Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB4SFH)

Drug Name
Mepyramine Drug Info
Synonyms
Anhistabs; Anhistol; Antalergan; Antallergan; Antamine; Anthisan; Copsamine; Coradon; Dipane; Dorantamin; Harvamine; Histacap; Histalon; Histapyran; Histasan; Isamin; Kriptin; Maranhist; Mepiramina; Mepiramine; Mepyramin; Mepyraminum; Mepyren; Neoantergan; Neobridal; Nyscaps; PYRA; Paraminyl; Parmal; Pyramal; Pyranisamine; Pyrilamide; Pyrilamine; Stamine; Stangen; Statomin; Thylogen; Mepyramin [German]; Pyrilamine salt with fine resin; RP 2786; [3H]mepyramine; [3H]pyrilamine; Afko-Hist; Mepiramina [INN-Spanish]; Mepyramine (INN); Mepyramine [INN:BAN]; Mepyraminum [INN-Latin]; Neo-Bridal; Wait's green mountain antihistamine; R.d. 2786; P-Methoxybenzyl-alpha-pyridyl-dimethyl-aethylendiamin; P-Methoxybenzyl-alpha-pyridyl-dimethyl-aethylendiamin [German]; P-Methoxy-benzyl-.alpha.-pyridyl-dimethyl-aethylendiamin; N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine; N-p-Methoxybenzyl-N',N'-dimethyl-N-alpha-pyridylethylenediamine; N-para-Methoxybenzyl-N',N'-dimethyl-N-alpha-pyridylethylenediamine; N-(p-Methoxybenzyl)-N',N'-dimethyl-N-2-pyridylethylenediamine; N-(para-Methoxybenzyl)-N',N'-dimethyl-N-2-pyridylethylenediamine; N',N'-Dimethyl-N-(p-methoxybenzyl)-N-(2-pyridyl)ethylenediamine; N-(p-Methoxybenzyl)-N',N'-dimethyl-N-(alpha-pyridyl)ethylenediamine; N-(p-Methoxybenzyl)-N',N'-dimethyl-N-2-(pyridylethylene)diamine; N-Dimethylamino-aethyl-N-p-methoxy-benzyl-.alpha.-amino-pyridin-maleat; N-(p-Methoxybenzyl)-N',N'-dimethyl-N-(alpha.-pyridyl)ethylenediamine; N-(p-Methoxybenzyl)-N',N'-dimethyl-N-2-pyridyl-1,2-ethanediamine; N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine; N-((4-Methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine; N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine; N,N-dimethyl-N'-{[4-(methyloxy)phenyl]methyl}-N'-pyridin-2-ylethane-1,2-diamine; 2-((2-(Dimethylamino)ethyl)-(p-methoxybenzyl)amino)pyridine; 2-((p-Methoxybenzyl)(2-(dimethylamino)ethyl)amino)pyridine; 2-[(p-Methoxybenzyl)[2-(dimethylamino)ethyl]amino]pyridine; 2-[[2-(Dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine; 2-[[2-(Dimethylamino)ethyl]-(p-methoxybenzyl)amino]pyridine; 2-dimethylaminoethyl-p-anisyl-(2-pyridyl)amine
Indication
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Approved [1]
Allergy 4A80-4A85 Approved [2]
Common cold CA00 Approved [3]
Dysmenorrhea GA34.3 Approved [4]
Seasonal allergic rhinitis CA08.01 Approved [1]
Urticaria EB00-EB05 Approved [5]
Vasomotor/allergic rhinitis CA08 Approved [6]
Pruritus EC90 Investigative [7]
Therapeutic Class
Antiasthmatic Agents
Cross-matching ID
PubChem CID
4992
ChEBI ID
CHEMBL6762
CAS Number
CAS 91-84-9
TTD Drug ID
DMB4SFH
VARIDT Drug ID
DR00564

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [12]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [13]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [14]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [15]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [16]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [14]
Doxepin DMPI98T Anxiety Approved [17]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [14]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [18]
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [19]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic cation/carnitine transporter 2 (SLC22A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [20]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [21]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [22]
Levacecarnine hci DMJBOCR Cognitive impairment 6D71 Approved [23]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [24]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [25]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [26]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [26]
Acetylcarnitine DM4UE3K Chronic fatigue syndrome 8E49 Phase 4 [27]
acetyl-L-carnitine DM74HGJ Discovery agent N.A. Investigative [21]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [28]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [31]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [32]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [36]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [34]
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Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [37]
Fluoxetine DM3PD2C Bipolar depression Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [40]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Aripiprazole DM3NUMH Bipolar I disorder Approved [44]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Antagonist [8]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation/carnitine transporter 2 (SLC22A5) DT3HUVD S22A5_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Protein Interaction/Cellular Processes [10]
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Protein Interaction/Cellular Processes [11]

References

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5 The widely used antihistamine mepyramine causes topical pain relief through direct blockade of nociceptor sodium channels. FASEB J. 2021 Dec;35(12):e22025.
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15 Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8.
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22 Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
23 Colistin is substrate of the carnitine/organic cation transporter 2 (OCTN2, SLC22A5). Drug Metab Dispos. 2017 Dec;45(12):1240-1244.
24 Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. J Pharmacol Exp Ther. 2005 Jan;312(1):192-8.
25 Mutations affecting GABAergic signaling in seizures and epilepsy. Pflugers Arch. 2010 Jul;460(2):505-23.
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27 Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2. Arch Biochem Biophys. 2006 Aug 1;452(1):29-37.
28 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
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32 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
33 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
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