Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB6VEG)

Drug Name

Nelarabine Drug Info

Synonyms

Arranon; ArranonG; Atriance; Nelzarabine; Nelarabine [USAN]; Nelzarabine [USAN]; GW 506U78; GW506U78; U78; Arranon (GlaxoSmithKline); Arranon (TN); Arranon, Nelarabine; Atriance (TN); GW-506U; GW-506U78; Nelarabine (INN); Nelzarabine (USAN); O-Methoxydeoxyguanosine; O-Methylguanosine; Nelarabine (JAN/USAN); (2R,3R,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-(2-Amino-6-methoxy-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol; 2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-Amino-6-methoxypurine arabinoside; 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine; 6'-O-Methylguanosine; 9-beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine; 9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine

Indication

Disease Entry	ICD 11	Status	REF
leukaemia	2A60-2B33	Approved	[1]
T-cell acute lymphoblastic leukaemia	2A90.5	Approved	[2]
T-lymphoblastic lymphoma		Approved	[2]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 3011155
ChEBI ID: CHEBI:63612
CAS Number: CAS 121032-29-9
TTD Drug ID: DMB6VEG
INTEDE Drug ID: DR1136

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting DNA synthesis (DNA synth)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glufosfamide	DMEFCTP	Pancreatic cancer	2C10	Phase 3	[5]
acelarin	DMY96O3	Biliary tract cancer	2C17	Phase 3	[5]
FF-10502-01	DMX5290	Lymphoma	2A80-2A86	Phase 1	[5]
TAR-200	DMSQZEP	Bladder cancer	2C94	Phase 1	[5]
CLOTURIN	DMKFMYR	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[6]
EPD-clofarabine	DM149HL	Solid tumour/cancer	2A00-2F9Z	Terminated	[7]
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Drug(s) Metabolized By Adenosine aminohydrolase (ADA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA synthesis (DNA synth)	TTUBNVO	NOUNIPROTAC	Binder	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Adenosine aminohydrolase (ADA)^{Main DME}	DEDQHBV	ADA_HUMAN	Substrate	[4]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7090).
2	Nelarabine FDA Label
3	Nelarabine. Drugs. 2008;68(4):439-47.
4	Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. Onco Targets Ther. 2009 Feb 18;2:219-28.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Inhibition of biosynthetic processes in P388 and Ehrlich ascites cells by cloturin. Drugs Exp Clin Res. 1988;14(9):575-80.
7	2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
8	A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15676-81.