Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAWTUL)

Drug Name

Trifluoroethanol Drug Info

Synonyms

2,2,2-TRIFLUOROETHANOL; 75-89-8; Trifluoroethanol; Ethanol, 2,2,2-trifluoro-; Trifluoroethyl alcohol; 2,2,2-Trifluoroethan-1-Ol; Fluorinol 85; 2,2,2-Trifluoroethyl alcohol; trifluoro ethanol; TFE; Perfluoro-1,1-dihydroethanol; tfetoh; NSC 451; CF3CH2OH; 2,2,2-trifluoro-ethanol; beta,beta,beta-Trifluoroethyl alcohol; UNII-8T8I76KYF1; TFEA; 2,2,2-TRIFLUORETHANOL; 1h,1h-trifluoroethanol; EINECS 200-913-6; BRN 1733203; ethanol, 2,2,2-trifluoro; AI3-25486; 8T8I76KYF1; CHEBI:42330; RHQDFWAXVIIEBN-UHFFFAOYSA-N; MFCD00004672

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6409
ChEBI ID: CHEMBL42330
CAS Number: CAS 75-89-8
TTD Drug ID: DMAWTUL

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[3]
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[3]
3,5-dichlorosalicylic acid	DMQ45WH	Discovery agent	N.A.	Investigative	[4]
Cyclopropyl	DMGFEPJ	Discovery agent	N.A.	Investigative	[5]
Cyclobutyl	DM35PIJ	Discovery agent	N.A.	Investigative	[5]
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Drug(s) Affected By Alternative prion protein (PRNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[6]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[8]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[13]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[14]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[14]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2)	TTJS7O4	ADH2_ENTHI	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Protein Interaction/Cellular Processes	[2]

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References

1	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
2	Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: the role of copper(II) ions, pH, and membrane mimicking environments. J Phys Chem B. 2010 Nov 4;114(43):13830-8. doi: 10.1021/jp1033036.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase. Bioorg Med Chem. 2009 Feb 1;17(3):1244-50.
5	Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) as a target for anti-amoebic agents. J Antimicrob Chemother. 2004 Jul;54(1):56-9.
6	Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
7	The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
8	Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
9	A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
10	Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
11	Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
12	The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
13	Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
14	Co-Administration of Melatonin Effectively Enhances the Therapeutic Effects of Pioglitazone on Mesenchymal Stem Cells Undergoing Indoxyl Sulfate-Induced Senescence through Modulation of Cellular Prion Protein Expression. Int J Mol Sci. 2018 May 4;19(5):1367. doi: 10.3390/ijms19051367.