HTR1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [3]
Eletriptan DMW649X Migraine 8A80 Approved [14]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [14]
Frovatriptan DM7RE8P Migraine 8A80 Approved [14]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [14]
Naratriptan DMO50U2 Headache 8A80-8A84 Approved [15]
Prolixin decanoate DMMJ1IS Schizophrenia 6A20 Approved [14]
Eltoprazine DMW6C81 Attention deficit hyperactivity disorder 6A05.Z Phase 3 [16]
NXN-188 DMMBAIH Migraine 8A80 Phase 2 [17]
[N-methyl-3H(3)]AZ-10419369 DMSCV02 Mood disorder 6A60-6E23 Phase 1 [18]
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Drug(s) Targeting 5-HT 1D receptor (HTR1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [4]
Eletriptan DMW649X Migraine 8A80 Approved [14]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [14]
Frovatriptan DM7RE8P Migraine 8A80 Approved [14]
Sumatriptan DMVYXR8 Cluster headache 8A81.0 Approved [19]
Rizatriptan DMDJMA3 Migraine 8A80 Approved [20]
Almogran DM7I64Z Migraine 8A80 Approved [21]
Neu-P11 DMIQDFW Alzheimer disease 8A20 Phase 2 [22]
FKB01MD DM2O7NM N. A. N. A. Phase 2 [23]
NXN-188 DMMBAIH Migraine 8A80 Phase 2 [17]
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Drug(s) Targeting 5-HT 5A receptor (HTR5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [24]
(+/-)-nantenine DM0L3GE Discovery agent N.A. Investigative [25]
SEROTONIN DMOFCRY Discovery agent N.A. Investigative [26]
5-CT DM260KD Discovery agent N.A. Investigative [27]
5,6-dichloro-3,4-dihydroquinazolin-2-amine DMN1S35 Discovery agent N.A. Investigative [28]
MPDT DMYX31S Discovery agent N.A. Investigative [29]
5-chloro-3,4-dihydroquinazolin-2-amine DMKEFJ0 Discovery agent N.A. Investigative [28]
EDMT DMS3AXK Discovery agent N.A. Investigative [29]
5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine DM7FZU2 Discovery agent N.A. Investigative [28]
[3H]5-CT DMEAHFZ Discovery agent N.A. Investigative [30]
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Drug(s) Targeting 5-HT 6 receptor (HTR6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LU AE58054 DMWGRQD Schizophrenia 6A20 Phase 3 [31]
SB-742457 DM6L4ZT Alzheimer disease 8A20 Phase 3 [32]
AVN 211 DMVB4OS Schizophrenia 6A20 Phase 2/3 [33]
SYN120 DMDF7XB Parkinson disease 8A00.0 Phase 2 [34]
AVN 101 DMJFLBC Alzheimer disease 8A20 Phase 2 [33]
SYN-120 DMPW0UL Alzheimer disease 8A20 Phase 2 [35]
PF-05212377 DMPVQYR Alzheimer disease 8A20 Phase 2 [36]
AVN 322 DMK2LGM Cognitive impairment 6D71 Phase 2 [32]
SAM-531 DMHVJZ6 Alzheimer disease 8A20 Phase 2 [37]
SUVN-502 DMQD753 Alzheimer disease 8A20 Phase 2 [38]
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Drug(s) Targeting 5-HT 2B receptor (HTR2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [7]
Triflupromazine DMKFQJP Nausea MD90 Approved [39]
Minaprine DM0EP7M Depression 6A70-6A7Z Approved [40]
SPN-812 DMTV7XH Attention deficit hyperactivity disorder 6A05.Z Phase 4 [41]
Vabicaserin DM9GZW6 Psychotic disorder 6A20-6A25 Phase 2 [42]
PRX-08066 DMR7H2V Pulmonary arterial hypertension BB01.0 Phase 2 [43]
Pyrimidine derivative 29 DMVOYJ8 N. A. N. A. Patented [44]
Pyrimidine derivative 26 DM90WKN N. A. N. A. Patented [44]
Pyrimidine derivative 23 DM5MLQU N. A. N. A. Patented [44]
Pyrimidine derivative 25 DM51MFS N. A. N. A. Patented [44]
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Drug(s) Targeting 5-HT 2A receptor (HTR2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [7]
ZOTEPINE DMF3VXA Anxiety disorder 6B00-6B0Z Approved [45]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [46]
Flibanserin DM70DTN Depression 6A70-6A7Z Approved [47]
Lurasidone hydrochloride DMCVPXO Schizophrenia 6A20 Approved [48]
Aniracetam DMOIFW0 Cerebrovascular ischaemia 8B1Z Approved [49]
lumateperone tosylate DMQ8HOJ Schizophrenia 6A20 Approved [50]
Sarpogrelate DMGLP6S Diabetic complication 5A2Y Approved [51]
Pimavanserin DMR7IVC Parkinson disease 8A00.0 Approved [52]
Zicronapine DMP8ESD Schizophrenia 6A20 Phase 3 [53]
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Drug(s) Targeting 5-HT 1F receptor (HTR1F)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [54]
Lasmiditan DMXLVDT Migraine 8A80 Approved [55]
LY-334370 DM43O9N Migraine 8A80 Phase 2 [56]
5-CT DM260KD Discovery agent N.A. Investigative [54]
1-naphthylpiperazine DM6BIWK Discovery agent N.A. Investigative [54]
BRL-15572 DMM61Y2 Discovery agent N.A. Investigative [57]
2-methyl-5-HT DM1S5CB N. A. N. A. Investigative [6]
alpha-methyl-5-HT DMCAYXF Discovery agent N.A. Investigative [6]
