Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFETDK)

Drug Name
Artemisinin SP Drug Info
Synonyms
Isoguvacine; isoguvacine; 1,2,3,6-tetrahydropyridine-4-carboxylic acid; 64603-90-3; 1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid; 1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid; UNII-YTF580771Y; CHEMBL39071; CHEBI:34799; YTF580771Y; 4-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-; AC1OEMUS; 1,2,3,6-tetrahydropyridinium-4-carboxylate; 1,2,3,6-tetrahydropyridin-1-ium-4-carboxylate; Tocris-0235; Spectrum_001974; Lopac-G-002; AC1L1GNT; Spectrum3_001869; Biomol-NT_000254; AC1Q5QG1; Lopac0_000561; KBioSS_002540; BSPBio_003318; DivK1c_000115
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [1]
Cross-matching ID
PubChem CID
3765
ChEBI ID
CHEBI:34799
CAS Number
CAS 64603-90-3
TTD Drug ID
DMFETDK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [1]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [1]
Piperaquine DMT70RC Malaria 1F40-1F45 Approved [1]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [1]
OZ277 DM1YB0R Malaria 1F40-1F45 Approved [1]
Pyronaridine DMUWAM2 Malaria 1F40-1F45 Approved [1]
Vanadate DMQL0KF Psoriatic arthritis FA21 Phase 3 [3]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [4]
Cyclopiazonic acid DMPJ08G Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Targeting Glutamate receptor AMPA (GRIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [5]
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [6]
Zopiclone DMPI6Z0 Insomnia 7A00-7A0Z Approved [7]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [8]
Enflurane DM0YJSB Anaesthesia 9A78.6 Approved [9]
Isoflurane DMY6T31 Anaesthesia 9A78.6 Approved [10]
Bromazepam DMY9TCW Anxiety disorder 6B00-6B0Z Approved [11]
Dihydroergotoxine DM5D6WZ Alzheimer disease 8A20 Approved [12]
Barbiturate DMJIA6T Anaesthesia 9A78.6 Approved [13]
Fospropofol disodium DMKLJRD Monitored anaesthesia care N.A. Approved [14]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor AMPA (GRIA) TTAN6JD NOUNIPROTAC Agonist [2]
Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) TTZVSJ2 NOUNIPROTAC Inhibitor [1]

References

1 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
2 GABA(A) receptor ligands and their therapeutic potentials. Curr Top Med Chem. 2002 Aug;2(8):817-32.
3 Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms. J Biol Chem. 2001 Apr 6;276(14):10782-7.
4 Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase. Bioorg Med Chem. 2010 Aug 1;18(15):5634-46.
5 Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1. Br J Pharmacol. 2007 Nov;152(6):939-45.
6 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
7 Eszopiclone: its use in the treatment of insomnia. Neuropsychiatr Dis Treat. 2007 Aug;3(4):441-453.
8 Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats. Can J Anaesth. 2009 Feb;56(2):126-35.
9 Enflurane directly depresses glutamate AMPA and NMDA currents in mouse spinal cord motor neurons independent of actions on GABAA or glycine receptors. Anesthesiology. 2000 Oct;93(4):1075-84.
10 Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Res. 2005 Jan 25;1032(1-2):30-5.
11 Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups. Psychopharmacology (Berl). 2009 May;204(1):61-71.
12 Pharmacologic management of Alzheimer disease, Part II: Antioxidants, antihypertensives, and ergoloid derivatives. Ann Pharmacother. 1999 Feb;33(2):188-97.
13 Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79.
14 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015