Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHC2AW)

Drug Name

SPI-205 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Low-affinity nerve growth factor receptor (NGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cenegermin	DM8Y2RU	Neurotrophic keratitis	9A74	Approved	[3]
Fulranumab	DMK38MV	Arthralgia	ME82	Phase 3	[4]
LM11A-31	DM095HQ	Alzheimer disease	8A20	Phase 1/2	[5]
LM11A-31	DM095HQ	Alzheimer disease	8A20	Phase 1/2	[6]
Org-2766	DMVRA8N	Cognitive impairment	6D71	Discontinued in Phase 3	[7]
BU-4514N	DMJDMTK	Alzheimer disease	8A20	Terminated	[8]
ReN-1820	DMWIAUK	Cystitis	GC00	Terminated	[9]
CEP-427	DMTI10C	Alzheimer disease	8A20	Terminated	[4]
TDI-0059	DMSI9QM	Motor neurone disease	8B60	Investigative	[4]
Nerve growth factor conjugated RAP peptide	DM3AW8X	Neurodegenerative disorder	8A20-8A23	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Low-affinity nerve growth factor receptor (NGFR)	TTEDJN4	TNR16_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00041795) Neotrofin for Treatment of Chemotherapy-Induced Peripheral Neuropathy. U.S. National Institutes of Health.
2	AIT-082 NeoTherapeutics Inc. IDrugs. 1998 Oct;1(6):694-9.
3	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888).
5	Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.Neurobiol Aging.2013 Aug;34(8):2052-63.
6	Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62(8):1488-1500.
7	Effects of the ACTH4-9 analog Org2766 on brain plasticity: modulation of excitatory neurotransmission. Psychoneuroendocrinology. 1992 Aug;17(4):315-25.
8	A new neuritogenetic compound BU-4514N produced by Microtetraspora sp. J Antibiot (Tokyo). 1993 Jun;46(6):875-83.
9	Phosphorylation of Extracellular Signal-Regulated Kinases (pERK1/2) in Bladder Afferent Pathways with Cyclophosphamide (CYP)-Induced Cystitis. Neuroscience. 2009 November 10; 163(4): 1353-1362.