Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGS4QH)

Drug Name

Methacholine Chloride Drug Info

Synonyms

Methacholine; methacholine; Acetylmethylcholine; Methacholin; Mecholine; Mecholin; Provocholine; Methacholinum; beta-Methylacetylcholine; 55-92-5; Choline, acetyl-beta-methyl-; Acetyl-beta-methylcholine; BRN 1769932; CHEBI:6804; 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; AMMONIUM, (2-HYDROXYPROPYL)TRIMETHYL-, ACETATE (ESTER); 2-acetyloxypropyl(trimethyl)azanium; C8H18NO2; AC1Q5XYD; AC1L1COQ; Prestwick2_000759; Prestwick0_000759; Prestwick3_000759; Prestwick1_000759; CHEMBL978; 2-(acetyloxy)-n,n,n-trimethylpropan-1-aminium; METHACHOLINE

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Approved	[1]
bronchial hyperreactivity	CB40	Approved	[2]

Cross-matching ID

PubChem CID: 6114
ChEBI ID: CHEMBL1200764
CAS Number: CAS 62-51-1
TTD Drug ID: DMGS4QH

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Muscarinic acetylcholine receptor M4 (CHRM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[6]
Tropicamide	DM1D90W	Mydriasis	LA11.62	Approved	[7]
Diphenidol	DMHPWOM	Nausea	MD90	Approved	[8]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one	DMM9X0G	Discovery agent	N.A.	Investigative	[9]
A-987306	DMU34BK	Discovery agent	N.A.	Investigative	[10]
ISOCLOZAPINE	DM52CPU	Discovery agent	N.A.	Investigative	[11]
FLUMEZAPINE	DMW0HOG	Discovery agent	N.A.	Investigative	[12]
ISOLOXAPINE	DMH1BN4	Discovery agent	N.A.	Investigative	[13]
Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester	DMVEH40	Discovery agent	N.A.	Investigative	[3]
GNF-PF-5618	DMT8VUS	Discovery agent	N.A.	Investigative	[14]
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Drug(s) Targeting Muscarinic acetylcholine receptor M2 (CHRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[6]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[15]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[16]
Gallamine Triethiodide	DMPO0MS	Stabilize muscle contraction	FB3Z	Approved	[17]
FP-1097	DMC1F2T	Urinary incontinence	MF50.2	Phase 2	[18]
PSD-506	DMT0KB1	Overactive bladder	GC50.0	Discontinued in Phase 2	[19]
Otenzepad	DMRXHAC	Heart failure	BD10-BD13	Discontinued in Phase 2	[20]
SCH-211803	DM92E0W	Parkinson disease	8A00.0	Discontinued in Phase 1	[21]
Alvameline	DMLN0Y5	Alzheimer disease	8A20	Terminated	[22]
HIMBACINE	DMGAKD8	N. A.	N. A.	Terminated	[23]
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Drug(s) Targeting Muscarinic acetylcholine receptor M3 (CHRM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolterodine	DMSHPW8	Overactive bladder	GC50.0	Approved	[24]
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[6]
Tiotropium	DMFDC0Q	Chronic obstructive pulmonary disease	CA22	Approved	[25]
Ipratropium	DMFQ320	Obstructive lung disease	CA22.Z	Approved	[26]
Darifenacin	DMWXLYZ	Overactive bladder	GC50.0	Approved	[27]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[15]
Solifenacin	DMG592Q	Overactive bladder	GC50.0	Approved	[28]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[29]
Cevimeline	DMWSMND	Sjogren syndrome	4A43.20	Approved	[30]
Methscopolamine Bromide	DMHP8FI	Nausea and vomiting	MD90	Approved	[31]
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Drug(s) Affected By Low affinity immunoglobulin epsilon Fc receptor (FCER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[37]
Nitrite	DMR5XT3	N. A.	N. A.	Investigative	[38]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M2 (CHRM2)	TTYEG6Q	ACM2_HUMAN	Inhibitor	[3]
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Modulator	[4]
Muscarinic acetylcholine receptor M4 (CHRM4)	TTQ3JTF	ACM4_HUMAN	Inhibitor	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Low affinity immunoglobulin epsilon Fc receptor (FCER2)	OTU40XWZ	FCER2_HUMAN	Gene/Protein Processing	[5]

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References

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2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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24	Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther. 2004 Jun;309(3):1148-53.
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26	Role of parasympathetic nerves and muscarinic receptors in allergy and asthma.Chem Immunol Allergy.2012;98:48-69.
27	M(1) and M(3) muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor. Pharmacol Res. 2009 May;59(5):300-5.
28	Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout ... Eur J Pharmacol. 2009 Aug 1;615(1-3):201-6.
29	Interaction of neuromuscular blocking drugs with recombinant human m1-m5 muscarinic receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1998 Nov;125(5):1088-94.
30	Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor ... Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G112-G123.
31	Agonist-regulated alteration of the affinity of pancreatic muscarinic cholinergic receptors. J Biol Chem. 1993 Oct 25;268(30):22436-43.
32	Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
33	Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
34	Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
35	Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
36	Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
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