Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEMRW0)

• Drug Name: Lipoteichoic acid Drug Info
• Synonyms: Oncomycin; Lipoteichoic acid (cancer); Lipoteichoic acid (cancer), Lunamed; TLR-2 modulator (subcutaneous, solid tumor), LUNAMeD; Toll like receptor-2 modulator (subcutaneous, solid tumor), LUNAMeD

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]

• Cross-matching ID:
  PubChem CID: 137349712
  CAS Number: CAS 56411-57-5
  TTD Drug ID: DMEMRW0

Molecule-Related Drug Atlas

Drug(s) Targeting Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cadi-05	DMPTCYB	Prostate cancer	2C82.0	Phase 3	[6]
MCS-18	DMX4U0B	Autoimmune diabetes	5A10	Phase 2	[7]
OPN-305	DM1IBRT	Myelodysplastic syndrome	2A37	Phase 2	[8]
MALP-2S	DMBZ68C	Pancreatic cancer	2C10	Phase 1/2	[9]
OM-174	DM2THBX	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
F-50040	DMMG6W5	Melanoma	2C30	Discontinued in Phase 1	[11]
S-(Dimethylarsenic)Cysteine	DMSCHL0	Discovery agent	N.A.	Investigative	[12]
CBLB-612	DMCFR8U	Radiation syndrome	NF00	Investigative	[13]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[14]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[21]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[22]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[23]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[24]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[26]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[27]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[28]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[31]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[29]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[32]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[36]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[37]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Toll-like receptor 2 (TLR2)	TTY7ZHS	TLR2_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Protein Interaction/Cellular Processes	[3]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Protein Interaction/Cellular Processes	[4]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Gene/Protein Processing	[5]

References

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