Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHVL0J)

Drug Name
Azelaic Acid Drug Info
Synonyms
AZA; Azelaic; Azelex; Finacea; Finevin; Skinorem; Skinoren; Acide azelaique; Acide azelaique [French]; Acido azelaico; Acido azelaico [Spanish]; Acidum azelaicum; Acidum azelaicum [Latin]; Anchoic acid; Azalaic Acid; Azelaic acid polyanhydride; Azelaic polyanhydride; Azelainic acid; Azleaic Acid; Heptanedicarboxylic acid; Lepargylic acid; NONANEDIOIC ACID; Nonanedioic acid; Polyazelaic anhydride; AZ1; Dicarboxylic acid C9; Emerox 1110; Emerox 1144; ZK 62498; A-9800; AGN-191861; Azelaic acid [USAN:INN]; Azelaic acid,technical grade; Azelex (TN); Finacea (TN); Finevin (TN); N-Nonanedioic acid; Nonanedioic acid, homopolymer; Poly(azelaic anhydride); SH-441; Skinoren (TN); ZK-62498; AZELAIC ACID, 95%; Azelaic acid (USAN/INN); Emery's L-110; 1,7-Heptanedicarboxylic acid; 1,9-Nonanedioic acid
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Therapeutic Class
Dermatologic Agents
Cross-matching ID
PubChem CID
2266
ChEBI ID
CHEBI:48131
CAS Number
CAS 123-99-9
TTD Drug ID
DMHVL0J
ACDINA Drug ID
D00854

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Finasteride DMWV3TZ Baldness, male pattern Approved [6]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [6]
Polyestradiol Phosphate DM0PMGJ Prostate cancer 2C82.0 Approved [7]
Dutasteride + tamsulosin DM6P8HU Benign prostatic hyperplasia GA90 Phase 3 [8]
Epristeride DM35T1O Hirsutism ED72 Phase 3 [9]
FK-143 DMEL15U Prostate disease GA91 Phase 2 [10]
Turosteride DMW7PFS Prostate disease GA91 Phase 2 [11]
IZONSTERIDE DM3KXMG Hirsutism ED72 Phase 1/2 [12]
ONO-3805 DM1RKWV Prostate disease GA91 Discontinued in Phase 3 [13]
CS-891B DM17I8O Alopecia ED70 Discontinued in Phase 2 [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [15]
Panobinostat DM58WKG Chronic graft versus host disease Approved [20]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [21]
Leflunomide DMR8ONJ Arthritis FA20 Approved [22]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [23]
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Drug(s) Affected By Tissue-type plasminogen activator (PLAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [25]
Etretinate DM2CZFA Keratosis ED56 Approved [26]
Prednisone DM2HG4X Acute asthma CA23 Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [31]
Fructose DM43AN2 Vomiting MD90 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
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Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [25]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [47]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [48]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [51]
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Drug(s) Affected By Guanine nucleotide-binding protein G(olf) subunit alpha (GNAL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Arsenic DMTL2Y1 N. A. N. A. Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [58]
Isoproterenol DMK7MEY Atrioventricular block Approved [3]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [59]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [60]
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Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-15 (GNA15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [62]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [63]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [64]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [66]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [62]
Caprylic acid DMLGS82 Discovery agent N.A. Investigative [3]
geraniol DMS3CBD Discovery agent N.A. Investigative [3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) TT2A0DR S5A1_HUMAN; S5A2_HUMAN; PORED_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Guanine nucleotide-binding protein G(olf) subunit alpha (GNAL) OTESDTEU GNAL_HUMAN Drug Response [3]
Guanine nucleotide-binding protein subunit alpha-15 (GNA15) OTFYRZGV GNA15_HUMAN Drug Response [3]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Gene/Protein Processing [4]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Gene/Protein Processing [5]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Gene/Protein Processing [5]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Gene/Protein Processing [5]

References

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4 Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation. Exp Dermatol. 2010 Sep;19(9):813-20. doi: 10.1111/j.1600-0625.2010.01107.x. Epub 2010 Jul 2.
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22 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
23 Atorvastatin affects several angiogenic mediators in human endothelial cells. Endothelium. 2005 Sep-Dec;12(5-6):233-41.
24 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
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27 Relation between long-term steroid treatment after heart transplantation, hypofibrinolysis and myocardial microthrombi generation. J Heart Lung Transplant. 1999 Jul;18(7):693-700. doi: 10.1016/s1053-2498(99)00021-2.
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31 Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
32 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
33 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
34 Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res. 2010 Oct;27(10):2162-74. doi: 10.1007/s11095-010-0219-2. Epub 2010 Jul 29.
35 Association of cell cycle arrest with anticancer drug-induced epithelial-mesenchymal transition in alveolar epithelial cells. Toxicology. 2019 Aug 1;424:152231. doi: 10.1016/j.tox.2019.06.002. Epub 2019 Jun 4.
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37 Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. Thromb Res. 2007;121(1):59-65. doi: 10.1016/j.thromres.2007.02.001. Epub 2007 Mar 26.
38 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
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40 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
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52 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
53 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
54 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
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56 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
57 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
58 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
59 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
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65 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
66 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.