Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME5Y64)

Drug Name
Tranilast Drug Info
Synonyms
tranilast; 53902-12-8; Rizaben; trans-Tranilast; Tranilastum; 70806-55-2; MK 341; N-(3,4-Dimethoxycinnamoyl)anthranilic acid; Tranilastum [INN-Latin]; Tranilast [USAN:INN:JAN]; Tranpro; UNII-HVF50SMY6E; SB-252218; MK-341; Tranilast (SB 252218); 3,4-DAA; n-(3',4'-dimethoxycinnamoyl) anthranilic acid; HVF50SMY6E; MLS000028468; CHEBI:77572; C18H17NO5; Anthranilic acid, N-(3,4-dimethoxycinnamoyl)-; NZHGWWWHIYHZNX-CSKARUKUSA-N; 2-((3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid; MFCD00864787; T 0318; NU-3450; Rizaben (TN); Tranilast (JAN/USAN/INN); Rizaben, SB 252218, MK 341, Tranpro ,Tranilast; N-(3',4'-dimethoxycinnamoyl) anthranilic acid; N-(3′ -Dimethoxycinnamoyl)anthranilic Acid; 2-({(2E)-3-[3,4-bis(methyloxy)phenyl]prop-2-enoyl}amino)benzoic acid; 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid; 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acid; Molecule 20
Indication
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Approved [1]
Ocular allergy 4A81 Approved [2]
Asthma CA23 Investigative [3]
Keloid EE60 Investigative [4]
Cross-matching ID
PubChem CID
5282230
ChEBI ID
CHEBI:77572
CAS Number
CAS 53902-12-8
TTD Drug ID
DME5Y64
INTEDE Drug ID
DR1628

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Steryl-sulfatase (STS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [11]
STX-140 DMJK5CT Osteoporosis FB83.0 Phase 2 [12]
PGL-2001 DMKA705 Endometriosis GA10 Phase 2 [13]
PGL-2 DMJTYO4 Endometriosis GA10 Phase 2 [13]
STX 64 DMJAPRK Prostate cancer 2C82.0 Phase 1 [14]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [15]
EMATE DMFQX1U Discovery agent N.A. Investigative [16]
Sulfamic acid 2-nonyl-4-oxo-4H-chromen-6-yl ester DMM70K1 Discovery agent N.A. Investigative [17]
Estradiol 17-O-sulfamate DM7K14V Discovery agent N.A. Investigative [12]
4-Sulfamoyloxy-benzoic acid pentyl ester DMZIFW7 Discovery agent N.A. Investigative [18]
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Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [19]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [20]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [21]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [22]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [23]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [21]
Doxepin DMPI98T Anxiety Approved [24]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [21]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [25]
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [26]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [28]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [40]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [39]
Verapamil DMA7PEW Angina pectoris BA40 Approved [41]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [42]
Estrone DM5T6US Acne vulgaris ED80 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [45]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [46]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [47]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [49]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [50]
Ethacrynic acid DM60QMR Edema MG29 Approved [51]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [52]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [53]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [54]
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Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [57]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [62]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [63]
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Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [9]
Carfilzomib DM48K0X Multiple myeloma 2A83 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [73]
Estrone DM5T6US Acne vulgaris ED80 Approved [74]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [75]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [76]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [77]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [78]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [79]
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Drug(s) Affected By Transient receptor potential cation channel subfamily V member 2 (TRPV2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [84]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [85]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [86]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [87]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [88]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [89]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Antagonist [5]
Steryl-sulfatase (STS) TTHM0R1 STS_HUMAN Inhibitor [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [9]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Gene/Protein Processing [9]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [9]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [9]
Transient receptor potential cation channel subfamily V member 2 (TRPV2) OT0A9AVD TRPV2_HUMAN Gene/Protein Processing [10]

References

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89 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.