Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDJYHK)

• Drug Name: 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane Drug Info
• Synonyms: 1,2-DIBROMO-4-(1,2-DIBROMOETHYL)CYCLOHEXANE; 3322-93-8; Citex BCL 462; Saytex BCL 462; Cyclohexane, 1,2-dibromo-4-(1,2-dibromoethyl)-; 1-(1,2-Dibromoethyl)-3,4-dibromocyclohexane; Vinylcyclohexene tetrabromide; 1,2-DIBROMO-4-(1,2-DIBROMOETHYL)-CYCLOHEXANE; 4-(1,2-Dibromoethyl)-1,2-dibromocyclohexane; CCRIS 3743; HSDB 6146; EINECS 222-036-8; BRN 1927455; CHEMBL375107; AK-78933; C8H12Br4; TBECH; AC1L2COC; DSSTox_CID_4947; DSSTox_RID_77594; DSSTox_GSID_24947; MLS002454355; 3-05-00-00093 (Beilstein Handbook Reference); SCHEMBL332771

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 18728
  ChEBI ID: CHEMBL375107
  CAS Number: CAS 3322-93-8
  TTD Drug ID: DMDJYHK

Molecule-Related Drug Atlas

Drug(s) Targeting Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[4]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[5]
Darolutamide	DMV7YFT	Prostate cancer	2C82.0	Approved	[6]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[7]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[8]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[9]
Fludrocortisone	DMUDIR8	Addison disease	5A74.0	Approved	[10]
ARN-509	DMT81LZ	Acute myeloid leukaemia	2A60	Approved	[11]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[12]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[13]

Drug(s) Targeting Androgen receptor messenger RNA (AR mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[14]
BAY 86-5044	DMRZLU4	Breast cancer	2C60-2C65	Phase 2	[15]
TRC-253	DMXI8CD	Prostate cancer	2C82.0	Phase 1/2	[16]
IONIS-AR-2.5Rx	DMF2DMS	Prostate cancer	2C82.0	Phase 1/2	[17]
ISIS-AR	DM8P3N5	Prostate cancer	2C82.0	Phase 1	[18]
EZN-4176	DMNPS59	Prostate cancer	2C82.0	Phase 1	[19]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[20]
RU-58841	DMMEAZ2	Acne vulgaris	ED80	Discontinued in Phase 1	[21]
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[22]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[22]

Drug(s) Affected By Plastin-2 (LCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[3]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[27]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[31]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[37]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[38]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Androgen receptor (AR)	TTS64P2	ANDR_HUMAN	Inhibitor	[1]
Androgen receptor messenger RNA (AR mRNA)	TTKPW01	ANDR_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Plastin-2 (LCP1)	OTK61F2A	PLSL_HUMAN	Gene/Protein Processing	[2]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Gene/Protein Processing	[3]

References

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• [23] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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• [32] Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005 Aug;90(8):4858-65. doi: 10.1210/jc.2005-0330. Epub 2005 May 24.
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• [34] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [35] Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
• [36] Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurol Scand Suppl. 2009;(189):14-21.
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