WAY-466 DMMOH51 Discovery agent N.A. Investigative [58]
[125I]LSD DMP69QG Discovery agent N.A. Investigative [59]
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Drug(s) Targeting 5-HT 1A receptor (HTR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [14]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [60]
OPC-34712 DMHG57U Major depressive disorder 6A70.3 Approved [61]
Vilazodone DM4LECQ Major depressive disorder 6A70.3 Approved [62]
Flibanserin DM70DTN Depression 6A70-6A7Z Approved [47]
Gepirone DMGX5Q0 Major depressive disorder 6A70.3 Approved [63]
TERTATOLOL DM2L3D5 Hypertension BA00-BA04 Approved [64]
Urapidil DMD59GI Hypertension BA00-BA04 Approved [65]
Treximet DMU54QB Migraine 8A80 Approved [66]
CM-2395 DMASPWR Schizophrenia 6A20 Phase 3 [67]
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Drug(s) Targeting 5-HT 7 receptor (HTR7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RP5063 DMKUE8O Schizophrenia 6A20 Phase 2 [23]
JNJ-18038683 DMV1T59 Major depressive disorder 6A70.3 Phase 2 [68]
AVN-101 DMOGFNI Cognitive impairment 6D71 Phase 2 [69]
ATI-9242 DM6GKMU Schizophrenia 6A20 Phase 1 [70]
PMID30124346-Compound-34TABLE4 DM2G3VE Attention deficit hyperactivity disorder 6A05.Z Patented [71]
PMID30124346-Compound-13TABLE4 DMHTJVA Attention deficit hyperactivity disorder 6A05.Z Patented [71]
Carbamide derivative 2 DMW5GI3 N. A. N. A. Patented [72]
4-oxadiazole derivative 1 DMWFHKR N. A. N. A. Patented [72]
SB-269970 DM8WTGA Sleep-wake disorder 7A00-7B2Z Terminated [73]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G Discovery agent N.A. Investigative [74]
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Drug(s) Targeting 5-HT 2C receptor (HTR2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [7]
Lorcaserin DMG6OYJ Obesity 5B81 Approved [75]
Tramadol DMRQD04 Osteoarthritis FA00-FA05 Approved [76]
Mirtazapine DML53ZJ Depression 6A70-6A7Z Approved [77]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [78]
Methysergide DM1EF73 Migraine 8A80 Approved [79]
Eltoprazine DMW6C81 Attention deficit hyperactivity disorder 6A05.Z Phase 3 [16]
M100907 DM7ZFBA Sleep-wake disorder 7A00-7B2Z Phase 3 [80]
SR46349B DM1ODMR Primary insomnia 7A00 Phase 3 [81]
Vabicaserin DM9GZW6 Psychotic disorder 6A20-6A25 Phase 2 [42]
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Drug(s) Targeting 5-HT 1E receptor (HTR1E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [5]
5-CT DM260KD Discovery agent N.A. Investigative [5]
1-naphthylpiperazine DM6BIWK Discovery agent N.A. Investigative [5]
BRL-15572 DMM61Y2 Discovery agent N.A. Investigative [57]
2-methyl-5-HT DM1S5CB N. A. N. A. Investigative [6]
alpha-methyl-5-HT DMCAYXF Discovery agent N.A. Investigative [5]
m-chlorophenylpiperazine DMM1J2D Discovery agent N.A. Investigative [5]
EDMT DMS3AXK Discovery agent N.A. Investigative [29]
9-OH-risperidone DMGORXQ Discovery agent N.A. Investigative [82]
[3H]5-HT DMYJXV7 Discovery agent N.A. Investigative [83]
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Drug(s) Affected By Trefoil factor 1 (TFF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Estrone DM5T6US Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [90]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [91]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [92]
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Drug(s) Affected By Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Estrone DM5T6US Acne vulgaris ED80 Approved [96]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [97]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [92]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [99]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Inhibitor [2]
5-HT 1B receptor (HTR1B) TTK8CXU 5HT1B_HUMAN Agonist [3]
5-HT 1D receptor (HTR1D) TT6MSOK 5HT1D_HUMAN Agonist [4]
5-HT 1E receptor (HTR1E) TTCPG9S 5HT1E_HUMAN Agonist [5]
5-HT 1F receptor (HTR1F) TT0MI3F 5HT1F_HUMAN Agonist [6]
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Agonist [7]
5-HT 2B receptor (HTR2B) TT0K1SC 5HT2B_HUMAN Agonist [8]
5-HT 2C receptor (HTR2C) TTWJBZ5 5HT2C_HUMAN Agonist [9]
5-HT 5A receptor (HTR5A) TTRUFDT 5HT5A_HUMAN Agonist [10]
5-HT 6 receptor (HTR6) TTJS8PY 5HT6R_HUMAN Agonist [11]
5-HT 7 receptor (HTR7) TTO9X1H 5HT7R_HUMAN Agonist [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Gene/Protein Processing [13]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Gene/Protein Processing [13]

References

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