General Information of Drug (ID: DMDBY30)

Drug Name
Nelipepimut S Drug Info
Synonyms E75
Indication
Disease Entry ICD 11 Status REF
Non-hodgkin lymphoma 2B33.5 Phase 3 [1]
Breast cancer 2C60-2C65 Phase 2 [2]
Gastric adenocarcinoma 2B72 Phase 1 [2]
Cross-matching ID
PubChem CID
9941306
CAS Number
CAS 160212-35-1
TTD Drug ID
DMDBY30

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [4]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [5]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [6]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [7]
NERATINIB MALEATE DMEDU7B HER2/NEU overexpressing breast cancer 2C60-2C65 Approved [8]
Margetuximab DMKEY6S HER2-positive breast cancer 2C60-2C65 Approved [9]
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [10]
Tucatinib DMBESUA HER2-positive breast cancer 2C60-2C65 Approved [11]
Pertuzumab DMHJV0X Adrenal gland neoplasm Approved [12]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Erbb2 tyrosine kinase receptor (HER2) TT6EO5L ERBB2_HUMAN Inhibitor [3]

References

1 ClinicalTrials.gov (NCT01479244) Efficacy and Safety Study of NeuVax (Nelipepimut-S or E75) Vaccine to Prevent Breast Cancer Recurrence. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 The HER2 peptide nelipepimut-S (E75) vaccine (NeuVax in breast cancer patients at risk for recurrence: correlation of immunologic data with clinical response. Immunotherapy. 2014;6(5):519-31.
4 Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):13-7.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7422).
6 Boehringer Ingelheim. Product Development Pipeline. June 2 2009.
7 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
8 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
9 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
10 Her2/neu is not a commonly expressed therapeutic target in melanoma -- a large cohort tissue microarray study. Melanoma Res. 2004 Jun;14(3):207-10.
11 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
12 Clinical pipeline report, company report or official report of Roche (2009).
13 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.