Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHN74V)

• Drug Name: Lanosterol Drug Info
• Synonyms: lanosterol; 79-63-0; Lanosterin; Lanster; Botalan base 138; Lanosta-8,24-dienol; Lanosta-8,24-dien-3beta-ol; (3beta)-lanosta-8,24-dien-3-ol; UNII-1J05Z83K3M; NSC60677; Botalan base; CHEBI:16521; Lanosta-8,24-dien-3.beta.-ol; CAHGCLMLTWQZNJ-BQNIITSRSA-N; 1J05Z83K3M; MFCD00021108; Lanostadien-3-beta-ol; NSC 60677; Lanosta-8,24-dien-3-ol, (3beta)-; Lanosta-8,24-dien-3-ol; Lanosta-8,24-dien-3-ol, (3.beta.)-; Lanosta-8,24-dien-3-beta-ol; 4,4',14alpha-Trimethyl-5alpha-cholesta-8,24-dien-3beta-ol; EINECS 201-214-9

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 246983
  ChEBI ID: CHEBI:16521
  CAS Number: CAS 79-63-0
  TTD Drug ID: DMHN74V
  INTEDE Drug ID: DR2470

Molecule-Related Drug Atlas

Drug(s) Targeting Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZD-9720	DMFV47R	Arteriosclerosis	BD40	Terminated	[8]
BIBB-515	DM6QT9P	Arteriosclerosis	BD40	Terminated	[9]
BIBX-79	DMRXWCO	Arteriosclerosis	BD40	Terminated	[10]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[2]
PMID22533316C1	DMYEMWB	Discovery agent	N.A.	Investigative	[11]
PMID22533316C4	DMW3UHO	Discovery agent	N.A.	Investigative	[11]
PMID9003518C4	DMYE64O	Discovery agent	N.A.	Investigative	[12]
29-methylidene-2,3-oxidosqualene	DMUQAP7	Discovery agent	N.A.	Investigative	[12]
Tetradecane	DMK8P61	Discovery agent	N.A.	Investigative	[2]
PMID9003518C3	DM1I578	Discovery agent	N.A.	Investigative	[12]

Drug(s) Metabolized By Cytochrome P450 51B1 (cyp51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrolanosterol	DMG0PXI	N. A.	N. A.	Investigative	[5]

Drug(s) Metabolized By Cytochrome P450 monooxygenase 51A (cyp51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrolanosterol	DMG0PXI	N. A.	N. A.	Investigative	[3] , [4]
Obtusifoldienol	DMA63FQ	N. A.	N. A.	Investigative	[3] , [4]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[13]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[6]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[15]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[17]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[18]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[13]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[6]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[23]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[27]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lanosterol synthase (LSS)	TT7O8ZA	ERG7_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 monooxygenase 51A (cyp51A)	DEVSF75	CP51A_ASPFU	Substrate	[3] , [4]
Cytochrome P450 51B1 (cyp51)	DEZNP5G	B2HH81_MYCMM	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)	OTBTA03N	MARH6_HUMAN	Protein Interaction/Cellular Processes	[6]
Sterol 26-hydroxylase, mitochondrial (CYP27A1)	OT649C01	CP27A_HUMAN	Regulation of Drug Effects	[7]

References

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