Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG1DTE)

• Drug Name: Penfluridol Drug Info
• Synonyms: PENFLURIDOL; 26864-56-2; Semap; 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol; TLP-607; McN-JR-16,341; 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol; Penfluridolum [INN-Latin]; C28H27ClF5NO; UNII-25TLU22Q8H; R 16341; EINECS 248-074-5; R-16341; BRN 1558826; CHEMBL47050; 25TLU22Q8H; MDLAAYDRRZXJIF-UHFFFAOYSA-N; 4-Piperidinol, 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)-; 4-Piperidinol,; Hydroxamates

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Approved	[1]

• Cross-matching ID:
  PubChem CID: 33630
  ChEBI ID: CHEMBL47050
  CAS Number: CAS 26864-56-2
  TTD Drug ID: DMG1DTE

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated calcium channel alpha Cav3.1 (CACNA1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[4]
Ethosuximide	DMDZ9LT	Epilepsy	8A60-8A68	Approved	[5]
Trimethadione	DM0Q8MZ	Absence epilepsy		Approved	[6]
Paramethadione	DMR5ZUP	Absence epilepsy		Approved	[6]
Methsuximide	DM6L5VO	Absence epilepsy		Approved	[7]
PD-200390	DMPW28M	Insomnia	7A00-7A0Z	Phase 2	[8]
NGD 94-1	DMM1Y8F	Schizophrenia	6A20	Phase 1	[2]
ML218	DM3D21X	Discovery agent	N.A.	Investigative	[9]
KYS-05001	DM3MID9	Discovery agent	N.A.	Investigative	[10]
KYS-05077	DMHW40F	Discovery agent	N.A.	Investigative	[11]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[12]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[16]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[17]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[21]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, liver type (PFKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[29]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[30]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha Cav3.1 (CACNA1G)	TT729IR	CAC1G_HUMAN	Blocker	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-dependent 6-phosphofructokinase, liver type (PFKL)	OTVHGAT7	PFKAL_HUMAN	Gene/Protein Processing	[3]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[3]

References

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